• Adelman, John (PI)

Project: Research project

Project Details


DESCRIPTION Large conductance,
calcium-activated potassium channels (BK) are widely distributed and
fundamentally important to excitable and secretory cells. These channels
comprise a large and diverse class which respond to a combination of
voltage and calcium, and possess a large unit conductance (130-300 pS).
Through sensitivity to calcium, a major intracellular messenger,
calcium-activated potassium channels serve to link basic cellular
metabolism to membrane potential. BK channels are present in neurons where
they contribute to the repolarizing phase of the action potential, and
possibly to transmitter secretion. They are also found in striated and
smooth muscle, endocrine and exocrine gland cells, kidney tubules and
epithelia. BK channel activity is absolutely dependent upon intracellular
calcium, but can be modulated by G-proteins and phosphorylation. These investigators have cloned and expressed a large family of BK-like
calcium-activated potassium channels from Drosophila. Although they share
an overall architecture with other cloned potassium channels, they differ
significantly in primary sequence and many fundamental functional aspects.
They propose to use an integrated combination of electrophysiology,
molecular biology, and biochemistry to: 1. Determine the mechanisms by
which calcium effects channel gating. 2. Determine the molecular basis of
the large unit conductance of these channels, and 3. Determine the
structure and function of mammalian calcium-activated potassium channels.
Effective start/end date3/6/942/28/98


  • National Institutes of Health: $251,220.00


  • Medicine(all)
  • Neuroscience(all)


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