Stephen Back

Professor

  • 7779 Citations
  • 46 h-Index
1983 …2020

Research output per year

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Research Output

  • 7779 Citations
  • 46 h-Index
  • 86 Article
  • 8 Chapter
  • 1 Letter
  • 1 Review article
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Article
2019

A modified flavonoid accelerates oligodendrocyte maturation and functional remyelination

Su, W., Matsumoto, S., Banine, F., Srivastava, T., Dean, J., Foster, S., Pham, P., Hammond, B., Peters, A., Girish, K. S., Rangappa, K. S., Basappa, Jose, J., Hennebold, J., Murphy, M. J., Bennett-Toomey, J., Back, S. & Sherman, L. L., Jan 1 2019, (Accepted/In press) In : GLIA.

Research output: Contribution to journalArticle

Cortical Dysmaturation in Congenital Heart Disease

Leonetti, C., Back, S., Gallo, V. & Ishibashi, N., Jan 1 2019, (Accepted/In press) In : Trends in Neurosciences.

Research output: Contribution to journalArticle

3 Scopus citations

Dysregulation of Hyaluronan Homeostasis During White Matter Injury

Srivastava, T., Sherman, L. S. & Back, S. A., Jan 1 2019, (Accepted/In press) In : Neurochemical Research.

Research output: Contribution to journalArticle

Transient Hypoxemia Disrupts Anatomical and Functional Maturation of Preterm Fetal Ovine CA1 Pyramidal Neurons

McClendon, E., Wang, K., Degener-O'Brien, K., Hagen, M. W., Gong, X., Nguyen, T., Wu, W. W., Maylie, J. & Back, S. A., Oct 2 2019, In : The Journal of neuroscience : the official journal of the Society for Neuroscience. 39, 40, p. 7853-7871 19 p.

Research output: Contribution to journalArticle

2018

A TLR/AKT/FoxO3 immune tolerance-like pathway disrupts the repair capacity of oligodendrocyte progenitors

Srivastava, T., Diba, P., Dean, J. M., Banine, F., Shaver, D., Hagen, M., Gong, X., Su, W., Emery, B., Marks, D., Harris, E. N., Baggenstoss, B., Weigel, P. H., Sherman, L. L. & Back, S., May 1 2018, In : Journal of Clinical Investigation. 128, 5, p. 2025-2041 17 p.

Research output: Contribution to journalArticle

10 Scopus citations

Vasodilator dysfunction and oligodendrocyte dysmaturation in aging white matter

Bagi, Z., Brandner, D. D., Le, P., McNeal, D. W., Gong, X., Dou, H., Fulton, D. J., Beller, A., Ngyuen, T., Larson, E. B., Montine, T. J., Keene, C. D. & Back, S., Jan 1 2018, In : Annals of Neurology. 83, 1, p. 142-152 11 p.

Research output: Contribution to journalArticle

8 Scopus citations
2017

Transient hypoxemia chronically disrupts maturation of preterm fetal ovine subplate neuron arborization and activity

McClendon, E., Shaver, D. C., Degener-O’Brien, K., Gong, X., Nguyen, T., Hoerder-Suabedissen, A., Molnár, Z., Mohr, C., Richardson, B. D., Rossi, D. J. & Back, S., Dec 6 2017, In : Journal of Neuroscience. 37, 49, p. 11912-11929 18 p.

Research output: Contribution to journalArticle

17 Scopus citations

Translational Stroke Research: Vision and Opportunities

Bosetti, F., Koenig, J. I., Ayata, C., Back, S., Becker, K., Broderick, J. P., Carmichael, T. T., Cho, S., Cipolla, M. J., Corbett, D., Corriveau, R. A., Cramer, S. C., Ferguson, A. R., Finklestein, S. P., Ford, B. D., Furie, K. L., Hemmen, T. M., Iadecola, C., Jakeman, L. B., Janis, S. & 22 others, Jauch, E. C., Johnston, K. C., Kochanek, P. M., Kohn, H., Lo, E. H., Lyden, P. D., Mallard, C., McCullough, L. D., McGavern, L. M., Meschia, J. F., Moy, C. S., Perez-Pinzon, M. A., Ramadan, I., Savitz, S. I., Schwamm, L. H., Steinberg, G. K., Stenzel-Poore, M., Tymianski, M., Warach, S., Wechsler, L. R., Zhang, J. H. & Koroshetz, W., Jul 27 2017, (Accepted/In press) In : Stroke.

Research output: Contribution to journalArticle

27 Scopus citations

White matter injury in the preterm infant: pathology and mechanisms

Back, S., May 22 2017, (Accepted/In press) In : Acta Neuropathologica. p. 1-19 19 p.

Research output: Contribution to journalArticle

59 Scopus citations
2016

Unbiased stereological analysis of reactive astrogliosis to estimate age-associated cerebral white matter injury

McNeal, D. W., Brandner, D. D., Gong, X., Postupna, N. O., Montine, T. J., Dirk Keene, C. & Back, S., Jun 1 2016, In : Journal of Neuropathology and Experimental Neurology. 75, 6, p. 539-554 16 p.

Research output: Contribution to journalArticle

5 Scopus citations
2015

An update on research priorities in hydrocephalus: Overview of the third National Institutes of Health-sponsored symposium "opportunities for Hydrocephalus Research: Pathways to Better Outcomes"

McAllister, J. P., Williams, M. A., Walker, M. L., Kestle, J. R. W., Relkin, N. R., Anderson, A. M., Gross, P. H., Browd, S. R., Back, S., Bhandari, M., Bradley, W. G., Chun, J., Church, P. T., Clement, T. J., Del Bigio, M. R., Dennis, M., Dobyns, W. B., Edwards, R. J., Fletcher, J. M., Jimenez, A. J. & 12 others, Kulkarni, A. V., Limbrick, D. D., Lutz, B., Morris, J. A., Morrison, R. S., Riva-Cambrin, J., Rodriguez, E., Wagshul, M., Warf, B., Watkins, L., Watson, D. A. & Zabel, A., Dec 1 2015, In : Journal of Neurosurgery. 123, 6, p. 1427-1438 12 p.

Research output: Contribution to journalArticle

38 Scopus citations

Brain injury in the preterm infant: New horizons for pathogenesis and prevention

Back, S., Sep 1 2015, In : Pediatric Neurology. 53, 3, p. 185-192 8 p.

Research output: Contribution to journalArticle

48 Scopus citations

Disease specific therapies in leukodystrophies and leukoencephalopathies

behalf of the GLIA Consortium, Apr 1 2015, In : Molecular Genetics and Metabolism. 114, 4, p. 527-536 10 p.

Research output: Contribution to journalArticle

23 Scopus citations

Hyaluronan Synthesis, Catabolism, and Signaling in Neurodegenerative Diseases

Sherman, L. L., Matsumoto, S., Su, W., Srivastava, T. & Back, S., 2015, In : International Journal of Cell Biology. 2015, 368584.

Research output: Contribution to journalArticle

27 Scopus citations
2014

Advances in Neonatal Neurology

Ballabh, P. & Back, S., Mar 2014, In : Clinics in Perinatology. 41, 1, p. 17-19 3 p.

Research output: Contribution to journalArticle

Brain injury in premature neonates: A primary cerebral dysmaturation disorder?

Back, S. & Miller, S. P., 2014, In : Annals of Neurology. 75, 4, p. 469-486 18 p.

Research output: Contribution to journalArticle

169 Scopus citations

Cerebral White and Gray Matter Injury in Newborns: New Insights into Pathophysiology and Management

Back, S., Mar 2014, In : Clinics in Perinatology. 41, 1, p. 1-24 24 p.

Research output: Contribution to journalArticle

40 Scopus citations

Isoflurane-induced apoptosis of neurons and oligodendrocytes in the fetal rhesus macaque brain

Creeley, C. E., Dikranian, K. T., Dissen, G., Back, S., Olney, J. W. & Brambrink, A., 2014, In : Anesthesiology. 120, 3, p. 626-638 13 p.

Research output: Contribution to journalArticle

101 Scopus citations

Pathophysiology of glia in perinatal white matter injury

Back, S. & Rosenberg, P. A., 2014, In : GLIA. 62, 11, p. 1790-1815 26 p.

Research output: Contribution to journalArticle

116 Scopus citations

Prenatal cerebral ischemia triggers dysmaturation of caudate projection neurons

McClendon, E., Chen, K., Gong, X., Sharifnia, E., Hagen, M., Cai, V., Shaver, D. C., Riddle, A., Dean, J. M., Gunn, A. J., Mohr, C., Kaplan, J. S., Rossi, D. J., Kroenke, C. C., Hohimer, A. R. & Back, S., 2014, In : Annals of Neurology. 75, 4, p. 508-524 17 p.

Research output: Contribution to journalArticle

38 Scopus citations

Role of recurrent hypoxia-ischemia in preterm white matter injury severity

Hagen, M. W., Riddle, A., McClendon, E., Gong, X., Shaver, D., Srivastava, T., Dean, J. M., Bai, J. Z., Fowke, T. M., Gunn, A. J., Jones, D. F., Sherman, L. L., Grafe, M., Hohimer, A. R. & Back, S., Nov 12 2014, In : PLoS One. 9, 11, e112800.

Research output: Contribution to journalArticle

20 Scopus citations

Unmyelinated axon loss with postnatal hypertonia after fetal hypoxia

Drobyshevsky, A., Jiang, R., Lin, L., Derrick, M., Luo, K., Back, S. & Tan, S., 2014, In : Annals of Neurology. 75, 4, p. 533-541 9 p.

Research output: Contribution to journalArticle

19 Scopus citations

What brakes the preterm brain? An arresting story

Dean, J. M., Bennet, L., Back, S., McClendon, E., Riddle, A. & Gunn, A. J., 2014, In : Pediatric Research. 75, 1-2, p. 227-233 7 p.

Research output: Contribution to journalArticle

35 Scopus citations
2013

Digestion products of the PH20 hyaluronidase inhibit remyelination

Preston, M., Gong, X., Su, W., Matsumoto, S., Banine, F., Winkler, C., Foster, S., Xing, R., Struve, J., Dean, J., Baggenstoss, B., Weigel, P. H., Montine, T. J., Back, S. & Sherman, L. L., Feb 2013, In : Annals of Neurology. 73, 2, p. 266-280 15 p.

Research output: Contribution to journalArticle

65 Scopus citations

Hemodynamic and metabolic correlates of perinatal white matter injury severity

Riddle, A., Maire, J., Cai, V., Nguyen, T., Gong, X., Hansen, K., Grafe, M., Hohimer, A. R. & Back, S., Dec 11 2013, In : PLoS One. 8, 12, e82940.

Research output: Contribution to journalArticle

10 Scopus citations

Prenatal cerebral ischemia disrupts MRI-defined cortical microstructure through disturbances in neuronal arborization

Dean, J. M., McClendon, E., Hansen, K., Azimi-Zonooz, A., Chen, K., Riddle, A., Gong, X., Sharifnia, E., Hagen, M., Ahmad, T., Leigland, L. A., Hohimer, A. R., Kroenke, C. C. & Back, S., Jan 16 2013, In : Science Translational Medicine. 5, 168

Research output: Contribution to journalArticle

96 Scopus citations
2012

Arrested preoligodendrocyte maturation contributes to myelination failure in premature infants

Buser, J. R., Maire, J., Riddle, A., Gong, X., Nguyen, T., Nelson, K., Luo, N. L., Ren, J., Struve, J., Sherman, L. L., Miller, S. P., Chau, V., Hendson, G., Ballabh, P., Grafe, M. & Back, S., Jan 2012, In : Annals of Neurology. 71, 1, p. 93-109 17 p.

Research output: Contribution to journalArticle

231 Scopus citations

Astrocytes in aged nonhuman primate brain gray matter synthesize excess hyaluronan

Cargill, R., Kohama, S., Struve, J., Su, W., Banine, F., Witkowski, E., Back, S. & Sherman, L. L., Apr 2012, In : Neurobiology of Aging. 33, 4

Research output: Contribution to journalArticle

30 Scopus citations

Cell therapy for neonatal hypoxia-ischemia and cerebral palsy

Bennet, L., Tan, S., Van Den Heuij, L., Derrick, M., Groenendaal, F., Van Bel, F., Juul, S., Back, S., Northington, F., Robertson, N. J., Mallard, C. & Gunn, A. J., May 2012, In : Annals of Neurology. 71, 5, p. 589-600 12 p.

Research output: Contribution to journalArticle

99 Scopus citations

Central axons preparing to myelinate are highly sensitivity to ischemic injury

Alix, J. J. P., Zammit, C., Riddle, A., Meshul, C. K., Back, S., Valentino, M. & Fern, R., Dec 2012, In : Annals of Neurology. 72, 6, p. 936-951 16 p.

Research output: Contribution to journalArticle

32 Scopus citations

Differential susceptibility to axonopathy in necrotic and non-necrotic perinatal white matter injury

Riddle, A., Maire, J., Gong, X., Chen, K. X., Kroenke, C. C., Hohimer, A. R. & Back, S., Jan 2012, In : Stroke. 43, 1, p. 178-184 7 p.

Research output: Contribution to journalArticle

46 Scopus citations

Human neural stem cells induce functional myelination in mice with severe dysmyelination

Uchida, N., Chen, K., Dohse, M., Hansen, K. D., Dean, J., Buser, J. R., Riddle, A., Beardsley, D. J., Wan, Y., Gong, X., Nguyen, T., Cummings, B. J., Anderson, A. J., Tamaki, S. J., Tsukamoto, A., Weissman, I. L., Matsumoto, S., Sherman, L. L., Kroenke, C. C. & Back, S., Oct 10 2012, In : Science Translational Medicine. 4, 155, 155ra136.

Research output: Contribution to journalArticle

80 Scopus citations

Human neural stem cells induce functional myelination in mice with severe dysmyelination (Science Translational Medicine (2012) 4, (165er7))

Uchida, N., Chen, K., Dohse, M., Hansen, K. D., Dean, J., Buser, J. R., Riddle, A., Beardsley, D. J., Wan, Y., Gong, X., Nguyen, T., Cummings, B. J., Anderson, A. J., Tamaki, S. J., Tsukamoto, A., Weissman, I. L., Matsumoto, S., Sherman, L. L., Kroenke, C. C. & Back, S., Dec 19 2012, In : Science Translational Medicine. 4, 165, 165er7.

Research output: Contribution to journalArticle

Isoflurane-induced apoptosis of oligodendrocytes in the neonatal primate brain

Brambrink, A., Back, S., Riddle, A., Gong, X., Moravec, M. D., Dissen, G., Creeley, C. E., Dikranian, K. T. & Olney, J. W., Oct 2012, In : Annals of Neurology. 72, 4, p. 525-535 11 p.

Research output: Contribution to journalArticle

160 Scopus citations

The Instrumented Fetal Sheep as a Model of Cerebral White Matter Injury in the Premature Infant

Back, S., Riddle, A., Dean, J. & Hohimer, A. R., Apr 2012, In : Neurotherapeutics. 9, 2, p. 359-370 12 p.

Research output: Contribution to journalArticle

82 Scopus citations

Which neuroprotective agents are ready for bench to bedside translation in the newborn infant?

Robertson, N. J., Tan, S., Groenendaal, F., Van Bel, F., Juul, S. E., Bennet, L., Derrick, M., Back, S., Chavez Valdez, R., Northington, F., Gunn, A. J. & Mallard, C., Apr 2012, In : Journal of Pediatrics. 160, 4

Research output: Contribution to journalArticle

103 Scopus citations
2011

An organotypic slice culture model of chronic white matter injury with maturation arrest of oligodendrocyte progenitors

Dean, J. M., Riddle, A., Maire, J., Hansen, K. D., Preston, M., Barnes, A., Sherman, L. L. & Back, S., 2011, In : Molecular Neurodegeneration. 6, 1, 46.

Research output: Contribution to journalArticle

21 Scopus citations

Diffusion characteristics associated with neuronal injury and glial activation following hypoxia-ischemia in the immature brain

Lodygensky, G. A., West, T., Moravec, M. D., Back, S., Dikranian, K., Holtzman, D. M. & Neil, J. J., Sep 2011, In : Magnetic Resonance in Medicine. 66, 3, p. 839-845 7 p.

Research output: Contribution to journalArticle

29 Scopus citations

Histopathological correlates of magnetic resonance imaging-defined chronic perinatal white matter injury

Riddle, A., Dean, J., Buser, J. R., Gong, X., Maire, J., Chen, K., Ahmad, T., Cai, V., Nguyen, T., Kroenke, C. C., Hohimer, A. R. & Back, S., Sep 2011, In : Annals of Neurology. 70, 3, p. 493-507 15 p.

Research output: Contribution to journalArticle

94 Scopus citations

Strain-specific differences in perinatal rodent oligodendrocyte lineage progression and its correlation with human

Dean, J. M., Moravec, M. D., Grafe, M., Abend, N., Ren, J., Gong, X., Volpe, J. J., Jensen, F. E., Hohimer, A. R. & Back, S., Oct 2011, In : Developmental Neuroscience. 33, 3-4, p. 251-260 10 p.

Research output: Contribution to journalArticle

51 Scopus citations

White matter lesions defined by diffusion tensor imaging in older adults

Back, S., Kroenke, C. C., Sherman, L. L., Lawrence, G., Gong, X., Taber, E. N., Sonnen, J. A., Larson, E. B. & Montine, T. J., Sep 2011, In : Annals of Neurology. 70, 3, p. 465-476 12 p.

Research output: Contribution to journalArticle

74 Scopus citations
2010

Timing of appearance of late oligodendrocyte progenitors coincides with enhanced susceptibility of preterm rabbit cerebral white matter to hypoxia-ischemia

Buser, J. R., Segovia, K. N., Dean, J. M., Nelson, K., Beardsley, D., Gong, X., Luo, N. L., Ren, J., Wan, Y., Riddle, A., McClure, M. M., Ji, X., Derrick, M., Hohimer, A. R., Back, S. & Tan, S., May 2010, In : Journal of Cerebral Blood Flow and Metabolism. 30, 5, p. 1053-1065 13 p.

Research output: Contribution to journalArticle

55 Scopus citations

Towards improved animal models of neonatal white matter injury associated with cerebral palsy

Silbereis, J. C., Huang, E. J., Back, S. & Rowitch, D. H., Nov 2010, In : DMM Disease Models and Mechanisms. 3, 11-12, p. 678-688 11 p.

Research output: Contribution to journalArticle

65 Scopus citations
2008

A 'GAG' reflex prevents repair of the damaged CNS

Sherman, L. L. & Back, S., Jan 2008, In : Trends in Neurosciences. 31, 1, p. 44-52 9 p.

Research output: Contribution to journalArticle

78 Scopus citations

Arrested oligodendrocyte lineage maturation in chronic perinatal white matter injury

Segovia, K. N., McClure, M., Moravec, M., Ning, L. L., Wan, Y., Gong, X., Riddle, A., Craig, A., Struve, J., Sherman, L. L. & Back, S., Apr 2008, In : Annals of Neurology. 63, 4, p. 520-530 11 p.

Research output: Contribution to journalArticle

214 Scopus citations

Cerebral blood flow heterogeneity in preterm sheep: Lack of physiologic support for vascular boundary zones in fetal cerebral white matter

McClure, M. M., Riddle, A., Manese, M., Luo, N. L., Rorvik, D. A., Kelly, K. A., Barlow, C. H., Kelly, J. J., Vinecore, K., Roberts, C., Hohimer, A. R. & Back, S., May 2008, In : Journal of Cerebral Blood Flow and Metabolism. 28, 5, p. 995-1008 14 p.

Research output: Contribution to journalArticle

50 Scopus citations
2007

Hypoxia-ischemia preferentially triggers glutamate depletion from oligodendroglia and axons in perinatal cerebral white matter

Back, S., Craig, A., Kayton, R. J., Luo, N. L., Meshul, C. K., Allcock, N. & Fern, R., Feb 2007, In : Journal of Cerebral Blood Flow and Metabolism. 27, 2, p. 334-347 14 p.

Research output: Contribution to journalArticle

83 Scopus citations

Large-scale generation of highly enriched neural stem-cell-derived oligodendroglial cultures: Maturation-dependent differences in insulin-like growth factor-mediated signal transduction

Broughton, S. K., Chen, H., Riddle, A., Kuhn, S. E., Nagalla, S., Roberts, C. & Back, S., Feb 2007, In : Journal of Neurochemistry. 100, 3, p. 628-638 11 p.

Research output: Contribution to journalArticle

31 Scopus citations

Maturation-dependent vulnerability of perinatal white matter in premature birth

Back, S., Riddle, A. & McClure, M. M., Feb 2007, In : Stroke. 38, 2 PART 2, p. 724-730 7 p.

Research output: Contribution to journalArticle

261 Scopus citations
2006
258 Scopus citations