Xiao-Xin Sun

Research output

Research output per year 2004 2008 2010 2012 2015 2017 2018 2020 2021 2023

• 34 Article
• 4 Comment/debate
• 3 Review article
• 1 Chapter

Research output per year

Research output per year

Search results

• 2023

  Artificial cells delivering itaconic acid induce anti-inflammatory memory-like macrophages to reverse acute liver failure and prevent reinjury

  Yin, N., Zhang, W., Sun, X. X., Wei, R., Yang, Q., He, F., Li, C., Guo, L. & Feng, M., Aug 15 2023, In: Cell Reports Medicine. 4, 8, 101132.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • itaconic acid 100%
  • Artificial Cells 78%
  • Itaconic Acid 73%
  • Acute Liver Failure 65%
  • Apoptotic 64%
  1 Scopus citations
• 2021

  Detection of post-translational modifications on MYC

  Daniel, C. J., Sun, X. X., Chen, Y., Zhang, X., Dai, M. S. & Sears, R. C., 2021, Methods in Molecular Biology. Humana Press Inc., p. 69-85 17 p. (Methods in Molecular Biology; vol. 2318).

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • Post Translational Protein Processing 100%
  • Phosphorylation 66%
  • Sumoylation 43%
  • Immunoprecipitation 31%
  • Formaldehyde 30%
  4 Scopus citations

• Targeting the MYC Ubiquitination-Proteasome Degradation Pathway for Cancer Therapy

  Sun, X. X., Li, Y., Sears, R. C. & Dai, M. S., Jun 11 2021, In: Frontiers in Oncology. 11, 679445.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Proteasome Endopeptidase Complex 96%
  • Sumoylation 31%
  • Neoplasms 29%
  • Protein Stability 27%
  • Oncogene Proteins 25%
  21 Scopus citations

• The deubiquitinase USP36 promotes snoRNP group SUMOylation and is essential for ribosome biogenesis

  Ryu, H., Sun, X. X., Chen, Y., Li, Y., Wang, X., Dai, R. S., Zhu, H. M., Klimek, J., David, L., Fedorov, L. M., Azuma, Y., Sears, R. C. & Dai, M. S., Jun 4 2021, In: EMBO Reports. 22, 6, e50684.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Small Nucleolar Ribonucleoproteins 100%
  • Deubiquitinating Enzymes 79%
  • Sumoylation 77%
  • Ribosomes 59%
  • Protein 23%
  12 Scopus citations

• The SUMO-specific protease SENP1 deSUMOylates p53 and regulates its activity

  Chauhan, K. M., Chen, Y., Chen, Y., Liu, A. T., Sun, X. X. & Dai, M. S., Feb 2021, In: Journal of cellular biochemistry. 122, 2, p. 189-197 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Tumor Suppressor Protein 100%
  • Etoposide 87%
  • Inhibition of Growth 82%
  • Sumoylation 56%
  • Peptide Hydrolases 53%
  14 Scopus citations
• 2020

  Deregulating MYC in a model of HER2+ breast cancer mimics human intertumoral heterogeneity

  Risom, T., Wang, X., Liang, J., Zhang, X., Pelz, C., Campbell, L. G., Eng, J., Chin, K., Farrington, C., Narla, G., Langer, E. M., Sun, X. X., Su, Y., Daniel, C. J., Dai, M. S., Löhr, C. V. & Sears, R. C., Jan 2 2020, In: Journal of Clinical Investigation. 130, 1, p. 231-246 16 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Breast Neoplasms 100%
  • Neoplasms 50%
  • Phosphorylation 40%
  • Oncogene Proteins 21%
  • Survival 21%
  24 Scopus citations

• Molecular Crosstalk Between MYC and HIF in Cancer

  Li, Y., Sun, X. X., Qian, D. Z. & Dai, M. S., Nov 5 2020, In: Frontiers in Cell and Developmental Biology. 8, 590576.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Hypoxia 100%
  • Neoplasms 40%
  • Oxygen 25%
  • Regulator Genes 18%
  • Transcription Factors 13%
  46 Scopus citations

• Parkin ubiquitinates phosphoglycerate dehydrogenase to suppress serine synthesis and tumor progression

  Liu, J., Zhang, C., Wu, H., Sun, X. X., Li, Y., Huang, S., Yue, X., Lu, S. E., Shen, Z., Su, X., White, E., Haffty, B. G., Hu, W. & Feng, Z., Jun 1 2020, In: Journal of Clinical Investigation. 130, 6, p. 3253-3269 17 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Phosphoglycerate Dehydrogenase 100%
  • Serine 55%
  • Neoplasms 18%
  • Lung Neoplasms 6%
  • Down-Regulation 5%
  53 Scopus citations
• 2019

  Erratum to: Interplay between hypoxia and androgen controls a metabolic switch conferring resistance to androgen/AR-targeted therapy (Nature Communications, (2018), 9, 1, (4972), 10.1038/s41467-018-07411-7)

  Geng, H., Xue, C., Mendonca, J., Sun, X. X., Liu, Q., Reardon, P. N., Chen, Y., Qian, K., Hua, V., Chen, A., Pan, F., Yuan, J., Dang, S., Beer, T. M., Dai, M. S., Kachhap, S. K. & Qian, D. Z., Dec 1 2019, In: Nature communications. 10, 1, 164.

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access

  • Relaxation Therapy 100%
  • hypoxia 93%
  • Androgen 93%
  • therapy 70%
  • Androgens 67%
  1 Scopus citations

• Writing and erasing MYC ubiquitination and SUMOylation

  Chen, Y., Sun, X. X., Sears, R. C. & Dai, M. S., Dec 2019, In: Genes and Diseases. 6, 4, p. 359-371 13 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Sumoylation 100%
  • Ubiquitin 37%
  • Protein 30%
  • Deubiquitinating Enzymes 25%
  • Protein Stability 21%
  37 Scopus citations
• 2018

  Interplay between hypoxia and androgen controls a metabolic switch conferring resistance to androgen/AR-targeted therapy

  Geng, H., Xue, C., Mendonca, J., Sun, X. X., Liu, Q., Reardon, P. N., Chen, Y., Qian, K., Hua, V., Chen, A., Pan, F., Yuan, J., Dang, S., Beer, T. M., Dai, M. S., Kachhap, S. K. & Qian, D. Z., Dec 1 2018, In: Nature communications. 9, 1, 4972.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • hypoxia 100%
  • Androgen 99%
  • Androgen Receptors 85%
  • therapy 75%
  • Androgens 72%
  37 Scopus citations

• microRNA-130a suppresses breast cancer cell migration and invasion by targeting FOSL1 and upregulating ZO-1

  Chen, X., Zhao, M., Huang, J., Li, Y., Wang, S., Harrington, C. A., Qian, D. Z., Sun, X. X. & Dai, M. S., Jun 2018, In: Journal of cellular biochemistry. 119, 6, p. 4945-4956 12 p.

  Research output: Contribution to journal › Article › peer-review

  • MicroRNA 100%
  • MicroRNAs 68%
  • Cell Movement 66%
  • Breast Neoplasms 51%
  • Microarrays 44%
  61 Scopus citations

• SUMO protease SENP1 deSUMOylates and stabilizes c-Myc

  Suna, X. X., Chena, Y., Sua, Y., Wanga, X., Chauhana, K. M., Lianga, J., Daniela, C. J., Searsa, R. C. & Daia, M. S., Oct 23 2018, In: Proceedings of the National Academy of Sciences of the United States of America. 115, 43, p. 10983-10988 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Sumoylation 100%
  • Ubiquitin 74%
  • Peptide Hydrolases 62%
  • Enzymes 40%
  • Proto-Oncogene Proteins c-myc 35%
  57 Scopus citations
• 2017

  Otub1 stabilizes MDMX and promotes its proapoptotic function at the mitochondria

  Chen, Y., Wang, Y. G., Li, Y., Sun, X. X. & Dai, M. S., 2017, In: Oncotarget. 8, 7, p. 11053-11062 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Mitochondria 100%
  • Apoptosis 73%
  • Ubiquitin-Conjugating Enzymes 58%
  • Deubiquitinating Enzymes 56%
  • Cytosol 38%
  27 Scopus citations

• p73 to the rescue: Role of RPL26

  Sun, X. X. & Dai, M. S., 2017, In: Oncotarget. 8, 4, p. 5641-5642 2 p.

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access

• RHEB1 insufficiency in aged male mice is associated with stress-induced seizures

  Tian, Q., Gromov, P., Clement, J. H., Wang, Y., Riemann, M., Weih, F., Sun, X. X., Dai, M. S. & Fedorov, L. M., Dec 1 2017, In: GeroScience. 39, 5-6, p. 557-570 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • rapamycin 100%
  • seizures 87%
  • Sirolimus 65%
  • Seizures 59%
  • mice 44%
  7 Scopus citations
• 2016

  Ribosomal protein L4 is a novel regulator of the MDM2-p53 loop

  He, X., Li, Y., Dai, M. S. & Sun, X. X., Mar 29 2016, In: Oncotarget. 7, 13, p. 16217-16226 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • ribosomal protein L4 100%
  • Ribosomal Proteins 27%
  • ribosomal protein L7-L12 19%
  • Cell Proliferation 14%
  • Ribosomes 11%
  35 Scopus citations
• 2015

  Deubiquitinating c-Myc: USP36 steps up in the nucleolus

  Sun, X. X., Sears, R. C. & Dai, M. S., Jan 1 2015, In: Cell Cycle. 14, 24, p. 3786-3793 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Deubiquitinating Enzymes 42%
  • Ligases 33%
  • Ubiquitin 30%
  • Transcriptional Activation 28%
  • Phosphorylation 21%
  25 Scopus citations

• Identification and characterization of nuclear and nucleolar localization signals in the adeno-associated virus serotype 2 assembly-activating protein

  Earley, L. F., Kawano, Y., Adachi, K., Sun, X. X., Dai, M. S. & Nakai, H., 2015, In: Journal of virology. 89, 6, p. 3038-3048 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Dependoparvovirus 100%
  • Adeno-associated virus-2 95%
  • Nuclear Localization Signals 81%
  • Serogroup 57%
  • serotypes 53%
  30 Scopus citations

• MicroRNA-130a associates with ribosomal protein L11 to suppress c-Myc expression in response to UV irradiation

  Li, Y., Challagundla, K. B., Sun, X. X., Zhang, Q. & Dai, M. S., 2015, In: Oncotarget. 6, 2, p. 1101-1114 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • ribosomal protein L11 100%
  • MicroRNAs 46%
  • Messenger RNA 31%
  • DNA Damage 13%
  • Proto-Oncogene Proteins c-myc 11%
  22 Scopus citations

• Nucleostemin stabilizes ARF by inhibiting the ubiquitin ligase ULF

  Lo, D., Zhang, Y., Dai, M. S., Sun, X. X., Zeng, S. X. & Lu, H., Mar 26 2015, In: Oncogene. 34, 13, p. 1688-1697 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Reading Frames 100%
  • Ligases 83%
  • Ubiquitin 76%
  • Growth 27%
  • Neoplasms 24%
  11 Scopus citations

• The nucleolar ubiquitin-specific protease USP36 deubiquitinates and stabilizes c-Myc

  Sun, X. X., He, X., Yin, L., Komada, M., Sears, R. C. & Dai, M. S., Mar 24 2015, In: Proceedings of the National Academy of Sciences of the United States of America. 112, 12, p. 3734-3739 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Ubiquitin-Specific Proteases 100%
  • Deubiquitinating Enzymes 92%
  • Ubiquitin 44%
  • Cullin 1 39%
  • F-Box Proteins 33%
  140 Scopus citations
• 2014

  Monoubiquitination is critical for ovarian tumor domain-containing ubiquitin aldehyde binding protein 1 (Otub1) to suppress UbcH5 enzyme and Stabilize p53 protein

  Li, Y., Sun, X. X., Elferich, J., Shinde, U., David, L. L. & Dai, M. S., Feb 21 2014, In: Journal of Biological Chemistry. 289, 8, p. 5097-5108 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • ubiquitin-aldehyde 100%
  • Carrier Proteins 42%
  • Aldehyde 34%
  • Enzymes 27%
  • Protein 20%
  41 Scopus citations
• 2013

  Fkbp1a controls ventricular myocardium trabeculation and compaction by regulating endocardial Notch1 activity

  Chen, H., Zhang, W., Sun, X., Yoshimoto, M., Chen, Z., Zhu, W., Liu, J., Shen, Y., Yong, W., Li, D., Zhang, J., Lin, Y., Li, B., VanDusen, N. J., Snider, P., Schwartz, R. J., Conway, S. J., Field, L. J., Yoder, M. C., Firulli, A. B., & 3 othersCarlesso, N., Towbin, J. A. & Shou, W., May 1 2013, In: Development (Cambridge). 140, 9, p. 1946-1957 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Myocardium 100%
  • Tacrolimus Binding Protein 1A 63%
  • Endothelial Cells 59%
  • Peptidylprolyl Isomerase 57%
  • Endocardium 52%
  69 Scopus citations
• 2012

  Phosphatase of regenerating liver 2 (PRL2) is essential for placental development by down-regulating PTEN (phosphatase and tensin homologue deleted on chromosome 10) and activating Akt protein

  Dong, Y., Zhang, L., Zhang, S., Bai, Y., Chen, H., Sun, X., Yong, W., Li, W., Colvin, S. C., Rhodes, S. J., Shou, W. & Zhang, Z. Y., Sep 14 2012, In: Journal of Biological Chemistry. 287, 38, p. 32172-32179 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • PTEN Phosphohydrolase 100%
  • Oncogenic 98%
  • Chromosomes, Human, Pair 10 91%
  • Tensins 91%
  • Placentation 88%
  39 Scopus citations

• Physical and functional interaction between ribosomal protein L11 and the tumor suppressor ARF

  Dai, M. S., Challagundla, K. B., Sun, X. X., Palam, L. R., Zeng, S. X., Wek, R. C. & Lu, H., May 18 2012, In: Journal of Biological Chemistry. 287, 21, p. 17120-17129 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • ribosomal protein L11 100%
  • Cell Cycle Checkpoints 53%
  • Tumor Suppressor Protein 43%
  • Activity Cycles 38%
  • Oncogenic 38%
  28 Scopus citations

• Positive regulation of p53 stability and activity by the deubiquitinating enzyme Otubain 1

  Sun, X. X., Challagundla, K. B. & Dai, M. S., Feb 1 2012, In: EMBO Journal. 31, 3, p. 576-592 17 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Deubiquitinating Enzymes 100%
  • Ubiquitin 72%
  • ubiquitin-aldehyde 47%
  • Silencing RNA 46%
  • Ablation 41%
  148 Scopus citations

• Ubiquitin- and MDM2 E3 ligase-independent proteasomal turnover of nucleostemin in response to GTP depletion

  Lo, D., Dai, M. S., Sun, X. X., Zeng, S. X. & Lu, H., Mar 23 2012, In: Journal of Biological Chemistry. 287, 13, p. 10013-10020 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Ubiquitin-Protein Ligases 100%
  • Mycophenolic Acid 67%
  • Ubiquitin 44%
  • Protein 36%
  • Fibroblasts 32%
  19 Scopus citations
• 2011

  Interplay between ribosomal protein S27a and MDM2 protein in p53 activation in response to ribosomal stress

  Sun, X. X., DeVine, T., Challagundla, K. B. & Dai, M. S., Jul 1 2011, In: Journal of Biological Chemistry. 286, 26, p. 22730-22741 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • ribosomal protein S27a 100%
  • Ribosomal Proteins 59%
  • Dactinomycin 36%
  • Actinomycin D 32%
  • ubiquitin precursor 31%
  78 Scopus citations

• Ribosomal protein L11 recruits miR-24/miRISC to repress c-Myc expression in response to ribosomal stress

  Challagundla, K. B., Sun, X. X., Zhang, X., DeVine, T., Zhang, Q., Sears, R. C. & Dai, M. S., Oct 2011, In: Molecular and cellular biology. 31, 19, p. 4007-4021 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • ribosomal protein L11 100%
  • MicroRNAs 46%
  • Messenger RNA 31%
  • Dactinomycin 14%
  • RNA Stability 6%
  90 Scopus citations
• 2010

  Perturbation of 60 S ribosomal biogenesis results in ribosomal protein L5- and L11-dependent p53 activation

  Sun, X. X., Wang, Y. G., Xirodimas, D. P. & Dai, M. S., Aug 13 2010, In: Journal of Biological Chemistry. 285, 33, p. 25812-25821 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • ribosomal protein L5 100%
  • L 30 97%
  • ribosomal protein L11 96%
  • Ribosomal Proteins 66%
  • ribosomal protein L30 27%
  71 Scopus citations

• Ribosomal protein L11 associates with c-Myc at 5 S rRNA and tRNA genes and regulates their expression

  Dai, M. S., Sun, X. X. & Lu, H., Apr 23 2010, In: Journal of Biological Chemistry. 285, 17, p. 12587-12594 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • ribosomal protein L11 100%
  • Transfer RNA 60%
  • rRNA Genes 57%
  • RNA Polymerase III 25%
  • Protein 22%
  52 Scopus citations

• Ribosomal protein L11 associates with c-Myc at 5 S rRNA and tRNA genes and regulates their expression (Journal of Biological Chemistry (2005) 280, (12587-12594))

  Dai, M. S., Sun, X. X. & Lu, H., Dec 10 2010, In: Journal of Biological Chemistry. 285, 50, p. 39574 1 p.

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access
  1 Scopus citations
• 2009

  Erratum: Inhibition of c-Myc activity by ribosomal protein L11 (The EMBO Journal (2009) 28 (993) DOI: 10.1038/emboj.2009.70)

  Dai, M. S., Arnold, H., Sun, X. X., Sears, R. & Lu, H., Apr 8 2009, In: EMBO Journal. 28, 7, p. 993 1 p.

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access
  1 Scopus citations
• 2008

  Aberrant expression of nucleostemin activates p53 and induces cell cycle arrest via inhibition of MDM2

  Dai, M. S., Sun, X. X. & Lu, H., Jul 2008, In: Molecular and cellular biology. 28, 13, p. 4365-4376 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Cell Cycle Checkpoints 100%
  • Cell Proliferation 67%
  • ribosomal protein L5 64%
  • ribosomal protein L11 61%
  • G1 Phase Cell Cycle Checkpoints 44%
  154 Scopus citations

• MDMX promotes proteasomal turnover of p21 at G₁ and early S phases independently of, but in cooperation with, MDM2

  Jin, Y., Zeng, S. X., Sun, X. X., Lee, H., Blattner, C., Xiao, Z. & Lu, H., Feb 2008, In: Molecular and cellular biology. 28, 4, p. 1218-1229 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • ATP dependent 26S protease 100%
  • S Phase 70%
  • Cyclin-Dependent Kinase Inhibitor p21 34%
  • Null Lymphocytes 30%
  • Proteasome Endopeptidase Complex 24%
  68 Scopus citations

• Mycophenolic acid activation of p53 requires ribosomal proteins L5 and L11

  Sun, X. X., Dai, M. S. & Lu, H., May 2 2008, In: Journal of Biological Chemistry. 283, 18, p. 12387-12392 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • ribosomal protein L5 100%
  • ribosomal protein L11 96%
  • Mycophenolic Acid 81%
  • Protein 21%
  • Guanine Nucleotides 18%
  97 Scopus citations
• 2007

  5-fluorouracil activation of p53 involves an MDM2-ribosomal protein interaction

  Sun, X. X., Dai, M. S. & Lu, H., Mar 16 2007, In: Journal of Biological Chemistry. 282, 11, p. 8052-8059 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Ribosomal Proteins 100%
  • 5-Fluorouracil 95%
  • Fluorouracil 76%
  • ribosomal protein L11 35%
  • Protein 21%
  156 Scopus citations

• Inhibition of c-Myc activity by ribosomal protein L11

  Dai, M. S., Arnold, H., Sun, X. X., Sears, R. & Lu, H., Jul 25 2007, In: EMBO Journal. 26, 14, p. 3332-3345 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • ribosomal protein L11 100%
  • Silencing RNA 71%
  • Histone 59%
  • Acetylation 55%
  • Large Ribosome Subunits 29%
  156 Scopus citations
• 2006

  Regulation of the MDM2-p53 pathway by ribosomal protein L11 involves a post-ubiquitination mechanism

  Dai, M. S., Shi, D., Jin, Y., Sun, X. X., Zhang, Y., Grossman, S. R. & Lu, H., Aug 25 2006, In: Journal of Biological Chemistry. 281, 34, p. 24304-24313 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • ribosomal protein L11 100%
  • Reaction Half Life 52%
  • ribosomal protein L5 52%
  • Block Like Crystal 37%
  • Ligases 30%
  110 Scopus citations
• 2004

  Identification and characterization of a novel Drosophila melanogaster glutathione S-transferase-containing FLYWCH zinc finger protein

  Dai, M. S., Sun, X. X., Qin, J., Smolik, S. M. & Lu, H., Nov 1 2004, In: Gene. 342, 1, p. 49-56 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Zinc Fingers 100%
  • Drosophila melanogaster 96%
  • Glutathione Transferase 93%
  • Proteins 32%
  • Diptera 31%
  16 Scopus citations

• Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibition

  Dai, M. S., Zeng, S. X., Jin, Y., Sun, X. X., David, L. & Lu, H., Sep 2004, In: Molecular and cellular biology. 24, 17, p. 7654-7668 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Ribosomal Proteins 100%
  • Polyribosomes 33%
  • Dactinomycin 30%
  • Ectopic Gene Expression 29%
  • Ribosomes 27%
  420 Scopus citations