Susan Ingram

Professor with Tenure, Professor with Tenure

  • 2486 Citations
  • 23 h-Index
1993 …2019
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Research Output 1993 2019

  • 2486 Citations
  • 23 h-Index
  • 54 Article
  • 2 Chapter
2019
1 Citation (Scopus)

Amphetamines signal through intracellular TAAR1 receptors coupled to Gα13 and GαS in discrete subcellular domains

Underhill, S. M., Hullihen, P. D., Chen, J., Fenollar-Ferrer, C., Rizzo, M. A., Ingram, S. & Amara, S. G., Jan 1 2019, (Accepted/In press) In : Molecular Psychiatry.

Research output: Contribution to journalArticle

Open Access
Amphetamines
Amphetamine
Dopaminergic Neurons
Amines
rhoA GTP-Binding Protein

Lack of Antinociceptive Cross-Tolerance With Co-Administration of Morphine and Fentanyl Into the Periaqueductal Gray of Male Sprague-Dawley Rats

Bobeck, E. N., Schoo, S. M., Ingram, S. & Morgan, M. M., Jan 1 2019, In : Journal of Pain.

Research output: Contribution to journalArticle

Periaqueductal Gray
Fentanyl
Morphine
Sprague Dawley Rats
Opioid Analgesics
2018
2 Citations (Scopus)

Neuronal excitatory amino acid transporter EAAT3: Emerging functions in health and disease

Underhill, S. M., Ingram, S., Ahmari, S. E., Veenstra-VanderWeele, J. & Amara, S. G., Jan 1 2018, (Accepted/In press) In : Neurochemistry International.

Research output: Contribution to journalArticle

Amino Acid Transport Systems
Excitatory Amino Acids
Health
2 Citations (Scopus)

Regulators of G-protein signaling (RGS) proteins promote receptor coupling to G-protein-coupled inwardly rectifying potassium (GIRK) channels

McPherson, K. B., Leff, E. R., Li, M., Meurice, C., Tai, S., Traynor, J. R. & Ingram, S., Oct 10 2018, In : Journal of Neuroscience. 38, 41, p. 8737-8744 8 p.

Research output: Contribution to journalArticle

RGS Proteins
Inwardly Rectifying Potassium Channel
GTP-Binding Proteins
Potassium
Opioid Receptors
2017
11 Citations (Scopus)

Amphetamine and Methamphetamine Increase NMDAR-GluN2B Synaptic Currents in Midbrain Dopamine Neurons

Li, M., Underhill, S. M., Reed, C., Phillips, T., Amara, S. G. & Ingram, S., Jun 1 2017, In : Neuropsychopharmacology. 42, 7, p. 1539-1547 9 p.

Research output: Contribution to journalArticle

Methamphetamine
Dopaminergic Neurons
Amphetamine
Mesencephalon
N-Methyl-D-Aspartate Receptors
13 Citations (Scopus)
Cannabinoid Receptor CB2
Freund's Adjuvant
gamma-Aminobutyric Acid
Pain
Cannabinoid Receptor CB1
14 Citations (Scopus)
Optogenetics
Neurons
Pain
2016
9 Citations (Scopus)

Ligand-biased activation of extracellular signal-regulated kinase 1/2 leads to differences in opioid induced antinociception and tolerance

Bobeck, E. N., Ingram, S., Hermes, S. M., Aicher, S. & Morgan, M. M., Feb 1 2016, In : Behavioural Brain Research. 298, p. 17-24 8 p.

Research output: Contribution to journalArticle

Ala(2)-MePhe(4)-Gly(5)-enkephalin
Mitogen-Activated Protein Kinase 3
Mitogen-Activated Protein Kinase 1
Fentanyl
Periaqueductal Gray
12 Citations (Scopus)

Sex differences in GABAA signaling in the periaqueductal gray induced by persistent inflammation

Tonsfeldt, K. J., Suchland, K. L., Beeson, K. A., Lowe, J. D., Li, M. & Ingram, S., Feb 3 2016, In : Journal of Neuroscience. 36, 5, p. 1669-1681 13 p.

Research output: Contribution to journalArticle

Periaqueductal Gray
Freund's Adjuvant
Sex Characteristics
GABA-A Receptors
Inflammation
2015
14 Citations (Scopus)

Change in functional selectivity of morphine with the development of antinociceptive tolerance

Macey, T. A., Bobeck, E. N., Suchland, K. L., Morgan, M. M. & Ingram, S., 2015, In : British Journal of Pharmacology. 172, 2, p. 549-561 13 p.

Research output: Contribution to journalArticle

Morphine
Dynamins
Opioid Receptors
Periaqueductal Gray
Opioid Analgesics
11 Citations (Scopus)

GABAergic transmission and enhanced modulation by opioids and endocannabinoids in adult rat rostral ventromedial medulla

Li, M., Suchland, K. L. & Ingram, S., Jan 1 2015, In : Journal of Physiology. 593, 1, p. 217-230 14 p.

Research output: Contribution to journalArticle

Endocannabinoids
Opioid Analgesics
Pain
Electric Stimulation
Neurons
2014
44 Citations (Scopus)

Amphetamine Modulates Excitatory Neurotransmission through Endocytosis of the Glutamate Transporter EAAT3 in Dopamine Neurons

Underhill, S. M., Wheeler, D. S., Li, M., Watts, S. D., Ingram, S. & Amara, S. G., Jul 16 2014, In : Neuron. 83, 2, p. 404-416 13 p.

Research output: Contribution to journalArticle

Amino Acid Transport System X-AG
Dopaminergic Neurons
Amphetamine
Endocytosis
Synaptic Transmission
15 Citations (Scopus)

Contribution of adenylyl cyclase modulation of pre- and postsynaptic GABA neurotransmission to morphine antinociception and tolerance

Bobeck, E. N., Chen, Q., Morgan, M. M. & Ingram, S., 2014, In : Neuropsychopharmacology. 39, 9, p. 2142-2152 11 p.

Research output: Contribution to journalArticle

Adenylyl Cyclases
Synaptic Transmission
gamma-Aminobutyric Acid
Morphine
Periaqueductal Gray
7 Citations (Scopus)

Pain: Novel analgesics from traditional Chinese medicines

Ingram, S., Feb 3 2014, In : Current Biology. 24, 3

Research output: Contribution to journalArticle

Chinese Traditional Medicine
analgesics
Corydalis yanhusuo
Medicine
Analgesics
2013

A New Take on Uptake: Dopamine Transporters and the Cellular Mechanisms of Amphetamine Action

Amara, S. G., Underhill, S. M., Wheeler, D. S., Hong, C. W., Murdoch, G. H., Romero, G., Ingram, S. & Thiels, E., Dec 2013, Catecholamine Research in the 21st Century: Abstracts and Graphical Abstracts, 10th International Catecholamine Symposium, 2012. Elsevier Inc., p. 44 1 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Dopamine Plasma Membrane Transport Proteins
Amphetamine
10 Citations (Scopus)

Chronic inflammatory pain prevents tolerance to the antinociceptive effect of morphine microinjected into the ventrolateral periaqueductal gray of the rat

Mehalick, M. L., Ingram, S., Aicher, S. & Morgan, M. M., Dec 2013, In : Journal of Pain. 14, 12, p. 1601-1610 10 p.

Research output: Contribution to journalArticle

Periaqueductal Gray
Chronic Pain
Morphine
Microinjections
Freund's Adjuvant
11 Citations (Scopus)

Columnar distribution of catecholaminergic neurons in the ventrolateral periaqueductal gray and their relationship to efferent pathways

Suckow, S. K., Deichsel, E. L., Ingram, S., Morgan, M. M. & Aicher, S., Feb 2013, In : Synapse. 67, 2, p. 94-108 15 p.

Research output: Contribution to journalArticle

Efferent Pathways
Periaqueductal Gray
Neurons
Dopaminergic Neurons
Ventral Tegmental Area
15 Citations (Scopus)

Differential control of opioid antinociception to thermal stimuli in a knock-in mouse expressing regulator of G-protein signaling-insensitive Gαo protein

Lamberts, J. T., Smith, C. E., Li, M., Ingram, S., Neubig, R. R. & Traynor, J. R., Mar 6 2013, In : Journal of Neuroscience. 33, 10, p. 4369-4377 9 p.

Research output: Contribution to journalArticle

RGS Proteins
GTP-Binding Protein Regulators
Morphine
Opioid Analgesics
Hot Temperature
313 Citations (Scopus)

Regulation of μ-opioid receptors: Desensitization, phosphorylation, internalization, and tolerance

Williams, J., Ingram, S., Henderson, G., Chavkin, C., von Zastrow, M., Schulz, S., Koch, T., Evans, C. J. & Christie, M. J., 2013, In : Pharmacological Reviews. 65, 1, p. 223-254 32 p.

Research output: Contribution to journalArticle

Opioid Receptors
Phosphorylation
Opioid Analgesics
Pain
Endocytosis
2012
7 Citations (Scopus)

A sensitive membrane-targeted biosensor for monitoring changes in intracellular chloride in neuronal processes

Watts, S. D., Suchland, K. L., Amara, S. G. & Ingram, S., Apr 10 2012, In : PLoS One. 7, 4, e35373.

Research output: Contribution to journalArticle

biosensors
Biosensing Techniques
Biosensors
Neurons
Chlorides
2 Citations (Scopus)
Receptor Aggregation
Periaqueductal Gray
mu Opioid Receptor
N-Methyl-D-Aspartate Receptors
Pain
1 Citation (Scopus)

Chronic psychostimulant exposure to adult, but not periadolescent rats reduces subsequent morphine antinociception

Cyr, M. C., Ingram, S., Aicher, S. & Morgan, M. M., Jun 2012, In : Pharmacology Biochemistry and Behavior. 101, 4, p. 538-543 6 p.

Research output: Contribution to journalArticle

Morphine
Rats
Methylphenidate
Methamphetamine
Opioid Analgesics
16 Citations (Scopus)

Differential development of antinociceptive tolerance to morphine and fentanyl is not linked to efficacy in the ventrolateral periaqueductal gray of the rat

Bobeck, E. N., Haseman, R. A., Hong, D., Ingram, S. & Morgan, M. M., Aug 2012, In : Journal of Pain. 13, 8, p. 799-807 9 p.

Research output: Contribution to journalArticle

Periaqueductal Gray
Fentanyl
Morphine
Microinjections
mu Opioid Receptor
2010
9 Citations (Scopus)

Functional characterization of rhesus embryonic stem cell-derived serotonin neurons

Tokuyama, Y., Ingram, S., Woodward, J. S. & Bethea, C., May 2010, In : Experimental Biology and Medicine. 235, 5, p. 649-657 9 p.

Research output: Contribution to journalArticle

Embryonic Stem Cells
Stem cells
Neurons
Serotonin
Primates
11 Citations (Scopus)

Opioid receptor internalization contributes to dermorphin-mediated antinociception

Macey, T. A., Ingram, S., Bobeck, E. N., Hegarty, D. M., Aicher, S., Arttamangkul, S. & Morgan, M. M., Jun 2010, In : Neuroscience. 168, 2, p. 543-550 8 p.

Research output: Contribution to journalArticle

Periaqueductal Gray
Microinjections
Opioid Receptors
Dynamins
mu Opioid Receptor
43 Citations (Scopus)

The Brainstem and Nociceptive Modulation

Heinricher, M. & Ingram, S., 2010, The Senses: A Comprehensive Reference. Elsevier Inc., Vol. 5. p. 593-626 34 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Periaqueductal Gray
Nociception
Brain Stem
Visceral Afferents
Reproductive Behavior
26 Citations (Scopus)

Tolerance to the antinociceptive effect of morphine in the absence of short-term presynaptic desensitization in rat periaqueductal gray neurons

Fyfe, L. W., Cleary, D. R., Macey, T. A., Morgan, M. M. & Ingram, S., Dec 2010, In : Journal of Pharmacology and Experimental Therapeutics. 335, 3, p. 674-680 7 p.

Research output: Contribution to journalArticle

Periaqueductal Gray
Morphine
Neurons
Opioid Analgesics
Inhibitory Postsynaptic Potentials
2009
14 Citations (Scopus)

Behavioral consequences of delta-opioid receptor activation in the periaqueductal gray of morphine tolerant rats

Morgan, M. M., Ashley, M. D., Ingram, S. & Christie, M. J., 2009, In : Neural Plasticity. 2009, 516328.

Research output: Contribution to journalArticle

Periaqueductal Gray
delta Opioid Receptor
Morphine
Microinjections
Injections
48 Citations (Scopus)

Contribution of dopamine receptors to periaqueductal gray-mediated antinociception

Meyer, P. J., Morgan, M. M., Kozell, L. B. & Ingram, S., Jun 2009, In : Psychopharmacology. 204, 3, p. 531-540 10 p.

Research output: Contribution to journalArticle

Periaqueductal Gray
Dopamine Receptors
Synaptic Potentials
Flupenthixol
Dopamine
32 Citations (Scopus)

Extracellular signal-regulated kinase 1/2 activation counteracts morphine tolerance in the periaqueductal gray of the rat

Macey, T. A., Bobeck, E. N., Hegarty, D. M., Aicher, S., Ingram, S. & Morgan, M. M., Nov 2009, In : Journal of Pharmacology and Experimental Therapeutics. 331, 2, p. 412-418 7 p.

Research output: Contribution to journalArticle

Periaqueductal Gray
Mitogen-Activated Protein Kinase 3
Mitogen-Activated Protein Kinase 1
Morphine
Microinjections
22 Citations (Scopus)

Glutamate modulation of antinociception, but not tolerance, produced by morphine microinjection into the periaqueductal gray of the rat

Morgan, M. M., Bobeck, E. N. & Ingram, S., Oct 12 2009, In : Brain Research. 1295, p. 59-66 8 p.

Research output: Contribution to journalArticle

Periaqueductal Gray
Microinjections
Morphine
Glutamic Acid
Excitatory Amino Acid Antagonists
11 Citations (Scopus)
Exploratory Behavior
Opioid Receptors
Protein Kinase C
Pharmacology
Protein Kinase C-alpha
2008
21 Citations (Scopus)

Microinjection of the vehicle dimethyl sulfoxide (DMSO) into the periaqueductal gray modulates morphine antinociception

Fossum, E. N., Lisowski, M. J., Macey, T. A., Ingram, S. & Morgan, M. M., Apr 14 2008, In : Brain Research. 1204, p. 53-58 6 p.

Research output: Contribution to journalArticle

Periaqueductal Gray
Microinjections
Dimethyl Sulfoxide
Morphine
Pharmaceutical Preparations
28 Citations (Scopus)

Tolerance to repeated morphine administration is associated with increased potency of opioid agonists

Ingram, S., Macey, T. A., Fossum, E. N. & Morgan, M. M., Sep 2008, In : Neuropsychopharmacology. 33, 10, p. 2494-2504 11 p.

Research output: Contribution to journalArticle

Morphine
Opioid Analgesics
Opioid Receptors
Periaqueductal Gray
GTP-Binding Proteins
2007
19 Citations (Scopus)

Analgesic tolerance to microinjection of the μ-opioid agonist DAMGO into the ventrolateral periaqueductal gray

Meyer, P. J., Fossum, E. N., Ingram, S. & Morgan, M. M., Jun 2007, In : Neuropharmacology. 52, 8, p. 1580-1585 6 p.

Research output: Contribution to journalArticle

Periaqueductal Gray
Microinjections
Morphine
Opioid Analgesics
Analgesics
23 Citations (Scopus)

Behavioral and electrophysiological evidence for opioid tolerance in adolescent rats

Ingram, S., Fossum, E. N. & Morgan, M. M., Mar 2007, In : Neuropsychopharmacology. 32, 3, p. 600-606 7 p.

Research output: Contribution to journalArticle

Opioid Analgesics
Morphine
Methionine Enkephalin
Neurons
Opiate Alkaloids
2006
51 Citations (Scopus)

Antinociceptive tolerance revealed by cumulative intracranial microinjections of morphine into the periaqueductal gray in the rat

Morgan, M. M., Fossum, E. N., Levine, C. S. & Ingram, S., Sep 2006, In : Pharmacology Biochemistry and Behavior. 85, 1, p. 214-219 6 p.

Research output: Contribution to journalArticle

Periaqueductal Gray
Microinjections
Morphine
Rats
Nociception
2005
18 Citations (Scopus)

Intermittent dosing prolongs tolerance to the antinociceptive effect of morphine microinjection into the periaqueductal gray

Morgan, M. M., Tierney, B. W. & Ingram, S., Oct 19 2005, In : Brain Research. 1059, 2, p. 173-178 6 p.

Research output: Contribution to journalArticle

Periaqueductal Gray
Microinjections
Morphine
Injections
2004
23 Citations (Scopus)

Cellular actions of somatostatin on rat periaqueductal grey neurons in vitro

Connor, M., Bagley, E. E., Mitchell, V. A., Ingram, S., Christie, M. J., Humphrey, P. P. A. & Vaughan, C. W., Aug 2004, In : British Journal of Pharmacology. 142, 8, p. 1273-1280 8 p.

Research output: Contribution to journalArticle

Periaqueductal Gray
Somatostatin
Neurons
Inhibitory Postsynaptic Potentials
Potassium
2002
161 Citations (Scopus)

Dopamine transporter-mediated conductances increase excitability of midbrain dopamine neurons

Ingram, S., Prasad, B. M. & Amara, S. G., Oct 2002, In : Nature Neuroscience. 5, 10, p. 971-978 8 p.

Research output: Contribution to journalArticle

Dopamine Plasma Membrane Transport Proteins
Dopaminergic Neurons
Mesencephalon
Dopamine
Neurotransmitter Transport Proteins
89 Citations (Scopus)

The multiple LIM domain-containing adaptor protein Hic-5 synaptically colocalizes and interacts with the dopamine transporter

Carneiro, A. M., Ingram, S., Beaulieu, J. M., Sweeney, A., Amara, S. G., Thomas, S. M., Caron, M. G. & Torres, G. E., Aug 15 2002, In : Journal of Neuroscience. 22, 16, p. 7045-7054 10 p.

Research output: Contribution to journalArticle

Dopamine Plasma Membrane Transport Proteins
Proteins
Corpus Striatum
Focal Adhesion Protein-Tyrosine Kinases
Two-Hybrid System Techniques
2000
31 Citations (Scopus)

Arachidonic acid stimulates a novel cocaine-sensitive cation conductance associated with the human dopamine transporter

Ingram, S. & Amara, S. G., Jan 15 2000, In : Journal of Neuroscience. 20, 2, p. 550-557 8 p.

Research output: Contribution to journalArticle

Dopamine Plasma Membrane Transport Proteins
Cocaine
Arachidonic Acid
Cations
Dopamine
75 Citations (Scopus)

Cellular actions of opioids and other analgesics: Implications for synergism in pain relief

Christie, M. J., Connor, M., Vaughan, C. W., Ingram, S. & Bagley, E. E., 2000, In : Clinical and Experimental Pharmacology and Physiology. 27, 7, p. 520-523 4 p.

Research output: Contribution to journalArticle

Periaqueductal Gray
Opioid Analgesics
Opioid Receptors
Pain
Lipoxygenase Inhibitors
13 Citations (Scopus)

Cellular and molecular mechanisms of opioid action

Ingram, S., 2000, In : Progress in Brain Research. 129, p. 483-492 10 p.

Research output: Contribution to journalArticle

Opioid Analgesics
1999
48 Citations (Scopus)

Opioids, NSAIDS and 5-lipoxygenase inhibitors act synergistically in brain via arachidonic acid metabolism

Christie, M. J., Vaughan, C. W. & Ingram, S., 1999, In : Inflammation Research. 48, 1, p. 1-4 4 p.

Research output: Contribution to journalArticle

Lipoxygenase Inhibitors
Arachidonic Acid
Metabolism
Opioid Analgesics
Brain
1998
126 Citations (Scopus)

Enhanced opioid efficacy in opioid dependence is caused by an altered signal transduction pathway

Ingram, S., Vaughan, C. W., Bagley, E. E., Connor, M. & Christie, M. J., Dec 15 1998, In : Journal of Neuroscience. 18, 24, p. 10269-10276 8 p.

Research output: Contribution to journalArticle

Opioid Analgesics
Signal Transduction
Periaqueductal Gray
Cyclic AMP-Dependent Protein Kinases
Protein Kinase Inhibitors
16 Citations (Scopus)

σ-Binding site ligands inhibit K+ currents in rat locus coeruleus neurons in vitro

Nguyen, V. H., Ingram, S., Kassiou, M. & Mac, M., Nov 13 1998, In : European Journal of Pharmacology. 361, 1, p. 157-163 7 p.

Research output: Contribution to journalArticle

Locus Coeruleus
Binding Sites
Ligands
Neurons
Action Potentials
1997
154 Citations (Scopus)

Actions of the ORL1 receptor ligand nociceptin on membrane properties of rat periaqueductal gray neurons in vitro

Vaughan, C. W., Ingram, S. & Christie, M. J., 1997, In : Journal of Neuroscience. 17, 3, p. 996-1003 8 p.

Research output: Contribution to journalArticle

Periaqueductal Gray
Ligands
Neurons
Membranes
Synaptic Potentials
21 Citations (Scopus)

Cortistatin increase of a potassium conductance in rat locus coeruleus in vitro

Connor, M., Ingram, S. & Christie, M. J., 1997, In : British Journal of Pharmacology. 122, 8, p. 1567-1572 6 p.

Research output: Contribution to journalArticle

Locus Coeruleus
Potassium
Neurons
cortistatin
In Vitro Techniques
32 Citations (Scopus)

Efficacy and kinetics of opioid action on acutely dissociated neurons

Ingram, S., Wilding, T. J., Mccleskey, E. W. & Williams, J., Jul 1997, In : Molecular Pharmacology. 52, 1, p. 136-143 8 p.

Research output: Contribution to journalArticle

Opioid Analgesics
Potassium
Neurons
Methionine Enkephalin
Locus Coeruleus