• Maurer, Richard (PI)
  • Sandra, Alexander (PI)
  • Donelson, John (PI)
  • Walder, Joseph (PI)
  • Bar, Robert (PI)
  • Feldbush, Thomas (PI)
  • Feldman, Ross (PI)
  • Yorek, Mark Anthony (PI)
  • Ginsberg, Barry (PI)

Project: Research project

Project Details


The purpose of this Center is to provide a multidisciplinary approach to
hormone action. The research theme is the cellular and subcellular
mechanism of action of insulin and insulin-like growth factors, but we also
study the mechanisms of action of steroid hormones and cyclic nucleotides,
giving a comprehensive approach to hormone action. The Center consists of several components. Resources include five Cores:
Administrative Services; Computer Services; Cell Biology (Media and Cell
Production and Monoclonal Antibody Production); Membrane Biology (Central
Facility for Peptide Iodination, Membrane Preparation and Analysis and
Receptor Localization); and Molecular Biology (Recombinant DNA and DNA
synthesis). These will be supplemented by an Enrichment Program (seminar
speakers and topical workshops) and a Pilot and Feasibility Program
(supports pilot studies related to the Center theme). This Center will benefit our work in the following ways: (1) The
multidisciplinary approach will afford us the talent and techniques
required for the contemporary approach to hormone action; (2) the
Enrichment Program and the communication through the Core facilities will
lead to collaboration and hence increased productivity; (3) the Core
resources will provide services not currently available and will allow us
to centralize many duplicated functions; and (4) the Center will allow us,
through the pilot studies, to test new ideas in insulin action and to
attact new investigators into this field.
Effective start/end date4/1/793/31/87


  • National Institutes of Health


  • Medicine(all)


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