Stephen Heitner

Assistant Professor

  • 566 Citations
  • 9 h-Index
20092019
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Research Output 2009 2019

  • 566 Citations
  • 9 h-Index
  • 25 Article
  • 3 Review article
  • 2 Letter
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Article
2019

Inotersen for the treatment of adults with polyneuropathy caused by hereditary transthyretin-mediated amyloidosis

Gertz, M. A., Scheinberg, M., Waddington-Cruz, M., Heitner, S., Karam, C., Drachman, B., Khella, S., Whelan, C. & Obici, L., Aug 3 2019, In : Expert Review of Clinical Pharmacology. 12, 8, p. 701-711 11 p.

Research output: Contribution to journalArticle

Open Access
Polyneuropathies
Antisense Oligonucleotides
Familial Amyloid Neuropathies
Familial Amyloidosis
Safety

Mavacamten treatment for obstructive hypertrophic cardiomyopathy a clinical trial

Heitner, S., Jacoby, D., Lester, S. J., Owens, A., Wang, A., Zhang, D., Lambing, J., Lee, J., Semigran, M. & Sehnert, A. J., Jun 4 2019, In : Annals of internal medicine. 170, 11, p. 741-748 8 p.

Research output: Contribution to journalArticle

Hypertrophic Cardiomyopathy
Stroke Volume
Clinical Trials
Dyspnea
Cardiac Myosins

Participation in thrill-seeking activities by patients with hypertrophic cardiomyopathy: Individual preferences, adverse events and physician attitude

Papoutsidakis, N., Heitner, S., Ingles, J., Semsarian, C., Mannello, M., Salberg, L., Waldman, C., Vaccaro, B., Maurizi, N., Olivotto, I. & Jacoby, D., Aug 1 2019, In : American heart journal. 214, p. 28-35 8 p.

Research output: Contribution to journalArticle

Hypertrophic Cardiomyopathy
Physicians
Skiing
Safety
Sudden Cardiac Death

Safety profile of ultrasound enhancing agents in echocardiography

Kumar, S., Purtell, C., Peterson, A., Gibbons, P., Khan, A. & Heitner, S., Jan 1 2019, In : Echocardiography.

Research output: Contribution to journalArticle

Echocardiography
Safety
Ventricular Heart Septal Defects
Back Pain
Exanthema
9 Citations (Scopus)

Transthyretin Stabilization by AG10 in Symptomatic Transthyretin Amyloid Cardiomyopathy

Judge, D. P., Heitner, S., Falk, R. H., Maurer, M. S., Shah, S. J., Witteles, R. M., Grogan, M., Selby, V. N., Jacoby, D., Hanna, M., Nativi-Nicolau, J., Patel, J., Rao, S., Sinha, U., Turtle, C. W. & Fox, J. C., Jul 23 2019, In : Journal of the American College of Cardiology. 74, 3, p. 285-295 11 p.

Research output: Contribution to journalArticle

Open Access
Prealbumin
Cardiomyopathies
Amyloid
Placebos
Serum
2018

Bortezomib-based Chemotherapy for Multiple Myeloma Patients Without Comorbid Cardiovascular Disease Shows No Cardiotoxicity

Heitner, S., Minnier, J., Naher, A., Van Woerkem, R., Ritts, A., Ferencik, M., Broberg, C., Medvedova, E., Silbermann, R. & Scott, E., Jan 1 2018, (Accepted/In press) In : Clinical Lymphoma, Myeloma and Leukemia.

Research output: Contribution to journalArticle

Multiple Myeloma
Cardiovascular Diseases
Drug Therapy
Stroke Volume
Biomarkers
4 Citations (Scopus)

Hereditary transthyretin amyloidosis: baseline characteristics of patients in the NEURO-TTR trial

Waddington-Cruz, M., Ackermann, E. J., Polydefkis, M., Heitner, S., Dyck, P. J., Barroso, F. A., Wang, A. K., Berk, J. L., Dyck, P. J. B., Monia, B. P., Hughes, S. G., Tai, L., Jesse Kwoh, T., Jung, S. W., Coelho, T., Benson, M. D. & Gertz, M. A., Jul 3 2018, In : Amyloid. 25, 3, p. 180-188 9 p.

Research output: Contribution to journalArticle

Familial Amyloidosis
Amyloidosis
Polyneuropathies
Quality of Life
Cardiomyopathies
143 Citations (Scopus)

Inotersen treatment for patients with Hereditary transthyretin amyloidosis

Benson, M. D., Waddington-Cruz, M., Berk, J. L., Polydefkis, M., Dyck, P. J., Wang, A. K., Planté-Bordeneuve, V., Barroso, F. A., Merlini, G., Obici, L., Scheinberg, M., Brannagan, T. H., Litchy, W. J., Whelan, C., Drachman, B. M., Adams, D., Heitner, S., Conceição, I., Schmidt, H. H., Vita, G. & 15 others, Campistol, J. M., Gamez, J., Gorevic, P. D., Gane, E., Shah, A. M., Solomon, S. D., Monia, B. P., Hughes, S. G., Jesse Kwoh, T., McEvoy, B. W., Jung, S. W., Baker, B. F., Ackermann, E. J., Gertz, M. A. & Coelho, T., Jul 5 2018, In : New England Journal of Medicine. 379, 1, p. 22-31 10 p.

Research output: Contribution to journalArticle

Familial Amyloidosis
Prealbumin
Placebos
Quality of Life
Therapeutics

Machine-Assisted Genotype Update System (MAGUS) for Inherited Cardiomyopathies

Papoutsidakis, N., Heitner, S., Mannello, M. C., Rodonski, A., Campbell, W., McElheran, K. & Jacoby, D. L., Oct 1 2018, In : Circulation. Cardiovascular quality and outcomes. 11, 10, p. e004835

Research output: Contribution to journalArticle

Genetic Testing
Computational Biology
Cardiomyopathies
Genotype
9 Citations (Scopus)

Ma et al. reply

Ma, H., Marti-Gutierrez, N., Park, S. W., Wu, J., Hayama, T., Darby, H., Van Dyken, C., Li, Y., Koski, A., Liang, D., Suzuki, K., Gu, Y., Gong, J., Xu, X., Ahmed, R., Lee, Y., Kang, E., Ji, D., Park, A. R., Kim, D. & 12 others, Kim, S. T., Heitner, S., Battaglia, D., Krieg, S. A., Lee, D., Wu, D., Wolf, D. P., Amato, P., Kaul, S., Belmonte, J. C. I., Kim, J. S. & Mitalipov, S., Aug 9 2018, In : Nature. 560, 7717, p. E10-E23

Research output: Contribution to journalArticle

1 Citation (Scopus)
Acute Kidney Injury
Thoracic Surgery
Echocardiography
Ventricular Pressure
Creatinine
4 Citations (Scopus)

Routine Papillary Muscle Realignment and Septal Myectomy for Obstructive Hypertrophic Cardiomyopathy

Song, H., Turner, J., Macfie, R., Kumar, S., Mannello, M. J., Smith, D., Bhamidipati, C., Raman, J., Tibayan, F. F. & Heitner, S., Sep 1 2018, In : Annals of Thoracic Surgery. 106, 3, p. 670-675 6 p.

Research output: Contribution to journalArticle

Papillary Muscles
Hypertrophic Cardiomyopathy
Mitral Valve Insufficiency
Ventricular Outflow Obstruction
Mitral Valve
1 Citation (Scopus)

Standardized Goal-Directed Valsalva Maneuver for Assessment of Inducible Left Ventricular Outflow Tract Obstruction in Hypertrophic Cardiomyopathy

Kumar, S., Van Ness, G., Bender, A., Yadava, M., Minnier, J., Ravi, S., McGrath, L., Song, H. & Heitner, S., Jan 1 2018, (Accepted/In press) In : Journal of the American Society of Echocardiography.

Research output: Contribution to journalArticle

Ventricular Outflow Obstruction
Valsalva Maneuver
Hypertrophic Cardiomyopathy
Exercise
Pressure
2017
17 Citations (Scopus)

Assessing mNIS+7Ionis and international neurologists' proficiency in a familial amyloidotic polyneuropathy trial

Dyck, P. J., Kincaid, J. C., Dyck, P. J. B., Chaudhry, V., Goyal, N. A., Alves, C., Salhi, H., Wiesman, J. F., Labeyrie, C., Robinson-Papp, J., Cardoso, M., Laura, M., Ruzhansky, K., Cortese, A., Brannagan, T. H., Khoury, J., Khella, S., Waddington-cruz, M., Ferreira, J., Wang, A. K. & 24 others, Pinto, M. V., Ayache, S. S., Benson, M. D., Berk, J. L., Coelho, T., Polydefkis, M., Gorevic, P., Adams, D. H., Plante-Bordeneuve, V., Whelan, C., Merlini, G., Heitner, S., Drachman, B. M., Conceição, I., Klein, C. J., Gertz, M. A., Ackermann, E. J., Hughes, S. G., Mauermann, M. L., Bergemann, R., Lodermeier, K. A., Davies, J. L., Carter, R. E. & Litchy, W. J., 2017, (Accepted/In press) In : Muscle and Nerve.

Research output: Contribution to journalArticle

Polyneuropathies
Health
Neurophysiology
Neurologic Manifestations
Oligonucleotides
306 Citations (Scopus)

Correction of a pathogenic gene mutation in human embryos

Ma, H., Marti-Gutierrez, N., Park, S. W., Wu, J., Lee, Y., Suzuki, K., Koski, A., Ji, D., Hayama, T., Ahmed, R., Darby, H., Van Dyken, C., Li, Y., Kang, E., Park, A. R., Kim, D., Kim, S. T., Gong, J., Gu, Y., Xu, X. & 11 others, Battaglia, D., Krieg, S. A., Lee, D., Wu, D., Wolf, D. P., Heitner, S., Belmonte, J. C. I., Amato, P., Kim, J. S., Kaul, S. & Mitalipov, S., Aug 24 2017, In : Nature. 548, 7668, p. 413-419 7 p.

Research output: Contribution to journalArticle

Embryonic Structures
Mutation
Genes
Clustered Regularly Interspaced Short Palindromic Repeats
Preimplantation Diagnosis

Hypertrophic cardiomyopathy: Contemporary evaluation and management

Kumar, S., Song, H., Chirpich, M. & Heitner, S., Mar 1 2017, In : Consultant. 57, 3

Research output: Contribution to journalArticle

Hypertrophic Cardiomyopathy
Inborn Genetic Diseases
Sudden Cardiac Death
Heart Diseases
Morbidity
2 Citations (Scopus)

Optimal right heart filling pressure in acute respiratory distress syndrome determined by strain echocardiography

Garcia-Montilla, R., Imam, F., Miao, M., Stinson, K., Khan, A. & Heitner, S., Jun 1 2017, In : Echocardiography. 34, 6, p. 851-861 11 p.

Research output: Contribution to journalArticle

Central Venous Pressure
Adult Respiratory Distress Syndrome
Echocardiography
Pressure
Severe Acute Respiratory Syndrome
13 Citations (Scopus)

Triheptanoin versus trioctanoin for long-chain fatty acid oxidation disorders: a double blinded, randomized controlled trial

Gillingham, M., Heitner, S., Martin, J., Rose, S., Goldstein, A., El-Gharbawy, A. H., Deward, S., Lasarev, M. R., Pollaro, J., DeLany, J. P., Burchill, L., Goodpaster, B., Shoemaker, J., Matern, D., Harding, C. & Vockley, J., Sep 4 2017, (Accepted/In press) In : Journal of Inherited Metabolic Disease. p. 1-13 13 p.

Research output: Contribution to journalArticle

Fatty Acids
Randomized Controlled Trials
Rhabdomyolysis
Triglycerides
Phosphocreatine
2015
5 Citations (Scopus)

Chronic GvHD-associated serositis and pericarditis

Leonard, J. T., Newell, L., Meyers, G., Hayes-Lattin, B., Gajewski, J., Heitner, S., Nonas, S., Allen, B., Stentz, A., Frires, R., Maziarz, R. & Holtan, S. G., Aug 8 2015, In : Bone Marrow Transplantation. 50, 8, p. 1098-1104 7 p.

Research output: Contribution to journalArticle

Serositis
Pericarditis
Monocytes
Immunosuppressive Agents
Serum Albumin
Adrenergic beta-Antagonists
Glucagon
Cardiomyopathies
Intravenous Injections
Echocardiography
2014
16 Citations (Scopus)

Induction bortezomib in AL amyloidosis followed by high dose melphalan and autologous stem cell transplantation: A single institution retrospective study

Scott, E., Heitner, S., Dibb, W., Meyers, G., Smith, S. D., Abar, F., Kovacsovics, T., Perez-Avraham, G., Stentz, A., Frires, R., Dibb, J. & Maziarz, R., Oct 1 2014, In : Clinical Lymphoma, Myeloma and Leukemia. 14, 5, p. 424-430.e1

Research output: Contribution to journalArticle

Melphalan
Stem Cell Transplantation
Amyloidosis
Retrospective Studies
Stem Cells
2013
10 Citations (Scopus)

Iatrogenic pulmonary artery rupture during Swan-Ganz catheter placement-A novel therapeutic approach

Kalra, A., Heitner, S. & Topalian, S., Jan 1 2013, In : Catheterization and Cardiovascular Interventions. 81, 1, p. 57-59 3 p.

Research output: Contribution to journalArticle

Pulmonary Artery
Rupture
Catheters
Catheterization
Blood Vessels
2010
3 Citations (Scopus)

Heat maps, random forests, and nearest neighbors: A peek into the new molecular diagnostic world

Heitner, S., Hollenberg, S. M. & Colilla, S. A., Jan 2010, In : Critical Care Medicine. 38, 1, p. 296-298 3 p.

Research output: Contribution to journalArticle

Animal Disease Models
Molecular Pathology
Gene Expression Profiling
Human Genome
Critical Care
2009
16 Citations (Scopus)

Pain management practices by internal medicine residentsg-a comparison before and after educational and institutional interventions

Scott, E., Borate, U., Heitner, S., Chaitowitz, M., Tester, W. & Eiger, G., Dec 2009, In : American Journal of Hospice and Palliative Medicine. 25, 6, p. 431-439 9 p.

Research output: Contribution to journalArticle

Pain Management
Internal Medicine
Documentation
Postal Service
Self Concept
6 Citations (Scopus)
Lipopolysaccharides
Sepsis
Critical Care
Therapeutics
phospholamban