Ujwal Shinde

Associate Professor

  • 2487 Citations
  • 29 h-Index
1989 …2020

Research output per year

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Research Output

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Article
2020

Cumulative deamidations of the major lens protein γS-crystallin increase its aggregation during unfolding and oxidation

Vetter, C. J., Thorn, D. C., Wheeler, S. G., Mundorff, C. C., Halverson, K. A., Wales, T. E., Shinde, U., Engen, J. R., David, L. L., Carver, J. A. & Lampi, K., Sep 1 2020, In : Protein Science. 29, 9, p. 1945-1963 19 p.

Research output: Contribution to journalArticle

2019

A ribose modification of Spinach aptamer accelerates lead(ii) cation association: In vitro

Savage, J. C., Shinde, P., Bächinger, H. P., Davare, M. A. & Shinde, U., Jan 1 2019, In : Chemical Communications. 55, 42, p. 5882-5885 4 p.

Research output: Contribution to journalArticle

2 Scopus citations
2018

Inhibition of interleukin-1 receptor-associated kinase-1 is a therapeutic strategy for acute myeloid leukemia subtypes

Hosseini, M. M., Kurtz, S. E., Abdelhamed, S., Mahmood, S., Davare, M. A., Kaempf, A., Elferich, J., McDermott, J. E., Liu, T., Payne, S. H., Shinde, U., Rodland, K. D., Mori, M., Druker, B. J., Singer, J. W. & Agarwal, A., Nov 1 2018, In : Leukemia. 32, 11, p. 2374-2387 14 p.

Research output: Contribution to journalArticle

9 Scopus citations
2017

Biochemical, molecular, and clinical characterization of succinate dehydrogenase subunit A variants of unknown significance

Bannon, A. E., Kent, J., Forquer, I., Town, A., Klug, L. R., McCann, K., Beadling, C., Harismendy, O., Sicklick, J. K., Corless, C., Shinde, U. & Heinrich, M. C., Nov 1 2017, In : Clinical Cancer Research. 23, 21, p. 6733-6743 11 p.

Research output: Contribution to journalArticle

3 Scopus citations
2015
3 Scopus citations
4 Scopus citations
2014

Cotranslational folding inhibits translocation from within the ribosome-Sec61 translocon complex

Conti, B. J., Elferich, J., Yang, Z., Shinde, U. & Skach, W. R., Mar 2014, In : Nature Structural and Molecular Biology. 21, 3, p. 228-235 8 p.

Research output: Contribution to journalArticle

19 Scopus citations

Identification of the intracellular gate for a member of the equilibrative nucleoside transporter (ENT) family

Valdés, R., Elferich, J., Shinde, U. & Landfear, S. M., Mar 30 2014, In : Journal of Biological Chemistry. 289, 13, p. 8799-8809 11 p.

Research output: Contribution to journalArticle

24 Scopus citations
28 Scopus citations
2013

Foretinib is a potent inhibitor of oncogenic ROS1 fusion proteins

Davare, M. A., Saborowski, A., Eide, C. A., Tognon, C., Smith, R. L., Elferich, J., Agarwal, A., Tyner, J. W., Shinde, U. P., Lowe, S. W. & Druker, B. J., Nov 26 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 48, p. 19519-19524 6 p.

Research output: Contribution to journalArticle

81 Scopus citations

Propeptides of eukaryotic proteases encode histidines to exploit organelle pH for regulation

Elferich, J., Williamson, D. M., Krishnamoorthy, B. & Shinde, U., Aug 2013, In : FASEB Journal. 27, 8, p. 2939-2945 7 p.

Research output: Contribution to journalArticle

1 Scopus citations

Proteomic analysis and molecular modelling characterize the iron-regulatory protein haemojuvelin/repulsive guidance molecule c

Nili, M., David, L., Elferich, J., Shinde, U. & Rotwein, P., May 15 2013, In : Biochemical Journal. 452, 1, p. 87-95 9 p.

Research output: Contribution to journalArticle

4 Scopus citations

Severe growth deficiency is associated with STAT5b mutations that disrupt protein folding and activity

Varco-Merth, B., Feigerlová, E., Shinde, U., Rosenfeld, R. G., Hwa, V. & Rotwein, P., 2013, In : Molecular Endocrinology. 27, 1, p. 150-161 12 p.

Research output: Contribution to journalArticle

13 Scopus citations

Substrate inhibition of uracil phosphoribosyltransferase by uracil can account for the uracil growth sensitivity of leishmania donovani pyrimidine auxotrophs

Soysa, R., Wilson, Z. N., Elferich, J., Forquer, I., Shinde, U., Riscoe, M. K., Yates, P. A. & Ullman, B., Oct 11 2013, In : Journal of Biological Chemistry. 288, 41, p. 29954-29964 11 p.

Research output: Contribution to journalArticle

9 Scopus citations

The mechanism by which a propeptide-encoded pH sensor regulates spatiotemporal activation of furin

Williamson, D. M., Elferich, J., Ramakrishnan, P., Thomas, G. & Shinde, U., Jun 28 2013, In : Journal of Biological Chemistry. 288, 26, p. 19154-19165 12 p.

Research output: Contribution to journalArticle

13 Scopus citations
2012

An interdomain binding site on HIV-1 Nef interacts with PACS-1 and PACS-2 on endosomes to down-regulate MHC-I

Dikeakos, J. D., Thomas, L., Kwon, G., Elferich, J., Shinde, U. & Thomas, G., Jun 1 2012, In : Molecular biology of the cell. 23, 11, p. 2184-2197 14 p.

Research output: Contribution to journalArticle

43 Scopus citations

Both sequence and context are important for flagellar targeting of a glucose transporter

Tran, K. D., Rodriguez-Contreras, D., Shinde, U. & Landfear, S. M., Jul 15 2012, In : Journal of Cell Science. 125, 14, p. 3293-3298 6 p.

Research output: Contribution to journalArticle

13 Scopus citations

Cysteine cross-linking defines the extracellular gate for the Leishmania donovani nucleoside transporter 1.1 (LdNT1.1)

Valdés, R., Shinde, U. & Landfear, S. M., Dec 28 2012, In : Journal of Biological Chemistry. 287, 53, p. 44036-44045 10 p.

Research output: Contribution to journalArticle

11 Scopus citations
8 Scopus citations

Propeptides are sufficient to regulate organelle-specific pH-dependent activation of furin and proprotein convertase 1/3

Dillon, S. L., Williamson, D. M., Elferich, J., Radler, D., Joshi, R., Thomas, G. & Shinde, U., Oct 12 2012, In : Journal of molecular biology. 423, 1, p. 47-62 16 p.

Research output: Contribution to journalArticle

17 Scopus citations
2011

The lumenal loop Met 672-Pro 707 of copper-transporting ATPase ATP7A binds metals and facilitates copper release from the intramembrane sites

Barry, A. N., Otoikhian, A., Bhatt, S., Shinde, U., Tsivkovskii, R., Blackburn, N. J. & Lutsenko, S., Jul 29 2011, In : Journal of Biological Chemistry. 286, 30, p. 26585-26594 10 p.

Research output: Contribution to journalArticle

28 Scopus citations
2010

Interactions between copper-binding sites determine the redox status and conformation of the regulatory N-terminal domain of ATP7B

LeShane, E. S., Shinde, U., Walker, J. M., Barry, A. N., Blackburn, N. J., Ralle, M. & Lutsenko, S., Feb 26 2010, In : Journal of Biological Chemistry. 285, 9, p. 6327-6336 10 p.

Research output: Contribution to journalArticle

28 Scopus citations
25 Scopus citations
2009

An ab initio structural model of a nucleoside permease predicts functionally important residues

Valdés, R., Arastu-Kapur, S., Landfear, S. M. & Shinde, U., Jul 10 2009, In : Journal of Biological Chemistry. 284, 28, p. 19067-19076 10 p.

Research output: Contribution to journalArticle

21 Scopus citations

A role for SSRP1 in recombination-mediated DNA damage response

Kumari, A., Mazina, O. M., Shinde, U., Mazin, A. V. & Lu, H., Oct 1 2009, In : Journal of cellular biochemistry. 108, 2, p. 508-518 11 p.

Research output: Contribution to journalArticle

22 Scopus citations

COMMD1 forms oligomeric complexes targeted to the endocytic membranes via specific interactions with phosphatidylinositol 4,5-Bisphosphate

Burkhead, J. L., Morgan, C. T., Shinde, U., Haddock, G. & Lutsenko, S., Jan 2 2009, In : Journal of Biological Chemistry. 284, 1, p. 696-707 12 p.

Research output: Contribution to journalArticle

31 Scopus citations
2008

Ras is required for the cyclic AMP-dependent activation of Rap1 via Epac2

Liu, C., Takahashi, M., Li, Y., Song, S., Dillon, T. J., Shinde, U. & Stork, P. J. S., Dec 2008, In : Molecular and cellular biology. 28, 23, p. 7109-7125 17 p.

Research output: Contribution to journalArticle

44 Scopus citations
2007

An Allosteric Rheostat in HIV-1 gp120 Reduces CCR5 Stoichiometry Required for Membrane Fusion and Overcomes Diverse Entry Limitations

Platt, E. J., Durnin, J. P., Shinde, U. & Kabat, D., Nov 16 2007, In : Journal of molecular biology. 374, 1, p. 64-79 16 p.

Research output: Contribution to journalArticle

20 Scopus citations
2006

Aberrant folding of a mutant Stat5b causes growth hormone insensitivity and proteasomal dysfunction

Chia, D. J., Subbian, E., Buck, T. M., Hwa, V., Rosenfeld, R. G., Skach, W. R., Shinde, U. & Rotwein, P., Mar 10 2006, In : Journal of Biological Chemistry. 281, 10, p. 6552-6558 7 p.

Research output: Contribution to journalArticle

26 Scopus citations

Identification of a pH sensor in the furin propeptide that regulates enzyme activation

Feliciangeli, S. F., Thomas, L., Scott, G. K., Subbian, E., Hung, C. H., Molloy, S. S., Jean, F., Shinde, U. & Thomas, G., Jun 9 2006, In : Journal of Biological Chemistry. 281, 23, p. 16108-16116 9 p.

Research output: Contribution to journalArticle

42 Scopus citations
2005

Folding pathway mediated by an intramolecular chaperone: Intrinsically unstructured propeptide modulates stochastic activation of subtilisin

Subbian, E., Yabuta, Y. & Shinde, U. P., Mar 25 2005, In : Journal of molecular biology. 347, 2, p. 367-383 17 p.

Research output: Contribution to journalArticle

43 Scopus citations
2004

Positive selection dictates the choice between kinetic and thermodynamic protein folding and stability in subtilases

Subbian, E., Yabuta, Y. & Shinde, U., Nov 16 2004, In : Biochemistry. 43, 45, p. 14348-14360 13 p.

Research output: Contribution to journalArticle

27 Scopus citations
2003

Folding pathway mediated by an intramolecular chaperone: A functional peptide chaperone designed using sequence databases

Yabuta, Y., Subbian, E., Oiry, C. & Shinde, U., Apr 25 2003, In : Journal of Biological Chemistry. 278, 17, p. 15246-15251 6 p.

Research output: Contribution to journalArticle

31 Scopus citations

The role of RbfA in 16 S rRNA processing and cell growth at low temperature in Escherichia coli

Xia, B., Ke, H., Shinde, U. & Inouye, M., Sep 19 2003, In : Journal of molecular biology. 332, 3, p. 575-584 10 p.

Research output: Contribution to journalArticle

57 Scopus citations
2002

Folding pathway mediated by an intramolecular chaperone: Dissecting conformational changes coincident with autoprocessing and the role of Ca2 in subtilisin maturation

Yabuta, Y., Subbian, E., Takagi, H., Shinde, U. & Inouye, M., Jan 1 2002, In : Journal of Biochemistry. 131, 1, p. 31-37 7 p.

Research output: Contribution to journalArticle

43 Scopus citations
2001

Backbone dynamics of the natively unfolded pro-peptide of subtilisin by heteronuclear NMR relaxation studies

Buevich, A. V., Shinde, U. P., Inouye, M. & Baum, J., Jan 1 2001, In : Journal of Biomolecular NMR. 20, 3, p. 233-249 17 p., 354326.

Research output: Contribution to journalArticle

62 Scopus citations

Folding pathway mediated by an intramolecular chaperone: The structural and functional characterization of the aqualysin I propeptide

Marie-Claire, C., Yabuta, Y., Suefuji, K., Matsuzawa, H. & Shinde, U., Jan 5 2001, In : Journal of molecular biology. 305, 1, p. 151-165 15 p.

Research output: Contribution to journalArticle

43 Scopus citations

Folding pathway mediated by an intramolecular chaperone: Propeptide release modulates activation precision of pro-subtilisin

Yabuta, Y., Takagi, H., Inouye, M. & Shinde, U., Nov 30 2001, In : Journal of Biological Chemistry. 276, 48, p. 44427-44434 8 p.

Research output: Contribution to journalArticle

90 Scopus citations

Functional analysis of the propeptides of subtilisin E and aqualysin I as intramolecular chaperones

Takagi, H., Koga, M., Katsurada, S., Yabuta, Y., Shinde, U., Inouye, M. & Nakamori, S., Nov 16 2001, In : FEBS Letters. 508, 2, p. 210-214 5 p.

Research output: Contribution to journalArticle

21 Scopus citations

Substrate-induced activation of a trapped IMC-mediated protein folding intermediate

Inouye, M., Fu, X. & Shinde, U., Apr 18 2001, In : Nature Structural Biology. 8, 4, p. 321-325 5 p.

Research output: Contribution to journalArticle

24 Scopus citations

Ubiquitin-associated (UBA) domains in Rad23 bind ubiquitin and promote inhibition of multi-ubiquitin chain assembly

Chen, L., Shinde, U., Ortolan, T. G. & Madura, K., 2001, In : EMBO Reports. 2, 10, p. 933-938 6 p.

Research output: Contribution to journalArticle

162 Scopus citations
2000
80 Scopus citations

Intramolecular chaperones: Polypeptide extensions that modulate protein folding

Shinde, U. & Inouye, M., Jan 1 2000, In : Seminars in Cell and Developmental Biology. 11, 1, p. 35-44 10 p.

Research output: Contribution to journalArticle

128 Scopus citations
1999

A pathway for conformational diversity in proteins mediated by intramolecular chaperones

Shinde, U., Fu, X. & Inouye, M., May 28 1999, In : Journal of Biological Chemistry. 274, 22, p. 15615-15621 7 p.

Research output: Contribution to journalArticle

69 Scopus citations

Characterization of a temperature-sensitive mutant of a ubiquitin- conjugating enzyme and its use as a heat-inducible degradation signal

Tongaonkar, P., Beck, K., Shinde, U. P. & Madura, K., Aug 1 1999, In : Analytical Biochemistry. 272, 2, p. 263-269 7 p.

Research output: Contribution to journalArticle

9 Scopus citations
1998

The crystal structure of an autoprocessed Ser221Cys-subtilisin E-propeptide complex at 2.0 Å resolution

Jain, S. C., Shinde, U., Li, Y., Inouye, M. & Berman, H. M., Nov 20 1998, In : Journal of molecular biology. 284, 1, p. 137-144 8 p.

Research output: Contribution to journalArticle

134 Scopus citations
1997

Protein memory through altered folding mediated by intramolecular chaperones

Shinde, U. P., Liu, J. J. & Inouye, M., Oct 22 1997, In : Nature. 389, 6650, p. 520-522 3 p.

Research output: Contribution to journalArticle

133 Scopus citations
1996

Propeptide-mediated folding in subtilisin: The intramolecular chaperone concept

Shinde, U. & Inouye, M., 1996, In : Advances in experimental medicine and biology. 379, p. 147-154 8 p.

Research output: Contribution to journalArticle

36 Scopus citations
1995
50 Scopus citations
1993

Folding pathway mediated by an intramolecular chaperone

Shinde, U., Li, Y., Chatterjee, S. & Inouye, M., 1993, In : Proceedings of the National Academy of Sciences of the United States of America. 90, 15, p. 6924-6928 5 p.

Research output: Contribution to journalArticle

Open Access
83 Scopus citations