Xiangshu Xiao

Associate Professor

  • 1088 Citations
  • 18 h-Index
20002019
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Research Output 2000 2019

  • 1088 Citations
  • 18 h-Index
  • 46 Article
  • 2 Review article
  • 1 Chapter
2019

Identification of lamins as the molecular targets of LBL1 using a clickable photoaffinity probe

Xiao, X. & Li, B. X., Jan 1 2019, Methods in Enzymology. Academic Press Inc., (Methods in Enzymology).

Research output: Chapter in Book/Report/Conference proceedingChapter

Lamins
Molecules
Cells
Lamin Type A
Intermediate Filament Proteins
2018
2 Citations (Scopus)

A Lamin-Binding Ligand Inhibits Homologous Recombination Repair of DNA Double-Strand Breaks

Li, B. X., Chen, J., Chao, B., Zheng, Y. & Xiao, X., Sep 26 2018, In : ACS Central Science. 4, 9, p. 1201-1210 10 p.

Research output: Contribution to journalArticle

Lamins
DNA
Repair
Ligands
Proteins
4 Citations (Scopus)

Anticancer Pyrroloquinazoline LBL1 Targets Nuclear Lamins

Li, B. X., Chen, J., Chao, B., David, L. & Xiao, X., May 18 2018, In : ACS Chemical Biology. 13, 5, p. 1380-1387 8 p.

Research output: Contribution to journalArticle

Lamins
Intermediate Filament Proteins
Lamin Type A
Cytoskeletal Proteins
Actin Cytoskeleton
1 Citation (Scopus)

CBP modulates sensitivity to dasatinib in pre-BCRþ acute lymphoblastic leukemia

Duque-Afonso, J., Lin, C. H., Han, K., Morgens, D. W., Jeng, E. E., Weng, Z., Jeong, J., Wong, S. H. K., Zhu, L., Wei, M. C., Chae, H. D., Schrappe, M., Cario, G., Duyster, J., Xiao, X., Sakamoto, K. M., Bassik, M. C. & Cleary, M. L., Nov 15 2018, In : Cancer Research. 78, 22, p. 6497-6508 12 p.

Research output: Contribution to journalArticle

Precursor Cell Lymphoblastic Leukemia-Lymphoma
Therapeutics
Catenins
Dasatinib
Protein-Tyrosine Kinases
1 Citation (Scopus)

Drugging homologous recombination: Back to the future

Sanford-Crane, H., Pejovic, T. & Xiao, X., Jun 1 2018, In : Future Medicinal Chemistry. 10, 11, p. 1279-1281 3 p.

Research output: Contribution to journalReview article

Homologous Recombination

Small molecule nAS-E targeting cAMP response element binding protein (CREB) and CREB-binding protein interaction inhibits breast cancer bone metastasis

Jiang, M., Yan, Y., Yang, K., Liu, Z., Qi, J., Zhou, H., Qian, N., Zhou, Q., Wang, T., Xu, X., Xiao, X. & Deng, L., Jan 1 2018, (Accepted/In press) In : Journal of Cellular and Molecular Medicine.

Research output: Contribution to journalArticle

Cyclic AMP Response Element-Binding Protein
Bone Neoplasms
Protein Binding
Carrier Proteins
Breast Neoplasms
5 Citations (Scopus)

Toward developing chemical modulators of Hsp60 as potential therapeutics

Meng, Q., Li, B. X. & Xiao, X., Apr 20 2018, In : Frontiers in Molecular Biosciences. 5, APR, 35.

Research output: Contribution to journalReview article

Chaperonins
Modulators
Heat-Shock Proteins
Chaperonin 10
Chaperonin 60
2017
1 Citation (Scopus)

Design, synthesis and evaluation of antitumor acylated monoaminopyrroloquinazolines

Chao, B., Li, B. X. & Xiao, X., Jul 15 2017, In : Bioorganic and Medicinal Chemistry Letters. 27, 14, p. 3107-3110 4 p.

Research output: Contribution to journalArticle

Tetrahydrofolate Dehydrogenase
Chemical modification
Scaffolds (biology)
Bioactivity
Antineoplastic Agents
2016
3 Citations (Scopus)
Cyclic AMP Response Element-Binding Protein
Transcription
Genes
Toxicity
Conformations
9 Citations (Scopus)

Functional screening for G protein-coupled receptor targets of 14,15-epoxyeicosatrienoic acid

Liu, X., Qian, Z. Y., Xie, F., Fan, W., Nelson, J. W., Xiao, X., Kaul, S., Barnes, A. & Alkayed, N., Apr 28 2016, (Accepted/In press) In : Prostaglandins and Other Lipid Mediators.

Research output: Contribution to journalArticle

G-Protein-Coupled Receptors
Screening
Cardiovascular Physiological Phenomena
Prostaglandin Receptors
Physiology
15 Citations (Scopus)

Small molecule inhibition of cAMP response element binding protein in human acute myeloid leukemia cells

Mitton, B., Chae, H. D., Hsu, K., Dutta, R., Aldana-Masangkay, G., Ferrari, R., Davis, K., Tiu, B. C., Kaul, A., Lacayo, N., Dahl, G., Xie, F., Li, B. X., Breese, M. R., Landaw, E. M., Nolan, G., Pellegrini, M., Romanov, S., Xiao, X. & Sakamoto, K. M., Dec 1 2016, In : Leukemia. 30, 12, p. 2302-2311 10 p.

Research output: Contribution to journalArticle

Cyclic AMP Response Element-Binding Protein
Myeloid Cells
Acute Myeloid Leukemia
CREB-Binding Protein
Cell Survival
8 Citations (Scopus)

Systemic Inhibition of CREB is Well-tolerated in vivo

Li, B. X., Gardner, R., Xue, C., Qian, Z. D., Xie, F., Thomas, G., Kazmierczak, S. S., Habecker, B. & Xiao, X., Oct 3 2016, In : Scientific Reports. 6, 34513.

Research output: Contribution to journalArticle

Cyclic AMP Response Element-Binding Protein
Neoplasms
Inhibition (Psychology)
Body Weight Changes
Blood Cell Count
4 Citations (Scopus)

Varicellazoster virus activates CREB, and inhibition of the pCREB-p300/CBP interaction inhibits viral replication in vitro and skin pathogenesis in vivo

François, S., Sen, N., Mitton, B., Xiao, X., Sakamoto, K. M. & Arvin, A., 2016, In : Journal of Virology. 90, 19, p. 8686-8697 12 p.

Research output: Contribution to journalArticle

Human herpesvirus 3
Human Herpesvirus 3
virus replication
skin (animal)
pathogenesis
2015
28 Citations (Scopus)

Identification of a Potent Inhibitor of CREB-Mediated Gene Transcription with Efficacious in Vivo Anticancer Activity

Xie, F., Li, B. X., Kassenbrock, A., Xue, C., Wang, X., Qian, Z. D., Sears, R. & Xiao, X., Jun 25 2015, In : Journal of Medicinal Chemistry. 58, 12, p. 5075-5087 13 p.

Research output: Contribution to journalArticle

Genes
Neoplasms
Growth
CREB-Binding Protein
Neoplasm Genes
1 Citation (Scopus)

Synthesis of 14,15-EET from Arachidonic Acid Using Urea-Hydrogen Peroxide as the Oxidant

Xie, F., Li, B. X., Alkayed, N. & Xiao, X., Jan 2 2015, In : Synthetic Communications. 45, 1, p. 105-110 6 p.

Research output: Contribution to journalArticle

Arachidonic Acid
Oxidants
Hydrogen Peroxide
Urea
Lipids
5 Citations (Scopus)

The chemistry and pharmacology of privileged pyrroloquinazolines

Chao, B., Li, B. X. & Xiao, X., Apr 1 2015, In : MedChemComm. 6, 4, p. 510-520 11 p.

Research output: Contribution to journalArticle

Scaffolds
Pharmacology
Quinazolines
Ligands
Pharmaceutical Preparations
43 Citations (Scopus)

The ITIM-containing receptor LAIR1 is essential for acute myeloid leukaemia development

Kang, X., Lu, Z., Cui, C., Deng, M., Fan, Y., Dong, B., Han, X., Xie, F., Tyner, J., Coligan, J. E., Collins, R. H., Xiao, X., You, M. J. & Zhang, C. C., May 5 2015, In : Nature Cell Biology. 17, 5, p. 665-677 13 p.

Research output: Contribution to journalArticle

Immunoreceptor Tyrosine-Based Inhibition Motif
Acute Myeloid Leukemia
Leukemia
Myeloid Progenitor Cells
Hematopoiesis
2014
Quinazolines
Diamines
Acylation
Neoplasms
4-iodo-2,5-dimethoxyphenylisopropylamine
5 Citations (Scopus)

Novel type of prodrug activation through a long-range O,N-acyl transfer: A case of water-soluble CREB inhibitor

Li, B. X., Xie, F., Fan, Q., Barnhart, K. M., Moore, C. E., Rheingold, A. L. & Xiao, X., Oct 9 2014, In : ACS Medicinal Chemistry Letters. 5, 10, p. 1104-1109 6 p.

Research output: Contribution to journalArticle

Cyclic AMP Response Element-Binding Protein
Prodrugs
Solubility
Chemical activation
Water
2013
8 Citations (Scopus)

Discovery of a potent anti-tumor agent through regioselective mono-N-acylation of 7H-pyrrolo[3,2-f]quinazoline-1,3-diamine

Chen, J., Kassenbrock, A., Li, B. X. & Xiao, X., 2013, In : MedChemComm. 4, 9, p. 1275-1282 8 p.

Research output: Contribution to journalArticle

Quinazolines
Acylation
Diamines
Tumors
Breast Neoplasms
13 Citations (Scopus)

Identification, synthesis and evaluation of substituted benzofurazans as inhibitors of CREB-mediated gene transcription

Xie, F., Li, B. X., Broussard, C. & Xiao, X., Oct 1 2013, In : Bioorganic and Medicinal Chemistry Letters. 23, 19, p. 5371-5375 5 p.

Research output: Contribution to journalArticle

Cyclic AMP Response Element-Binding Protein
Transcription
Genes
CREB-Binding Protein
Phosphotransferases
14 Citations (Scopus)

Soluble epoxide hydrolase dimerization is required for hydrolase activity

Nelson, J. W., Subrahmanyan, R. M., Summers, S. A., Xiao, X. & Alkayed, N., Mar 15 2013, In : Journal of Biological Chemistry. 288, 11, p. 7697-7703 7 p.

Research output: Contribution to journalArticle

Epoxide Hydrolases
Dimerization
Hydrolases
Polymorphism
Mutation
2 Citations (Scopus)

Synthesis and evaluation of an O-Aminated naphthol AS-E as a prodrug of CREB-mediated gene transcription inhibition

Xie, F., Li, B. X. & Xiao, X., Jun 2013, In : Letters in Organic Chemistry. 10, 5, p. 380-384 5 p.

Research output: Contribution to journalArticle

Prodrugs
Transcription
Genes
Oxazoles
Solubility
2012
15 Citations (Scopus)

Design, synthesis, and biological evaluation of conformationally constrained analogues of naphthol AS-E as inhibitors of CREB-mediated gene transcription

Jiang, M., Li, B. X., Xie, F., Delaney, F. & Xiao, X., Apr 26 2012, In : Journal of Medicinal Chemistry. 55, 8, p. 4020-4024 5 p.

Research output: Contribution to journalArticle

Cyclic AMP Response Element-Binding Protein
Genes
Neoplasms
Pharmaceutical Preparations
naphthol AS-E
21 Citations (Scopus)
Cyclic AMP Response Element-Binding Protein
Transcription
Structure-Activity Relationship
Antineoplastic Agents
Genes
2010
83 Citations (Scopus)

Targeting CREB for cancer therapy: Friend or foe

Xiao, X., Li, B. X., Mitton, B., Ikeda, A. & Sakamoto, K. M., 2010, In : Current Cancer Drug Targets. 10, 4, p. 384-391 8 p.

Research output: Contribution to journalArticle

Cyclic AMP Response Element-Binding Protein
Neoplasms
Therapeutics
Transcription Factors
Phosphorylation
2009
43 Citations (Scopus)

Discovery of a small-molecule inhibitor of the KIX-KID interaction

Li, B. X. & Xiao, X., Nov 23 2009, In : ChemBioChem. 10, 17, p. 2721-2724 4 p.

Research output: Contribution to journalArticle

Renilla Luciferases
Transcription
Assays
Genes
Cells
16 Citations (Scopus)

Rapid identification of improved protein ligands using peptoid microarrays

Lim, H. S., Muralidhar Reddy, M., Xiao, X., Wilson, J., Wilson, R., Connell, S. & Kodadek, T., Jul 15 2009, In : Bioorganic and Medicinal Chemistry Letters. 19, 14, p. 3866-3869 4 p.

Research output: Contribution to journalArticle

Peptoids
Click Chemistry
Microarrays
Protein Binding
Ligands
2007
61 Citations (Scopus)

A cell-permeable synthetic transcription factor mimic

Xiao, X., Yu, P., Lim, H. S., Sikder, D. & Kodadek, T., 2007, In : Angewandte Chemie - International Edition. 46, 16, p. 2865-2868 4 p.

Research output: Contribution to journalArticle

Peptoids
Transcription factors
Nylons
Transcription
Polyamides
26 Citations (Scopus)
Chromophore-Assisted Light Inactivation
2,2'-Dipyridyl
Chromophores
Singlet Oxygen
Proteins
40 Citations (Scopus)

Design and synthesis of a cell-permeable synthetic transcription factor mimic

Xiao, X., Yu, P., Lim, H. S., Sikder, D. & Kodadek, T., Jul 2007, In : Journal of Combinatorial Chemistry. 9, 4, p. 592-600 9 p.

Research output: Contribution to journalArticle

Peptoids
Artificial Cells
Nylons
Transcription Factor
Transcription Factors
2006
37 Citations (Scopus)

Isolation and characterization of coactivator-binding peptoids from a combinatorial library

Alluri, P., Liu, B., Yu, P., Xiao, X. & Kodadek, T., 2006, In : Molecular BioSystems. 2, 11, p. 568-579 12 p.

Research output: Contribution to journalArticle

Peptoids
CREB-Binding Protein
Chemical activation
Transcription Factors
DNA
13 Citations (Scopus)

On the mechanism of conversion of 4-carboxy-3,4-dihydro-3-phenyl-1(2H)-isoquinolones to indeno[1,2-c]isoquinolines by thionyl chloride

Xiao, X., Morrell, A., Fanwick, P. E. & Cushman, M., Oct 9 2006, In : Tetrahedron. 62, 41, p. 9705-9712 8 p.

Research output: Contribution to journalArticle

Isoquinolines
Dehydrogenation
Electrons
Lactams
Deprotonation
50 Citations (Scopus)

Total synthesis and biological evaluation of 22-hydroxyacuminatine

Xiao, X., Antony, S., Pommier, Y. & Cushman, M., Feb 23 2006, In : Journal of Medicinal Chemistry. 49, 4, p. 1408-1412 5 p.

Research output: Contribution to journalArticle

Type I DNA Topoisomerase
Camptotheca
Hydrogen bonds
Topoisomerase I Inhibitors
Camptothecin
2005
9 Citations (Scopus)

A convergent and stereoselective synthesis of a seco-precursor of macrolactin A

Li, S., Xiao, X., Yan, X., Liu, X., Xu, R. & Bai, D., Nov 21 2005, In : Tetrahedron. 61, 47, p. 11291-11298 8 p.

Research output: Contribution to journalArticle

Organophosphonates
Sulfones
Alkylation
Anions
macrolactin A
14 Citations (Scopus)

A facile method to transform trans-4-carboxy-3,4-dihydro-3-phenyl-1(2H)- isoquinolones to indeno[1,2-c]isoquinolines

Xiao, X. & Cushman, M., Aug 5 2005, In : Journal of Organic Chemistry. 70, 16, p. 6496-6498 3 p.

Research output: Contribution to journalArticle

Isoquinolines
Topoisomerase I Inhibitors
Schiff Bases
Anhydrides
Cyclization
53 Citations (Scopus)
Camptothecin
Type I DNA Topoisomerase
DNA Cleavage
Quantum theory
DNA sequences
21 Citations (Scopus)

Dihydroindenoisoquinolines function as prodrugs of indenoisoquinolines

Xiao, X., Miao, Z. H., Antony, S., Pommier, Y. & Cushman, M., Jun 2 2005, In : Bioorganic and Medicinal Chemistry Letters. 15, 11, p. 2795-2798 4 p.

Research output: Contribution to journalArticle

Prodrugs
Cytotoxicity
Topoisomerase I Inhibitors
Cells
Neoplasms
19 Citations (Scopus)

Effect of E-ring modifications in camptothecin on topoisomerase I inhibition: A quantum mechanics treatment

Xiao, X. & Cushman, M., Nov 11 2005, In : Journal of Organic Chemistry. 70, 23, p. 9584-9587 4 p.

Research output: Contribution to journalArticle

Camptothecin
Type I DNA Topoisomerase
Quantum theory
Lactams
Hydrogen bonds
64 Citations (Scopus)

On the binding of indeno[1,2-c]isoquinolines in the DNA-topoisomerase I cleavage complex

Xiao, X., Antony, S., Pommier, Y. & Cushman, M., May 5 2005, In : Journal of Medicinal Chemistry. 48, 9, p. 3231-3238 8 p.

Research output: Contribution to journalArticle

Isoquinolines
Type I DNA Topoisomerase
Base Pairing
Static Electricity
DNA
4 Citations (Scopus)

Synthesis of a sec-precursor and analogues of macrolactin A

Xiao, X., Li, S., Yan, X., Liu, X., Xu, R. & Bai, D., Jul 5 2005, In : Chemistry Letters. 34, 7, p. 906-907 2 p.

Research output: Contribution to journalArticle

macrolactin A
2004
44 Citations (Scopus)

Design, synthesis, and biological evaluation of cytotoxic 11-aminoalkenylindenoisoquinoline and 11-diaminoalkenylindenoisoquinoline topoisomerase I inhibitors

Xiao, X., Antony, S., Kohlhagen, G., Pommier, Y. & Cushman, M., Oct 1 2004, In : Bioorganic and Medicinal Chemistry. 12, 19, p. 5147-5160 14 p.

Research output: Contribution to journalArticle

NSC 314622
Topoisomerase I Inhibitors
Camptothecin
Type I DNA Topoisomerase
Molecular modeling
11 Citations (Scopus)

Novel autoxidative cleavage reaction of 9-fluoredenes discovered during synthesis of a potential DNA-threading indenoisoquinoline

Xiao, X., Antony, S., Kohlhagen, G., Pommier, Y. & Cushman, M., Oct 29 2004, In : Journal of Organic Chemistry. 69, 22, p. 7495-7501 7 p.

Research output: Contribution to journalArticle

Topoisomerase I Inhibitors
Lactams
DNA
Nitrogen
Cytotoxicity
5 Citations (Scopus)

Synthesis, crystal structure, and conversion of the polycyclic tris-anhydrotetramer of O-aminobenzaldehyde to Cu(TAAB)2+

Xiao, X., Fanwick, P. E. & Cushman, M., 2004, In : Synthetic Communications. 34, 21, p. 3901-3907 7 p.

Research output: Contribution to journalArticle

2-nitrobenzaldehyde
Crystal structure
X ray crystallography
Coordination Complexes
copper tetrabenzo(b,f,j,n)-1,5,9,13-tetraazacyclohexadecine
2003
89 Citations (Scopus)

Design, synthesis, and biological evaluation of cytotoxic 11-alkenylindenoisoquinoline topoisomerase I inhibitors and indenoisoquinoline-camptothecin hybrids

Fox, B. M., Xiao, X., Antony, S., Kohlhagen, G., Pommier, Y., Staker, B. L., Stewart, L. & Cushman, M., Jul 17 2003, In : Journal of Medicinal Chemistry. 46, 15, p. 3275-3282 8 p.

Research output: Contribution to journalArticle

Topoisomerase I Inhibitors
Camptothecin
Cytotoxicity
Cell culture
DNA
126 Citations (Scopus)

Design, Synthesis, and Biological Evaluation of Indenoisoquinoline Topoisomerase I Inhibitors Featuring Polyamine Side Chains on the Lactam Nitrogen

Nagarajan, M., Xiao, X., Antony, S., Kohlhagen, G., Pommier, Y. & Cushman, M., Dec 18 2003, In : Journal of Medicinal Chemistry. 46, 26, p. 5712-5724 13 p.

Research output: Contribution to journalArticle

Topoisomerase I Inhibitors
Lactams
Polyamines
Camptothecin
Nitrogen
2002

The unexpected reductive products of δ- alkoxyenal by sodium borohydride in methanol with a trace of magnesium methoxide

Xia, Y., Xiao, X., He, X. C. & Bai, D. L., Sep 2002, In : Chinese Chemical Letters. 13, 9, p. 809-810 2 p.

Research output: Contribution to journalArticle

Magnesium
Methanol
alkoxyl radical
sodium borohydride
2001
43 Citations (Scopus)

An efficient and selective method for hydrolysis of acetonides

Xiao, X. & Bai, D., 2001, In : Synlett. 4, p. 535-537 3 p.

Research output: Contribution to journalArticle

Oxalic Acid
Hydrolysis
Acids
acetonitrile
cerous chloride
2000
9 Citations (Scopus)

A stereoselective synthesis of the C(3)-C(13) and C(14)-C(24) fragments of macrolactin A

Li, S. K., Xu, R., Xiao, X. & Bai, D. L., 2000, In : Chinese Journal of Chemistry. 18, 6, p. 910-923 14 p.

Research output: Contribution to journalArticle

Sulfones
Alkylation
Bromides
Antiviral Agents
macrolactin A