Virginia Brooks

Professor

  • 2289 Citations
  • 28 h-Index
1973 …2019
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Research Output 1973 2019

  • 2289 Citations
  • 28 h-Index
  • 107 Article
  • 1 Chapter
2019

Resistance to the sympathoexcitatory effects of insulin and leptin in late pregnant rats

Shi, Z., Hansen, K. M., Bullock, K. M., Morofuji, Y., Banks, W. A. & Brooks, V., Jan 1 2019, In : Journal of Physiology.

Research output: Contribution to journalArticle

Leptin
Insulin
Pregnancy
Brain
Cerebrospinal Fluid
2 Citations (Scopus)

Sex differences in the sympathoexcitatory response to insulin in obese rats: role of neuropeptide Y

Shi, Z., Cassaglia, P. A., Pelletier, N. E. & Brooks, V., Jan 1 2019, In : Journal of Physiology.

Research output: Contribution to journalArticle

Neuropeptide Y
Sex Characteristics
Obesity
Insulin
Paraventricular Hypothalamic Nucleus
2018
14 Citations (Scopus)

Vagal afferent activation suppresses systemic inflammation via the splanchnic anti-inflammatory pathway

Komegae, E. N., Farmer, D. G. S., Brooks, V., McKinley, M. J., McAllen, R. M. & Martelli, D., Jan 1 2018, (Accepted/In press) In : Brain, Behavior, and Immunity.

Research output: Contribution to journalArticle

Viscera
Splanchnic Nerves
Anti-Inflammatory Agents
Inflammation
Tumor Necrosis Factor-alpha
2017
10 Citations (Scopus)

Arcuate neuropeptide y inhibits sympathetic nerve activity via multiple neuropathways

Shi, Z., Madden, C. C. & Brooks, V., Jun 30 2017, In : Journal of Clinical Investigation. 127, 7, p. 2868-2880 13 p.

Research output: Contribution to journalArticle

Neuropeptide Y
Neuropeptides
Arcuate Nucleus of Hypothalamus
Paraventricular Hypothalamic Nucleus
Hypothalamus
2016
7 Citations (Scopus)
Paraventricular Hypothalamic Nucleus
Neuropeptides
Arcuate Nucleus of Hypothalamus
Hypothalamus
Insulin
2015
8 Citations (Scopus)

Hypothalamic Paraventricular and Arcuate Nuclei Contribute to Elevated Sympathetic Nerve Activity in Pregnant Rats: Roles of Neuropeptide Y and α-Melanocyte-Stimulating Hormone

Shi, Z., Cassaglia, P. A., Gotthardt, L. C. & Brooks, V., Dec 1 2015, In : Hypertension. 66, 6, p. 1191-1198 8 p.

Research output: Contribution to journalArticle

Melanocyte-Stimulating Hormones
Arcuate Nucleus of Hypothalamus
Paraventricular Hypothalamic Nucleus
Neuropeptide Y
Arterial Pressure
21 Citations (Scopus)

Leptin differentially increases sympathetic nerve activity and its baroreflex regulation in female rats: Role of oestrogen

Shi, Z. & Brooks, V., Apr 1 2015, In : Journal of Physiology. 593, 7, p. 1633-1647 15 p.

Research output: Contribution to journalArticle

Baroreflex
Leptin
Estrogens
Estrus
Diestrus
19 Citations (Scopus)

Obesity-induced increases in sympathetic nerve activity: Sex matters

Brooks, V., Shi, Z., Holwerda, S. W. & Fadel, P. J., Jan 1 2015, In : Autonomic Neuroscience: Basic and Clinical. 187, p. 18-26 9 p.

Research output: Contribution to journalArticle

Sex Characteristics
Obesity
Adiposity
Hypertension
Blood Vessels
18 Citations (Scopus)

Role of the paraventricular nucleus of the hypothalamus in the sympathoexcitatory effects of leptin

Shi, Z., Li, B. & Brooks, V., Nov 1 2015, In : Hypertension. 66, 5, p. 1034-1041 8 p.

Research output: Contribution to journalArticle

Paraventricular Hypothalamic Nucleus
Leptin
Hypothalamus
Receptor, Melanocortin, Type 3
Receptor, Melanocortin, Type 4
2014
21 Citations (Scopus)

Neuropeptide Y acts in the paraventricular nucleus to suppress sympathetic nerve activity and its baroreflex regulation

Cassaglia, P. A., Shi, Z., Li, B., Reis, W. L., Clute-Reinig, N. M., Stern, J. E. & Brooks, V., Apr 1 2014, In : Journal of Physiology. 592, 7, p. 1655-1675 21 p.

Research output: Contribution to journalArticle

Baroreflex
Paraventricular Hypothalamic Nucleus
Neuropeptide Y
Hypothalamus
Melanocyte-Stimulating Hormones
2 Citations (Scopus)

Roles of the subfornical organ and area postrema in arterial pressure increases induced by 48-h water deprivation in normal rats

Collister, J. P., Nahey, D. B., Hendel, M. D. & Brooks, V., 2014, In : Physiological Reports. 2, 1, e00191.

Research output: Contribution to journalArticle

Subfornical Organ
Area Postrema
Water Deprivation
Arterial Pressure
Blood Pressure
2013
23 Citations (Scopus)

Leptin acts in the forebrain to differentially influence baroreflex control of lumbar, renal, and splanchnic sympathetic nerve activity and heart rate

Li, B., Shi, Z., Cassaglia, P. A. & Brooks, V., Apr 2013, In : Hypertension. 61, 4, p. 812-819 8 p.

Research output: Contribution to journalArticle

Splanchnic Nerves
Baroreflex
Prosencephalon
Leptin
Heart Rate
18 Citations (Scopus)
Cardiac Arrhythmias
Obesity
Diet
High Fat Diet
Norepinephrine
11 Citations (Scopus)

Upregulation of brain-derived neurotrophic factor expression in nodose ganglia and the lower brainstem of hypertensive rats

Vermehren-Schmaedick, A., Jenkins, V. K., Hsieh, H. Y., Brown, A. L., Page, M. P., Brooks, V. & Balkowiec, A., Feb 2013, In : Journal of Neuroscience Research. 91, 2, p. 220-229 10 p.

Research output: Contribution to journalArticle

Nodose Ganglion
Brain-Derived Neurotrophic Factor
Brain Stem
Up-Regulation
Pressoreceptors
2012
1 Citation (Scopus)

Autonomic Control During Pregnancy

Brooks, V., McCully, B. & Cassaglia, P. A., 2012, Primer on the Autonomic Nervous System. Elsevier Inc., p. 265-268 4 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Pregnancy
Baroreflex
Glucose
Autonomic Nervous System
Sympathetic Nervous System
19 Citations (Scopus)

Baroreflex function in females: Changes with the reproductive cycle and pregnancy

Brooks, V., Cassaglia, P. A., Zhao, D. & Goldman, R. K., Apr 2012, In : Gender Medicine. 9, 2, p. 61-67 7 p.

Research output: Contribution to journalArticle

Baroreflex
pregnancy
Pregnancy
Estrogens
death
16 Citations (Scopus)
Baroreflex
Obesity
Diet
Pressoreceptors
Myelinated Nerve Fibers
1 Citation (Scopus)

High-fat food, sympathetic nerve activity, and hypertension: Danger soon after the first bite?

Brooks, V. & Osborn, J. W., Dec 2012, In : Hypertension. 60, 6, p. 1387-1388 2 p.

Research output: Contribution to journalArticle

Sympathetic Nervous System
Adiposity
High Fat Diet
Bites and Stings
Arterial Pressure
18 Citations (Scopus)
rosiglitazone
Baroreflex
Insulin Resistance
Obesity
Diet
2011
9 Citations (Scopus)
Baroreflex
Paraventricular Hypothalamic Nucleus
gamma-Aminobutyric Acid
Hypothalamus
Pregnancy
16 Citations (Scopus)

Impaired baroreflex gain during pregnancy in conscious rats: Role of brain insulin

Azar, A. S. & Brooks, V., Feb 2011, In : Hypertension. 57, 2, p. 283-288 6 p.

Research output: Contribution to journalArticle

Baroreflex
Insulin
Pregnancy
Brain
Cerebrospinal Fluid
70 Citations (Scopus)

Insulin acts in the arcuate nucleus to increase lumbar sympathetic nerve activity and baroreflex function in rats

Cassaglia, P. A., Hermes, S. M., Aicher, S. & Brooks, V., Apr 2011, In : Journal of Physiology. 589, 7, p. 1643-1662 20 p.

Research output: Contribution to journalArticle

Arcuate Nucleus of Hypothalamus
Baroreflex
Insulin
Paraventricular Hypothalamic Nucleus
Hypothalamus
10 Citations (Scopus)

Renal nerves, WNK4, glucocorticoids, and salt transport

Ellison, D. & Brooks, V., Jun 8 2011, In : Cell Metabolism. 13, 6, p. 619-620 2 p.

Research output: Contribution to journalArticle

Glucocorticoids
Salts
Hypertension
Kidney
Sympathetic Nervous System
2010
3 Citations (Scopus)

Insulin: A sweet deal for human baroreflex function

Brooks, V., Oct 2010, In : Journal of Physiology. 588, 19, p. 3629 1 p.

Research output: Contribution to journalArticle

Brain Chemistry
Baroreflex
Sympathetic Nervous System
Insulin Resistance
Young Adult
32 Citations (Scopus)

Pregnancy and the endocrine regulation of the baroreceptor reflex

Brooks, V., Dampney, R. A. L. & Heesch, C. M., Aug 2010, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 299, 2

Research output: Contribution to journalArticle

Baroreflex
Pregnancy
Neurotransmitter Agents
Arterial Pressure
Brain
15 Citations (Scopus)

Pregnancy impairs baroreflex control of heart rate in rats: Role of insulin sensitivity

Brooks, V., Mulvaney, J. M., Azar, A. S., Zhao, D. & Goldman, R. K., Feb 2010, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 298, 2

Research output: Contribution to journalArticle

Baroreflex
Insulin Resistance
Heart Rate
Pregnancy
Glucose Clamp Technique
2009
35 Citations (Scopus)

Baroreflex sensitivity varies during the rat estrous cycle: Role of gonadal steroids

Goldman, R. K., Azar, A. S., Mulvaney, J. M., Hinojosa-Laborde, C., Haywood, J. R. & Brooks, V., May 2009, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 296, 5

Research output: Contribution to journalArticle

Estrous Cycle
Baroreflex
Steroids
Arterial Pressure
Heart Rate
2008
35 Citations (Scopus)

Insulin in the brain increases gain of baroreflex control of heart rate and lumbar sympathetic nerve activity

Pricher, M. P., Freeman, K. L. & Brooks, V., Feb 2008, In : Hypertension. 51, 2 PART 2, p. 514-520 7 p.

Research output: Contribution to journalArticle

Baroreflex
Heart Rate
Insulin
Brain
Fourth Ventricle
2007
38 Citations (Scopus)
Water Deprivation
Paraventricular Hypothalamic Nucleus
Blood Pressure
Water
Valsartan
24 Citations (Scopus)

Insulin resistance and impaired baroreflex gain during pregnancy

Daubert, D. L., Chung, M. Y. & Brooks, V., Jun 2007, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 292, 6

Research output: Contribution to journalArticle

Baroreflex
Insulin Resistance
Pregnancy
Insulin
rosiglitazone
3 Citations (Scopus)
Baroreflex
Corticosterone
Psychological Stress
Nitric Oxide
Rabbits
7 Citations (Scopus)
Baroreflex
Angiotensin II
Nitric Oxide
Nitric Oxide Synthase
Pregnancy
2006
25 Citations (Scopus)

Central action of increased osmolality to support blood pressure in deoxycorticosterone acetate-salt rats

O'Donaughy, T. L., Yue, Q. & Brooks, V., Oct 2006, In : Hypertension. 48, 4, p. 658-663 6 p.

Research output: Contribution to journalArticle

Desoxycorticosterone
Osmolar Concentration
Acetates
Salts
Blood Pressure
35 Citations (Scopus)

Deoxycorticosterone acetate-salt rats: Hypertension and sympathoexcitation driven by increased NaCl levels

O'Donaughy, T. L. & Brooks, V., Apr 2006, In : Hypertension. 47, 4, p. 680-685 6 p.

Research output: Contribution to journalArticle

Desoxycorticosterone
Acetates
Salts
Hypertension
Blood Pressure
13 Citations (Scopus)
Desoxycorticosterone Acetate
Vasopressins
Salts
Blood Pressure
Liver
2005
33 Citations (Scopus)
Osmolar Concentration
Arterial Pressure
Water
Brain
Heart Rate
23 Citations (Scopus)
Afferent Pathways
Pressoreceptors
Sinoatrial Node
Baroreflex
Arterial Pressure
80 Citations (Scopus)

Translation of salt retention to central activation of the sympathetic nervous system in hypertension

Brooks, V., Haywood, J. R. & Johnson, A. K., May 2005, In : Clinical and Experimental Pharmacology and Physiology. 32, 5-6, p. 426-432 7 p.

Research output: Contribution to journalArticle

Sympathetic Nervous System
Salts
Hypertension
Osmolar Concentration
Neuronal Plasticity
2004
35 Citations (Scopus)
Excitatory Amino Acids
Osmolar Concentration
Microinjections
Blood Volume
Water
33 Citations (Scopus)
Water Deprivation
Excitatory Amino Acids
Blood Pressure
Water
Microinjections
9 Citations (Scopus)
Angiotensin II
Nitric Oxide
Kidney
Nitric Oxide Synthase
NG-Nitroarginine Methyl Ester
2003
19 Citations (Scopus)

Ganglionic tyrosine hydroxylase and norepinephrine transporter are decreased by increased sodium chloride in vivo and in vitro

Habecker, B., Grygielko, E. T., Huhtala, T. A., Foote, B. & Brooks, V., Sep 30 2003, In : Autonomic Neuroscience: Basic and Clinical. 107, 2, p. 85-98 14 p.

Research output: Contribution to journalArticle

Norepinephrine Plasma Membrane Transport Proteins
Tyrosine 3-Monooxygenase
Sodium Chloride
Salts
Sympathetic Ganglia
10 Citations (Scopus)

Pregnancy alters hemodynamic responses to hemorrhage in conscious rabbits

Clow, K. A., Giraud, G., Ogden, B. E. & Brooks, V., Apr 1 2003, In : American Journal of Physiology - Heart and Circulatory Physiology. 284, 4 53-4

Research output: Contribution to journalArticle

Cardiac Output
Hemodynamics
Hemorrhage
Rabbits
Arterial Pressure
28 Citations (Scopus)
Norepinephrine Plasma Membrane Transport Proteins
Sympathetic Ganglia
Tyrosine 3-Monooxygenase
Superior Cervical Ganglion
Adrenal Glands
2002
23 Citations (Scopus)
Osmolar Concentration
Arterial Pressure
Kidney
Water
Vasopressin Receptors
10 Citations (Scopus)

Pregnancy and acute baroreflex resetting in conscious rabbits

Brooks, V., Clow, K. A. & O'Hagan, K. P., 2002, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 283, 2 52-2

Research output: Contribution to journalArticle

Baroreflex
Phenylephrine
Rabbits
Methoxamine
Heart Rate
2001
11 Citations (Scopus)
Vasodilation
Nitric Oxide
Rabbits
Pregnancy
Blood Vessels
13 Citations (Scopus)

Role of angiotensin II in altered baroreflex function of conscious rabbits during late pregnancy

Brooks, V., Welch, L. S. & Kane, C. M., 2001, In : American Journal of Obstetrics and Gynecology. 184, 3, p. 476-482 7 p.

Research output: Contribution to journalArticle

Baroreflex
Angiotensin II
Heart Rate
Rabbits
Pregnancy
36 Citations (Scopus)
Angiotensin II
Osmolar Concentration
Salts
Arterial Pressure
Intake
2000
19 Citations (Scopus)
Methysergide
Receptor, Serotonin, 5-HT1A
8-Hydroxy-2-(di-n-propylamino)tetralin
Hemorrhage
Receptor, Serotonin, 5-HT1B