Xiao-Xin Sun

Assistant Professor

  • 1664 Citations
  • 19 h-Index
20042020

Research output per year

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Research Output

  • 1664 Citations
  • 19 h-Index
  • 30 Article
  • 4 Comment/debate
  • 1 Review article
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Article
Article

5-fluorouracil activation of p53 involves an MDM2-ribosomal protein interaction

Sun, X. X., Dai, M. S. & Lu, H., Mar 16 2007, In : Journal of Biological Chemistry. 282, 11, p. 8052-8059 8 p.

Research output: Contribution to journalArticle

117 Scopus citations

Aberrant expression of nucleostemin activates p53 and induces cell cycle arrest via inhibition of MDM2

Dai, M. S., Sun, X. X. & Lu, H., Jul 2008, In : Molecular and cellular biology. 28, 13, p. 4365-4376 12 p.

Research output: Contribution to journalArticle

141 Scopus citations

Deregulating MYC in a model of HER2+ breast cancer mimics human intertumoral heterogeneity

Risom, T., Wang, X., Liang, J., Zhang, X., Pelz, C., Campbell, L. G., Eng, J., Chin, K., Farrington, C., Narla, G., Langer, E. M., Sun, X. X., Su, Y., Daniel, C. J., Dai, M. S., Löhr, C. V. & Sears, R. C., Jan 2 2020, In : Journal of Clinical Investigation. 130, 1, p. 231-246 16 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Deubiquitinating c-Myc: USP36 steps up in the nucleolus

Sun, X. X., Sears, R. C. & Dai, M. S., Jan 1 2015, In : Cell Cycle. 14, 24, p. 3786-3793 8 p.

Research output: Contribution to journalArticle

14 Scopus citations

Fkbp1a controls ventricular myocardium trabeculation and compaction by regulating endocardial Notch1 activity

Chen, H., Zhang, W., Sun, X., Yoshimoto, M., Chen, Z., Zhu, W., Liu, J., Shen, Y., Yong, W., Li, D., Zhang, J., Lin, Y., Li, B., VanDusen, N. J., Snider, P., Schwartz, R. J., Conway, S. J., Field, L. J., Yoder, M. C., Firulli, A. B. & 3 others, Carlesso, N., Towbin, J. A. & Shou, W., May 1 2013, In : Development (Cambridge). 140, 9, p. 1946-1957 12 p.

Research output: Contribution to journalArticle

46 Scopus citations

Identification and characterization of a novel Drosophila melanogaster glutathione S-transferase-containing FLYWCH zinc finger protein

Dai, M. S., Sun, X. X., Qin, J., Smolik, S. M. & Lu, H., Nov 1 2004, In : Gene. 342, 1, p. 49-56 8 p.

Research output: Contribution to journalArticle

11 Scopus citations

Identification and characterization of nuclear and nucleolar localization signals in the adeno-associated virus serotype 2 assembly-activating protein

Earley, L. F., Kawano, Y., Adachi, K., Sun, X. X., Dai, M. S. & Nakai, H., 2015, In : Journal of virology. 89, 6, p. 3038-3048 11 p.

Research output: Contribution to journalArticle

22 Scopus citations

Inhibition of c-Myc activity by ribosomal protein L11

Dai, M. S., Arnold, H., Sun, X. X., Sears, R. & Lu, H., Jul 25 2007, In : EMBO Journal. 26, 14, p. 3332-3345 14 p.

Research output: Contribution to journalArticle

124 Scopus citations

Interplay between hypoxia and androgen controls a metabolic switch conferring resistance to androgen/AR-targeted therapy

Geng, H., Xue, C., Mendonca, J., Sun, X. X., Liu, Q., Reardon, P. N., Chen, Y., Qian, K., Hua, V., Chen, A., Pan, F., Yuan, J., Dang, S., Beer, T. M., Dai, M. S., Kachhap, S. K. & Qian, D. Z., Dec 1 2018, In : Nature communications. 9, 1, 4972.

Research output: Contribution to journalArticle

9 Scopus citations

Interplay between ribosomal protein S27a and MDM2 protein in p53 activation in response to ribosomal stress

Sun, X. X., DeVine, T., Challagundla, K. B. & Dai, M. S., Jul 1 2011, In : Journal of Biological Chemistry. 286, 26, p. 22730-22741 12 p.

Research output: Contribution to journalArticle

60 Scopus citations

MDMX promotes proteasomal turnover of p21 at G1 and early S phases independently of, but in cooperation with, MDM2

Jin, Y., Zeng, S. X., Sun, X. X., Lee, H., Blattner, C., Xiao, Z. & Lu, H., Feb 2008, In : Molecular and cellular biology. 28, 4, p. 1218-1229 12 p.

Research output: Contribution to journalArticle

59 Scopus citations

MicroRNA-130a associates with ribosomal protein L11 to suppress c-Myc expression in response to UV irradiation

Li, Y., Challagundla, K. B., Sun, X. X., Zhang, Q. & Dai, M. S., 2015, In : Oncotarget. 6, 2, p. 1101-1114 14 p.

Research output: Contribution to journalArticle

Open Access
17 Scopus citations

microRNA-130a suppresses breast cancer cell migration and invasion by targeting FOSL1 and upregulating ZO-1

Chen, X., Zhao, M., Huang, J., Li, Y., Wang, S., Harrington, C. C., Qian, Z. D., Sun, X-X. & Dai, M., Jan 1 2018, (Accepted/In press) In : Journal of Cellular Biochemistry.

Research output: Contribution to journalArticle

22 Scopus citations
27 Scopus citations

Mycophenolic acid activation of p53 requires ribosomal proteins L5 and L11

Sun, X. X., Dai, M. S. & Lu, H., May 2 2008, In : Journal of Biological Chemistry. 283, 18, p. 12387-12392 6 p.

Research output: Contribution to journalArticle

79 Scopus citations

Nucleostemin stabilizes ARF by inhibiting the ubiquitin ligase ULF

Lo, D., Zhang, Y., Dai, M. S., Sun, X. X., Zeng, S. X. & Lu, H., Mar 26 2015, In : Oncogene. 34, 13, p. 1688-1697 10 p.

Research output: Contribution to journalArticle

7 Scopus citations

Otub1 stabilizes MDMX and promotes its proapoptotic function at the mitochondria

Chen, Y., Wang, Y. G., Li, Y., Sun, X. X. & Dai, M. S., 2017, In : Oncotarget. 8, 7, p. 11053-11062 10 p.

Research output: Contribution to journalArticle

13 Scopus citations

Perturbation of 60 S ribosomal biogenesis results in ribosomal protein L5- and L11-dependent p53 activation

Sun, X. X., Wang, Y. G., Xirodimas, D. P. & Dai, M. S., Aug 13 2010, In : Journal of Biological Chemistry. 285, 33, p. 25812-25821 10 p.

Research output: Contribution to journalArticle

58 Scopus citations

Phosphatase of regenerating liver 2 (PRL2) is essential for placental development by down-regulating PTEN (phosphatase and tensin homologue deleted on chromosome 10) and activating Akt protein

Dong, Y., Zhang, L., Zhang, S., Bai, Y., Chen, H., Sun, X., Yong, W., Li, W., Colvin, S. C., Rhodes, S. J., Shou, W. & Zhang, Z. Y., Sep 14 2012, In : Journal of Biological Chemistry. 287, 38, p. 32172-32179 8 p.

Research output: Contribution to journalArticle

30 Scopus citations

Physical and functional interaction between ribosomal protein L11 and the tumor suppressor ARF

Dai, M. S., Challagundla, K. B., Sun, X. X., Palam, L. R., Zeng, S. X., Wek, R. C. & Lu, H., May 18 2012, In : Journal of Biological Chemistry. 287, 21, p. 17120-17129 10 p.

Research output: Contribution to journalArticle

22 Scopus citations

Positive regulation of p53 stability and activity by the deubiquitinating enzyme Otubain 1

Sun, X. X., Challagundla, K. B. & Dai, M. S., Feb 1 2012, In : EMBO Journal. 31, 3, p. 576-592 17 p.

Research output: Contribution to journalArticle

102 Scopus citations

Regulation of the MDM2-p53 pathway by ribosomal protein L11 involves a post-ubiquitination mechanism

Dai, M. S., Shi, D., Jin, Y., Sun, X. X., Zhang, Y., Grossman, S. R. & Lu, H., Aug 25 2006, In : Journal of Biological Chemistry. 281, 34, p. 24304-24313 10 p.

Research output: Contribution to journalArticle

97 Scopus citations

RHEB1 insufficiency in aged male mice is associated with stress-induced seizures

Tian, Q., Gromov, P., Clement, J. H., Wang, Y., Riemann, M., Weih, F., Sun, X. X., Dai, M. S. & Fedorov, L. M., Dec 1 2017, In : GeroScience. 39, 5-6, p. 557-570 14 p.

Research output: Contribution to journalArticle

6 Scopus citations

Ribosomal protein L11 associates with c-Myc at 5 S rRNA and tRNA genes and regulates their expression

Dai, M. S., Sun, X. X. & Lu, H., Apr 23 2010, In : Journal of Biological Chemistry. 285, 17, p. 12587-12594 8 p.

Research output: Contribution to journalArticle

41 Scopus citations

Ribosomal protein L11 recruits miR-24/miRISC to repress c-Myc expression in response to ribosomal stress

Challagundla, K. B., Sun, X. X., Zhang, X., DeVine, T., Zhang, Q., Sears, R. C. & Dai, M. S., Oct 2011, In : Molecular and cellular biology. 31, 19, p. 4007-4021 15 p.

Research output: Contribution to journalArticle

69 Scopus citations

Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibition

Dai, M. S., Zeng, S. X., Jin, Y., Sun, X. X., David, L. & Lu, H., Sep 2004, In : Molecular and cellular biology. 24, 17, p. 7654-7668 15 p.

Research output: Contribution to journalArticle

369 Scopus citations

Ribosomal protein L4 is a novel regulator of the MDM2-p53 loop

He, X., Li, Y., Dai, M. S. & Sun, X. X., Mar 29 2016, In : Oncotarget. 7, 13, p. 16217-16226 10 p.

Research output: Contribution to journalArticle

19 Scopus citations

The nucleolar ubiquitin-specific protease USP36 deubiquitinates and stabilizes c-Myc

Sun, X. X., He, X., Yin, L., Komada, M., Sears, R. C. & Dai, M. S., Mar 24 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 12, p. 3734-3739 6 p.

Research output: Contribution to journalArticle

61 Scopus citations

The SUMO-specific protease SENP1 deSUMOylates p53 and regulates its activity

Chauhan, K. M., Chen, Y., Chen, Y., Liu, A. T., Sun, X. X. & Dai, M. S., 2020, (Accepted/In press) In : Journal of cellular biochemistry.

Research output: Contribution to journalArticle

Ubiquitin- and MDM2 E3 ligase-independent proteasomal turnover of nucleostemin in response to GTP depletion

Lo, D., Dai, M. S., Sun, X. X., Zeng, S. X. & Lu, H., Mar 23 2012, In : Journal of Biological Chemistry. 287, 13, p. 10013-10020 8 p.

Research output: Contribution to journalArticle

17 Scopus citations