Ujwal Shinde

Associate Professor

  • 2452 Citations
  • 29 h-Index
1989 …2019

Research output per year

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Research Output

2019

A ribose modification of Spinach aptamer accelerates lead(ii) cation association: In vitro

Savage, J. C., Shinde, P., Bächinger, H. P., Davare, M. A. & Shinde, U., Jan 1 2019, In : Chemical Communications. 55, 42, p. 5882-5885 4 p.

Research output: Contribution to journalArticle

1 Scopus citations
2018

Inhibition of interleukin-1 receptor-associated kinase-1 is a therapeutic strategy for acute myeloid leukemia subtypes

Hosseini, M. M., Kurtz, S. E., Abdelhamed, S., Mahmood, S., Davare, M. A., Kaempf, A., Elferich, J., McDermott, J. E., Liu, T., Payne, S. H., Shinde, U., Rodland, K. D., Mori, M., Druker, B. J., Singer, J. W. & Agarwal, A., Nov 1 2018, In : Leukemia. 32, 11, p. 2374-2387 14 p.

Research output: Contribution to journalArticle

8 Scopus citations
2017

Biochemical, molecular, and clinical characterization of succinate dehydrogenase subunit A variants of unknown significance

Bannon, A. E., Kent, J., Forquer, I., Town, A., Klug, L. R., McCann, K., Beadling, C., Harismendy, O., Sicklick, J. K., Corless, C., Shinde, U. & Heinrich, M., Nov 1 2017, In : Clinical Cancer Research. 23, 21, p. 6733-6743 11 p.

Research output: Contribution to journalArticle

3 Scopus citations

Caught in the act -protein adaptation and the expanding roles of the PACS proteins in tissue homeostasis and disease

Thomas, G., Aslan, J., Thomas, L., Shinde, P., Shinde, U. & Simmen, T., Jun 1 2017, In : Journal of Cell Science. 130, 11, p. 1865-1876 12 p.

Research output: Contribution to journalComment/debate

13 Scopus citations
2015
3 Scopus citations

Mechanism of Fine-tuning pH Sensors in Proprotein Convertases: IDENTIFICATION OF A pH-SENSING HISTIDINE PAIR IN THE PROPEPTIDE OF PROPROTEIN CONVERTASE 1/3

Williamson, D. M., Elferich, J. & Shinde, U., Sep 18 2015, In : Journal of Biological Chemistry. 290, 38, p. 23214-23225 12 p.

Research output: Contribution to journalArticle

3 Scopus citations
2014

Cotranslational folding inhibits translocation from within the ribosome-Sec61 translocon complex

Conti, B. J., Elferich, J., Yang, Z., Shinde, U. & Skach, W. R., Mar 2014, In : Nature Structural and Molecular Biology. 21, 3, p. 228-235 8 p.

Research output: Contribution to journalArticle

19 Scopus citations

Identification of the intracellular gate for a member of the equilibrative nucleoside transporter (ENT) family

Valdés, R., Elferich, J., Shinde, U. & Landfear, S. M., Mar 30 2014, In : Journal of Biological Chemistry. 289, 13, p. 8799-8809 11 p.

Research output: Contribution to journalArticle

22 Scopus citations
27 Scopus citations
2013

Foretinib is a potent inhibitor of oncogenic ROS1 fusion proteins

Davare, M. A., Saborowski, A., Eide, C. A., Tognon, C., Smith, R. L., Elferich, J., Agarwal, A., Tyner, J. W., Shinde, U. P., Lowe, S. W. & Druker, B. J., Nov 26 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 48, p. 19519-19524 6 p.

Research output: Contribution to journalArticle

79 Scopus citations

Propeptides of eukaryotic proteases encode histidines to exploit organelle pH for regulation

Elferich, J., Williamson, D. M., Krishnamoorthy, B. & Shinde, U., Aug 1 2013, In : FASEB Journal. 27, 8, p. 2939-2945 7 p.

Research output: Contribution to journalArticle

1 Scopus citations

Proteomic analysis and molecular modelling characterize the iron-regulatory protein haemojuvelin/repulsive guidance molecule c

Nili, M., David, L., Elferich, J., Shinde, U. & Rotwein, P., May 15 2013, In : Biochemical Journal. 452, 1, p. 87-95 9 p.

Research output: Contribution to journalArticle

4 Scopus citations

Severe growth deficiency is associated with STAT5b mutations that disrupt protein folding and activity

Varco-Merth, B., Feigerlová, E., Shinde, U., Rosenfeld, R. G., Hwa, V. & Rotwein, P., Jan 7 2013, In : Molecular Endocrinology. 27, 1, p. 150-161 12 p.

Research output: Contribution to journalArticle

13 Scopus citations

Substrate inhibition of uracil phosphoribosyltransferase by uracil can account for the uracil growth sensitivity of leishmania donovani pyrimidine auxotrophs

Soysa, R., Wilson, Z. N., Elferich, J., Forquer, I., Shinde, U., Riscoe, M. K., Yates, P. A. & Ullman, B., Oct 11 2013, In : Journal of Biological Chemistry. 288, 41, p. 29954-29964 11 p.

Research output: Contribution to journalArticle

8 Scopus citations

The mechanism by which a propeptide-encoded pH sensor regulates spatiotemporal activation of furin

Williamson, D. M., Elferich, J., Ramakrishnan, P., Thomas, G. & Shinde, U., Jun 28 2013, In : Journal of Biological Chemistry. 288, 26, p. 19154-19165 12 p.

Research output: Contribution to journalArticle

13 Scopus citations
2012

An interdomain binding site on HIV-1 Nef interacts with PACS-1 and PACS-2 on endosomes to down-regulate MHC-I

Dikeakos, J. D., Thomas, L., Kwon, G., Elferich, J., Shinde, U. & Thomas, G., Jun 1 2012, In : Molecular biology of the cell. 23, 11, p. 2184-2197 14 p.

Research output: Contribution to journalArticle

42 Scopus citations

Both sequence and context are important for flagellar targeting of a glucose transporter

Tran, K. D., Rodriguez-Contreras, D., Shinde, U. & Landfear, S. M., Jul 15 2012, In : Journal of Cell Science. 125, 14, p. 3293-3298 6 p.

Research output: Contribution to journalArticle

13 Scopus citations

Cysteine cross-linking defines the extracellular gate for the Leishmania donovani nucleoside transporter 1.1 (LdNT1.1)

Valdés, R., Shinde, U. & Landfear, S. M., Dec 28 2012, In : Journal of Biological Chemistry. 287, 53, p. 44036-44045 10 p.

Research output: Contribution to journalArticle

11 Scopus citations
8 Scopus citations

Propeptides are sufficient to regulate organelle-specific pH-dependent activation of furin and proprotein convertase 1/3

Dillon, S. L., Williamson, D. M., Elferich, J., Radler, D., Joshi, R., Thomas, G. & Shinde, U., Oct 12 2012, In : Journal of molecular biology. 423, 1, p. 47-62 16 p.

Research output: Contribution to journalArticle

17 Scopus citations
2011

Insights from bacterial subtilases into the mechanisms of intramolecular chaperone-mediated activation of furin

Shinde, U. & Thomas, G., Oct 24 2011, Proprotein Convertases. Mbikay, M. & Seidah, N. G. (eds.). p. 59-106 48 p. (Methods in Molecular Biology; vol. 768).

Research output: Chapter in Book/Report/Conference proceedingChapter

37 Scopus citations

The lumenal loop Met 672-Pro 707 of copper-transporting ATPase ATP7A binds metals and facilitates copper release from the intramembrane sites

Barry, A. N., Otoikhian, A., Bhatt, S., Shinde, U., Tsivkovskii, R., Blackburn, N. J. & Lutsenko, S., Jul 29 2011, In : Journal of Biological Chemistry. 286, 30, p. 26585-26594 10 p.

Research output: Contribution to journalArticle

28 Scopus citations
2010

Interactions between copper-binding sites determine the redox status and conformation of the regulatory N-terminal domain of ATP7B

LeShane, E. S., Shinde, U., Walker, J. M., Barry, A. N., Blackburn, N. J., Ralle, M. & Lutsenko, S., Feb 26 2010, In : Journal of Biological Chemistry. 285, 9, p. 6327-6336 10 p.

Research output: Contribution to journalArticle

27 Scopus citations
25 Scopus citations

Structural organization of human Cu-transporting ATPases: Learning from building blocks

Barry, A. N., Shinde, U. & Lutsenko, S., Jan 1 2010, In : Journal of Biological Inorganic Chemistry. 15, 1, p. 47-59 13 p.

Research output: Contribution to journalShort survey

59 Scopus citations
2009

An ab initio structural model of a nucleoside permease predicts functionally important residues

Valdés, R., Arastu-Kapur, S., Landfear, S. M. & Shinde, U., Jul 10 2009, In : Journal of Biological Chemistry. 284, 28, p. 19067-19076 10 p.

Research output: Contribution to journalArticle

21 Scopus citations

A role for SSRP1 in recombination-mediated DNA damage response

Kumari, A., Mazina, O. M., Shinde, U., Mazin, A. V. & Lu, H., Oct 1 2009, In : Journal of cellular biochemistry. 108, 2, p. 508-518 11 p.

Research output: Contribution to journalArticle

22 Scopus citations

At the crossroads of homoeostasis and disease: Roles of the PACS proteins in membrane traffic and apoptosis

Youker, R. T., Shinde, U., Day, R. & Thomas, G., Jul 1 2009, In : Biochemical Journal. 421, 1, p. 1-15 15 p.

Research output: Contribution to journalReview article

45 Scopus citations

COMMD1 forms oligomeric complexes targeted to the endocytic membranes via specific interactions with phosphatidylinositol 4,5-Bisphosphate

Burkhead, J. L., Morgan, C. T., Shinde, U., Haddock, G. & Lutsenko, S., Jan 2 2009, In : Journal of Biological Chemistry. 284, 1, p. 696-707 12 p.

Research output: Contribution to journalArticle

31 Scopus citations

Molecular biology, genetics and biochemistry of the repulsive guidance molecule family

Severyn, C. J., Shinde, U. & Rotwein, P., Sep 15 2009, In : Biochemical Journal. 422, 3, p. 393-403 11 p.

Research output: Contribution to journalReview article

42 Scopus citations
2008

Ras is required for the cyclic AMP-dependent activation of Rap1 via Epac2

Liu, C., Takahashi, M., Li, Y., Song, S., Dillon, T. J., Shinde, U. & Stork, P. J. S., Dec 2008, In : Molecular and cellular biology. 28, 23, p. 7109-7125 17 p.

Research output: Contribution to journalArticle

42 Scopus citations
2007

An Allosteric Rheostat in HIV-1 gp120 Reduces CCR5 Stoichiometry Required for Membrane Fusion and Overcomes Diverse Entry Limitations

Platt, E. J., Durnin, J. P., Shinde, U. & Kabat, D., Nov 16 2007, In : Journal of molecular biology. 374, 1, p. 64-79 16 p.

Research output: Contribution to journalArticle

20 Scopus citations

Biochemical basis of regulation of human copper-transporting ATPases

Lutsenko, S., LeShane, E. S. & Shinde, U., Jul 15 2007, In : Archives of Biochemistry and Biophysics. 463, 2, p. 134-148 15 p.

Research output: Contribution to journalShort survey

93 Scopus citations
2006

Aberrant folding of a mutant Stat5b causes growth hormone insensitivity and proteasomal dysfunction

Chia, D. J., Subbian, E., Buck, T. M., Hwa, V., Rosenfeld, R. G., Skach, W. R., Shinde, U. & Rotwein, P., Mar 10 2006, In : Journal of Biological Chemistry. 281, 10, p. 6552-6558 7 p.

Research output: Contribution to journalArticle

26 Scopus citations

Erratum: Aberrant folding of amutant Stat5b causes growth hormone insensitivity and proteasomal dysfunction (Journal of Biological Chemistry (2006) 281 (6552-6558))

Chia, D. J., Subbian, E., Buck, T. M., Hwa, V., Rosenfeld, R. G., Skach, W. R., Shinde, U. & Rotwein, P., Jun 2 2006, In : Journal of Biological Chemistry. 281, 22, 1 p.

Research output: Contribution to journalComment/debate

Identification of a pH sensor in the furin propeptide that regulates enzyme activation

Feliciangeli, S. F., Thomas, L., Scott, G. K., Subbian, E., Hung, C. H., Molloy, S. S., Jean, F., Shinde, U. & Thomas, G., Jun 9 2006, In : Journal of Biological Chemistry. 281, 23, p. 16108-16116 9 p.

Research output: Contribution to journalArticle

42 Scopus citations
2005

Folding pathway mediated by an intramolecular chaperone: Intrinsically unstructured propeptide modulates stochastic activation of subtilisin

Subbian, E., Yabuta, Y. & Shinde, U. P., Mar 25 2005, In : Journal of molecular biology. 347, 2, p. 367-383 17 p.

Research output: Contribution to journalArticle

41 Scopus citations
2004

Positive selection dictates the choice between kinetic and thermodynamic protein folding and stability in subtilases

Subbian, E., Yabuta, Y. & Shinde, U., Nov 16 2004, In : Biochemistry. 43, 45, p. 14348-14360 13 p.

Research output: Contribution to journalArticle

27 Scopus citations
2003

Folding pathway mediated by an intramolecular chaperone: A functional peptide chaperone designed using sequence databases

Yabuta, Y., Subbian, E., Oiry, C. & Shinde, U., Apr 25 2003, In : Journal of Biological Chemistry. 278, 17, p. 15246-15251 6 p.

Research output: Contribution to journalArticle

31 Scopus citations

The role of RbfA in 16 S rRNA processing and cell growth at low temperature in Escherichia coli

Xia, B., Ke, H., Shinde, U. & Inouye, M., Sep 19 2003, In : Journal of molecular biology. 332, 3, p. 575-584 10 p.

Research output: Contribution to journalArticle

57 Scopus citations
2002

Folding pathway mediated by an intramolecular chaperone: Dissecting conformational changes coincident with autoprocessing and the role of Ca2 in subtilisin maturation

Yabuta, Y., Subbian, E., Takagi, H., Shinde, U. & Inouye, M., Jan 1 2002, In : Journal of Biochemistry. 131, 1, p. 31-37 7 p.

Research output: Contribution to journalArticle

40 Scopus citations
2001

Backbone dynamics of the natively unfolded pro-peptide of subtilisin by heteronuclear NMR relaxation studies

Buevich, A. V., Shinde, U. P., Inouye, M. & Baum, J., Jan 1 2001, In : Journal of Biomolecular NMR. 20, 3, p. 233-249 17 p., 354326.

Research output: Contribution to journalArticle

62 Scopus citations

Folding pathway mediated by an intramolecular chaperone: Propeptide release modulates activation precision of pro-subtilisin

Yabuta, Y., Takagi, H., Inouye, M. & Shinde, U., Nov 30 2001, In : Journal of Biological Chemistry. 276, 48, p. 44427-44434 8 p.

Research output: Contribution to journalArticle

88 Scopus citations

Folding pathway mediated by an intramolecular chaperone: The structural and functional characterization of the aqualysin I propeptide

Marie-Claire, C., Yabuta, Y., Suefuji, K., Matsuzawa, H. & Shinde, U., Jan 5 2001, In : Journal of molecular biology. 305, 1, p. 151-165 15 p.

Research output: Contribution to journalArticle

42 Scopus citations

Functional analysis of the propeptides of subtilisin E and aqualysin I as intramolecular chaperones

Takagi, H., Koga, M., Katsurada, S., Yabuta, Y., Shinde, U., Inouye, M. & Nakamori, S., Nov 16 2001, In : FEBS Letters. 508, 2, p. 210-214 5 p.

Research output: Contribution to journalArticle

21 Scopus citations

Substrate-induced activation of a trapped IMC-mediated protein folding intermediate

Inouye, M., Fu, X. & Shinde, U., Apr 18 2001, In : Nature Structural Biology. 8, 4, p. 321-325 5 p.

Research output: Contribution to journalArticle

24 Scopus citations

Ubiquitin-associated (UBA) domains in Rad23 bind ubiquitin and promote inhibition of multi-ubiquitin chain assembly

Chen, L., Shinde, U., Ortolan, T. G. & Madura, K., Nov 20 2001, In : EMBO Reports. 2, 10, p. 933-938 6 p.

Research output: Contribution to journalArticle

160 Scopus citations
2000
80 Scopus citations

Intramolecular chaperones: Polypeptide extensions that modulate protein folding

Shinde, U. & Inouye, M., Jan 1 2000, In : Seminars in Cell and Developmental Biology. 11, 1, p. 35-44 10 p.

Research output: Contribution to journalArticle

127 Scopus citations
1999

A pathway for conformational diversity in proteins mediated by intramolecular chaperones

Shinde, U., Fu, X. & Inouye, M., May 28 1999, In : Journal of Biological Chemistry. 274, 22, p. 15615-15621 7 p.

Research output: Contribution to journalArticle

69 Scopus citations