4 TELSA MRI BOLUS CR STUDIES OF HUMAN BBB PERMEABILITY

Project: Research project

Description

DESCRIPTION The long-term goal is advancement of dynamic-contrast-enhanced [bolus-tracking (B-T)] MRI - the high (time/space) resolution recording of contrast reagent (CR) passage following bolus injection. Though applied to all tissues, the low-MW Gd(111) chelates are particularly good probes for blood-brain-barrier (BBB) integrity. Even slight compromises of the para(endothelial)cellular pathway defining BBB tightness are detected. Basic B-T pharmacokinetic parameters (CR as tracer) measure: a) perfusion CR delivery, b) capillary wall CR permeability, and c) CR-accessible (interstitial) space. These lead to efficacious B-T studies of multiple sclerosis (MS) white matter (WM) lesions and brain tumors. The usual determination of concentration, [CR], from a linear relationship with the measured longitudinal tissue 'H2O relaxation time (T') reciprocal requires the fast exchange limit (FXL) for equilibrium transcytolemmal water exchange. But, new results show that (though fast) the system departs the FXL at very low tissue [CR]s (
StatusFinished
Effective start/end date4/15/012/29/16

Funding

  • National Institutes of Health: $320,791.00
  • National Institutes of Health: $358,388.00
  • National Institutes of Health: $319,744.00
  • National Institutes of Health: $321,897.00
  • National Institutes of Health: $333,399.00
  • National Institutes of Health: $376,261.00
  • National Institutes of Health: $312,772.00
  • National Institutes of Health: $381,479.00
  • National Institutes of Health: $392,752.00
  • National Institutes of Health: $511,768.00

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Blood-Brain Barrier
Permeability
Pharmacokinetics
Multiple Sclerosis
Brain
Water
Brain Neoplasms
Magnetic Fields
Injections
Polymerase Chain Reaction
Perfusion
Physical Chemistry
Pathology
Biophysics
Molecular Probes

ASJC

  • Medicine(all)
  • Neuroscience(all)