Yiu Huen Tsang

Research Assistant Professor

  • 543 Citations
  • 12 h-Index
20072019
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Research Output 2007 2019

  • 543 Citations
  • 12 h-Index
  • 16 Article
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Article
2019

A-to-I-edited miRNA-379-5p inhibits cancer cell proliferation through CD97-induced apoptosis

Xu, X., Wang, Y., Mojumdar, K., Zhou, Z., Jeong, K. J., Mangala, L. S., Yu, S., Tsang, Y. H., Rodriguez-Aguayo, C., Lu, Y., Lopez-Berestein, G., Sood, A. K., Mills, G. B. & Liang, H., Dec 2 2019, In : Journal of Clinical Investigation. 129, 12, p. 5343-5356 14 p.

Research output: Contribution to journalArticle

Open Access
MicroRNAs
Cell Proliferation
Apoptosis
RNA Editing
Neoplasms
2018
27 Citations (Scopus)

A-to-I RNA Editing Contributes to Proteomic Diversity in Cancer

Peng, X., Xu, X., Wang, Y., Hawke, D. H., Yu, S., Han, L., Zhou, Z., Mojumdar, K., Jeong, K. J., Labrie, M., Tsang, Y. H., Zhang, M., Lu, Y., Hwu, P., Scott, K. L., Liang, H. & Mills, G., May 14 2018, In : Cancer Cell. 33, 5, p. 817-828.e7

Research output: Contribution to journalArticle

RNA Editing
Proteomics
Neoplasms
Amino Acid Sequence
Proteins
20 Citations (Scopus)

Comprehensive Molecular Characterization of the Hippo Signaling Pathway in Cancer

The Cancer Genome Atlas Research Network, Oct 30 2018, In : Cell Reports. 25, 5, p. 1304-1317.e5

Research output: Contribution to journalArticle

Genes
Neoplasms
Squamous Cell Neoplasms
Tumors
Atlases
2 Citations (Scopus)

In vivo screening identifies GATAD2B as a metastasis driver in KRAS-driven lung cancer

Grzeskowiak, C. L., Kundu, S. T., Mo, X., Ivanov, A. A., Zagorodna, O., Lu, H., Chapple, R. H., Tsang, Y. H., Moreno, D., Mosqueda, M., Eterovic, K., Fradette, J. J., Ahmad, S., Chen, F., Chong, Z., Chen, K., Creighton, C. J., Fu, H., Mills, G., Gibbons, D. L. & 1 others, Scott, K. L., Dec 1 2018, In : Nature Communications. 9, 1, 2732.

Research output: Contribution to journalArticle

metastasis
lungs
Lung Neoplasms
Screening
screening
14 Citations (Scopus)

RNA editing derived epitopes function as cancer antigens to elicit immune responses

Zhang, M., Fritsche, J., Roszik, J., Williams, L. J., Peng, X., Chiu, Y., Tsou, C. C., Hoffgaard, F., Goldfinger, V., Schoor, O., Talukder, A., Forget, M. A., Haymaker, C., Bernatchez, C., Han, L., Tsang, Y. H., Kong, K., Xu, X., Scott, K. L., Singh-Jasuja, H. & 5 others, Lizee, G., Liang, H., Weinschenk, T., Mills, G. & Hwu, P., Dec 1 2018, In : Nature Communications. 9, 1, 3919.

Research output: Contribution to journalArticle

RNA Editing
editing
antigens
peptides
Epitopes
38 Citations (Scopus)

Systematic Functional Annotation of Somatic Mutations in Cancer

Ng, P. K. S., Li, J., Jeong, K. J., Shao, S., Chen, H., Tsang, Y. H., Sengupta, S., Wang, Z., Bhavana, V. H., Tran, R., Soewito, S., Minussi, D. C., Moreno, D., Kong, K., Dogruluk, T., Lu, H., Gao, J., Tokheim, C., Zhou, D. C., Johnson, A. M. & 20 others, Zeng, J., Ip, C. K. M., Ju, Z., Wester, M., Yu, S., Li, Y., Vellano, C. P., Schultz, N., Karchin, R., Ding, L., Lu, Y., Cheung, L. W. T., Chen, K., Shaw, K. R., Meric-Bernstam, F., Scott, K. L., Yi, S., Sahni, N., Liang, H. & Mills, G., Mar 12 2018, In : Cancer Cell. 33, 3, p. 450-462.e10

Research output: Contribution to journalArticle

Mutation
Neoplasms
Gene Amplification
Gene Fusion
Point Mutation
2017
91 Citations (Scopus)

A Pan-Cancer Proteogenomic Atlas of PI3K/AKT/mTOR Pathway Alterations

Zhang, Y., Kwok-Shing Ng, P., Kucherlapati, M., Chen, F., Liu, Y., Tsang, Y. H., de Velasco, G., Jeong, K. J., Akbani, R., Hadjipanayis, A., Pantazi, A., Bristow, C. A., Lee, E., Mahadeshwar, H. S., Tang, J., Zhang, J., Yang, L., Seth, S., Lee, S., Ren, X. & 22 others, Song, X., Sun, H., Seidman, J., Luquette, L. J., Xi, R., Chin, L., Protopopov, A., Westbrook, T. F., Shelley, C. S., Choueiri, T. K., Ittmann, M., Van Waes, C., Weinstein, J. N., Liang, H., Henske, E. P., Godwin, A. K., Park, P. J., Kucherlapati, R., Scott, K. L., Mills, G., Kwiatkowski, D. J. & Creighton, C. J., Jun 12 2017, In : Cancer Cell. 31, 6, p. 820-832.e3

Research output: Contribution to journalArticle

Atlases
Phosphatidylinositol 3-Kinases
Mutation
Neoplasms
Gene Frequency
8 Citations (Scopus)

Engineering and functional characterization of fusion genes identifies novel oncogenic drivers of cancer

Lu, H., Villafane, N., Dogruluk, T., Grzeskowiak, C. L., Kong, K., Tsang, Y. H., Zagorodna, O., Pantazi, A., Yang, L., Neill, N. J., Kim, Y. W., Creighton, C. J., Verhaak, R. G., Mills, G., Park, P. J., Kucherlapati, R. & Scott, K. L., Jul 1 2017, In : Cancer Research. 77, 13, p. 3502-3512 11 p.

Research output: Contribution to journalArticle

Gene Fusion
Oncogene Fusion
Neoplasms
Mutation
Proto-Oncogene Proteins B-raf
40 Citations (Scopus)

Systematic characterization of A-to-I RNA editing hotspots in microRNAs across human cancers

Wang, Y., Xu, X., Yu, S., Jeong, K. J., Zhou, Z., Han, L., Tsang, Y. H., Li, J., Chen, H., Mangala, L. S., Yuan, Y., Eterovic, A. K., Lu, Y., Sood, A. K., Scott, K. L., Mills, G. & Liang, H., Jul 1 2017, In : Genome Research. 27, 7, p. 1112-1125 14 p.

Research output: Contribution to journalArticle

RNA Editing
Inosine
MicroRNAs
Adenosine
Neoplasms
2016
27 Citations (Scopus)

Functional annotation of rare gene aberration drivers of pancreatic cancer

Tsang, Y. H., Dogruluk, T., Tedeschi, P. M., Wardwell-Ozgo, J., Lu, H., Espitia, M., Nair, N., Minelli, R., Chong, Z., Chen, F., Chang, Q. E., Dennison, J. B., Dogruluk, A., Li, M., Ying, H., Bertino, J. R., Gingras, M. C., Ittmann, M., Kerrigan, J., Chen, K. & 4 others, Creighton, C. J., Eterovic, K., Mills, G. & Scott, K. L., Jan 25 2016, In : Nature Communications. 7, 10500.

Research output: Contribution to journalArticle

annotations
Molecular Sequence Annotation
Aberrations
Pancreatic Neoplasms
genes
2015
44 Citations (Scopus)

Identification of variant-specific functions of PIK3CA by rapid phenotyping of rare mutations

Dogruluk, T., Tsang, Y. H., Espitia, M., Chen, F., Chen, T., Chong, Z., Appadurai, V., Dogruluk, A., Eterovic, A. K., Bonnen, P. E., Creighton, C. J., Chen, K., Mills, G. & Scott, K. L., Dec 15 2015, In : Cancer Research. 75, 24, p. 5341-5354 14 p.

Research output: Contribution to journalArticle

Mutation
Neoplasms
Mutation Rate
Mitogen-Activated Protein Kinase 1
Proteomics
157 Citations (Scopus)

The Genomic Landscape and Clinical Relevance of A-to-I RNA Editing in Human Cancers

Han, L., Diao, L., Yu, S., Xu, X., Li, J., Zhang, R., Yang, Y., Werner, H. M. J., Eterovic, A. K., Yuan, Y., Li, J., Nair, N., Minelli, R., Tsang, Y. H., Cheung, L. W. T., Jeong, K. J., Roszik, J., Ju, Z., Woodman, S. E., Lu, Y. & 4 others, Scott, K. L., Li, J. B., Mills, G. & Liang, H., Oct 12 2015, In : Cancer Cell. 28, 4, p. 515-528 14 p., 2143.

Research output: Contribution to journalArticle

RNA Editing
Inosine
Adenosine
Neoplasms
Atlases
2014
6 Citations (Scopus)

Salt-inducible kinase 3 is a novel mitotic regulator and a target for enhancing antimitotic therapeutic-mediated cell death

Chen, H., Huang, S., Han, X., Zhang, J., Shan, C., Tsang, Y. H., Ma, H. T. & Poon, R. Y. C., Jan 1 2014, In : Cell Death and Disease. 5, 4, e1177.

Research output: Contribution to journalArticle

Open Access
Antimitotic Agents
Cell Death
Phosphotransferases
Salts
Therapeutics
2012
12 Citations (Scopus)

Novel Functions of the Phosphatase SHP2 in the DNA Replication and Damage Checkpoints

Tsang, Y. H., Han, X., Man, W. Y., Lee, N. & Poon, R. Y. C., Nov 26 2012, In : PloS one. 7, 11, e49943.

Research output: Contribution to journalArticle

Open Access
Non-Receptor Type 11 Protein Tyrosine Phosphatase
DNA replication
DNA Replication
DNA damage
DNA Damage
2009
40 Citations (Scopus)
Open Access
Cyclin A2
Anaphase-Promoting Complex-Cyclosome
Cyclin-Dependent Kinase 2
Mitosis
CDC2 Protein Kinase
2007
17 Citations (Scopus)

An inducible system for expression and validation of the specificity of short hairpin RNA in mammalian cells

Ma, H. T., On, K. F., Tsang, Y. H. & Poon, R. Y. C., Feb 1 2007, In : Nucleic acids research. 35, 4, e22.

Research output: Contribution to journalArticle

Open Access
Small Interfering RNA
Complementary DNA
RNA Interference
Cell Line
Proteins