Xiangshu Xiao

Associate Professor

  • 1189 Citations
  • 19 h-Index
20002019

Research output per year

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Research Output

  • 1189 Citations
  • 19 h-Index
  • 46 Article
  • 2 Chapter
  • 2 Review article
  • 1 Comment/debate
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Article
2019

Discovery of a Synergistic Inhibitor of cAMP-Response Element Binding Protein (CREB)-Mediated Gene Transcription with 666 - 15

Xie, F., Fan, Q., Li, B. X. & Xiao, X., Jan 1 2019, (Accepted/In press) In : Journal of Medicinal Chemistry.

Research output: Contribution to journalArticle

2018

A Lamin-Binding Ligand Inhibits Homologous Recombination Repair of DNA Double-Strand Breaks

Li, B. X., Chen, J., Chao, B., Zheng, Y. & Xiao, X., Sep 26 2018, In : ACS Central Science. 4, 9, p. 1201-1210 10 p.

Research output: Contribution to journalArticle

5 Scopus citations

Anticancer Pyrroloquinazoline LBL1 Targets Nuclear Lamins

Li, B. X., Chen, J., Chao, B., David, L. & Xiao, X., May 18 2018, In : ACS Chemical Biology. 13, 5, p. 1380-1387 8 p.

Research output: Contribution to journalArticle

5 Scopus citations

CBP modulates sensitivity to dasatinib in pre-BCRþ acute lymphoblastic leukemia

Duque-Afonso, J., Lin, C. H., Han, K., Morgens, D. W., Jeng, E. E., Weng, Z., Jeong, J., Wong, S. H. K., Zhu, L., Wei, M. C., Chae, H. D., Schrappe, M., Cario, G., Duyster, J., Xiao, X., Sakamoto, K. M., Bassik, M. C. & Cleary, M. L., Nov 15 2018, In : Cancer Research. 78, 22, p. 6497-6508 12 p.

Research output: Contribution to journalArticle

1 Scopus citations

Small molecule nAS-E targeting cAMP response element binding protein (CREB) and CREB-binding protein interaction inhibits breast cancer bone metastasis

Jiang, M., Yan, Y., Yang, K., Liu, Z., Qi, J., Zhou, H., Qian, N., Zhou, Q., Wang, T., Xu, X., Xiao, X. & Deng, L., Jan 1 2018, (Accepted/In press) In : Journal of Cellular and Molecular Medicine.

Research output: Contribution to journalArticle

2 Scopus citations
2017

Design, synthesis and evaluation of antitumor acylated monoaminopyrroloquinazolines

Chao, B., Li, B. X. & Xiao, X., Jul 15 2017, In : Bioorganic and Medicinal Chemistry Letters. 27, 14, p. 3107-3110 4 p.

Research output: Contribution to journalArticle

1 Scopus citations
2016
5 Scopus citations

Functional screening for G protein-coupled receptor targets of 14,15-epoxyeicosatrienoic acid

Liu, X., Qian, Z. Y., Xie, F., Fan, W., Nelson, J. W., Xiao, X., Kaul, S., Barnes, A. & Alkayed, N., Apr 28 2016, (Accepted/In press) In : Prostaglandins and Other Lipid Mediators.

Research output: Contribution to journalArticle

14 Scopus citations

Small molecule inhibition of cAMP response element binding protein in human acute myeloid leukemia cells

Mitton, B., Chae, H. D., Hsu, K., Dutta, R., Aldana-Masangkay, G., Ferrari, R., Davis, K., Tiu, B. C., Kaul, A., Lacayo, N., Dahl, G., Xie, F., Li, B. X., Breese, M. R., Landaw, E. M., Nolan, G., Pellegrini, M., Romanov, S., Xiao, X. & Sakamoto, K. M., Dec 1 2016, In : Leukemia. 30, 12, p. 2302-2311 10 p.

Research output: Contribution to journalArticle

19 Scopus citations

Systemic Inhibition of CREB is Well-tolerated in vivo

Li, B. X., Gardner, R., Xue, C., Qian, Z. D., Xie, F., Thomas, G., Kazmierczak, S. S., Habecker, B. & Xiao, X., Oct 3 2016, In : Scientific Reports. 6, 34513.

Research output: Contribution to journalArticle

10 Scopus citations

Varicellazoster virus activates CREB, and inhibition of the pCREB-p300/CBP interaction inhibits viral replication in vitro and skin pathogenesis in vivo

François, S., Sen, N., Mitton, B., Xiao, X., Sakamoto, K. M. & Arvin, A., 2016, In : Journal of Virology. 90, 19, p. 8686-8697 12 p.

Research output: Contribution to journalArticle

5 Scopus citations
2015

Identification of a Potent Inhibitor of CREB-Mediated Gene Transcription with Efficacious in Vivo Anticancer Activity

Xie, F., Li, B. X., Kassenbrock, A., Xue, C., Wang, X., Qian, D. Z., Sears, R. C. & Xiao, X., Jun 25 2015, In : Journal of Medicinal Chemistry. 58, 12, p. 5075-5087 13 p.

Research output: Contribution to journalArticle

36 Scopus citations

Synthesis of 14,15-EET from Arachidonic Acid Using Urea-Hydrogen Peroxide as the Oxidant

Xie, F., Li, B. X., Alkayed, N. J. & Xiao, X., Jan 2 2015, In : Synthetic Communications. 45, 1, p. 105-110 6 p.

Research output: Contribution to journalArticle

1 Scopus citations

The chemistry and pharmacology of privileged pyrroloquinazolines

Chao, B., Li, B. X. & Xiao, X., Apr 1 2015, In : MedChemComm. 6, 4, p. 510-520 11 p.

Research output: Contribution to journalArticle

6 Scopus citations

The ITIM-containing receptor LAIR1 is essential for acute myeloid leukaemia development

Kang, X., Lu, Z., Cui, C., Deng, M., Fan, Y., Dong, B., Han, X., Xie, F., Tyner, J. W., Coligan, J. E., Collins, R. H., Xiao, X., You, M. J. & Zhang, C. C., May 5 2015, In : Nature Cell Biology. 17, 5, p. 665-677 13 p.

Research output: Contribution to journalArticle

55 Scopus citations
2014

Novel type of prodrug activation through a long-range O,N-acyl transfer: A case of water-soluble CREB inhibitor

Li, B. X., Xie, F., Fan, Q., Barnhart, K. M., Moore, C. E., Rheingold, A. L. & Xiao, X., Oct 9 2014, In : ACS Medicinal Chemistry Letters. 5, 10, p. 1104-1109 6 p.

Research output: Contribution to journalArticle

7 Scopus citations
2013

Discovery of a potent anti-tumor agent through regioselective mono-N-acylation of 7H-pyrrolo[3,2-f]quinazoline-1,3-diamine

Chen, J., Kassenbrock, A., Li, B. X. & Xiao, X., Sep 2013, In : MedChemComm. 4, 9, p. 1275-1282 8 p.

Research output: Contribution to journalArticle

8 Scopus citations

Identification, synthesis and evaluation of substituted benzofurazans as inhibitors of CREB-mediated gene transcription

Xie, F., Li, B. X., Broussard, C. & Xiao, X., Oct 1 2013, In : Bioorganic and Medicinal Chemistry Letters. 23, 19, p. 5371-5375 5 p.

Research output: Contribution to journalArticle

14 Scopus citations

Soluble epoxide hydrolase dimerization is required for hydrolase activity

Nelson, J. W., Subrahmanyan, R. M., Summers, S. A., Xiao, X. & Alkayed, N. J., Mar 15 2013, In : Journal of Biological Chemistry. 288, 11, p. 7697-7703 7 p.

Research output: Contribution to journalArticle

16 Scopus citations

Synthesis and evaluation of an O-Aminated naphthol AS-E as a prodrug of CREB-mediated gene transcription inhibition

Xie, F., Li, B. X. & Xiao, X., Jun 1 2013, In : Letters in Organic Chemistry. 10, 5, p. 380-384 5 p.

Research output: Contribution to journalArticle

3 Scopus citations
2012

Design, synthesis, and biological evaluation of conformationally constrained analogues of naphthol AS-E as inhibitors of CREB-mediated gene transcription

Jiang, M., Li, B. X., Xie, F., Delaney, F. & Xiao, X., Apr 26 2012, In : Journal of Medicinal Chemistry. 55, 8, p. 4020-4024 5 p.

Research output: Contribution to journalArticle

17 Scopus citations
24 Scopus citations
2010

Targeting CREB for cancer therapy: Friend or foe

Xiao, X., Li, B. X., Mitton, B., Ikeda, A. & Sakamoto, K. M., Jun 23 2010, In : Current Cancer Drug Targets. 10, 4, p. 384-391 8 p.

Research output: Contribution to journalArticle

88 Scopus citations
2009

Discovery of a small-molecule inhibitor of the KIX-KID interaction

Li, B. X. & Xiao, X., Nov 23 2009, In : ChemBioChem. 10, 17, p. 2721-2724 4 p.

Research output: Contribution to journalArticle

46 Scopus citations

Rapid identification of improved protein ligands using peptoid microarrays

Lim, H. S., Muralidhar Reddy, M., Xiao, X., Wilson, J., Wilson, R., Connell, S. & Kodadek, T., Jul 15 2009, In : Bioorganic and Medicinal Chemistry Letters. 19, 14, p. 3866-3869 4 p.

Research output: Contribution to journalArticle

16 Scopus citations
2007

A cell-permeable synthetic transcription factor mimic

Xiao, X., Yu, P., Lim, H. S., Sikder, D. & Kodadek, T., Jul 2 2007, In : Angewandte Chemie - International Edition. 46, 16, p. 2865-2868 4 p.

Research output: Contribution to journalArticle

64 Scopus citations
27 Scopus citations

Design and synthesis of a cell-permeable synthetic transcription factor mimic

Xiao, X., Yu, P., Lim, H. S., Sikder, D. & Kodadek, T., Jul 1 2007, In : Journal of Combinatorial Chemistry. 9, 4, p. 592-600 9 p.

Research output: Contribution to journalArticle

43 Scopus citations
2006

Isolation and characterization of coactivator-binding peptoids from a combinatorial library

Alluri, P., Liu, B., Yu, P., Xiao, X. & Kodadek, T., Oct 23 2006, In : Molecular BioSystems. 2, 11, p. 568-579 12 p.

Research output: Contribution to journalArticle

38 Scopus citations

On the mechanism of conversion of 4-carboxy-3,4-dihydro-3-phenyl-1(2H)-isoquinolones to indeno[1,2-c]isoquinolines by thionyl chloride

Xiao, X., Morrell, A., Fanwick, P. E. & Cushman, M., Oct 9 2006, In : Tetrahedron. 62, 41, p. 9705-9712 8 p.

Research output: Contribution to journalArticle

13 Scopus citations

Total synthesis and biological evaluation of 22-hydroxyacuminatine

Xiao, X., Antony, S., Pommier, Y. & Cushman, M., Feb 23 2006, In : Journal of Medicinal Chemistry. 49, 4, p. 1408-1412 5 p.

Research output: Contribution to journalArticle

53 Scopus citations
2005

A convergent and stereoselective synthesis of a seco-precursor of macrolactin A

Li, S., Xiao, X., Yan, X., Liu, X., Xu, R. & Bai, D., Nov 21 2005, In : Tetrahedron. 61, 47, p. 11291-11298 8 p.

Research output: Contribution to journalArticle

11 Scopus citations

A facile method to transform trans-4-carboxy-3,4-dihydro-3-phenyl-1(2H)- isoquinolones to indeno[1,2-c]isoquinolines

Xiao, X. & Cushman, M., Aug 5 2005, In : Journal of Organic Chemistry. 70, 16, p. 6496-6498 3 p.

Research output: Contribution to journalArticle

14 Scopus citations
55 Scopus citations

Dihydroindenoisoquinolines function as prodrugs of indenoisoquinolines

Xiao, X., Miao, Z. H., Antony, S., Pommier, Y. & Cushman, M., Jun 2 2005, In : Bioorganic and Medicinal Chemistry Letters. 15, 11, p. 2795-2798 4 p.

Research output: Contribution to journalArticle

22 Scopus citations

Effect of E-ring modifications in camptothecin on topoisomerase I inhibition: A quantum mechanics treatment

Xiao, X. & Cushman, M., Nov 11 2005, In : Journal of Organic Chemistry. 70, 23, p. 9584-9587 4 p.

Research output: Contribution to journalArticle

19 Scopus citations

On the binding of indeno[1,2-c]isoquinolines in the DNA-topoisomerase I cleavage complex

Xiao, X., Antony, S., Pommier, Y. & Cushman, M., May 5 2005, In : Journal of Medicinal Chemistry. 48, 9, p. 3231-3238 8 p.

Research output: Contribution to journalArticle

65 Scopus citations

Synthesis of a sec-precursor and analogues of macrolactin A

Xiao, X., Li, S., Yan, X., Liu, X., Xu, R. & Bai, D., Jul 5 2005, In : Chemistry Letters. 34, 7, p. 906-907 2 p.

Research output: Contribution to journalArticle

4 Scopus citations
2004

Design, synthesis, and biological evaluation of cytotoxic 11-aminoalkenylindenoisoquinoline and 11-diaminoalkenylindenoisoquinoline topoisomerase I inhibitors

Xiao, X., Antony, S., Kohlhagen, G., Pommier, Y. & Cushman, M., Oct 1 2004, In : Bioorganic and Medicinal Chemistry. 12, 19, p. 5147-5160 14 p.

Research output: Contribution to journalArticle

47 Scopus citations

Novel autoxidative cleavage reaction of 9-fluoredenes discovered during synthesis of a potential DNA-threading indenoisoquinoline

Xiao, X., Antony, S., Kohlhagen, G., Pommier, Y. & Cushman, M., Oct 29 2004, In : Journal of Organic Chemistry. 69, 22, p. 7495-7501 7 p.

Research output: Contribution to journalArticle

11 Scopus citations

Synthesis, crystal structure, and conversion of the polycyclic tris-anhydrotetramer of O-aminobenzaldehyde to Cu(TAAB)2+

Xiao, X., Fanwick, P. E. & Cushman, M., Nov 16 2004, In : Synthetic Communications. 34, 21, p. 3901-3907 7 p.

Research output: Contribution to journalArticle

6 Scopus citations
2003

Design, synthesis, and biological evaluation of cytotoxic 11-alkenylindenoisoquinoline topoisomerase I inhibitors and indenoisoquinoline-camptothecin hybrids

Fox, B. M., Xiao, X., Antony, S., Kohlhagen, G., Pommier, Y., Staker, B. L., Stewart, L. & Cushman, M., Jul 17 2003, In : Journal of Medicinal Chemistry. 46, 15, p. 3275-3282 8 p.

Research output: Contribution to journalArticle

91 Scopus citations

Design, Synthesis, and Biological Evaluation of Indenoisoquinoline Topoisomerase I Inhibitors Featuring Polyamine Side Chains on the Lactam Nitrogen

Nagarajan, M., Xiao, X., Antony, S., Kohlhagen, G., Pommier, Y. & Cushman, M., Dec 18 2003, In : Journal of Medicinal Chemistry. 46, 26, p. 5712-5724 13 p.

Research output: Contribution to journalArticle

127 Scopus citations
2002

The unexpected reductive products of δ- alkoxyenal by sodium borohydride in methanol with a trace of magnesium methoxide

Xia, Y., Xiao, X. S., He, X. C. & Bai, D. L., Sep 1 2002, In : Chinese Chemical Letters. 13, 9, p. 809-810 2 p.

Research output: Contribution to journalArticle

2001

An efficient and selective method for hydrolysis of acetonides

Xiao, X. & Bai, D., Jan 1 2001, In : Synlett. 4, p. 535-537 3 p.

Research output: Contribution to journalArticle

44 Scopus citations
2000

A stereoselective synthesis of the C(3)-C(13) and C(14)-C(24) fragments of macrolactin A

Li, S. K., Xu, R., Xiao, X. S. & Bai, D. L., Dec 1 2000, In : Chinese Journal of Chemistry. 18, 6, p. 910-923 14 p.

Research output: Contribution to journalArticle

10 Scopus citations