Summer Gibbs

Associate Professor

  • 1952 Citations
  • 19 h-Index
20042020

Research output per year

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Research Output

2020

Fluorescence image-guided surgery: A perspective on contrast agent development

Barth, C. W. & Gibbs, S. L., Jan 1 2020, Molecular-Guided Surgery: Molecules, Devices, and Applications VI. Gioux, S., Gibbs, S. L. & Pogue, B. W. (eds.). SPIE, 112220J. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; vol. 11222).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Fluorescent imaging technologies for in situ measurement of drug target engagement and cell signaling pathways

McMahon, N. P., Solanki, A., Jones, J., Kwon, S., Chang, Y. H., Chin, K., Nederlof, M. A., Gray, J. W. & Gibbs, S. L., Jan 1 2020, Visualizing and Quantifying Drug Distribution in Tissue IV. Chan, K. F. & Evans, C. L. (eds.). SPIE, 112190O. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; vol. 11219).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Intracellular paired agent imaging enables improved evaluation of tyrosine kinase inhibitor target engagement

Solanki, A., Wang, L., Korber, J., McMahon, N., Tichauer, K., Samkoe, K. S. & Gibbs, S. L., Jan 1 2020, Visualizing and Quantifying Drug Distribution in Tissue IV. Chan, K. F. & Evans, C. L. (eds.). SPIE, 112190F. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; vol. 11219).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

In vivo nerve-specificity of rhodamines and Si-rhodamines

Montano, A. R., Wang, L. G., Barth, C. W., Shams, N. A., Kumarapeli, K. A. S. U. & Gibbs, S. L., Jan 1 2020, Molecular-Guided Surgery: Molecules, Devices, and Applications VI. Gioux, S., Gibbs, S. L. & Pogue, B. W. (eds.). SPIE, 112220I. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; vol. 11222).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Near-infrared nerve-binding fluorophores for buried nerve tissue imaging

Wang, L. G., Barth, C. W., Kitts, C. H., Mebrat, M. D., Montaño, A. R., House, B. J., McCoy, M. E., Antaris, A. L., Galvis, S. N., McDowall, I., Sorger, J. M. & Gibbs, S. L., May 6 2020, In : Science translational medicine. 12, 542

Research output: Contribution to journalArticle

Noninvasive in vivo mapping of intracellular signaling proteins using a pairing of targeted and untargeted fluorescently labeled small molecule kinase inhibitors

Tichauer, K. M., Wang, L., Solanki, A., Korber, J. R., Gibbs, S. L. & Samkoe, K. S., Jan 1 2020, Visualizing and Quantifying Drug Distribution in Tissue IV. Chan, K. F. & Evans, C. L. (eds.). SPIE, 112190K. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; vol. 11219).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Oligonucleotide conjugated antibodies permit highly multiplexed immunofluorescence for future use in clinical histopathology

Mcmahon, N. P., Jones, J. A., Kwon, S., Chin, K., Nederlof, M. A., Gray, J. W. & Gibbs, S. L., May 1 2020, In : Journal of biomedical optics. 25, 5, 056004.

Research output: Contribution to journalArticle

Open Access

Quantification of fluorophore distribution and therapeutic response in matched in vivo and ex vivo pancreatic cancer model systems

Solanki, A., King, D., Thibault, G., Wang, L. & Gibbs, S. L., 2020, In : PloS one. 15, 2, e0229407.

Research output: Contribution to journalArticle

Open Access
2019

Assessment of human pancreas cancer tissue and precursor lesions via a fluorophore with inherent PDAC selectivity

Munhenzva, I. R., Barth, C. W., Sibrian-Vazquez, M., Wang, L. G., Escobedo, J. O., Gibbs, S. & Strongin, R. M., Jan 1 2019, In : Methods.

Research output: Contribution to journalArticle

2 Scopus citations

cmIF: A Python Library for Scalable Multiplex Imaging Pipelines

Eng, J., Bucher, E., Gray, E., Campbell, L. G., Thibault, G., Heiser, L., Gibbs, S., Gray, J. W., Chin, K. & Chang, Y. H., Jan 1 2019, Mathematical and Computational Oncology - 1st International Symposium, ISMCO 2019, Proceedings. Bebis, G., Benos, T., Chen, K., Jahn, K. & Lima, E. (eds.). Springer, p. 37-43 7 p. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); vol. 11826 LNCS).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Diagnostic performance of receptor-specific surgical specimen staining correlates with receptor expression level

Schaefer, J. M., Barth, C. W., Davis, S. C. & Gibbs, S. L., Feb 1 2019, In : Journal of biomedical optics. 24, 2, 026002.

Research output: Contribution to journalArticle

5 Scopus citations

Investigation of oxazine and rhodamine derivatives as peripheral nerve tissue targeting contrast agent for in Vivo fluorescence imaging

Wang, L. G., Barth, C. W., Combs, J. R., Montaño, A. R. & Gibbs, S. L., Jan 1 2019, Molecular-Guided Surgery: Molecules, Devices, and Applications V. Pogue, B. W. & Gioux, S. (eds.). SPIE, 108620H. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; vol. 10862).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Signal removal methods for highly multiplexed immunofluorescent staining using antibody conjugated oligonucleotides

McMahon, N., Jones, J., Eng, J., Kwon, S., Chang, Y. H., Thibault, G., Chin, K., Nederlof, M., Gray, J. & Gibbs, S. L., Jan 1 2019, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XVII. Leary, J. F., Tarnok, A. & Farkas, D. L. (eds.). SPIE, 108810X. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; vol. 10881).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Simultaneous extracellular and intracellular quantification of EGFR using paired-agent imaging in an in ovo tumor model

Samkoe, K. S., Schultz, E., Solanki, A., Wang, L., Korber, J., Tichauer, K. M. & Gibbs, S., Jan 1 2019, Visualizing and Quantifying Drug Distribution in Tissue III. Chan, K. F. & Evans, C. L. (eds.). SPIE, 108590F. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; vol. 10859).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2018

Nile Red derivatives enable improved ratiometric imaging for nerve-specific contrast

Korber, J. R., Barth, C. W. & Gibbs, S., Jul 1 2018, In : Journal of Biomedical Optics. 23, 7, 076002.

Research output: Contribution to journalArticle

3 Scopus citations

Simultaneous Multicolor Single-Molecule Tracking with Single-Laser Excitation via Spectral Imaging

Huang, T., Phelps, C., Wang, J., Lin, L. J., Bittel, A., Scott, Z., Jacques, S., Gibbs, S., Gray, J. & Nan, X., Jan 23 2018, In : Biophysical Journal. 114, 2, p. 301-310 10 p.

Research output: Contribution to journalArticle

15 Scopus citations

Superresolution microscopy with novel BODIPY-based fluorophores

Bittel, A. M., Saldivar, I. S., Dolman, N. J., Nan, X. & Gibbs, S. L., Oct 2018, In : PloS one. 13, 10, e0206104.

Research output: Contribution to journalArticle

4 Scopus citations

Varied Length Stokes Shift BODIPY-Based Fluorophores for Multicolor Microscopy

Bittel, A. M., Davis, A. M., Wang, L., Nederlof, M. A., Escobedo, J. O., Strongin, R. M. & Gibbs, S. L., Dec 1 2018, In : Scientific Reports. 8, 1, 4590.

Research output: Contribution to journalArticle

5 Scopus citations
2017

Direct administration of nerve-specific contrast to improve nerve sparing radical prostatectomy

Barth, C. W. & Gibbs, S. L., 2017, In : Theranostics. 7, 3, p. 573-593 21 p.

Research output: Contribution to journalArticle

21 Scopus citations

Far-Red and Near-Infrared Seminaphthofluorophores for Targeted Pancreatic Cancer Imaging

Wang, L., Barth, C. W., Sibrian-Vazquez, M., Escobedo, J. O., Lowry, M., Muschler, J., Li, H., Gibbs, S. L. & Strongin, R. M., Jan 31 2017, In : ACS Omega. 2, 1, p. 154-163 10 p.

Research output: Contribution to journalArticle

11 Scopus citations

Optimizing fresh specimen staining for rapid identification of tumor biomarkers during surgery

Barth, C. W., Schaefer, J. M., Rossi, V. M., Davis, S. C. & Gibbs, S. L., 2017, In : Theranostics. 7, 19, p. 4722-4734 13 p.

Research output: Contribution to journalArticle

13 Scopus citations

Superresolution imaging of clinical formalin fixed paraffin embedded breast cancer with single molecule localization microscopy

Creech, M. K., Wang, J., Nan, X. & Gibbs, S., Jan 18 2017, In : Scientific Reports. 7, 40766.

Research output: Contribution to journalArticle

13 Scopus citations
2016

Methodology for quantitative characterization of fluorophore photoswitching to predict superresolution microscopy image quality

Bittel, A. M., Nickerson, A., Saldivar, I. S., Dolman, N. J., Nan, X. & Gibbs, S., Jul 14 2016, In : Scientific Reports. 6, 29687.

Research output: Contribution to journalArticle

9 Scopus citations

Visualizing Oxazine 4 nerve-specific fluorescence ex vivo in frozen tissue sections

Barth, C. W. & Gibbs, S. L., Jan 1 2016, Molecular-Guided Surgery: Molecules, Devices, and Applications II. Pogue, B. W. & Gioux, S. (eds.). SPIE, 96960R. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; vol. 9696).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

5 Scopus citations
2015

Charge and hydrophobicity effects of NIR fluorophores on bone-specific imaging

Bao, K., Nasr, K. A., Hyun, H., Lee, J. H., Gravier, J., Gibbs, S. L. & Choi, H. S., 2015, In : Theranostics. 5, 6, p. 609-617 9 p.

Research output: Contribution to journalArticle

19 Scopus citations

Effect of labeling density and time post labeling on quality of antibody-based super resolution microscopy images

Bittel, A. M., Saldivar, I., Dolman, N., Nickerson, A. K., Lin, L. J., Nan, X. & Gibbs, S. L., Jan 1 2015, Single Molecule Spectroscopy and Superresolution Imaging VIII. Gregor, I., Gryczynski, Z. K., Koberling, F., Enderlein, J. & Erdmann, R. (eds.). SPIE, 93310M. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; vol. 9331).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Near-infrared fluorescent digital pathology for the automation of disease diagnosis and biomarker assessment

Gibbs, S. L., Genega, E., Salemi, J., Kianzad, V., Goodwill, H. L., Xie, Y., Oketokoun, R., Khurd, P., Kamen, A. & Frangioni, J. V., Jun 1 2015, In : Molecular Imaging. 14, 4

Research output: Contribution to journalArticle

3 Scopus citations

Polymeric Micelles as Carriers for Nerve-Highlighting Fluorescent Probe Delivery

Hackman, K. M., Doddapaneni, B. S., Barth, C. W., Wierzbicki, I. H., Alani, A. W. G. & Gibbs, S. L., Oct 20 2015, In : Molecular Pharmaceutics. 12, 12, p. 4386-4394 9 p.

Research output: Contribution to journalArticle

14 Scopus citations
2014

Design and development of BODIPY-based photoswitchable fluorophores to visualize cell signaling with multispectral super resolution microscopy

Bittel, A. M., Nickerson, A. K., Lin, L. J., Nan, X. & Gibbs, S. L., Jan 1 2014, Single Molecule Spectroscopy and Superresolution Imaging VII. SPIE, 89500S. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; vol. 8950).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Microscopic validation of macroscopic in vivo imagesenabled by same-slide optical and nuclear fusion

Inoue, K., Gibbs, S. L., Liu, F., Lee, J. H., Xie, Y., Ashitate, Y., Fujii, H., Frangioni, J. V. & Choi, H. S., Nov 1 2014, In : Journal of Nuclear Medicine. 55, 11, p. 1899-1904 6 p.

Research output: Contribution to journalArticle

1 Scopus citations

Molecular imaging: From bench to clinic

Wáng, Y. X. J., Choi, Y., Chen, Z., Laurent, S. & Gibbs, S. L., Dec 29 2014, In : BioMed Research International. 2014, 357258.

Research output: Contribution to journalEditorial

19 Scopus citations
2013

Structure-Activity Relationship of Nerve-Highlighting Fluorophores

Gibbs, S. L., Xie, Y., Goodwill, H. L., Nasr, K. A., Ashitate, Y., Madigan, V. J., Siclovan, T. M., Zavodszky, M., Tan Hehir, C. A. & Frangioni, J. V., Sep 9 2013, In : PloS one. 8, 9, e73493.

Research output: Contribution to journalArticle

21 Scopus citations

Targeted zwitterionic near-infrared fluorophores for improved optical imaging

Choi, H. S., Gibbs, S. L., Lee, J. H., Kim, S. H., Ashitate, Y., Liu, F., Hyun, H., Park, G. L., Xie, Y., Bae, S., Henary, M. & Frangioni, J. V., Feb 1 2013, In : Nature biotechnology. 31, 2, p. 148-153 6 p.

Research output: Contribution to journalArticle

281 Scopus citations

Topical dual-stain difference imaging for rapid intra-operative tumor identification in fresh specimens

Davis, S. C., Gibbs, S. L., Gunn, J. R. & Pogue, B. W., Dec 1 2013, In : Optics Letters. 38, 23, p. 5184-5187 4 p.

Research output: Contribution to journalArticle

24 Scopus citations
2012

Nanoparticle migration and delivery of paclitaxel to regional lymph nodes in a large animal model

Khullar, O. V., Griset, A. P., Gibbs-Strauss, S. L., Chirieac, L. R., Zubris, K. A. V., Frangioni, J. V., Grinstaff, M. W. & Colson, Y. L., Mar 1 2012, In : Journal of the American College of Surgeons. 214, 3, p. 328-337 10 p.

Research output: Contribution to journalArticle

27 Scopus citations

Real-time monitoring of tumorigenesis, dissemination, & drug response in a preclinical model of lymphangioleiomyomatosis/tuberous sclerosis complex

Liu, F., Lunsford, E. P., Tong, J., Ashitate, Y., Gibbs, S. L., Yu, J., Choi, H. S., Henske, E. P. & Frangioni, J. V., Jun 15 2012, In : PloS one. 7, 6, e38589.

Research output: Contribution to journalArticle

12 Scopus citations
2011

Image contrast in fluorescence and magnetic resonance images for glioblastoma detection

Samkoe, K. S., Gibbs-Strauss, S. L., Yang, H. H., Hekmatyar, S. K., Hoopes, P. J., O'Hara, J. A., Kauppinen, R. A. & Pogue, B. W., May 2 2011, Multimodal Biomedical Imaging VI. 78920O. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; vol. 7892).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Nerve-highlighting fluorescent contrast agents for image-guided surgery

Gibbs-Strauss, S. L., Nasr, K. A., Fish, K. M., Khullar, O., Ashitate, Y., Siclovan, T. M., Johnson, B. F., Barnhardt, N. E., Tan Hehir, C. A. & Frangioni, J. V., Mar 1 2011, In : Molecular Imaging. 10, 2, p. 91-101 11 p.

Research output: Contribution to journalArticle

69 Scopus citations

Network cycle features: Application to computer-aided Gleason grading of prostate cancer histopathological images

Khurd, P., Grady, L., Kamen, A., Gibbs-Strauss, S., Genega, E. M. & Frangioni, J. V., Nov 2 2011, 2011 8th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI'11. p. 1632-1636 5 p. 5872716. (Proceedings - International Symposium on Biomedical Imaging).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

28 Scopus citations

Protoporphyrin IX fluorescence contrast in invasive glioblastomas is linearly correlated with Gd enhanced magnetic resonance image contrast but has higher diagnostic accuracy

Samkoe, K. S., Gibbs-Strauss, S. L., Yang, H. H., Khan Hekmatyar, S., Jack Hoopes, P., O'Hara, J. A., Kauppinen, R. A. & Pogue, B. W., Sep 1 2011, In : Journal of biomedical optics. 16, 9, 096008.

Research output: Contribution to journalArticle

15 Scopus citations

Toward optimization of imaging system and lymphatic tracer for near-infrared fluorescent sentinel lymph node mapping in breast cancer

Mieog, J. S. D., Troyan, S. L., Hutteman, M., Donohoe, K. J., Van Der Vorst, J. R., Stockdale, A., Liefers, G. J., Choi, H. S., Gibbs-Strauss, S. L., Putter, H., Gioux, S., Kuppen, P. J. K., Ashitate, Y., Löwik, C. W. G. M., Smit, V. T. H. B. M., Oketokoun, R., Ngo, L. H., Van De Velde, C. J. H., Frangioni, J. V. & Vahrmeijer, A. L., Sep 1 2011, In : Annals of surgical oncology. 18, 9, p. 2483-2491 9 p.

Research output: Contribution to journalArticle

171 Scopus citations
2010

Comparing implementations of magnetic-resonance-guided fluorescence molecular tomography for diagnostic classification of brain tumors

Davis, S. C., Samkoe, K. S., O'Hara, J. A., Gibbs-Strauss, S. L., Paulsen, K. D. & Pogue, B. W., Sep 2010, In : Journal of biomedical optics. 15, 5, 051602.

Research output: Contribution to journalArticle

29 Scopus citations

Computer-aided gleason grading of prostate cancer histopathological images using texton forests

Khurd, P., Bahlmann, C., Maday, P., Kamen, A., Gibbs-Strauss, S., Genega, E. M. & Frangioni, J. V., Aug 9 2010, 2010 7th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2010 - Proceedings. p. 636-639 4 p. 5490096. (2010 7th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2010 - Proceedings).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

43 Scopus citations

Detecting Epidermal Growth Factor Receptor Tumor Activity In Vivo During Cetuximab Therapy of Murine Gliomas

Gibbs-Strauss, S. L., Samkoe, K. S., O'Hara, J. A., Davis, S. C., Hoopes, P. J., Hasan, T. & Pogue, B. W., Jan 1 2010, In : Academic radiology. 17, 1, p. 7-17 11 p.

Research output: Contribution to journalArticle

17 Scopus citations

Ease of synthesis, controllable sizes, and in vivo large-animal-lymph migration of polymeric nanoparticles

Zubris, K. A. V., Khullar, O. V., Griset, A. P., Gibbs-Strauss, S., Frangioni, J. V., Colson, Y. L. & Grinstaff, M. W., Sep 3 2010, In : ChemMedChem. 5, 9, p. 1435-1438 4 p.

Research output: Contribution to journalArticle

18 Scopus citations

Erratum: Review of neurosurgical fluorescence imaging methodologies (IEEE Journal on Selected Topics in Quantum Electronics (2010) 16: 3 (493-505))

Pogue, B. W., Gibbs-Strauss, S., Valdés, P. A., Samkoe, K., Roberts, D. W. & Paulsen, K. D., Nov 1 2010, In : IEEE Journal on Selected Topics in Quantum Electronics. 16, 6, 1 p., 5640636.

Research output: Contribution to journalComment/debate

1 Scopus citations

Fluorescent molecular imaging and dosimetry tools in photodynamic therapy

Pogue, B. W., Samkoe, K. S., Gibbs-Strauss, S. L. & Davis, S. C., Dec 1 2010, Photodynamic Therapy: Methods and Protocols. p. 207-222 16 p. (Methods in Molecular Biology; vol. 635).

Research output: Chapter in Book/Report/Conference proceedingChapter

8 Scopus citations

Intraoperative localization of insulinoma and normal pancreas using invisible near-infrared fluorescent light

Winer, J. H., Choi, H. S., Gibbs-Strauss, S. L., Ashitate, Y., Colson, Y. L. & Frangioni, J. V., Apr 2010, In : Annals of surgical oncology. 17, 4, p. 1094-1100 7 p.

Research output: Contribution to journalArticle

44 Scopus citations

Molecular imaging agents specific for the annulus fibrosus of the intervertebral disk

Gibbs-Strauss, S. L., Vooght, C., Fish, K. M., Nasr, K. A., Siclovan, T. M., Barnhardt, N. E., Hehir, C. A. T. & Frangioni, J. V., May 1 2010, In : Molecular Imaging. 9, 3, p. 128-140 13 p.

Research output: Contribution to journalArticle

15 Scopus citations

MRI-coupled Fluorescence Tomography Quantifies EGFR Activity in Brain Tumors

Davis, S. C., Samkoe, K. S., O'Hara, J. A., Gibbs-Strauss, S. L., Payne, H. L., Hoopes, P. J., Paulsen, K. D. & Pogue, B. W., Mar 1 2010, In : Academic radiology. 17, 3, p. 271-276 6 p.

Research output: Contribution to journalArticle

36 Scopus citations