Wayne Clark

Professor

  • 17152 Citations
  • 54 h-Index
1981 …2019

Research output per year

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Research Output

2019

Deferoxamine mesylate in patients with intracerebral haemorrhage (i-DEF): a multicentre, randomised, placebo-controlled, double-blind phase 2 trial

i-DEF Investigators, May 2019, In : The Lancet Neurology. 18, 5, p. 428-438 11 p.

Research output: Contribution to journalArticle

18 Scopus citations
1 Scopus citations
44 Scopus citations
2018
67 Scopus citations

Imaging features and safety and efficacy of endovascular stroke treatment: a meta-analysis of individual patient-level data

on behalf of the HERMES collaborators, Oct 1 2018, In : The Lancet Neurology. 17, 10, p. 895-904 10 p.

Research output: Contribution to journalArticle

52 Scopus citations

Influence of multiple stents on periprocedural stroke after carotid artery stenting in the Carotid Revascularization Endarterectomy versus Stent Trial (CREST)

Lal, B. K., Roubin, G. S., Jones, M., Clark, W., Mackey, A., Hill, M. D., Voeks, J. H., Howard, G., Hobson, R. W. & Brott, T. G., Jan 1 2018, (Accepted/In press) In : Journal of Vascular Surgery.

Research output: Contribution to journalArticle

2 Scopus citations

Primary results of the multicenter ARISE II study (Analysis of Revascularization in Ischemic Stroke With EmboTrap)

Zaidat, O. O., Bozorgchami, H., Ribó, M., Saver, J. L., Mattle, H. P., Chapot, R., Narata, A. P., Francois, O., Jadhav, A. P., Grossberg, J. A., Riedel, C. H., Tomasello, A., Clark, W. M., Nordmeyer, H., Lin, E., Nogueira, R. G., Yoo, A. J., Jovin, T. G., Siddiqui, A. H., Bernard, T. & 2 others, Claffey, M. & Andersson, T., Jan 1 2018, In : Stroke. 49, 5, p. 1107-1115 9 p.

Research output: Contribution to journalArticle

Open Access
24 Scopus citations

Rivaroxaban or aspirin for patent foramen ovale and embolic stroke of undetermined source: a prespecified subgroup analysis from the NAVIGATE ESUS trial

NAVIGATE ESUS Investigators, Dec 2018, In : The Lancet Neurology. 17, 12, p. 1053-1060 8 p.

Research output: Contribution to journalArticle

42 Scopus citations
1 Scopus citations
2017

Combined intravenous Thrombolysis and Thrombectomy vs Thrombectomy alone for acute ischemic stroke: A pooled analysis of the SWIFT and STAR studies

Coutinho, J. M., Liebeskind, D. S., Slater, L. A., Nogueira, R. G., Clark, W., Dávalos, A., Bonafé, A., Jahan, R., Fischer, U., Gralla, J., Saver, J. L. & Pereira, V. M., Mar 1 2017, In : JAMA Neurology. 74, 3, p. 268-274 7 p.

Research output: Contribution to journalArticle

81 Scopus citations

Safety and efficacy of multipotent adult progenitor cells in acute ischaemic stroke (MASTERS): a randomised, double-blind, placebo-controlled, phase 2 trial

Hess, D. C., Wechsler, L. R., Clark, W., Savitz, S. I., Ford, G. A., Chiu, D., Yavagal, D. R., Uchino, K., Liebeskind, D. S., Auchus, A. P., Sen, S., Sila, C. A., Vest, J. D. & Mays, R. W., May 1 2017, In : The Lancet Neurology. 16, 5, p. 360-368 9 p.

Research output: Contribution to journalArticle

82 Scopus citations
2016

Analysis of workflow and time to treatment and the effects on outcome in endovascular treatment of acute ischemic stroke: Results from the SWIFT PRIME randomized controlled trial

The SWIFT PRIME investigators are as follows, Jun 2016, In : RADIOLOGY. 279, 3, p. 888-897 10 p.

Research output: Contribution to journalArticle

109 Scopus citations

Effects of Acute Stroke Serum on Non-Ischemic Cerebral and Mesenteric Vascular Function

Canavero, I., Sherburne, H. A., Tremble, S. M., Clark, W. M. & Cipolla, M. J., Apr 1 2016, In : Translational Stroke Research. 7, 2, p. 156-165 10 p.

Research output: Contribution to journalArticle

4 Scopus citations

Long-term results of stenting versus endarterectomy for carotid-artery stenosis

the CREST Investigators, Mar 17 2016, In : New England Journal of Medicine. 374, 11, p. 1021-1031 11 p.

Research output: Contribution to journalArticle

294 Scopus citations

Pioglitazone after ischemic stroke or Transient Ischemic attack

Kernan, W. N., Viscoli, C. M., Furie, K. L., Young, L. H., Inzucchi, S. E., Gorman, M., Guarino, P. D., Lovejoy, A. M., Peduzzi, P. N., Conwit, R., Brass, L. M., Schwartz, G. G., Adams, H. P., Berger, L., Carolei, A., Clark, W., Coull, B., Ford, G. A., Kleindorfer, D., O'Leary, J. R. & 7 others, Parsons, M. W., Ringleb, P., Sen, S., Spence, J. D., Tanne, D., Wang, D. & Winder, T. R., Apr 7 2016, In : New England Journal of Medicine. 374, 14, p. 1321-1331 11 p.

Research output: Contribution to journalArticle

433 Scopus citations

Rapid learning curve for Solitaire FR stent retriever therapy: Evidence from roll-in and randomised patients in the SWIFT trial

Sheth, S. A., Jahan, R., Levy, E. I., Jovin, T. G., Baxter, B., Nogueira, R. G., Clark, W., Budzik, R., Zaidat, O. O. & Saver, J. L., Apr 1 2016, In : Journal of NeuroInterventional Surgery. 8, 4, p. 347-352 6 p.

Research output: Contribution to journalArticle

4 Scopus citations
2015

Characteristics of participants consenting versus declining follow-up for up to 10 years in a randomized clinical trial

Sheffet, A. J., Voeks, J. H., MacKey, A., Brooks, W., Clark, W. M., Hill, M. D., Howard, V. J., Hughes, S. E., Tom, M. L., Longbottom, M. E. & Brott, T. G., Dec 1 2015, In : Clinical Trials. 12, 6, p. 657-663 7 p.

Research output: Contribution to journalArticle

5 Scopus citations

Determinants of intracranial hemorrhage occurrence and outcome after neurothrombectomy therapy: Insights from the solitaire fr with intention for thrombectomy randomized trial

Raychev, R., Jahan, R., Liebeskind, D., Clark, W., Nogueira, R. G. & Saver, J., Dec 1 2015, In : American Journal of Neuroradiology. 36, 12, p. 2303-2307 5 p.

Research output: Contribution to journalArticle

11 Scopus citations
2014

Association of intraprocedural blood pressure and end tidal carbon dioxide with outcome after acute stroke intervention

Takahashi, C. E., Brambrink, A. M., Aziz, M. F., Macri, E., Raines, J., Multani-Kohol, A., Hinson, H. E., Lutsep, H. L., Clark, W. M. & Fields, J. D., Apr 2014, In : Neurocritical Care. 20, 2, p. 202-208 7 p.

Research output: Contribution to journalArticle

37 Scopus citations

SOLITAIRE™ with the intention for thrombectomy (SWIFT) trial: Design of a randomized, controlled, multicenter study comparing the SOLITAIRE™ Flow Restoration device and the MERCI Retriever in acute ischaemic stroke

Saver, J. L., Jahan, R., Levy, E. I., Jovin, T. G., Baxter, B., Nogueira, R., Clark, W., Budzik, R. & Zaidat, O. O., Jul 2014, In : International Journal of Stroke. 9, 5, p. 658-668 11 p.

Research output: Contribution to journalArticle

43 Scopus citations

Transcranial laser therapy in acute stroke treatment: Results of neurothera effectiveness and safety trial 3, a phase III clinical end point device trial

Hacke, W., Schellinger, P. D., Albers, G. W., Bornstein, N. M., Dahlof, B. L., Fulton, R., Kasner, S. E., Shuaib, A., Richieri, S. P., Dilly, S. G., Zivin, J., Lees, K. R., Zivin, J. A., Broderick, J., Ivanova, A., Johnston, K., Norrving, B., Albars, G., Alexandrov, A., Brown, D. & 43 others, Capone, P., Chiu, D., Clark, W., Cochran, J., Deredyn, C., Devlin, T., Hickling, W., Howell, G., Huang, D., Hussain, S., Mallenbaum, S., Moonis, M., Nash, M., Rymer, M., Taylor, R., Tremwel, M., Buck, B., Perez, J., Gerloff, C., Greiwing, B., Grond, M., Hamman, G., Haarmeiter, T., Jander, S., Köhrmann, M., Ritter, M., Schallinger, P., Schneider, D., Sobesky, J., Steiner, T., Steinmetz, H., Veltkamp, R., Weimar, C., Gruber, F., Andersson, B., Welin, L., Leys, D., Tatlisumak, T., Luft, A., Lyrer, P., Michel, P., Molina, C. & Segura, T., Jan 1 2014, In : Stroke. 45, 11, p. 3187-3193 7 p.

Research output: Contribution to journalArticle

39 Scopus citations
2013

Dabigatran etexilate: Management in acute ischemic stroke

Javedani, P. P., Horowitz, Z. Z., Clark, W. M. & Lutsep, H. L., Mar 1 2013, In : American Journal of Critical Care. 22, 2, p. 169-176 8 p.

Research output: Contribution to journalArticle

8 Scopus citations

Endovascular therapy after intravenous t-PA versus t-PA alone for stroke

Broderick, J. P., Palesch, Y. Y., Demchuk, A. M., Yeatts, S. D., Khatri, P., Hill, M. D., Jauch, E. C., Jovin, T. G., Yan, B., Silver, F. L., Von Kummer, R., Molina, C. A., Demaerschalk, B. M., Budzik, R., Clark, W. M., Zaidat, O. O., Malisch, T. W., Goyal, M., Schonewille, W. J., Mazighi, M. & 9 others, Engelter, S. T., Anderson, C., Spilker, J., Carrozzella, J., Ryckborst, K. J., Janis, L. S., Martin, R. H., Foster, L. D. & Tomsick, T. A., Mar 7 2013, In : New England Journal of Medicine. 368, 10, p. 893-903 11 p.

Research output: Contribution to journalArticle

1237 Scopus citations
2012

Costs and cost-effectiveness of carotid stenting versus endarterectomy for patients at standard surgical risk: Results from the Carotid Revascularization Endarterectomy Versus Stenting Trial (CREST)

Vilain, K. R., Magnuson, E. A., Li, H., Clark, W. M., Begg, R. J., Sam, A. D., Sternbergh, W. C., Weaver, F. A., Gray, W. A., Voeks, J. H., Brott, T. G. & Cohen, D. J., Sep 1 2012, In : Stroke. 43, 9, p. 2408-2416 9 p.

Research output: Contribution to journalArticle

49 Scopus citations

Safety and efficacy of NA-1 in patients with iatrogenic stroke after endovascular aneurysm repair (ENACT): A phase 2, randomised, double-blind, placebo-controlled trial

Hill, M. D., Martin, R. H., Mikulis, D., Wong, J. H., Silver, F. L., terBrugge, K. G., Milot, G., Clark, W. M., MacDonald, R. L., Kelly, M. E., Boulton, M., Fleetwood, I., McDougall, C., Gunnarsson, T., Chow, M., Lum, C., Dodd, R., Poublanc, J., Krings, T., Demchuk, A. M. & 5 others, Goyal, M., Anderson, R., Bishop, J., Garman, D. & Tymianski, M., Nov 1 2012, In : The Lancet Neurology. 11, 11, p. 942-950 9 p.

Research output: Contribution to journalArticle

214 Scopus citations

Solitaire flow restoration device versus the Merci Retriever in patients with acute ischaemic stroke (SWIFT): A randomised, parallel-group, non-inferiority trial

Saver, J. L., Jahan, R., Levy, E. I., Jovin, T. G., Baxter, B., Nogueira, R. G., Clark, W., Budzik, R. & Zaidat, O. O., Oct 2012, In : The Lancet. 380, 9849, p. 1241-1249 9 p.

Research output: Contribution to journalArticle

947 Scopus citations

Stroke: Treatment for acute strokeĝ€"the end of the citicoline saga

Clark, W. M. & Clark, T. D., Sep 1 2012, In : Nature Reviews Neurology. 8, 9, p. 484-485 2 p.

Research output: Contribution to journalShort survey

12 Scopus citations

Stroke after carotid stenting and endarterectomy in the carotid revascularization endarterectomy versus stenting trial (CREST)

Hill, M. D., Brooks, W., MacKey, A., Clark, W. M., Meschia, J. F., Morrish, W. F., Mohr, J. P., Rhodes, J. D., Popma, J. J., Lal, B. K., Longbottom, M. E., Voeks, J. H., Howard, G. & Brott, T. G., Dec 18 2012, In : Circulation. 126, 25, p. 3054-3061 8 p.

Research output: Contribution to journalArticle

100 Scopus citations
2011

Boosting enrolment in clinical trials: Validation of a regional network model

Kernan, W., Viscoli, C., Brass, L., Amatangelo, M., Birch, A., Clark, W., Conwit, R., Furie, K., Gorman, M., Pesapane, B., Kleindorfer, D., Lovejoy, A., Osborne, J., Silliman, S., Zweifler, R. & Horwitz, R., Oct 1 2011, In : Clinical Trials. 8, 5, p. 645-653 9 p.

Research output: Contribution to journalArticle

4 Scopus citations

Drug eluting stents for symptomatic intracranial and vertebral artery stenosis.

Fields, J. D., Petersen, B. D., Lutsep, H. L., Nesbit, G. M., Liu, K. C., Dogan, A., Lee, D. S., Clark, W. M. & Barnwell, S. L., Jun 2011, In : Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences. 17, 2, p. 241-247 7 p.

Research output: Contribution to journalArticle

16 Scopus citations

Health-related quality of life after carotid stenting versus carotid endarterectomy: Results from CREST (Carotid Revascularization Endarterectomy versus Stenting Trial)

Cohen, D. J., Stolker, J. M., Wang, K., Magnuson, E. A., Clark, W. M., Demaerschalk, B. M., Sam, A. D., Elmore, J. R., Weaver, F. A., Aronow, H. D., Goldstein, L. B., Roubin, G. S., Howard, G. & Brott, T. G., Oct 4 2011, In : Journal of the American College of Cardiology. 58, 15, p. 1557-1565 9 p.

Research output: Contribution to journalArticle

102 Scopus citations

Intracranial hemorrhage complicating carotid artery stenting and carotid endarterectomy

Clark, W. M. & Brott, T. G., Oct 1 2011, In : Stroke. 42, 10, p. 2720-2721 2 p.

Research output: Contribution to journalEditorial

3 Scopus citations

Matrix metalloproteinase-9 in an exploratory trial of intravenous minocycline for acute ischemic stroke

Switzer, J. A., Hess, D. C., Ergul, A., Waller, J. L., MacHado, L. S., Portik-Dobos, V., Pettigrew, L. C., Clark, W. M. & Fagan, S. C., Sep 1 2011, In : Stroke. 42, 9, p. 2633-2635 3 p.

Research output: Contribution to journalArticle

70 Scopus citations

Meta-analysis of randomized intra-arterial thrombolytic trials for the treatment of acute stroke due to middle cerebral artery occlusion

Fields, J. D., Khatri, P., Nesbit, G. M., Liu, K. C., Barnwell, S. L., Lutsep, H. L., Clark, W. M. & Lansberg, M. G., Jun 1 2011, In : Journal of neurointerventional surgery. 3, 2, p. 151-155 5 p.

Research output: Contribution to journalArticle

34 Scopus citations

Potentiating intra-arterial sonothrombolysis for acute ischemic stroke by the addition of the ultrasound contrast agents (Optison™ & SonoVue®)

Soltani, A., Singhal, R., Obtera, M., Roy, R. A., Clark, W. M. & Hansmann, D. R., Jan 1 2011, In : Journal of Thrombosis and Thrombolysis. 31, 1, p. 71-84 14 p.

Research output: Contribution to journalArticle

15 Scopus citations

Safety of stenting and endarterectomy by symptomatic status in the Carotid Revascularization Endarterectomy Versus Stenting Trial (CREST)

Silver, F. L., Mackey, A., Clark, W. M., Brooks, W., Timaran, C. H., Chiu, D., Goldstein, L. B., Meschia, J. F., Ferguson, R. D., Moore, W. S., Howard, G. & Brott, T. G., Mar 2011, In : Stroke. 42, 3, p. 675-680 6 p.

Research output: Contribution to journalArticle

234 Scopus citations

Sonothrombolysis: An Emerging Modality for the Treatment of Acute Ischemic and Hemorrhagic Stroke

Soltani, A., Clark, W. M. & Hansmann, D. R., Jun 1 2011, In : Translational Stroke Research. 2, 2, p. 159-170 12 p.

Research output: Contribution to journalReview article

4 Scopus citations
2010

Carotid stenting vs surgery: Parsing the risk of stroke and MI

Aksoy, O., Kapadia, S. R., Bajzer, C., Clark, W. M. & Shishehbor, M. H., Dec 1 2010, In : Cleveland Clinic journal of medicine. 77, 12, p. 892-902 11 p.

Research output: Contribution to journalArticle

15 Scopus citations

Indications and applications of arterial stents for stroke prevention in atherosclerotic intracranial stenosis

Fields, J. D., Liu, K. C., Barnwell, S. L., Clark, W. M. & Lutsep, H. L., Jan 1 2010, In : Current cardiology reports. 12, 1, p. 20-28 9 p.

Research output: Contribution to journalReview article

6 Scopus citations

Minocycline to Improve Neurologic Outcome in Stroke (MINOS): A dose-finding study

Fagan, S. C., Waller, J. L., Nichols, F. T., Edwards, D. J., Pettigrew, L. C., Clark, W. M., Hall, C. E., Switzer, J. A., Ergul, A. & Hess, D. C., Oct 1 2010, In : Stroke. 41, 10, p. 2283-2287 5 p.

Research output: Contribution to journalArticle

154 Scopus citations

Stenting versus endarterectomy for treatment of carotid-artery stenosis

Brott, T. G., Hobson, R. W., Howard, G., Roubin, G. S., Clark, W. M., Brooks, W., Mackey, A., Hill, M. D., Leimgruber, P. P., Sheffet, A. J., Howard, V. J., Moore, W. S., Voeks, J. H., Hopkins, L. N., Cutlip, D. E., Cohen, D. J., Popma, J. J., Ferguson, R. D., Cohen, S. N., Blackshear, J. L. & 4 others, Silver, F. L., Mohr, J. P., Lal, B. K. & Meschia, J. F., Jul 1 2010, In : New England Journal of Medicine. 363, 1, p. 11-23 13 p.

Research output: Contribution to journalArticle

1911 Scopus citations
2009

Efficacy of citicoline as an acute stroke treatment

Clark, W. M., Apr 1 2009, In : Expert Opinion on Pharmacotherapy. 10, 5, p. 839-846 8 p.

Research output: Contribution to journalReview article

27 Scopus citations

Keep the Three Hour TPA Window: The Lost Study of Atlantis

Clark, W. M. & Madden, K. P., Jan 2009, In : Journal of Stroke and Cerebrovascular Diseases. 18, 1, p. 78-79 2 p.

Research output: Contribution to journalLetter

6 Scopus citations
2006

Reply from the authors [4]

Egan, R. A., McGee, H. T. & Clark, W. M., Jan 1 2006, In : Neurology. 66, 2, p. 293-294 2 p.

Research output: Contribution to journalLetter

2005

Adiponectin: Spectator or player?

Clark, W. M., Sep 1 2005, In : Stroke. 36, 9, p. 1919-1920 2 p.

Research output: Contribution to journalComment/debate

3 Scopus citations

Visual field defect and intracerebral hemorrhage associated with use of vardenafil (Levitra)

McGee, H. T., Egan, R. A. & Clark, W. M., Mar 22 2005, In : Neurology. 64, 6, p. 1095-1096 2 p.

Research output: Contribution to journalArticle

16 Scopus citations
2003

Design and baseline characteristics of the Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) Study

Sillesen, H., Albers, G., Altafullah, I., Benavente, O., Book, D., Broderick, J., Calder, C., Callahan, A. S., Carlini, W., Chaturvedi, S., Chippendale, T., Clark, W., Collins, G., Coull, B., Davis, P., Devlin, T., Dick, A. R., Dirr-Ledbetter, L. Y., Dooneief, G., Duff, R. S. & 124 others, Estronza, N., Forteza, A., Frankel, M. R., Frey, J. L., Friday, G., Goldstein, J., Goldstein, S., Graham, G., Harper, W., Harris, J., Hendin, B., Hess, D. C., Hinton, R., Hollander, J., Hsu, C. Y., Hughes, R. L., Kasner, S., Kent, T. A., Kim, L., Kirshner, H., LaMonte, M., Levin, K., Libman, R., McDowell, P., McGee, F. E., Meyer, B., Minagar, A., Munschauer, F. E., Munson, R., Nash, M., Orr, S. C., Ratinov, G., Salanga, V., Sen, S., Silliman, S., Singer, R., Smith, D., Sullivan, H., Thaler, D., Tietjen, G., Tuchman, M., Uskavitch, D., Verro, P., Vicari, R., Weinstein, R., Wilterdink, J., Zweifler, R., Beaudry, M., Cote, R., Hoyte, K., Lebrun, L. H., Norris, J., Selchen, D., Shuaib, A., Simard, D., Spence, D., Teal, P., Winger, M., Schmidt, R., Pramsohler, B., Schmidauer, C., Kaste, M., Sivenius, J., Wagner, A., Terent, A., Amarenco, P., Milandre, L., Chollet, F., de Broucker, T., Moulin, T., Roullet, E., Leys, D., Mahagne, M. H., Hennerici, M., Heiss, W. D., Busse, O., Haberl, R., Harms, L., Diener, C., Hamann, G., Ringelstein, E. B., Canal, N., Capurso, A., Mamoli, A., Frattola, L., Gandolfo, C., Senin, U., Zito, M., de Keyser, K., Netherlands, T., Koudstaal, P. J., Haas, J. A., de Jong, G., Bogousslavsky, J., Mattie, H., Baumgartner, R., MacWalter, R. S., Dijkhuizen, R., Ekpo, E. B., Bath, P., Lees, K. R., Ferro, J., Cunha, L., Davalos, A., Chamorro, A., Sabin, A., Jimenez, D., Gonzalez, J. R., Lago, A., Egido, J., Vivancos, J., Guiu, M., Dorman, G., Davis, S., Gilles, D., Frayne, J., Crimmins, D., Dimmit, S., Singh, G. P., Scott, R., Anderson, N. E., Carr, J., Kruger, A. K. & Gardiner, J., Jan 1 2003, In : Cerebrovascular Diseases. 16, 4, p. 389-395 7 p.

Research output: Contribution to journalArticle

156 Scopus citations

Failure of ischemic neuroprotection by potentiators of gamma-aminobutyric acid.

Madden, K., Clark, W. & Lessov, N., Apr 2003, In : Clinical medicine & research. 1, 2, p. 119-124 6 p.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

North American clinical experience with the EKOS MicroLysUS infusion catheter for the treatment of embolic stroke

Mahon, B. R., Nesbit, G. M., Barnwell, S. L., Clark, W., Marotta, T. R., Weill, A., Teal, P. A. & Qureshi, A. I., Mar 1 2003, In : American Journal of Neuroradiology. 24, 3, p. 534-538 5 p.

Research output: Contribution to journalArticle

186 Scopus citations

Strokes, thromboembolic events, and IVIg: Rare incidents blemish an excellent safety record

Dalakas, M. C. & Clark, W. M., Jun 10 2003, In : Neurology. 60, 11, p. 1736-1737 2 p.

Research output: Contribution to journalEditorial

61 Scopus citations