DOSIMETRY OF LASER-TISSUE INTERACTIONS

  • Jacques, Steven, (PI)

Project: Research project

Description

The proposed research will integrate experimental and theoretical
descriptions of the dosimetry of laser and conventional light sources for
therapeutic and diagnostic applications in medicine. One goal is the
development of experimental techniques to specify tissue optical
properties, and measurement of a variety of tissue types to yield a LIBRARY
of tissue optical properties over the ultraviolet-visible-near infrared
spectrum. A second goal is COMPUTER SIMULATION OF RADIATIVE TRANSPORT in
complex turbid tissues. Steady-state dosimetry will be studied in
homogeneous and heterogeneous tissues for variable boundary conditions and
geometries of irradiation. Time-variant dosimetry will be studied in which
thermally induced changes in tissue optical properties dynamically alter
dosimetry during the laser exposure. The research involves computer
simulations, phantom tissue models, and in vitro and in vivo animal
experiments. The research goals would aid the development of therapeutic
protocols and optical devices for dosimetry and diagnostics. Three
clinical situations will be considered to focus the general concepts: (1)
laser therapy of portwine stain lesions, (2) screening pigmented nevi for
melanoma. and (3) NdYAG irradiation of bladder and prostate during surface
cooling by irrigation. The work will be conducted in a basic research
laboratory within a hospital environment and motivated to yield information
pertinent to practical clinical applications.
StatusFinished
Effective start/end date4/1/913/31/97

Funding

  • National Institutes of Health: $93,956.00
  • National Institutes of Health: $103,402.00
  • National Institutes of Health
  • National Institutes of Health: $95,112.00
  • National Institutes of Health

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dosimeters
lasers
interactions
optical properties
irrigation
irradiation
bladder
medicine
lesions
therapy
light sources
screening
computerized simulation
boundary conditions

ASJC

  • Medicine(all)