William Rooney

Professor

  • 4434 Citations
  • 42 h-Index
1988 …2019
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Research Output 1988 2019

2012
120 Citations (Scopus)

Neuroimaging features of neurodegeneration with brain iron accumulation

Kruer, M. C., Boddaert, N., Schneider, A., Houlden, H., Bhatia, K. P., Gregory, A., Anderson, J. J., Rooney, W., Hogarth, P. P. & Hayflick, S., Mar 2012, In : American Journal of Neuroradiology. 33, 3, p. 407-414 8 p.

Research output: Contribution to journalArticle

Neuroimaging
Iron
Basal Ganglia Diseases
Movement Disorders
Genetic Testing
27 Citations (Scopus)
Pharmacokinetics
Signal-To-Noise Ratio
Magnetic resonance
Noise
Signal to noise ratio
52 Citations (Scopus)

Use of Skeletal Muscle MRI in Diagnosis and Monitoring Disease Progression in Duchenne Muscular Dystrophy

Finanger, E., Russman, B., Forbes, S. C., Rooney, W., Walter, G. A. & Vandenborne, K., Feb 2012, In : Physical Medicine and Rehabilitation Clinics of North America. 23, 1, p. 1-10 10 p.

Research output: Contribution to journalArticle

Duchenne Muscular Dystrophy
Disease Progression
Skeletal Muscle
Magnetic Resonance Imaging
Magnetic Resonance Spectroscopy
2011
49 Citations (Scopus)

Brain functional magnetic resonance imaging response to glucose and fructose infusions in humans

Purnell, J., Klopfenstein, B., Stevens, A., Havel, P. J., Adams, S. H., Dunn, T. N., Krisky, C. & Rooney, W., Mar 2011, In : Diabetes, Obesity and Metabolism. 13, 3, p. 229-234 6 p.

Research output: Contribution to journalArticle

Fructose
Magnetic Resonance Imaging
Glucose
Brain
Weights and Measures
48 Citations (Scopus)

Comparative analysis of ferumoxytol and gadoteridol enhancement using T1- and T2-weighted MRI in neuroimaging

Hamilton, B., Nesbit, G., Dosa, E., Gahramanov, S., Rooney, W., Nesbit, E. G., Raines, J. & Neuwelt, E., Oct 2011, In : American Journal of Roentgenology. 197, 4, p. 981-988 8 p.

Research output: Contribution to journalArticle

Ferrosoferric Oxide
Neuroimaging
Contrast Media
Gadolinium
Glioma
66 Citations (Scopus)

Discrimination of benign and malignant breast lesions by using shutter-speed dynamic contrast-enhanced MR imaging 1

Huang, W., Tudorica, L. A., Li, X., Thakur, S. B., Chen, Y., Morris, E. A., Tagge, I. J., Korenblit, M. E., Rooney, W., Koutcher, J. A. & Springer, C. J., Nov 2011, In : Radiology. 261, 2, p. 394-403 10 p.

Research output: Contribution to journalArticle

Breast
Magnetic Resonance Imaging
Interventional Magnetic Resonance Imaging
Pharmacokinetics
Breast Neoplasms
28 Citations (Scopus)

Japanese macaque encephalomyelitis: A spontaneous multiple sclerosis-like disease in a nonhuman primate

Axthelm, M., Bourdette, D., Marracci, G., Su, W., Mullaney, E. T., Manoharan, M., Kohama, S., Pollaro, J., Witkowski, E., Wang, P., Rooney, W., Sherman, L. L. & Wong, S., Sep 2011, In : Annals of Neurology. 70, 3, p. 362-373 12 p.

Research output: Contribution to journalArticle

Encephalomyelitis
Macaca
Primates
Multiple Sclerosis
Demyelinating Diseases
32 Citations (Scopus)

Magnetic resonance imaging of intracranial tumors: Intra-patient comparison of gadoteridol and ferumoxytol

Dósa, E., Guillaume, D. J., Haluska, M., Lacy, C. A., Hamilton, B., Njus, J. M., Rooney, W., Kraemer, D., Muldoon, L. & Neuwelt, E., Feb 2011, In : Neuro-Oncology. 13, 2, p. 251-260 10 p.

Research output: Contribution to journalArticle

Ferrosoferric Oxide
Magnetic Resonance Imaging
Magnetic Resonance Angiography
Neoplasms
Perfusion
47 Citations (Scopus)

MRI using ferumoxytol improves the visualization of central nervous system vascular malformations

Dósa, E., Tuladhar, S., Muldoon, L., Hamilton, B., Rooney, W. & Neuwelt, E., Jun 2011, In : Stroke. 42, 6, p. 1581-1588 8 p.

Research output: Contribution to journalArticle

Ferrosoferric Oxide
Central Nervous System Vascular Malformations
Vascular Malformations
Telangiectasis
Arteriovenous Malformations
104 Citations (Scopus)
Ferrosoferric Oxide
blood volume
progressions
magnetic resonance
tumors
13 Citations (Scopus)

The blood-brain barrier and microvascular water exchange in alzheimer's disease

Anderson, V., Lenar, D. P., Quinn, J. & Rooney, W., 2011, In : Cardiovascular Psychiatry and Neurology. 615829.

Research output: Contribution to journalArticle

Blood-Brain Barrier
Alzheimer Disease
Water
Neurofibrillary Tangles
Amyloid Plaques
2010
12 Citations (Scopus)

Cocaine is pharmacologically active in the nonhuman primate fetal brain

Benveniste, H., Fowler, J. S., Rooney, W., Scharf, B. A., Backus, W. W., Izrailtyan, I., Knudsen, G. M., Hasselbalch, S. G. & Volkow, N. D., Jan 26 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 4, p. 1582-1587 6 p.

Research output: Contribution to journalArticle

Cocaine
Primates
Brain
Glucose
Mothers
38 Citations (Scopus)

Dynamic-contrast-enhanced-MRI with extravasating contrast reagent: Rat cerebral glioma blood volume determination

Li, X., Rooney, W., Várallyay, C. G., Gahramanov, S., Muldoon, L., Goodman, J. A., Tagge, I. J., Selzer, A. H., Pike, M., Neuwelt, E. & Springer, C. J., Oct 2010, In : Journal of Magnetic Resonance. 206, 2, p. 190-199 10 p.

Research output: Contribution to journalArticle

Blood Volume Determination
blood volume
Glioma
Magnetic resonance imaging
rats
9 Citations (Scopus)

MR imaging of inflammation during myelin-specific T cell-mediated autoimmune attack in the EAE mouse spinal cord

Robinson, K. M., Njus, J. M., Phillips, D. A., Proctor, T. M., Rooney, W. & Jones, R. E., Jun 2010, In : Molecular Imaging and Biology. 12, 3, p. 240-249 10 p.

Research output: Contribution to journalArticle

Autoimmune Experimental Encephalomyelitis
Myelin Sheath
Spinal Cord
Magnetic Resonance Imaging
Inflammation
323 Citations (Scopus)
Nanoparticles
Central Nervous System
Magnetic Resonance Imaging
Pathology
Nervous System Trauma
2009
181 Citations (Scopus)

Ultrasmall superparamagnetic iron oxides (USPIOs): A future alternative magnetic resonance (MR) contrast agent for patients at risk for nephrogenic systemic fibrosis (NSF)?

Neuwelt, E., Hamilton, B., Varallyay, C. G., Rooney, W., Edelman, R. D., Jacobs, P. M. & Watnick, S., Mar 2009, In : Kidney International. 75, 5, p. 465-474 10 p.

Research output: Contribution to journalArticle

Nephrogenic Fibrosing Dermopathy
Contrast Media
Magnetic Resonance Spectroscopy
Ferrosoferric Oxide
Magnetic Resonance Imaging
2008
47 Citations (Scopus)

Dynamic NMR effects in breast cancer dynamic-contrast-enhanced MRI

Li, X., Huang, W., Morris, E. A., Tudorica, L. A., Seshan, V. E., Rooney, W., Tagge, I., Wang, Y., Xu, J. & Springer, C. J., Nov 18 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 46, p. 17937-17942 6 p.

Research output: Contribution to journalArticle

Breast Neoplasms
Water
Biopsy
Waxes
Blood Vessels
69 Citations (Scopus)

The magnetic resonance shutter speed discriminates vascular properties of malignant and benign breast tumors in vivo

Huang, W., Li, X., Morris, E. A., Tudorica, L. A., Seshan, V. E., Rooney, W., Tagge, I., Wang, Y., Xu, J. & Springer, C. J., Nov 18 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 46, p. 17943-17948 6 p.

Research output: Contribution to journalArticle

Blood Vessels
Magnetic Resonance Spectroscopy
Breast Neoplasms
Pathology
Biopsy
2007
349 Citations (Scopus)

Magnetic field and tissue dependencies of human brain longitudinal 1H2O relaxation in vivo

Rooney, W., Johnson, G., Li, X., Cohen, E. R., Kim, S. G., Ugurbil, K. & Springer, C. J., Feb 2007, In : Magnetic Resonance in Medicine. 57, 2, p. 308-318 11 p.

Research output: Contribution to journalArticle

Magnetic Fields
Brain
Cerebrospinal Fluid
Protons
Iron
66 Citations (Scopus)

Preliminary studies of a simultaneous PET/MRI scanner based on the RatCAP small animal tomograph

Woody, C., Schlyer, D., Vaska, P., Tomasi, D., Solis-Najera, S., Rooney, W., Pratte, J. F., Junnarkar, S., Stoll, S., Master, Z., Purschke, M., Park, S. J., Southekal, S., Kriplani, A., Krishnamoorthy, S., Maramraju, S., O'Connor, P. & Radeka, V., Feb 1 2007, In : Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment. 571, 1-2 SPEC. ISS., p. 102-105 4 p.

Research output: Contribution to journalArticle

Positron emission tomography
Magnetic resonance
scanners
magnetic resonance
animals
8 Citations (Scopus)

Preliminary studies of a simultaneous PET/MRI scanner based on the RatCAP small animal tomograph

Schlyer, D., Vaska, P., Tomasi, D., Woody, C., Solis-Najera, S., Southekal, S., Rooney, W., Pratte, J. F., Junnarkar, S., Stoll, S., Purschke, M., Park, S. J., Master, Z., Maramraju, S. H., Krishnamoorthy, S., Kriplani, A., Schiffer, W. & O'Connor, P., 2007, IEEE Nuclear Science Symposium Conference Record. Vol. 4. p. 2340-2344 5 p. 4179497

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Positron emission tomography
Animals
Detectors
Magnetic Resonance Imaging
Avalanche photodiodes
2005
102 Citations (Scopus)
Pharmacokinetics
Magnetic Resonance Imaging
Water
Magnetic Fields
Brain
1 Citation (Scopus)

Bayesian image decomposition applied to relaxographic imaging

Brown, T. R., Ochs, M. F., Rooney, W., Stoyanova, R. S., Li, X. & Springer, C. J., 2005, In : International Journal of Imaging Systems and Technology. 15, 1, p. 2-9 8 p.

Research output: Contribution to journalArticle

Tissue
Decomposition
Imaging techniques
decomposition
Recovery
68 Citations (Scopus)

Evidence for shutter-speed variation in CR bolus-tracking studies of human pathology

Yankeelov, T. E., Rooney, W., Huang, W., Dyke, J. P., Li, X., Tudorica, L. A., Lee, J. H., Koutcher, J. A. & Springer, C. J., May 2005, In : NMR in Biomedicine. 18, 3, p. 173-185 13 p.

Research output: Contribution to journalArticle

Pathology
Leg
Ductal Carcinoma
Extracellular Space
Osteosarcoma
32 Citations (Scopus)

Maternal and fetal 11C-cocaine uptake and kinetics measured in vivo by combined PET and MRI in pregnant nonhuman primates

Benveniste, H., Fowler, J. S., Rooney, W., Ding, Y. S., Baumann, A. L., Moller, D. H., Du, C., Backus, W., Logan, J., Carter, P., Coplan, J. D., Biegon, A., Rosenblum, L., Scharf, B., Gatley, J. S. & Volkow, N. D., 2005, In : Journal of Nuclear Medicine. 46, 2, p. 312-320 9 p.

Research output: Contribution to journalArticle

Cocaine
Primates
Mothers
Brain
Macaca radiata
5 Citations (Scopus)

Recent advances in the neuroimaging of multiple sclerosis

Rooney, W. & Coyle, P. K., May 2005, In : Current Neurology and Neuroscience Reports. 5, 3, p. 217-224 8 p.

Research output: Contribution to journalArticle

Neuroimaging
Multiple Sclerosis
Clinical Laboratory Techniques
Central Nervous System Diseases
Myelin Sheath
48 Citations (Scopus)
Breast Diseases
Fibroadenoma
Ductal Carcinoma
Animal Models
Pharmacokinetics
2004
83 Citations (Scopus)

6-[18F]fluoro-A-85380, a new PET tracer for the nicotinic acetylcholine receptor: Studies in the human brain and in vivo demonstration of specific binding in white matter

Ding, Y. S., Fowler, J. S., Logan, J., Wang, G. J., Telang, F., Garza, V., Biegon, A., Pareto, D., Rooney, W., Shea, C., Alexoff, D., Volkow, N. D. & Vocci, F., Sep 1 2004, In : Synapse. 53, 3, p. 184-189 6 p.

Research output: Contribution to journalArticle

Fluorine Radioisotopes
Azetidines
A 85380
Emission-Computed Tomography
Radioactive Tracers
10 Citations (Scopus)

Development of a simultaneous PET/MRI scanner

Schlyer, D., Rooney, W., Woody, C., Vaska, P., Kriplani, A. & Stoll, S., 2004, IEEE Nuclear Science Symposium Conference Record. Seibert, J. A. (ed.). Vol. 6. p. 3419-3421 3 p. M9-75

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Positron emission tomography
Photomultipliers
Electronic states
Magnetic resonance spectroscopy
Magnetic fields
2003
45 Citations (Scopus)

Maternal-fetal in vivo imaging: A combined PET and MRI study

Benveniste, H., Fowler, J. S., Rooney, W., Moller, D. H., Backus, W. W., Warner, D. A., Carter, P., King, P., Scharf, B., Alexoff, D. A., Ma, Y., Vaska, P., Schlyer, D. & Volkow, N. D., Sep 2003, In : Journal of Nuclear Medicine. 44, 9, p. 1522-1530 9 p.

Research output: Contribution to journalArticle

Mothers
Primates
Fluorodeoxyglucose F18
Pharmaceutical Preparations
Macaca
131 Citations (Scopus)
Water
Blood Vessels
Pharmacokinetics
Injections
2001
38 Citations (Scopus)

Reanalysis of multislice 1h MRSI in amyotrophic lateral sclerosis

Schuff, N., Rooney, W., Miller, R., Gelinas, D. F., Amend, D. L., Maudsley, A. A. & Weiner, M. W., 2001, In : Magnetic Resonance in Medicine. 45, 3, p. 513-516 4 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Internal Capsule
Motor Cortex
Choline
Spectrum Analysis
2000
79 Citations (Scopus)

1H MRSI comparison of white matter and lesions in primary progressive and relapsing-remitting MS

Suhy, J., Rooney, W., Goodkin, D. E., Capizzano, A. A., Soher, B. J., Maudsley, A. A., Waubant, E., Andersson, P. B. & Weiner, M. W., Jun 2000, In : Multiple Sclerosis. 6, 3, p. 148-155 8 p.

Research output: Contribution to journalArticle

Creatine
Gliosis
White Matter
Protons
Magnetic Resonance Imaging
10 Citations (Scopus)

4.0 T water proton T1 relaxation times in normal human brain and during acute ethanol intoxication

Rooney, W., Lee, J. H., Li, X., Wang, G. J., Franceschi, D., Springer, C. J. & Volkow, N. D., Jun 2000, In : Alcoholism: Clinical and Experimental Research. 24, 6, p. 830-836 7 p.

Research output: Contribution to journalArticle

Relaxation time
Protons
Brain
Ethanol
Water
169 Citations (Scopus)

Determination of the MRI contrast agent concentration time course in vivo following bolus injection: Effect of equilibrium transcytolemmal water exchange

Landis, C. S., Li, X., Telang, F. W., Coderre, J. A., Micca, P. L., Rooney, W., Latour, L. L., Vétek, G., Pályka, I. & Springer, C. J., 2000, In : Magnetic Resonance in Medicine. 44, 4, p. 563-574 12 p.

Research output: Contribution to journalArticle

Contrast Media
Gliosarcoma
Injections
Water
Thigh
7 Citations (Scopus)

Resting brain metabolic activity in a 4 Tesla magnetic field

Volkow, N. D., Wang, G. J., Fowler, J. S., Rooney, W., Felder, C. A., Lee, J. H., Franceschi, D., Maynard, L., Schlyer, D. J., Pan, J. W., Gatley, S. J. & Springer, C. J., 2000, In : Magnetic Resonance in Medicine. 44, 5, p. 701-705 5 p.

Research output: Contribution to journalArticle

Magnetic Fields
Positron-Emission Tomography
Brain
Deoxyglucose
Visual Fields
1999
13 Citations (Scopus)

Intimate combination of low- and high-resolution image data: I. Real- space PET and 1H2O MRI, PETAMRI

Sammi, M., Felder, C. A., Fowler, J. S., Lee, J. H., Levy, A. V., Li, X., Logan, J., Pályka, I., Rooney, W., Volkow, N. D., Wang, G. J. & Springer, C. J., 1999, In : Magnetic Resonance in Medicine. 42, 2, p. 345-360 16 p.

Research output: Contribution to journalArticle

Color
Fluorodeoxyglucose F18
Positron-Emission Tomography
Magnetic Resonance Spectroscopy
Brain
1998
164 Citations (Scopus)

A serial study of new MS lesions and the white matter from which they arise

Goodkin, D. E., Rooney, W., Sloan, R., Bacchetti, P., Gee, L., Vermathen, M., Waubant, E., Abundo, M., Majumdar, S., Nelson, S. & Weiner, M. W., Dec 1998, In : Neurology. 51, 6, p. 1689-1697 9 p.

Research output: Contribution to journalArticle

Protons
Gadolinium
White Matter
Water
Healthy Volunteers
100 Citations (Scopus)

Decreased N-acetylaspartate in motor cortex and corticospinal tract in ALS

Rooney, W., Miller, R. G., Gelinas, D., Schuff, N., Maudsley, A. A. & Weiner, M. W., Jun 1998, In : Neurology. 50, 6, p. 1800-1805 6 p.

Research output: Contribution to journalArticle

Pyramidal Tracts
Motor Cortex
Choline
Internal Capsule
Motor Neurons
48 Citations (Scopus)

Reduced MTR in the corticospinal tract and normal T2 in amyotrophic lateral sclerosis

Tanabe, J. L., Vermathen, M., Miller, R., Gelinas, D., Weiner, M. W. & Rooney, W., Dec 1998, In : Magnetic Resonance Imaging. 16, 10, p. 1163-1169 7 p.

Research output: Contribution to journalArticle

Pyramidal Tracts
Amyotrophic Lateral Sclerosis
Magnetization
magnetization
cortexes
1997
54 Citations (Scopus)

1H MRSI of normal appearing white matter in multiple sclerosis

Rooney, W., 1997, In : Multiple Sclerosis. 3, 4, p. 231-237 7 p.

Research output: Contribution to journalArticle

Multiple Sclerosis
Choline
Phosphocreatine
Creatine
White Matter
46 Citations (Scopus)

Effects of severe global ischemia on N-acetylaspartate and other metabolites in the rat brain

Higuchi, T., Graham, S. H., Fernandez, E. J., Rooney, W., Gaspary, H. L., Weiner, M. W. & Maudsley, A. A., Jun 1997, In : Magnetic Resonance in Medicine. 37, 6, p. 851-857 7 p.

Research output: Contribution to journalArticle

Ischemia
Brain
Necrosis
Neurons
N-acetylaspartate

Inorganic phosphate and coronary perfusion pressure mediate contractile dysfunction during mild ischemia

Miyamae, M., Albert Camacho, S., Rooney, W., Modin, G., Zhou, H. Z., Weiner, M. W. & Figueredo, V. M., 1997, In : American Journal of Physiology - Heart and Circulatory Physiology. 42, 2

Research output: Contribution to journalArticle

Ventricular Pressure
Ischemia
Perfusion
Phosphates
Pressure
8 Citations (Scopus)

Inorganic phosphate and coronary perfusion pressure mediate contractile dysfunction during mild ischemia

Miyamae, M., Albert Camacho, S., Rooney, W., Modin, G., Zhou, H. Z., Weiner, M. W. & Figueredo, V. M., 1997, In : American Journal of Physiology - Heart and Circulatory Physiology. 273, 2 42-2

Research output: Contribution to journalArticle

Ventricular Pressure
Ischemia
Perfusion
Phosphates
Pressure
1996
27 Citations (Scopus)

Evidence of multiple ethanol pools in the brain: An in vivo proton magnetization transfer study

Meyerhoff, D. J., Rooney, W., Tokumitsu, T. & Weiner, M. W., 1996, In : Alcoholism: Clinical and Experimental Research. 20, 7, p. 1283-1288 6 p.

Research output: Contribution to journalArticle

Protons
Magnetization
Brain
Ethanol
Cell membranes
14 Citations (Scopus)

Metabolite 1H relaxation in normal and hyponatremic brain

Rooney, W., Ebisu, T., Mancuso, A., Graham, S., Weiner, M. W. & Maudsley, A. A., May 1996, In : Magnetic Resonance in Medicine. 35, 5, p. 688-696 9 p.

Research output: Contribution to journalArticle

Creatine
Protons
Brain
Choline
Lactic Acid
59 Citations (Scopus)

MR spectroscopic imaging and diffusion-weighted MRI for early detection of kainate-induced status epilepticus in the rat

Ebisu, T., Rooney, W., Graham, S. H., Mancuso, A., Weiner, M. W. & Maudsley, A. A., Dec 1996, In : Magnetic Resonance in Medicine. 36, 6, p. 821-828 8 p.

Research output: Contribution to journalArticle

Diffusion Magnetic Resonance Imaging
Status Epilepticus
Kainic Acid
Lactic Acid
Magnetic Resonance Imaging
1995
43 Citations (Scopus)

Correlation of early reduction in the apparent diffusion coefficient of water with blood flow reduction during middle cerebral artery occlusion in rats

Mancuso, A., Karibe, H., Rooney, W., Zarow, G. J., Graham, S. H., Weiner, M. W. & Weinstein, P. R., 1995, In : Magnetic Resonance in Medicine. 34, 3, p. 368-377 10 p.

Research output: Contribution to journalArticle

Cerebrovascular Circulation
Middle Cerebral Artery Infarction
Water
Diffusion Magnetic Resonance Imaging
Infarction
1994
93 Citations (Scopus)

N-acetylaspartate as an in vivo marker of neuronal viability in kainate-induced status epilepticus: 1H magnetic resonance spectroscopic imaging

Ebisu, T., Rooney, W., Graham, S. H., Weiner, M. W. & Maudsley, A. A., May 1994, In : Journal of Cerebral Blood Flow and Metabolism. 14, 3, p. 373-382 10 p.

Research output: Contribution to journalArticle

Status Epilepticus
Kainic Acid
Magnetic Resonance Imaging
Wounds and Injuries
Hippocampus
1993
2 Citations (Scopus)

An analysis of intracellular 23Na relaxation using the double-quantum filtered NMR signal from the perfused rat salivary gland

Seo, Y., Rooney, W. & Murakami, M., Jun 6 1993, In : BBA - Molecular Cell Research. 1177, 2, p. 111-116 6 p.

Research output: Contribution to journalArticle

Ouabain
Salivary Glands
Viscosity
Acetylcholine
Magnetic Resonance Spectroscopy