Vivek Unni

Associate Professor

  • 3551 Citations
  • 14 h-Index

Research output per year

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Research Output

  • 3551 Citations
  • 14 h-Index
  • 15 Article
  • 2 Review article

Alpha-synuclein is a DNA binding protein that modulates DNA repair with implications for Lewy body disorders

Schaser, A. J., Osterberg, V. R., Dent, S. E., Stackhouse, T. L., Wakeham, C. M., Boutros, S. W., Weston, L. J., Owen, N., Weissman, T. A., Luna, E., Raber, J., Luk, K. C., McCullough, A., Woltjer, R. R. & Unni, V., Dec 1 2019, In : Scientific Reports. 9, 1, 10919.

Research output: Contribution to journalArticle

Open Access
13 Scopus citations

Multicolor lineage tracing using in vivo time-lapse imaging reveals coordinated death of clonally related cells in the developing vertebrate brain

Brockway, N. L., Cook, Z. T., O'Gallagher, M. J., Tobias, Z. J. C., Gedi, M., Carey, K. M., Unni, V. K., Pan, Y. A., Metz, M. R. & Weissman, T. A., Sep 15 2019, In : Developmental Biology. 453, 2, p. 130-140 11 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

G2019s-LRRK2 expression augments α-synuclein sequestration into inclusions in neurons

Volpicelli-Daley, L. A., Abdelmotilib, H., Liu, Z., Stoyka, L., Daher, J. P. L., Milnerwood, A. J., Unni, V., Hirst, W. D., Yue, Z., Zhao, H. T., Fraser, K., Kennedy, R. E. & West, A. B., Jul 13 2016, In : Journal of Neuroscience. 36, 28, p. 7415-7427 13 p.

Research output: Contribution to journalArticle

57 Scopus citations

Curcumin treatment improves motor behavior in α-synuclein transgenic mice

Spinelli, K. J., Osterberg, V. R., Meshul, C. K., Soumyanath, A. & Unni, V. K., Jun 2 2015, In : PloS one. 10, 6, e0128510.

Research output: Contribution to journalArticle

20 Scopus citations

Mutations in XPR1 cause primary familial brain calcification associated with altered phosphate export

Legati, A., Giovannini, D., Nicolas, G., López-Sánchez, U., Quintáns, B., Oliveira, J. R. M., Sears, R. L., Ramos, E. M., Spiteri, E., Sobrido, M. J., Carracedo, Á., Castro-Fernández, C., Cubizolle, S., Fogel, B. L., Goizet, C., Jen, J. C., Kirdlarp, S., Lang, A. E., Miedzybrodzka, Z., Mitarnun, W. & 21 others, Paucar, M., Paulson, H., Pariente, J., Richard, A. C., Salins, N. S., Simpson, S. A., Striano, P., Svenningsson, P., Tison, F., Unni, V. K., Vanakker, O., Wessels, M. W., Wetchaphanphesat, S., Yang, M., Boller, F., Campion, D., Hannequin, D., Sitbon, M., Geschwind, D. H., Battini, J. L. & Coppola, G., May 27 2015, In : Nature genetics. 47, 6, p. 579-581 3 p.

Research output: Contribution to journalArticle

126 Scopus citations

Progressive Aggregation of Alpha-Synuclein and Selective Degeneration of Lewy Inclusion-Bearing Neurons in a Mouse Model of Parkinsonism

Osterberg, V. R., Spinelli, K. J., Weston, L. J., Luk, K. C., Woltjer, R. L. & Unni, V. K., Mar 3 2015, In : Cell Reports. 10, 8, p. 1252-1260 9 p.

Research output: Contribution to journalArticle

91 Scopus citations

Presynaptic alpha-synuclein aggregation in a mouse model of Parkinson's disease

Spinelli, K. J., Taylor, J. K., Osterberg, V. R., Churchill, M. J., Pollock, E., Moore, C., Meshul, C. K. & Unni, V. K., Feb 7 2014, In : Journal of Neuroscience. 34, 6, p. 2037-2050 14 p.

Research output: Contribution to journalArticle

67 Scopus citations

Specific splice variants are associated with Parkinson's disease

Santiago, J. A., Scherzer, C. R., Potashkin, J. A., Hyman, B. T., Ivinson, A. J., Trisini-Lipsanopoulos, A., Dhima, K., Bayer, S., Lockhart, K. C., Yi, T., Liao, Z., Hoesing, A. N., Duong, K., Roderick, S., Sudarsky, L. R., Hayes, M. T., Sperling, R., Growdon, J. H., Schwarzschild, M. A., Hung, A. Y. & 15 others, Flaherty, A. W., Blacker, D., Wills, A. M., Sohur, U. S., Unni, V. K., Mejia, N. I., Viswanathan, A., Gomperts, S. N., Khurana, V., Albers, M. W., Rudel, R. K., Locascio, J. J., Selkoe, D. J., Schlossmacher, M. G. & Ascherio, A., Oct 2013, In : Movement Disorders. 28, 12, p. 1724-1727 4 p.

Research output: Contribution to journalArticle

17 Scopus citations

Association of SNCA with Parkinson: Replication in the Harvard NeuroDiscovery Center Biomarker Study

Ding, H., Sarokhan, A. K., Roderick, S. S., Bakshi, R., Maher, N. E., Ashourian, P., Kan, C. G., Chang, S., Santarlasci, A., Swords, K. E., Ravina, B. M., Hayes, M. T., Sohur, U. S., Wills, A. M., Flaherty, A. W., Unni, V. K., Hung, A. Y., Selkoe, D. J., Schwarzschild, M. A., Schlossmacher, M. G. & 5 others, Sudarsky, L. R., Growdon, J. H., Ivinson, A. J., Hyman, B. T. & Scherzer, C. R., Oct 1 2011, In : Movement Disorders. 26, 12, p. 2283-2286 4 p.

Research output: Contribution to journalArticle

19 Scopus citations

Distinct roles in vivo for the Ubiquitin-Proteasome system and the Autophagy-Lysosomal Pathway in the Degradation of α-Synuclein

Ebrahimi-Fakhari, D., Cantuti-Castelvetri, I., Fan, Z., Rockenstein, E., Masliah, E., Hyman, B. T., McLean, P. J. & Unni, V. K., Oct 12 2011, In : Journal of Neuroscience. 31, 41, p. 14508-14520 13 p.

Research output: Contribution to journalArticle

224 Scopus citations

Studying protein degradation pathways in vivo using a cranial window-based approach

Unni, V. K., Ebrahimi-Fakhari, D., Vanderburg, C. R., McLean, P. J. & Hyman, B. T., Mar 1 2011, In : Methods. 53, 3, p. 194-200 7 p.

Research output: Contribution to journalArticle

4 Scopus citations

In vivo imaging of α-synuclein in mouse cortex demonstrates stable expression and differential subcellular compartment mobility

Unni, V. K., Weissman, T. A., Rockenstein, E., Masliah, E., McLean, P. J. & Hyman, B. T., Sep 17 2010, In : PloS one. 5, 5, e10589.

Research output: Contribution to journalArticle

32 Scopus citations

Calcium release from presynaptic ryanodine-sensitive stores is required for long-term depression at hippocampal CA3-CA3 pyramidal neuron synapses

Unni, V. K., Zakharenko, S. S., Zablow, L., DeCostanzo, A. J. & Siegelbaum, S. A., Oct 27 2004, In : Journal of Neuroscience. 24, 43, p. 9612-9622 11 p.

Research output: Contribution to journalArticle

52 Scopus citations

Essential roles in synaptic plasticity for synaptogyrin I and synaptophysin I

Janz, R., Südhof, T. C., Hammer, R. E., Unni, V., Siegelbaum, S. A. & Bolshakov, V. Y., Nov 1999, In : Neuron. 24, 3, p. 687-700 14 p.

Research output: Contribution to journalArticle

Open Access
223 Scopus citations

Networks of coactive neurons in developing layer 1

Schwartz, T. H., Rabinowitz, D., Unni, V., Kumar, V. S., Smetters, D. K., Tsiola, A. & Yuste, R., Mar 1998, In : Neuron. 20, 3, p. 541-552 12 p.

Research output: Contribution to journalArticle

120 Scopus citations