Ujwal Shinde

Associate Professor

  • 2384 Citations
  • 29 h-Index
1989 …2019
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Research Output 1989 2019

  • 2384 Citations
  • 29 h-Index
  • 64 Article
  • 1 Chapter
  • 1 Comment/debate
2019

A ribose modification of Spinach aptamer accelerates lead(ii) cation association: In vitro

Savage, J. C., Shinde, P., Bächinger, H. P., Davare, M. & Shinde, U., Jan 1 2019, In : Chemical Communications. 55, 42, p. 5882-5885 4 p.

Research output: Contribution to journalArticle

Ribose
Cations
Lead
Positive ions
Fluorescence
2018
4 Citations (Scopus)

Inhibition of interleukin-1 receptor-associated kinase-1 is a therapeutic strategy for acute myeloid leukemia subtypes

Hosseini, M. M., Kurtz, S. E., Abdelhamed, S., Mahmood, S., Davare, M., Kaempf, A., Elferich, J., McDermott, J. E., Liu, T., Payne, S. H., Shinde, U., Rodland, K. D., Mori, M. T., Druker, B., Singer, J. W. & Agarwal, A., Mar 29 2018, (Accepted/In press) In : Leukemia. p. 1-14 14 p.

Research output: Contribution to journalArticle

Interleukin-1 Receptor-Associated Kinases
Acute Myeloid Leukemia
Myeloid Cells
Therapeutics
Heterografts
2017
2 Citations (Scopus)

Biochemical, molecular, and clinical characterization of succinate dehydrogenase subunit A variants of unknown significance

Bannon, A. E., Kent, J., Forquer, I., Town, A., Klug, L. R., McCann, K., Beadling, C., Harismendy, O., Sicklick, J. K., Corless, C., Shinde, U. & Heinrich, M., Nov 1 2017, In : Clinical Cancer Research. 23, 21, p. 6733-6743 11 p.

Research output: Contribution to journalArticle

Succinate Dehydrogenase
Yeasts
Neoplasms
Early Detection of Cancer
Genes
9 Citations (Scopus)

Caught in the act -protein adaptation and the expanding roles of the PACS proteins in tissue homeostasis and disease

Thomas, G., Aslan, J., Thomas, L., Shinde, P., Shinde, U. & Simmen, T., Jun 1 2017, In : Journal of Cell Science. 130, 11, p. 1865-1876 12 p.

Research output: Contribution to journalComment/debate

Homeostasis
Vertebrates
Proteins
Cell Physiological Phenomena
Communication
2015
3 Citations (Scopus)

Determination of Histidine pKa Values in the Propeptides of Furin and Proprotein Convertase 1/3 Using Histidine Hydrogen-Deuterium Exchange Mass Spectrometry

Elferich, J., Williamson, D. M., David, L. & Shinde, U., Aug 4 2015, In : Analytical Chemistry. 87, 15, p. 7909-7917 9 p.

Research output: Contribution to journalArticle

Proprotein Convertase 1
Furin
Deuterium
Histidine
Mass spectrometry
2 Citations (Scopus)

Mechanism of Fine-tuning pH Sensors in Proprotein Convertases: IDENTIFICATION OF A pH-SENSING HISTIDINE PAIR IN THE PROPEPTIDE OF PROPROTEIN CONVERTASE 1/3

Williamson, D. M., Elferich, J. & Shinde, U., Sep 18 2015, In : Journal of Biological Chemistry. 290, 38, p. 23214-23225 12 p.

Research output: Contribution to journalArticle

Proprotein Convertase 1
Proprotein Convertases
pH sensors
Histidine
Tuning
2014
18 Citations (Scopus)

Cotranslational folding inhibits translocation from within the ribosome-Sec61 translocon complex

Conti, B. J., Elferich, J., Yang, Z., Shinde, U. & Skach, W., 2014, In : Nature Structural and Molecular Biology. 21, 3, p. 228-235 8 p.

Research output: Contribution to journalArticle

Ribosomes
Endoplasmic Reticulum
Cytosol
Zinc Fingers
Protein Sorting Signals
20 Citations (Scopus)

Identification of the intracellular gate for a member of the equilibrative nucleoside transporter (ENT) family

Valdés, R., Elferich, J., Shinde, U. & Landfear, S., Mar 30 2014, In : Journal of Biological Chemistry. 289, 13, p. 8799-8809 11 p.

Research output: Contribution to journalArticle

Nucleoside Transport Proteins
Leishmania donovani
Conformations
Crystal structure
Physiological Phenomena
26 Citations (Scopus)
Tumors
Carrier Proteins
Chemical activation
Enzymes
Neoplasms
2013
74 Citations (Scopus)

Foretinib is a potent inhibitor of oncogenic ROS1 fusion proteins

Davare, M., Saborowski, A., Eide, C. A., Tognon, C., Smith, R. L., Elferich, J., Agarwal, A., Tyner, J., Shinde, U., Lowe, S. W. & Druker, B., Nov 26 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 48, p. 19519-19524 6 p.

Research output: Contribution to journalArticle

Proteins
Lung Neoplasms
Phosphotransferases
Cholangiocarcinoma
Glioblastoma
1 Citation (Scopus)

Propeptides of eukaryotic proteases encode histidines to exploit organelle pH for regulation

Elferich, J., Williamson, D. M., Krishnamoorthy, B. & Shinde, U., Aug 2013, In : FASEB Journal. 27, 8, p. 2939-2945 7 p.

Research output: Contribution to journalArticle

Histidine
Organelles
Peptide Hydrolases
Proton-Motive Force
pH sensors
4 Citations (Scopus)

Proteomic analysis and molecular modelling characterize the iron-regulatory protein haemojuvelin/repulsive guidance molecule c

Nili, M., David, L., Elferich, J., Shinde, U. & Rotwein, P., May 15 2013, In : Biochemical Journal. 452, 1, p. 87-95 9 p.

Research output: Contribution to journalArticle

Iron-Regulatory Proteins
Molecular modeling
Disulfides
Proteomics
Molecules
11 Citations (Scopus)

Severe growth deficiency is associated with STAT5b mutations that disrupt protein folding and activity

Varco-Merth, B., Feigerlová, E., Shinde, U., Rosenfeld, R. R., Hwa, V. & Rotwein, P., 2013, In : Molecular Endocrinology. 27, 1, p. 150-161 12 p.

Research output: Contribution to journalArticle

src Homology Domains
Protein Folding
Mutation
Growth
Inclusion Bodies
8 Citations (Scopus)

Substrate inhibition of uracil phosphoribosyltransferase by uracil can account for the uracil growth sensitivity of leishmania donovani pyrimidine auxotrophs

Soysa, R., Wilson, Z. N., Elferich, J., Forquer, I., Shinde, U., Riscoe, M., Yates, P. & Ullman, B., Oct 11 2013, In : Journal of Biological Chemistry. 288, 41, p. 29954-29964 11 p.

Research output: Contribution to journalArticle

uracil phosphoribosyltransferase
Leishmania donovani
Uracil
Salvaging
Substrates
12 Citations (Scopus)

The mechanism by which a propeptide-encoded pH sensor regulates spatiotemporal activation of furin

Williamson, D. M., Elferich, J., Ramakrishnan, P., Thomas, G. & Shinde, U., Jun 28 2013, In : Journal of Biological Chemistry. 288, 26, p. 19154-19165 12 p.

Research output: Contribution to journalArticle

Furin
pH sensors
Chemical activation
Protonation
Proprotein Convertases
2012
39 Citations (Scopus)

An interdomain binding site on HIV-1 Nef interacts with PACS-1 and PACS-2 on endosomes to down-regulate MHC-I

Dikeakos, J. D., Thomas, L., Kwon, G., Elferich, J., Shinde, U. & Thomas, G., Jun 1 2012, In : Molecular Biology of the Cell. 23, 11, p. 2184-2197 14 p.

Research output: Contribution to journalArticle

nef Gene Products
Endosomes
Major Histocompatibility Complex
HIV-1
Down-Regulation
11 Citations (Scopus)

Both sequence and context are important for flagellar targeting of a glucose transporter

Tran, K. D., Rodriguez-Contreras, D., Shinde, U. & Landfear, S., Jul 15 2012, In : Journal of Cell Science. 125, 14, p. 3293-3298 6 p.

Research output: Contribution to journalArticle

Facilitative Glucose Transport Proteins
Membrane Proteins
Amino Acid Motifs
Flagella
Cilia
10 Citations (Scopus)

Cysteine cross-linking defines the extracellular gate for the Leishmania donovani nucleoside transporter 1.1 (LdNT1.1)

Valdés, R., Shinde, U. & Landfear, S., Dec 28 2012, In : Journal of Biological Chemistry. 287, 53, p. 44036-44045 10 p.

Research output: Contribution to journalArticle

Nucleoside Transport Proteins
Leishmania donovani
Cysteine
Nucleosides
Disulfides
8 Citations (Scopus)
Insulin-Like Growth Factor Binding Protein 5
Tandem Mass Spectrometry
Disulfides
Mass spectrometry
Insulin-Like Growth Factor Binding Proteins
16 Citations (Scopus)

Propeptides are sufficient to regulate organelle-specific pH-dependent activation of furin and proprotein convertase 1/3

Dillon, S. L., Williamson, D. M., Elferich, J., Radler, D., Joshi, R., Thomas, G. & Shinde, U., Oct 12 2012, In : Journal of Molecular Biology. 423, 1, p. 47-62 16 p.

Research output: Contribution to journalArticle

Proprotein Convertase 1
Furin
Organelles
Histidine
Proprotein Convertases
2011
35 Citations (Scopus)

Insights from bacterial subtilases into the mechanisms of intramolecular chaperone-mediated activation of furin

Shinde, U. & Thomas, G., 2011, Methods in Molecular Biology. Vol. 768. p. 59-106 48 p. (Methods in Molecular Biology; vol. 768).

Research output: Chapter in Book/Report/Conference proceedingChapter

Proprotein Convertases
Furin
Subtilisins
Subtilisin
Enzyme Precursors
28 Citations (Scopus)

The lumenal loop Met 672-Pro 707 of copper-transporting ATPase ATP7A binds metals and facilitates copper release from the intramembrane sites

Barry, A. N., Otoikhian, A., Bhatt, S., Shinde, U., Tsivkovskii, R., Blackburn, N. & Lutsenko, S., Jul 29 2011, In : Journal of Biological Chemistry. 286, 30, p. 26585-26594 10 p.

Research output: Contribution to journalArticle

Copper
Metals
histidylhistidine
Secretory Pathway
alanylglycine
2010
26 Citations (Scopus)

Interactions between copper-binding sites determine the redox status and conformation of the regulatory N-terminal domain of ATP7B

LeShane, E. S., Shinde, U., Walker, J. M., Barry, A. N., Blackburn, N., Ralle, M. & Lutsenko, S., Feb 26 2010, In : Journal of Biological Chemistry. 285, 9, p. 6327-6336 10 p.

Research output: Contribution to journalArticle

Oxidation-Reduction
Conformations
Copper
Metals
Binding Sites
25 Citations (Scopus)
Bone Morphogenetic Proteins
Gene expression
Hepcidins
Gene Expression
Molecules
58 Citations (Scopus)

Structural organization of human Cu-transporting ATPases: Learning from building blocks

Barry, A. N., Shinde, U. & Lutsenko, S., Jan 2010, In : Journal of Biological Inorganic Chemistry. 15, 1, p. 47-59 13 p.

Research output: Contribution to journalArticle

Adenosine Triphosphatases
Learning
Copper
Physiological Phenomena
Secretory Pathway
2009
20 Citations (Scopus)

An ab initio structural model of a nucleoside permease predicts functionally important residues

Valdés, R., Arastu-Kapur, S., Landfear, S. & Shinde, U., Jul 10 2009, In : Journal of Biological Chemistry. 284, 28, p. 19067-19076 10 p.

Research output: Contribution to journalArticle

Membrane Transport Proteins
Structural Models
Nucleosides
Substrate Specificity
Mutation
22 Citations (Scopus)

A role for SSRP1 in recombination-mediated DNA damage response

Kumari, A., Mazina, O. M., Shinde, U., Mazin, A. V. & Lu, H., Oct 1 2009, In : Journal of Cellular Biochemistry. 108, 2, p. 508-518 11 p.

Research output: Contribution to journalArticle

Genetic Recombination
DNA Damage
DNA
Proteins
Recombinational DNA Repair
42 Citations (Scopus)

At the crossroads of homoeostasis and disease: Roles of the PACS proteins in membrane traffic and apoptosis

Youker, R. T., Shinde, U., Day, R. & Thomas, G., Jul 1 2009, In : Biochemical Journal. 421, 1, p. 1-15 15 p.

Research output: Contribution to journalArticle

Protein Transport
Sorting
Membrane Proteins
Homeostasis
Apoptosis
31 Citations (Scopus)

COMMD1 forms oligomeric complexes targeted to the endocytic membranes via specific interactions with phosphatidylinositol 4,5-Bisphosphate

Burkhead, J. L., Morgan, C. T., Shinde, U., Haddock, G. & Lutsenko, S., Jan 2 2009, In : Journal of Biological Chemistry. 284, 1, p. 696-707 12 p.

Research output: Contribution to journalArticle

Phosphatidylinositols
Metabolism
Copper
Membranes
Proteins
41 Citations (Scopus)

Molecular biology, genetics and biochemistry of the repulsive guidance molecule family

Severyn, C. J., Shinde, U. & Rotwein, P., Sep 15 2009, In : Biochemical Journal. 422, 3, p. 393-403 11 p.

Research output: Contribution to journalArticle

Biochemistry
Molecular biology
Molecular Biology
Bone Morphogenetic Proteins
Molecules
2008
41 Citations (Scopus)

Ras is required for the cyclic AMP-dependent activation of Rap1 via Epac2

Liu, C., Takahashi, M., Li, Y., Song, S., Dillon, T. J., Shinde, U. & Stork, P., Dec 2008, In : Molecular and Cellular Biology. 28, 23, p. 7109-7125 17 p.

Research output: Contribution to journalArticle

Cyclic AMP
Guanine Nucleotide Exchange Factors
Monomeric GTP-Binding Proteins
PC12 Cells
Exocytosis
2007
20 Citations (Scopus)

An Allosteric Rheostat in HIV-1 gp120 Reduces CCR5 Stoichiometry Required for Membrane Fusion and Overcomes Diverse Entry Limitations

Platt, E. J., Durnin, J. P., Shinde, U. & Kabat, D., Nov 16 2007, In : Journal of Molecular Biology. 374, 1, p. 64-79 16 p.

Research output: Contribution to journalArticle

Membrane Fusion
HIV-1
HIV
Mutation
Viruses
91 Citations (Scopus)

Biochemical basis of regulation of human copper-transporting ATPases

Lutsenko, S., LeShane, E. S. & Shinde, U., Jul 15 2007, In : Archives of Biochemistry and Biophysics. 463, 2, p. 134-148 15 p.

Research output: Contribution to journalArticle

Adenosine Triphosphatases
Copper
trans-Golgi Network
Transport Vesicles
Cell membranes
2006
24 Citations (Scopus)

Aberrant folding of a mutant Stat5b causes growth hormone insensitivity and proteasomal dysfunction

Chia, D. J., Subbian, E., Buck, T. M., Hwa, V., Rosenfeld, R. R., Skach, W., Shinde, U. & Rotwein, P., Mar 10 2006, In : Journal of Biological Chemistry. 281, 10, p. 6552-6558 7 p.

Research output: Contribution to journalArticle

Inclusion Bodies
Growth Hormone
Transcription Factors
src Homology Domains
Agglomeration

Erratum: Aberrant folding of amutant Stat5b causes growth hormone insensitivity and proteasomal dysfunction (Journal of Biological Chemistry (2006) 281 (6552-6558))

Chia, D. J., Subbian, E., Buck, T. M., Hwa, V., Rosenfeld, R. R., Skach, W., Shinde, U. & Rotwein, P., Jun 2 2006, In : Journal of Biological Chemistry. 281, 22, p. 15592 1 p.

Research output: Contribution to journalArticle

Growth Hormone
41 Citations (Scopus)

Identification of a pH sensor in the furin propeptide that regulates enzyme activation

Feliciangeli, S. F., Thomas, L., Scott, G. K., Subbian, E., Hung, C. H., Molloy, S. S., Jean, F., Shinde, U. & Thomas, G., Jun 9 2006, In : Journal of Biological Chemistry. 281, 23, p. 16108-16116 9 p.

Research output: Contribution to journalArticle

Furin
pH sensors
Enzyme Activation
Chemical activation
Enzymes
2005
41 Citations (Scopus)

Folding pathway mediated by an intramolecular chaperone: Intrinsically unstructured propeptide modulates stochastic activation of subtilisin

Subbian, E., Yabuta, Y. & Shinde, U., Mar 25 2005, In : Journal of Molecular Biology. 347, 2, p. 367-383 17 p.

Research output: Contribution to journalArticle

Subtilisin
Peptide Hydrolases
Subtilisins
Computer Simulation
Proteolysis
2004
27 Citations (Scopus)

Positive selection dictates the choice between kinetic and thermodynamic protein folding and stability in subtilases

Subbian, E., Yabuta, Y. & Shinde, U., Nov 16 2004, In : Biochemistry. 43, 45, p. 14348-14360 13 p.

Research output: Contribution to journalArticle

Subtilisins
Protein folding
Protein Stability
Protein Folding
Serine Proteases
2003
31 Citations (Scopus)

Folding pathway mediated by an intramolecular chaperone: A functional peptide chaperone designed using sequence databases

Yabuta, Y., Subbian, E., Oiry, C. & Shinde, U., Apr 25 2003, In : Journal of Biological Chemistry. 278, 17, p. 15246-15251 6 p.

Research output: Contribution to journalArticle

Subtilisin
Databases
Peptides
Scaffolds
Catalytic Domain
53 Citations (Scopus)

The role of RbfA in 16 S rRNA processing and cell growth at low temperature in Escherichia coli

Xia, B., Ke, H., Shinde, U. & Inouye, M., Sep 19 2003, In : Journal of Molecular Biology. 332, 3, p. 575-584 10 p.

Research output: Contribution to journalArticle

Escherichia coli
Temperature
Growth
Ribosomes
RNA Precursors
2002
40 Citations (Scopus)

Folding pathway mediated by an intramolecular chaperone: Dissecting conformational changes coincident with autoprocessing and the role of Ca2 in subtilisin maturation

Yabuta, Y., Subbian, E., Takagi, H., Shinde, U. & Inouye, M., 2002, In : Journal of Biochemistry. 131, 1, p. 31-37 7 p.

Research output: Contribution to journalArticle

Subtilisin
Ions
Conformations
Peptide Hydrolases
Metals
2001
62 Citations (Scopus)

Backbone dynamics of the natively unfolded pro-peptide of subtilisin by heteronuclear NMR relaxation studies

Buevich, A. V., Shinde, U., Inouye, M. & Baum, J., 2001, In : Journal of Biomolecular NMR. 20, 3, p. 233-249 17 p.

Research output: Contribution to journalArticle

Biomolecular Nuclear Magnetic Resonance
Subtilisin
Nuclear magnetic resonance
Peptides
Spectral density
87 Citations (Scopus)

Folding pathway mediated by an intramolecular chaperone: Propeptide release modulates activation precision of pro-subtilisin

Yabuta, Y., Takagi, H., Inouye, M. & Shinde, U., Nov 30 2001, In : Journal of Biological Chemistry. 276, 48, p. 44427-44434 8 p.

Research output: Contribution to journalArticle

Peptide Hydrolases
Chemical activation
Protein folding
Protein Folding
Molten materials
42 Citations (Scopus)

Folding pathway mediated by an intramolecular chaperone: The structural and functional characterization of the aqualysin I propeptide

Marie-Claire, C., Yabuta, Y., Suefuji, K., Matsuzawa, H. & Shinde, U., Jan 5 2001, In : Journal of Molecular Biology. 305, 1, p. 151-165 15 p.

Research output: Contribution to journalArticle

Subtilisin
Protein Folding
Peptide Hydrolases
aqualysin I
Proteins
20 Citations (Scopus)

Functional analysis of the propeptides of subtilisin E and aqualysin I as intramolecular chaperones

Takagi, H., Koga, M., Katsurada, S., Yabuta, Y., Shinde, U., Inouye, M. & Nakamori, S., Nov 16 2001, In : FEBS Letters. 508, 2, p. 210-214 5 p.

Research output: Contribution to journalArticle

Subtilisins
Functional analysis
Subtilisin
Peptide Hydrolases
aqualysin I
24 Citations (Scopus)

Substrate-induced activation of a trapped IMC-mediated protein folding intermediate

Inouye, M., Fu, X. & Shinde, U., 2001, In : Nature Structural Biology. 8, 4, p. 321-325 5 p.

Research output: Contribution to journalArticle

Protein folding
Subtilisin
Protein Folding
Chemical activation
Disulfides
153 Citations (Scopus)

Ubiquitin-associated (UBA) domains in Rad23 bind ubiquitin and promote inhibition of multi-ubiquitin chain assembly

Chen, L., Shinde, U., Ortolan, T. G. & Madura, K., 2001, In : EMBO Reports. 2, 10, p. 933-938 6 p.

Research output: Contribution to journalArticle

Ubiquitin
DNA Repair
Repair
Substrates
Proteins
2000
80 Citations (Scopus)
Subtilisin
Degradation
Point Mutation
Hydrogen
Catalytic Domain
125 Citations (Scopus)

Intramolecular chaperones: Polypeptide extensions that modulate protein folding

Shinde, U. & Inouye, M., 2000, In : Seminars in Cell and Developmental Biology. 11, 1, p. 35-44 10 p.

Research output: Contribution to journalArticle

Protein Folding
Peptides
Proteins
Protein Stability
Protein Sorting Signals
1999
69 Citations (Scopus)

A pathway for conformational diversity in proteins mediated by intramolecular chaperones

Shinde, U., Fu, X. & Inouye, M., May 28 1999, In : Journal of Biological Chemistry. 274, 22, p. 15615-15621 7 p.

Research output: Contribution to journalArticle

Subtilisin
Proteins
Scrapie
Serine Proteases
Point Mutation