Chitosan Endoluminal Hemostatic Dressing

Project: Research project

Description

DESCRIPTION (provided by applicant): HemCon, Inc. PA-08-051 Chitosan Endoluminal Hemostatic Dressing Project Summary Abstract P.I. - Hua Xie Page 1 Co-PI - Simon McCarthy Abstract The goal of this proposal is to demonstrate Phase I feasibility of a chitosan endoluminal hemostatic dressing (CEHD) that can be delivered through a Foley catheter to control and prevent urethral bleeding in a swine model. This swine model is a model of efficacy of blocking hemorrhage associated with transurethral resection of the prostate (TURP). TURP is the first line surgical treatment for benign prostate hyperplasia (BPH). TURP is performed about 100,000 times per year in the US. Post-operative hemorrhage after TURP is one of the major causes of prolonged catheterization and hospitalization, occurring in 6-10% of patients. Our device will be used to place a relatively inexpensive proprietary bandage via the catheter to prevent prolonged bleeding. This would allow for early catheter removal, improved patient comfort, accelerated recovery and significantly reduced hospital costs due to shorter hospital stays. Proprietary chitosan based dressings have been developed by HemCon and are FDA approved for controlling hemorrhage, especially on the battlefield. We have adapted the HemCon dressing as the CEHD to enable it to be used to control bleeding and facilitate surgery in the TURP procedure. Modifications to the HemCon dressing have been reduction in wall thickness (from 1.2 mm to ~200
StatusFinished
Effective start/end date4/1/078/31/17

Funding

  • National Institutes of Health: $424,827.00
  • National Institutes of Health: $467,742.00
  • National Institutes of Health: $226,185.00
  • National Institutes of Health: $467,742.00

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Chitosan
Hemostatics
Bandages
Hemorrhage
Transurethral Resection of Prostate
Neck Injuries
Length of Stay
Catheters
Urinary Bladder
Swine
Equipment and Supplies
Tissue Adhesions
Urinary Catheterization
Safety
Urinary Catheters
Hospitalization
Indwelling Catheters
Hematuria
Patient Care

ASJC

  • Medicine(all)