CENTRAL VEIN OCCLUSION STUDY - PARTICIPATING CENTER

Project: Research project

Description

This application is for a participating center of a national
collaborative randomized controlled clinical trial of
photocoagulation treatment for central vein occlusion. The study
will be conducted at 8 clinical centers with the Reading Center at
the Bascom Palmer Eye Institute (University of Miami), and the
Coordinating Center at Scott and White Hospital in Temple, Texas
(Texas A&M University). Patients will be entered into four study
groups: Non-perfused (Group N); Macular Edema (Group M);
Perfused (Group P); and Indeterminant (Group I). Eyes in the first
two groups will be randomly assigned to photocoagulation
treatment and a control group. Patients in Groups P and I will be
followed for natural history and for possible later entry into the
randomized study. Estimated recruitment is 240 patients in
Group N; 480 in Group P and 240 in Group I. Approximately 50%
of these patients will also qualify for Group M. Patients will be
recruited for the first three years of this five year study, and all
patients will be followed until termination of the study. The
study is designed to provide information regarding whether or not
photocoagulation is efficacious in preventing neovascular
glaucoma in eyes with central vein occlusion and retinal non-
perfusion, central vein occlusion and macular edema. Information
collected at base line and each follow-up visit will be forwarded
to the Coordinating Center for processing and analysis.
Photographs will be reviewed at the Reading Center to ascertain
eligibility and adequacy of treatment. A Data Monitoring
Committee will review interim results of the study every six
months.
StatusFinished
Effective start/end date3/1/882/28/94

Funding

  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $123,876.00
  • National Institutes of Health: $110,100.00

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Veins
Macular Edema
Reading
Retinal Vein
Natural History
Randomized Controlled Trials
Control Groups
Therapeutics

Keywords

  • Medicine(all)