Stephen Smith &ndash; Publications

1-(2-pyrimidinyl)piperazine antagonizes GABA-activated currents in cultured spinal neurones of the rat

Smith, S. & Hughes, D., Jul 31 1989, In : Brain Research. 493, 2, p. 366-367 2 p.

Research output: Contribution to journal › Article

Buspirone

gamma-Aminobutyric Acid

Flurazepam

Aminobutyrates

Neurons

15th Annual Spring Brain Conference, March 10-13, 2004, summary report

Anstrom, K., Bergles, D., Bradley, K., Cao, Y., Cestnick, L., Lee, S., Piedras-Rentería, E., Savoie, K., Smith, S. & Woolsey, T. A., Jun 2004, In : Somatosensory and Motor Research. 21, 2, p. 137-143 7 p.

Research output: Contribution to journal › Article

Neurophysiology

Brain

358 Citations (Scopus)

Ablation of P/Q-type Ca2+ channel currents, altered synaptic transmission, and progressive ataxia in mice lacking the α(1A)-subunit

Jun, K., Piedras-Rentería, E. S., Smith, S., Wheeler, D. B., Lee, S. B., Lee, T. G., Chin, H., Adams, M. E., Scheller, R. H., Tsien, R. W. & Shin, H. S., Dec 21 1999, In : Proceedings of the National Academy of Sciences of the United States of America. 96, 26, p. 15245-15250 6 p.

Research output: Contribution to journal › Article

Dystonia

Ataxia

Synaptic Transmission

Purkinje Cells

Migraine Disorders

39 Citations (Scopus)

Baclofen and gamma-hydroxybutyrate withdrawal

LeTourneau, J. L., Hagg, D. & Smith, S., Jun 2008, In : Neurocritical Care. 8, 3, p. 430-433 4 p.

Research output: Contribution to journal › Article

Sodium Oxybate

Baclofen

Delirium

Tremor

Benzodiazepines

Bleeding from the gastrointestinal tract during prolonged ventilation

Smith, S., Bihari, J., Zandstra, D. F. & Stoutenbeek, C. P., Jun 1995, In : Intensive Care Medicine. 21, 6, p. 543-544 2 p.

Research output: Contribution to journal › Article

Anti-Ulcer Agents

Gastrointestinal Hemorrhage

Artificial Respiration

Ventilation

Gastrointestinal Tract

4 Citations (Scopus)

Caesium ions: A glycine-activated channel agonist in rat spinal cord neurones grown in cell culture

Smith, S. & McBurney, R. N., 1989, In : British Journal of Pharmacology. 96, 4, p. 940-948 9 p.

Research output: Contribution to journal › Article

Cesium

Glycine

Spinal Cord

Cell Culture Techniques

Ions

15 Citations (Scopus)

Caesium ions activate chloride channels in rat cultured spinal cord neurones.

Hughes, D., McBurney, R. N., Smith, S. & Zorec, R., Nov 1 1987, In : The Journal of physiology. 392, 1, p. 231-251 21 p.

Research output: Contribution to journal › Article

Cesium

Chloride Channels

Spinal Cord

Neurons

Ions

11 Citations (Scopus)

Calcium dependence of spontaneous neurotransmitter release

Williams, C. L. & Smith, S., 2017, (Accepted/In press) In : Journal of Neuroscience Research.

Research output: Contribution to journal › Article

Synapses

Neurotransmitter Agents

Calcium

Calcium-Sensing Receptors

28 Citations (Scopus)

Calcium regulation of spontaneous and asynchronous neurotransmitter release

Smith, S., Chen, W., Vyleta, N. P., Williams, C., Lee, C. H., Phillips, C. & Andresen, M., Sep 2012, In : Cell Calcium. 52, 3-4, p. 226-233 8 p.

Research output: Contribution to journal › Article

Synapses

Neurotransmitter Agents

Calcium

Transient Receptor Potential Channels

Calcium-Sensing Receptors

9 Citations (Scopus)

Calcium-sensing receptor: A high-affinity presynaptic target for aminoglycoside-induced weakness

Harnett, M. T., Chen, W. & Smith, S., Oct 2009, In : Neuropharmacology. 57, 5-6, p. 502-505 4 p.

Research output: Contribution to journal › Article

Calcium-Sensing Receptors

Aminoglycosides

Calcium Channels

Inhibitory Concentration 50

Cations

18 Citations (Scopus)

Calcium-sensing receptor: A key target for extracellular calcium signaling in neurons

Jones, B. L. & Smith, S., Mar 30 2016, In : Frontiers in Physiology. 7, MAR, 116.

Research output: Contribution to journal › Article

Calcium-Sensing Receptors

Calcium Signaling

Calcium

Neurons

Nerve Tissue

38 Citations (Scopus)

Calcium-sensing receptor activation depresses synaptic transmission

Phillips, C. G., Harnett, M. T., Chen, W. & Smith, S., Nov 12 2008, In : Journal of Neuroscience. 28, 46, p. 12062-12070 9 p.

Research output: Contribution to journal › Article

Calcium-Sensing Receptors

Synaptic Transmission

Spermidine

Carisoprodol

Synapses

32 Citations (Scopus)

Cerebral blood flow is proportional to cardiac index in patients with septic shock

Smith, S., Padayachee, S., Modaresi, K. B., Smithies, M. N. & Bihari, D. J., Sep 1998, In : Journal of Critical Care. 13, 3, p. 104-109 6 p.

Research output: Contribution to journal › Article

Cerebrovascular Circulation

Septic Shock

Extremities

Doppler Ultrasonography

Regional Blood Flow

4 Citations (Scopus)

Choice of crystalloid and mortality in sepsis-all in the timing? To the editor

Jones, B. L. & Smith, S., 2014, In : Critical Care Medicine. 42, 12, p. e796

Research output: Contribution to journal › Article

Isotonic Solutions

Fluid Therapy

Hospital Mortality

Critical Illness

Sepsis

29 Citations (Scopus)

Coactivation of multiple tightly coupled calcium channels triggers spontaneous release of GABA

Williams, C., Chen, W., Lee, C. H., Yaeger, D., Vyleta, N. P. & Smith, S., Sep 2012, In : Nature Neuroscience. 15, 9, p. 1195-1197 3 p.

Research output: Contribution to journal › Article

Calcium Channels

Synapses

gamma-Aminobutyric Acid

Action Potentials

Neurotransmitter Agents

14 Citations (Scopus)

Colorimetric enzymatic measurement of serum total 3α-hydroxy bile acid concentrations without extraction

Qureshi, M. Y., Smith, S. & Murphy, G. M., 1984, In : Journal of Clinical Pathology. 37, 3, p. 317-320 4 p.

Research output: Contribution to journal › Article

Hydroxy Acids

Enzyme Assays

Bile Acids and Salts

Serum

Sensitivity and Specificity

31 Citations (Scopus)

Conductance states activated by glycine and GABA in rat cultured spinal neurones

Smith, S., Zorec, R. & McBurney, R. N., Apr 1989, In : The Journal of Membrane Biology. 108, 1, p. 45-52 8 p.

Research output: Contribution to journal › Article

Glycine

gamma-Aminobutyric Acid

Neurons

Chlorides

Spinal Cord

4 Citations (Scopus)

Crystal violet reactions of coagulase negative staphylococci

Freeman, R., Burdess, D. & Smith, S., 1994, In : Journal of Clinical Pathology. 47, 3, p. 283-285 3 p.

Research output: Contribution to journal › Article

Gentian Violet

Coagulase

Staphylococcus

Staphylococcus saprophyticus

Bacteriophages

10 Citations (Scopus)

Distinct actions of voltage-activated Ca²⁺ channel block on spontaneous release at excitatory and inhibitory central synapses

Tsintsadze, T., Williams, C. L., Weingarten, D. J., Von Gersdorff, H. & Smith, S., Apr 19 2017, In : Journal of Neuroscience. 37, 16, p. 4301-4310 10 p.

Research output: Contribution to journal › Article

Synapses

Calcium Channels

Calcium Channel Blockers

Synaptic Transmission

Brain Stem

Examination of the central nervous system in the critically ill patient: Important clinical signs and diagnoses

Smith, S., 1994, In : British Journal of Intensive Care. 4, 4

Research output: Contribution to journal › Article

Critical Illness

Intensive Care Units

Central Nervous System

Drug Overdose

Neurologic Examination

1 Citation (Scopus)

Extravascular lung water as a predictor of mortality in acute respiratory distress syndrome

Smith, S. & Phillips, C. R., Jul 2008, In : Critical Care Medicine. 36, 7, p. 2221-2222 2 p.

Research output: Contribution to journal › Article

Extravascular Lung Water

Adult Respiratory Distress Syndrome

Mortality

143 Citations (Scopus)

Extravascular lung water in sepsis-associated acute respiratory distress syndrome: Indexing with predicted body weight improves correlation with severity of illness and survival

Phillips, C. R., Chestnutt, M. & Smith, S., Jan 2008, In : Critical Care Medicine. 36, 1, p. 69-73 5 p.

Research output: Contribution to journal › Article

Extravascular Lung Water

Adult Respiratory Distress Syndrome

Sepsis

Body Weight

Lung Injury

12 Citations (Scopus)

Fast inhibition of glutamate-activated currents by caffeine

Vyleta, N. P. & Smith, S., Sep 10 2008, In : PLoS One. 3, 9, e3155.

Research output: Contribution to journal › Article

caffeine

Caffeine

glutamates

Glutamic Acid

Excitatory Postsynaptic Potentials

Glucose variance in ICU patients receiving insulin infusions

Smith, S. & Hagg, D., May 2008, In : Chest. 133, 5, p. 1288 1 p.

Research output: Contribution to journal › Article

Insulin

Glucose

1 Citation (Scopus)

Magnesium activation of the calcium-sensing receptor, a mechanism to reduce infarction and vasospasm in subarachnoid hemorrhage

Smith, S., 2010, In : Critical Care Medicine. 38, 10, p. 2083 1 p.

Research output: Contribution to journal › Article

Brain Hypoxia-Ischemia

Calcium-Sensing Receptors

Intracranial Vasospasm

Magnesium Sulfate

Calcium Channel Blockers

8 Citations (Scopus)

Measurement of conjugated and unconjugated serum bile acid concentrations using 3alpha-hydroxysteroid dehydrogenase

Smith, S., Myszor, M., Setchell, K. D. R. & Murphy, G. M., 1983, In : Journal of Clinical Pathology. 36, 2, p. 235-236 2 p.

Research output: Contribution to journal › Article

10 Citations (Scopus)

Membrane capacitance changes induced by thrombin and calcium in single endothelial cells cultured from human umbilical vein

Carter, T. D., Zupancic, G., Smith, S., Wheeler-Jones, C. & Ogden, D., Dec 15 1998, In : Journal of Physiology. 513, 3, p. 845-855 11 p.

Research output: Contribution to journal › Article

Human Umbilical Vein Endothelial Cells

Thrombin

Photolysis

Calcium

Membranes

12 Citations (Scopus)

Modulation of neuronal voltage-activated calcium and sodium channels by polyamines and Ph

Chen, W., Harnett, M. T. & Smith, S., Jul 2007, In : Channels. 1, 4, p. 281-290 10 p.

Research output: Contribution to journal › Article

Sodium Channels

Polyamines

Calcium Channels

Modulation

Electric potential

32 Citations (Scopus)

N-Acetylcysteine for patients with prolonged hypotension as prophylaxis for acute renal failure (NEPHRON)

Komisarof, J. A., Gilkey, G. M., Peters, D., Koudelka, C. W., Meyer, M. M. & Smith, S., Feb 2007, In : Critical Care Medicine. 35, 2, p. 435-441 7 p.

Research output: Contribution to journal › Article

Acetylcysteine

Acute Kidney Injury

Hypotension

Organ Dysfunction Scores

Placebos

7 Citations (Scopus)

Neuronal voltage-activated calcium channels: On the roles of the α(1E) and β₃ subunits

Smith, S., Piedras-Renterìa, E. S., Namkung, Y., Shin, H. S. & Tsien, R. W., 1999, In : Annals of the New York Academy of Sciences. 868, p. 175-198 24 p.

Research output: Contribution to journal › Article

Calcium Channels

Neurons

Antisense Oligonucleotides

Electric potential

Gene Targeting

14 Citations (Scopus)

Optical tracking of phenotypically diverse individual synapses on solitary tract nucleus neurons

Jin, Y. H., Cahill, E. A., Fernandes, L. G., Wang, X., Chen, W., Smith, S. & Andresen, M., Feb 2 2010, In : Brain Research. 1312, p. 54-66 13 p.

Research output: Contribution to journal › Article

Solitary Nucleus

Synapses

Neurons

Glutamic Acid

Visceral Afferents

2 Citations (Scopus)

Patient-specific insulin-resistanceguided infusion improves glycemic control in cardiac surgery

Caddell, K. A., Komanapalli, C. B., Slater, M., Hagg, D., Tibayan, F. F., Smith, S., Ahmann, A., Guyton, S. W. & Song, H., Dec 2010, In : Annals of Thoracic Surgery. 90, 6, p. 1818-1823 6 p.

Research output: Contribution to journal › Article

Thoracic Surgery

Insulin

Glycemic Index

Blood Glucose

Hypoglycemia

10 Citations (Scopus)

Polyamine distribution in the rat intestinal mucosa

Hosomi, M., Smith, S., Murphy, G. M. & Dowling, R. H., 1986, In : Journal of Chromatography B: Biomedical Sciences and Applications. 375, C, p. 267-275 9 p.

Research output: Contribution to journal › Article

Spermidine

Polyamines

Intestinal Mucosa

Rats

Putrescine

10 Citations (Scopus)

Predicted body weight-indexed extravascular lung water is elevated in acute respiratory distress syndrome

Phillips, C. R. & Smith, S., Jan 2009, In : Critical Care Medicine. 37, 1, p. 377-378 2 p.

Research output: Contribution to journal › Article

Extravascular Lung Water

Adult Respiratory Distress Syndrome

Body Weight

28 Citations (Scopus)

Presynaptic external calcium signaling involves the calcium-sensing receptor in neocortical nerve terminals

Chen, W., Bergsman, J. B., Wang, X., Gilkey, G., Pierpoint, C. R., Daniel, E. A., Awumey, E. M., Dauban, P., Dodd, R. H., Ruat, M. & Smith, S., Jan 5 2010, In : PLoS One. 5, 1, e8563.

Research output: Contribution to journal › Article

Calcium-Sensing Receptors

Calcium Signaling

Cations

nerve tissue

Calcium

116 Citations (Scopus)

Primary Afferent Activation of Thermosensitive TRPV1 Triggers Asynchronous Glutamate Release at Central Neurons

Peters, J. H., McDougall, S. J., Fawley, J. A., Smith, S. & Andresen, M., Mar 11 2010, In : Neuron. 65, 5, p. 657-669 13 p.

Research output: Contribution to journal › Article

Visceral Afferents

Glutamic Acid

Neurons

Neuronal Plasticity

Solitary Nucleus

Radioimmunoassay for unconjugated and conjugated ursodeoxycholic acid in normal sera

Myszor, M. F., Smith, S., Murphy, G. M. & Dowling, R. H., 1982, In : Clinical Science. 62, 2

Research output: Contribution to journal › Article

Ursodeoxycholic Acid

Radioimmunoassay

Serum

39 Citations (Scopus)

Recordings from Single Neocortical Nerve Terminals Reveal a Nonselective Cation Channel Activated by Decreases in Extracellular Calcium

Smith, S., Bergsman, J. B., Harata, N. C., Scheller, R. H. & Tsien, R. W., Jan 22 2004, In : Neuron. 41, 2, p. 243-256 14 p.

Research output: Contribution to journal › Article

Cations

Presynaptic Terminals

Calcium

Spermidine

Neocortex

32 Citations (Scopus)

Role of polyamines in intestinal adaptation in the rat

Hosomi, M., Stace, N. H., Lirussi, F., Smith, S., Murphy, G. M. & Dowling, R. H., 1987, In : European Journal of Clinical Investigation. 17, 5, p. 375-385 11 p.

Research output: Contribution to journal › Article

Polyamines

Spermidine

Spermine

Rats

Intestines

62 Citations (Scopus)

Spontaneous glutamate release is independent of calcium influx and tonically activated by the calcium-sensing receptor

Vyleta, N. P. & Smith, S., Mar 23 2011, In : Journal of Neuroscience. 31, 12, p. 4593-4606 14 p.

Research output: Contribution to journal › Article

Calcium-Sensing Receptors

Glutamic Acid

Calcium

Calcium Channels

Neurons

Strong G-Protein-Mediated Inhibition of Sodium Channels

Mattheisen, G. B., Tsintsadze, T. & Smith, S., May 29 2018, In : Cell Reports. 23, 9, p. 2770-2781 12 p.

Research output: Contribution to journal › Article

Voltage-Gated Sodium Channels

Sodium Channels

GTP-Binding Proteins

Calcium-Sensing Receptors

Neurons

99 Citations (Scopus)

Synaptic vesicle endocytosis: fast and slow modes of membrane retrieval

Smith, S., Renden, R. & Von Gersdorff, H., Nov 2008, In : Trends in Neurosciences. 31, 11, p. 559-568 10 p.

Research output: Contribution to journal › Article

Synaptic Vesicles

Endocytosis

Exocytosis

Membranes

Flicker Fusion

41 Citations (Scopus)

Synthesis and characterization of a series of diarylguanidines that are noncompetitive N-methyl-D-aspartate receptor antagonists with neuroprotective properties

Keana, J. F. W., McBurney, R. N., Scherz, M. W., Fischer, J. B., Hamilton, P. N., Smith, S., Server, A. C., Finkbeiner, S., Stevens, C. F., Jahr, C. & Weber, E., 1989, In : Proceedings of the National Academy of Sciences of the United States of America. 86, 14, p. 5631-5635 5 p.

Research output: Contribution to journal › Article

tenocyclidine

N-Methylaspartate

N-Methyl-D-Aspartate Receptors

Phencyclidine Receptors

Dizocilpine Maleate

72 Citations (Scopus)

Targeted disruption of the Ca²⁺ channel β₃ subunit reduces N- and L- type Ca²⁺ channel activity and alters the voltage-dependent activation of P/Q-type Ca²⁺ channels in neurons

Namkung, Y., Smith, S., Lee, S. B., Skrypnyk, N. V., Kim, H. L., Chin, H., Scheller, R. H., Tsien, R. W. & Shin, H. S., Sep 29 1998, In : Proceedings of the National Academy of Sciences of the United States of America. 95, 20, p. 12010-12015 6 p.

Research output: Contribution to journal › Article

Neurons

Gene Targeting

Synaptic Transmission

Norepinephrine

6 Citations (Scopus)

Ultradian variation of blood glucose in intensive care unit patients receiving insulin infusions

Smith, S., Oveson, K. E., Strauss, W., Raven, K., Lefevre, M. C., Ahmann, A. & Hagg, D., Oct 2007, In : Diabetes Care. 30, 10, p. 2503-2505 3 p.

Research output: Contribution to journal › Article

Insulin Infusion Systems

Activity Cycles

Intensive Care Units

Blood Glucose

Prospective Studies

82 Citations (Scopus)

Vasopressin inhibits glutamate release via two distinct modes in the brainstem.

Bailey, T. W., Jin, Y. H., Doyle, M. W., Smith, S. & Andresen, M., Jun 7 2006, In : The Journal of neuroscience : the official journal of the Society for Neuroscience. 26, 23, p. 6131-6142 12 p.

Research output: Contribution to journal › Article

Arginine Vasopressin

Vasopressins

Brain Stem

Glutamic Acid

Neurons