DISCRIMINATIVE STIMULUS EFFECTS OF ETHANOL

    Project: Research project

    Description

    The overall goal of the proposed research is to assess the contribution
    of several receptor systems in mediating the interoceptive effects of a
    low and a moderate dose of ethanol in male and female non human primates.
    The interoceptive, or subjective, stimulus effects of ethanol can
    function as discriminative stimuli using drug discrimination procedures
    and can be used to evaluate possible receptor mechanisms implicated in
    mediating of these effects. Recent studies have suggested several
    receptor systems may mediate the discriminative stimulus effects of
    ethanol, including the GABA(A) receptor complex, the NMDA subtype of
    glutamate receptor complex, the 5-HT3 and 5-HT1 subtypes of serotonin
    receptors. However, very little information is available concerning the
    receptor systems that mediate the discriminative effects of ethanol in
    non human primates. The degree to which data gathered on the
    pharmacological basis of the ethanol cue in rodents extends to primates
    is important to evaluate, particularly considering at least one of the
    receptor systems (5-HT1B) suggested to mediate a component of the
    discriminative stimulus effects of ethanol shows species specificity.
    Therefore, it remains to be determined (1) whether the same receptor
    systems mediate the ethanol due in rodents and primates, and (2) the
    dose-dependent nature of the ethanol cue in primates. Furthermore,
    virtually all the data gathered on the discriminative stimulus effects
    of ethanol have been in male subjects. We propose to characterize the
    pharmacological basis of the discriminative effects of ethanol in both
    male and female of a species that has a estrous cycle similar to that of
    humans. To accomplish the goals of the proposed research, male and
    female cynomolgus monkeys (Macaca fascicularis) will be used.
    StatusFinished
    Effective start/end date9/30/913/31/06

    Funding

    • National Institutes of Health: $235,836.00
    • National Institutes of Health: $45,648.00
    • National Institutes of Health: $145,132.00
    • National Institutes of Health: $250,733.00
    • National Institutes of Health: $229,168.00
    • National Institutes of Health
    • National Institutes of Health
    • National Institutes of Health: $223,263.00
    • National Institutes of Health: $197,264.00
    • National Institutes of Health
    • National Institutes of Health: $157,243.00

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    Ethanol
    GABA-A Receptors
    Primates
    Neurotransmitter Agents
    Macaca fascicularis
    Menstrual Cycle
    N-Methylaspartate
    Research
    Cues
    Rodentia
    Pharmacology
    Species Specificity
    Serotonin Receptors
    Estrous Cycle
    N-Methyl-D-Aspartate Receptors
    Pharmaceutical Preparations
    Serotonin 5-HT1 Receptors

    ASJC

    • Medicine(all)