• Dawson, David (PI)
  • Zadunaisky, Jose (PI)
  • Kleinzeller, Arnost (PI)
  • Shuttleworth, Trevor (PI)
  • Greger, Rainer (PI)
  • Dawson, David (PI)
  • Stokes, John (PI)
  • Goldstein, Leon (PI)
  • Charney, Alan (PI)
  • Kleinzeller, Arnost (PI)
  • Stolte, Hilmar (PI)
  • Epstein, Franklin (PI)
  • Evans, David (PI)
  • Evans, David (PI)
  • Barnes, David (PI)
  • Henson, John (PI)
  • Kinne, Rolf (PI)
  • Kinne, Rolf (PI)
  • Preston, Robert (PI)
  • Silva, Patricio (PI)
  • Kent, Barbara (PI)
  • Forrest, John (PI)
  • Ausiello, Dennis (PI)
  • Boyer, James (PI)

Project: Research project

Project Details


A Marine and Freshwater Biomedical Sciences Specialized Center of Research
is proposed which will utilize components of the administration,
facilities, and scientific staff of the Mt. Desert Island Biological
Laboratory. The MFBS SCOR will provide the administrative and technical
assistance, experimental animals, supplies, and capital equipment to
promote the interaction, collaboration, and training of biomedical
scientists (both clinicians and physiologists) investigating the toxic
effects of heavy metals on membrane function. In addition, it will provide
for the rapid dissemination of data derived from these studies. Animal
systems will be used which model both passive and active membrane transport
processes found in the human renal, intestinal and hepatic
epithelia--tissues with known sensitivity to heavy metal toxicity.
Specifically, research groups will examine the effects of heavy metals on:
1. Transport of ammonia, H, and HCO3 across the fish gill; 2. Transport of
K by the fish urinary bladder; 3. Transport of glucose and amino acids
across flounder renal microvesicles, and cotransport of NaCl/KC1 across
shark rectal gland microvesicles; 4. Transport of NaCl/KC1 across isolated
rectal gland tubules; 5. Maintenance of intracellular pH, Ca concentration,
and membrane PD in isolated rectal gland cells; 6. Cellular work of
isolated, perfused, and in vitro rectal gland; 7. Transport of amino acids
across the fish gut; 8. Volume regulation by rectal gland cells; 9.
Stimulus/response coupling of hormonal stimulation of transport of Cl, and
vasoactivity, of fish gills; 10. Transport pathways for Na, K and Cl across
the fish urinary bladder; 11. Glomerular permeability of the hagfish
kidney; 12. Transport of Na and Cl across the fish gill; 13. Transport of
Na and Cl across the fish cornea; as well as, 14. The mode of transport of
methlymercury across the hepatic duct epithelium. It is proposed that this MFBS SCOR will provide a unique milieu for
research and training of present and future biomedical scientists
interested in the cellular and sub-cellular mechanisms of the toxic effects
of heavy metals.
Effective start/end date9/27/853/31/10


  • National Institutes of Health


  • Environmental Science(all)
  • Medicine(all)


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