Sudarshan Anand

Assistant Professor

  • 1304 Citations
  • 16 h-Index
20042018
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Research Output 2004 2018

  • 1304 Citations
  • 16 h-Index
  • 24 Article
  • 2 Review article
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Article
2018
7 Citations (Scopus)

Integrin CD11b activation drives anti-tumor innate immunity

Schmid, M. C., Khan, S. Q., Kaneda, M. M., Pathria, P., Shepard, R., Louis, T. L., Anand, S., Woo, G., Leem, C., Faridi, M. H., Geraghty, T., Rajagopalan, A., Gupta, S., Ahmed, M., Vazquez-Padron, R. I., Cheresh, D. A., Gupta, V. & Varner, J. A., Dec 1 2018, In : Nature Communications. 9, 1, 5379.

Research output: Contribution to journalArticle

immunity
Innate Immunity
Integrins
Tumors
tumors
9 Citations (Scopus)

microRNA-451a regulates colorectal cancer proliferation in response to radiation

Ruhl, R., Rana, S., Kelley, K., Espinosa-Diez, C., Hudson, C., Lanciault, C., Thomas, C., Tsikitis, V. & Anand, S., May 3 2018, In : BMC Cancer. 18, 1, 517.

Research output: Contribution to journalArticle

MicroRNAs
Colorectal Neoplasms
Radiation
Radiation Dosage
Neoplasms
2 Citations (Scopus)

MicroRNA regulation of the MRN complex impacts DNA damage, cellular senescence, and angiogenic signaling article

Espinosa-Diez, C., Wilson, R., Chatterjee, N., Hudson, C., Ruhl, R., Hipfinger, C., Helms, E., Khan, O. F., Anderson, D. G. & Anand, S., Jun 1 2018, In : Cell Death and Disease. 9, 6, 632.

Research output: Contribution to journalArticle

Cell Aging
MicroRNAs
DNA Damage
DNA Repair
Vascular Endothelial Growth Factor A
2017
1 Citation (Scopus)

Understanding and Resetting Radiation Sensitivity in Rectal Cancer

Kelley, K. A., Ruhl, R. A., Rana, S. R., Dewey, E., Espinosa, C., Thomas, C., Martindale, R., Anand, S. & Tsikitis, V., Jul 24 2017, (Accepted/In press) In : Annals of Surgery.

Research output: Contribution to journalArticle

Radiation Tolerance
Rectal Neoplasms
MicroRNAs
Chemoradiotherapy
Colorectal Neoplasms
2016
18 Citations (Scopus)

MicroRNA regulation of endothelial TREX1 reprograms the tumour microenvironment

Wilson, R. A., Espinosa-Diez, C., Kanner, N., Chatterjee, N., Ruhl, R., Hipfinger, C., Advani, S. J., Li, J., Khan, O. F., Franovic, A., Weis, S. M., Kumar, S., Coussens, L., Anderson, D. G., Chen, C. C., Cheresh, D. A. & Anand, S., Nov 25 2016, In : Nature Communications. 7, 13597.

Research output: Contribution to journalArticle

Tumor Microenvironment
MicroRNAs
Tumors
tumors
Neoplasms
2015
13 Citations (Scopus)

Kinase-independent role for CRAF-driving tumour radioresistance via CHK2

Advani, S. J., Camargo, M. F., Seguin, L., Mielgo, A., Anand, S., Hicks, A. M., Aguilera, J., Franovic, A., Weis, S. M. & Cheresh, D. A., Sep 3 2015, In : Nature Communications. 6, 8154.

Research output: Contribution to journalArticle

Tumors
Phosphotransferases
tumors
deoxyribonucleic acid
Cells
2014
165 Citations (Scopus)

An integrin β 3-KRAS-RalB complex drives tumour stemness and resistance to EGFR inhibition

Seguin, L., Kato, S., Franovic, A., Camargo, M. F., Lesperance, J., Elliott, K. C., Yebra, M., Mielgo, A., Lowy, A. M., Husain, H., Cascone, T., Diao, L., Wang, J., Wistuba, I. I., Heymach, J. V., Lippman, S. M., Desgrosellier, J. S., Anand, S., Weis, S. M. & Cheresh, D. A., 2014, In : Nature Cell Biology. 16, 5, p. 457-468 12 p.

Research output: Contribution to journalArticle

Integrins
Neoplasms
Cell Membrane
Neoplastic Stem Cells
Receptor Protein-Tyrosine Kinases
3 Citations (Scopus)

Manipulating MicroRNAs to regulate macrophage polarization in gliomas

Anand, S. & Coussens, L., Aug 1 2014, In : Journal of the National Cancer Institute. 106, 8, dju230.

Research output: Contribution to journalArticle

MicroRNAs
Glioma
Macrophages
2013
31 Citations (Scopus)

A brief primer on microRNAs and their roles in angiogenesis

Anand, S., 2013, In : Vascular Cell. 5, 1, 2.

Research output: Contribution to journalArticle

MicroRNAs
Gene expression
Cell signaling
Complex networks
Cell death
43 Citations (Scopus)

Ras pathway inhibition prevents neovascularization by repressing endothelial cell sprouting

Westenskow, P. D., Kurihara, T., Aguilar, E., Scheppke, E. L., Moreno, S. K., Wittgrove, C., Marchetti, V., Michael, I. P., Anand, S., Nagy, A., Cheresh, D. & Friedlander, M., Nov 1 2013, In : Journal of Clinical Investigation. 123, 11, p. 4900-4908 9 p.

Research output: Contribution to journalArticle

Vascular Endothelial Growth Factor A
Endothelial Cells
Blood Vessels
p120 GTPase Activating Protein
Eye Diseases
2012
37 Citations (Scopus)

EGFR-dependent pancreatic carcinoma cell metastasis through Rap1 activation

Huang, M., Anand, S., Murphy, E. A., Desgrosellier, J. S., Stupack, D. G., Shattil, S. J., Schlaepfer, D. D. & Cheresh, D. A., May 31 2012, In : Oncogene. 31, 22, p. 2783-2793 11 p.

Research output: Contribution to journalArticle

ras Proteins
Epidermal Growth Factor Receptor
Neoplasm Metastasis
Crk-Associated Substrate Protein
Growth
29 Citations (Scopus)

EGFR-mediated carcinoma cell metastasis mediated by integrin αvβ5 depends on activation of c-Src and cleavage of MUC1

Lau, S. K. M., Shields, D. J., Murphy, E. A., Desgrosellier, J. S., Anand, S., Huang, M., Kato, S., Lim, S. T., Weis, S. M., Stupack, D. G., Schlaepfer, D. D. & Cheresh, D. A., May 7 2012, In : PLoS One. 7, 5, e36753.

Research output: Contribution to journalArticle

integrins
Integrins
metastasis
carcinoma
Chemical activation
8 Citations (Scopus)

Expression of anti-HVEM single-chain antibody on tumor cells induces tumor-specific immunity with long-term memory

Park, J. J., Anand, S., Zhao, Y., Matsumura, Y., Sakoda, Y., Kuramasu, A., Strome, S. E., Chen, L. & Tamada, K., Feb 2012, In : Cancer Immunology, Immunotherapy. 61, 2, p. 203-214 12 p.

Research output: Contribution to journalArticle

Single-Chain Antibodies
Virus Internalization
Long-Term Memory
Immunity
Neoplasms
2011
37 Citations (Scopus)

A MEK-independent role for CRAF in mitosis and tumor progression

Mielgo, A., Seguin, L., Huang, M., Camargo, M. F., Anand, S., Franovic, A., Weis, S. M., Advani, S. J., Murphy, E. A. & Cheresh, D. A., Dec 2011, In : Nature Medicine. 17, 12, p. 1641-1645 5 p.

Research output: Contribution to journalArticle

Mitogen-Activated Protein Kinase Kinases
Mitosis
Tumors
Neoplasms
Prometaphase
29 Citations (Scopus)

Emerging Role of Micro-RNAs in the Regulation of Angiogenesis

Anand, S. & Cheresh, D. A., Dec 2011, In : Genes and Cancer. 2, 12, p. 1134-1138 5 p.

Research output: Contribution to journalArticle

MicroRNAs
Blood Vessels
Endothelial Cells
RNA
Inflammation
8 Citations (Scopus)

Herpesvirus entry mediator regulates hypoxiainducible factor-1α and erythropoiesis in mice

Sakoda, Y., Anand, S., Zhao, Y., Park, J. J., Liu, Y., Kuramasu, A., Van Rooijen, N., Chen, L., Strome, S. E., Hancock, W. W., Chen, L. & Tamada, K., Dec 1 2011, In : Journal of Clinical Investigation. 121, 12, p. 4810-4819 10 p.

Research output: Contribution to journalArticle

Receptors, Tumor Necrosis Factor, Member 14
Erythropoiesis
Hypoxia-Inducible Factor 1
Oxygen
Erythropoietin
43 Citations (Scopus)

MicroRNA-mediated regulation of the angiogenic switch

Anand, S. & Cheresh, D. A., May 2011, In : Current Opinion in Hematology. 18, 3, p. 171-176 6 p.

Research output: Contribution to journalArticle

MicroRNAs
p120 GTPase Activating Protein
Pathologic Neovascularization
Endothelium
Blood Vessels
2010
194 Citations (Scopus)

B7-H1/CD80 interaction is required for the induction and maintenance of peripheral T-cell tolerance

Park, J. J., Omiya, R., Matsumura, Y., Sakoda, Y., Kuramasu, A., Augustine, M. M., Yao, S., Tsushima, F., Narazaki, H., Anand, S., Liu, Y., Strome, S. E., Chen, L. & Tamada, K., Aug 26 2010, In : Blood. 116, 8, p. 1291-1298 8 p.

Research output: Contribution to journalArticle

T-cells
Maintenance
T-Lymphocytes
Antigens
Central Tolerance
41 Citations (Scopus)

Disruption of angiogenesis and tumor growth with an orally active drug that stabilizes the inactive state of PDGFRβ/B-RAF

Murphy, E. A., Shields, D. J., Stoletov, K., Dneprovskaia, E., McElroy, M., Greenberg, J. I., Lindquist, J., Acevedo, L. M., Anand, S., Majeti, B. K., Tsigelny, I., Saldanha, A., Walsh, B., Hoffman, R. M., Bouvet, M., Klemke, R. L., Vogt, P. K., Arnold, L., Wrasidlo, W. & Cheresh, D. A., Mar 2 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 9, p. 4299-4304 6 p.

Research output: Contribution to journalArticle

Phosphotransferases
Growth
Pharmaceutical Preparations
Neoplasms
Adenosine Triphosphate
365 Citations (Scopus)

MicroRNA-132-mediated loss of p120RasGAP activates the endothelium to facilitate pathological angiogenesis

Anand, S., Majeti, B. K., Acevedo, L. M., Murphy, E. A., Mukthavaram, R., Scheppke, L., Huang, M., Shields, D. J., Lindquist, J. N., Lapinski, P. E., King, P. D., Weis, S. M. & Cheresh, D. A., Aug 2010, In : Nature Medicine. 16, 8, p. 909-914 6 p.

Research output: Contribution to journalArticle

p120 GTPase Activating Protein
Pathologic Neovascularization
MicroRNAs
Endothelium
Tumors
2009
61 Citations (Scopus)

B7-H4-deficient mice display augmented neutrophil-mediated innate immunity

Zhu, G., Augustine, M. M., Azuma, T., Luo, L., Yao, S., Anand, S., Rietz, A. C., Huang, J., Xu, H., Flies, A. S., Flies, S. J., Tamada, K., Colonna, M., Van Deursen, J. M. A. & Chen, L., Feb 19 2009, In : Blood. 113, 8, p. 1759-1767 9 p.

Research output: Contribution to journalArticle

Innate Immunity
Neutrophils
Display devices
Listeria
T-cells
2007
48 Citations (Scopus)

Selective targeting of the LIGHT-HVEM costimulatory system for the treatment of graft-versus-host disease

Xu, Y., Flies, A. S., Flies, D. B., Zhu, G., Anand, S., Flies, S. J., Xu, H., Anders, R. A., Hancock, W. W., Chen, L. & Tamada, K., May 1 2007, In : Blood. 109, 9, p. 4097-4104 8 p.

Research output: Contribution to journalArticle

Graft vs Host Disease
Grafts
T-cells
Light
Lymphotoxin-alpha
2006
56 Citations (Scopus)

Essential role of TNF family molecule LIGHT as a cytokine in the pathogenesis of hepatitis

Anand, S., Wang, P., Yoshimura, K., Choi, I. H., Hilliard, A., Chen, Y. H., Wang, C. R., Schulick, R., Flies, A. S., Flies, D. B., Zhu, G., Xu, Y., Pardoll, D. M., Chen, L. & Tamada, K., Apr 1 2006, In : Journal of Clinical Investigation. 116, 4, p. 1045-1051 7 p.

Research output: Contribution to journalArticle

Hepatitis
Cytokines
Light
Lymphotoxin-alpha
Tumor Necrosis Factor Ligand Superfamily Member 14
2004
8 Citations (Scopus)

Control of autoimmune diseases by the B7-CD28 family molecules

Anand, S. & Chen, L., 2004, In : Current Pharmaceutical Design. 10, 2, p. 121-128 8 p.

Research output: Contribution to journalArticle

Autoimmune Diseases
Humoral Immunity
Cellular Immunity