Stephen Back

Professor

  • 7837 Citations
  • 46 h-Index
1983 …2020

Research output per year

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Research Output

2019

A modified flavonoid accelerates oligodendrocyte maturation and functional remyelination

Su, W., Matsumoto, S., Banine, F., Srivastava, T., Dean, J., Foster, S., Pham, P., Hammond, B., Peters, A., Girish, K. S., Rangappa, K. S., Basappa, Jose, J., Hennebold, J., Murphy, M. J., Bennett-Toomey, J., Back, S. & Sherman, L. L., Jan 1 2019, (Accepted/In press) In : GLIA.

Research output: Contribution to journalArticle

Cortical Dysmaturation in Congenital Heart Disease

Leonetti, C., Back, S., Gallo, V. & Ishibashi, N., Jan 1 2019, (Accepted/In press) In : Trends in Neurosciences.

Research output: Contribution to journalArticle

3 Scopus citations

Dysregulation of Hyaluronan Homeostasis During White Matter Injury

Srivastava, T., Sherman, L. S. & Back, S. A., Jan 1 2019, (Accepted/In press) In : Neurochemical Research.

Research output: Contribution to journalArticle

Transient Hypoxemia Disrupts Anatomical and Functional Maturation of Preterm Fetal Ovine CA1 Pyramidal Neurons

McClendon, E., Wang, K., Degener-O'Brien, K., Hagen, M. W., Gong, X., Nguyen, T., Wu, W. W., Maylie, J. & Back, S. A., Oct 2 2019, In : The Journal of neuroscience : the official journal of the Society for Neuroscience. 39, 40, p. 7853-7871 19 p.

Research output: Contribution to journalArticle

2018

A TLR/AKT/FoxO3 immune tolerance-like pathway disrupts the repair capacity of oligodendrocyte progenitors

Srivastava, T., Diba, P., Dean, J. M., Banine, F., Shaver, D., Hagen, M., Gong, X., Su, W., Emery, B., Marks, D., Harris, E. N., Baggenstoss, B., Weigel, P. H., Sherman, L. L. & Back, S., May 1 2018, In : Journal of Clinical Investigation. 128, 5, p. 2025-2041 17 p.

Research output: Contribution to journalArticle

10 Scopus citations

Vasodilator dysfunction and oligodendrocyte dysmaturation in aging white matter

Bagi, Z., Brandner, D. D., Le, P., McNeal, D. W., Gong, X., Dou, H., Fulton, D. J., Beller, A., Ngyuen, T., Larson, E. B., Montine, T. J., Keene, C. D. & Back, S., Jan 1 2018, In : Annals of Neurology. 83, 1, p. 142-152 11 p.

Research output: Contribution to journalArticle

8 Scopus citations
2017

Brain Injury in the Preterm Infant

Back, S. & Miller, S. P., Dec 27 2017, Avery's Diseases of the Newborn: Tenth Edition. Elsevier Inc., p. 879-896.e6

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Encephalopathy of Prematurity: Pathophysiology. Pathophysiology.

Back, S. & Volpe, J. J., Nov 3 2017, Volpe's Neurology of the Newborn. Elsevier, p. 405-424 20 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations

Transient hypoxemia chronically disrupts maturation of preterm fetal ovine subplate neuron arborization and activity

McClendon, E., Shaver, D. C., Degener-O’Brien, K., Gong, X., Nguyen, T., Hoerder-Suabedissen, A., Molnár, Z., Mohr, C., Richardson, B. D., Rossi, D. J. & Back, S., Dec 6 2017, In : Journal of Neuroscience. 37, 49, p. 11912-11929 18 p.

Research output: Contribution to journalArticle

18 Scopus citations

Translational Stroke Research: Vision and Opportunities

Bosetti, F., Koenig, J. I., Ayata, C., Back, S., Becker, K., Broderick, J. P., Carmichael, T. T., Cho, S., Cipolla, M. J., Corbett, D., Corriveau, R. A., Cramer, S. C., Ferguson, A. R., Finklestein, S. P., Ford, B. D., Furie, K. L., Hemmen, T. M., Iadecola, C., Jakeman, L. B., Janis, S. & 22 others, Jauch, E. C., Johnston, K. C., Kochanek, P. M., Kohn, H., Lo, E. H., Lyden, P. D., Mallard, C., McCullough, L. D., McGavern, L. M., Meschia, J. F., Moy, C. S., Perez-Pinzon, M. A., Ramadan, I., Savitz, S. I., Schwamm, L. H., Steinberg, G. K., Stenzel-Poore, M., Tymianski, M., Warach, S., Wechsler, L. R., Zhang, J. H. & Koroshetz, W., Jul 27 2017, (Accepted/In press) In : Stroke.

Research output: Contribution to journalArticle

27 Scopus citations

White matter injury in the preterm infant: pathology and mechanisms

Back, S., May 22 2017, (Accepted/In press) In : Acta Neuropathologica. p. 1-19 19 p.

Research output: Contribution to journalArticle

64 Scopus citations
2016

Controversies in preterm brain injury

Penn, A. A., Gressens, P., Fleiss, B., Back, S. & Gallo, V., 2016, In : Neurobiology of Disease. 92, Part A, p. 90-101 12 p.

Research output: Contribution to journalReview article

32 Scopus citations

Prenatal determinants of brain development: Recent studies and methodological advances

Back, S. A. & Hohimer, A. R., Nov 1 2016, Neuromethods. Humana Press Inc., p. 303-326 24 p. (Neuromethods; vol. 109).

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Unbiased stereological analysis of reactive astrogliosis to estimate age-associated cerebral white matter injury

McNeal, D. W., Brandner, D. D., Gong, X., Postupna, N. O., Montine, T. J., Dirk Keene, C. & Back, S., Jun 1 2016, In : Journal of Neuropathology and Experimental Neurology. 75, 6, p. 539-554 16 p.

Research output: Contribution to journalArticle

6 Scopus citations
2015

An update on research priorities in hydrocephalus: Overview of the third National Institutes of Health-sponsored symposium "opportunities for Hydrocephalus Research: Pathways to Better Outcomes"

McAllister, J. P., Williams, M. A., Walker, M. L., Kestle, J. R. W., Relkin, N. R., Anderson, A. M., Gross, P. H., Browd, S. R., Back, S., Bhandari, M., Bradley, W. G., Chun, J., Church, P. T., Clement, T. J., Del Bigio, M. R., Dennis, M., Dobyns, W. B., Edwards, R. J., Fletcher, J. M., Jimenez, A. J. & 12 others, Kulkarni, A. V., Limbrick, D. D., Lutz, B., Morris, J. A., Morrison, R. S., Riva-Cambrin, J., Rodriguez, E., Wagshul, M., Warf, B., Watkins, L., Watson, D. A. & Zabel, A., Dec 1 2015, In : Journal of Neurosurgery. 123, 6, p. 1427-1438 12 p.

Research output: Contribution to journalArticle

39 Scopus citations

Brain injury in the preterm infant: New horizons for pathogenesis and prevention

Back, S. A., Sep 1 2015, In : Pediatric Neurology. 53, 3, p. 185-192 8 p.

Research output: Contribution to journalReview article

48 Scopus citations

Disease specific therapies in leukodystrophies and leukoencephalopathies

behalf of the GLIA Consortium, Apr 1 2015, In : Molecular Genetics and Metabolism. 114, 4, p. 527-536 10 p.

Research output: Contribution to journalReview article

23 Scopus citations

Hyaluronan Synthesis, Catabolism, and Signaling in Neurodegenerative Diseases

Sherman, L. S., Matsumoto, S., Su, W., Srivastava, T. & Back, S. A., Jan 1 2015, In : International Journal of Cell Biology. 2015, 368584.

Research output: Contribution to journalReview article

27 Scopus citations

The sheep as a model of brain injury in the premature infant

Back, S. A., Riddle, A. & Hohimer, A. R., Sep 22 2015, Neuromethods. Humana Press Inc., p. 107-128 22 p. (Neuromethods; vol. 104).

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations
2014

Advances in Neonatal Neurology

Ballabh, P. & Back, S. A., Mar 1 2014, In : Clinics in Perinatology. 41, 1, p. 17-19 3 p.

Research output: Contribution to journalEditorial

Brain injury in premature neonates: A primary cerebral dysmaturation disorder?

Back, S. A. & Miller, S. P., Apr 2014, In : Annals of Neurology. 75, 4, p. 469-486 18 p.

Research output: Contribution to journalReview article

171 Scopus citations

Cerebral White and Gray Matter Injury in Newborns: New Insights into Pathophysiology and Management

Back, S. A., Mar 1 2014, In : Clinics in Perinatology. 41, 1, p. 1-24 24 p.

Research output: Contribution to journalReview article

41 Scopus citations

Isoflurane-induced apoptosis of neurons and oligodendrocytes in the fetal rhesus macaque brain

Creeley, C. E., Dikranian, K. T., Dissen, G. A., Back, S. A., Olney, J. W. & Brambrink, A. M., Mar 2014, In : Anesthesiology. 120, 3, p. 626-638 13 p.

Research output: Contribution to journalArticle

107 Scopus citations

Pathophysiology of glia in perinatal white matter injury

Back, S. A. & Rosenberg, P. A., Jan 1 2014, In : GLIA. 62, 11, p. 1790-1815 26 p.

Research output: Contribution to journalReview article

117 Scopus citations

Prenatal cerebral ischemia triggers dysmaturation of caudate projection neurons

McClendon, E., Chen, K., Gong, X., Sharifnia, E., Hagen, M., Cai, V., Shaver, D. C., Riddle, A., Dean, J. M., Gunn, A. J., Mohr, C., Kaplan, J. S., Rossi, D. J., Kroenke, C. D., Hohimer, A. R. & Back, S. A., Apr 2014, In : Annals of Neurology. 75, 4, p. 508-524 17 p.

Research output: Contribution to journalArticle

38 Scopus citations

Role of recurrent hypoxia-ischemia in preterm white matter injury severity

Hagen, M. W., Riddle, A., McClendon, E., Gong, X., Shaver, D., Srivastava, T., Dean, J. M., Bai, J. Z., Fowke, T. M., Gunn, A. J., Jones, D. F., Sherman, L. S., Grafe, M. R., Hohimer, A. R. & Back, S. A., Nov 12 2014, In : PloS one. 9, 11, e112800.

Research output: Contribution to journalArticle

21 Scopus citations

Unmyelinated axon loss with postnatal hypertonia after fetal hypoxia

Drobyshevsky, A., Jiang, R., Lin, L., Derrick, M., Luo, K., Back, S. A. & Tan, S., Apr 2014, In : Annals of Neurology. 75, 4, p. 533-541 9 p.

Research output: Contribution to journalArticle

19 Scopus citations

What brakes the preterm brain? An arresting story

Dean, J. M., Bennet, L., Back, S. A., McClendon, E., Riddle, A. & Gunn, A. J., Jan 2014, In : Pediatric Research. 75, 1-2, p. 227-233 7 p.

Research output: Contribution to journalReview article

36 Scopus citations
2013

Digestion products of the PH20 hyaluronidase inhibit remyelination

Preston, M., Gong, X., Su, W., Matsumoto, S. G., Banine, F., Winkler, C., Foster, S., Xing, R., Struve, J., Dean, J., Baggenstoss, B., Weigel, P. H., Montine, T. J., Back, S. A. & Sherman, L. S., Feb 1 2013, In : Annals of Neurology. 73, 2, p. 266-280 15 p.

Research output: Contribution to journalArticle

66 Scopus citations

Hemodynamic and metabolic correlates of perinatal white matter injury severity

Riddle, A., Maire, J., Cai, V., Nguyen, T., Gong, X., Hansen, K., Grafe, M. R., Hohimer, A. R. & Back, S. A., Dec 11 2013, In : PloS one. 8, 12, e82940.

Research output: Contribution to journalArticle

10 Scopus citations

Prenatal cerebral ischemia disrupts MRI-defined cortical microstructure through disturbances in neuronal arborization

Dean, J. M., McClendon, E., Hansen, K., Azimi-Zonooz, A., Chen, K., Riddle, A., Gong, X., Sharifnia, E., Hagen, M., Ahmad, T., Leigland, L. A., Hohimer, A. R., Kroenke, C. D. & Back, S. A., Jan 16 2013, In : Science translational medicine. 5, 168, p. 168ra7

Research output: Contribution to journalArticle

96 Scopus citations
2012

Arrested preoligodendrocyte maturation contributes to myelination failure in premature infants

Buser, J. R., Maire, J., Riddle, A., Gong, X., Nguyen, T., Nelson, K., Luo, N. L., Ren, J., Struve, J., Sherman, L. S., Miller, S. P., Chau, V., Hendson, G., Ballabh, P., Grafe, M. R. & Back, S. A., Jan 1 2012, In : Annals of Neurology. 71, 1, p. 93-109 17 p.

Research output: Contribution to journalArticle

234 Scopus citations

Astrocytes in aged nonhuman primate brain gray matter synthesize excess hyaluronan

Cargill, R., Kohama, S. G., Struve, J., Su, W., Banine, F., Witkowski, E., Back, S. A. & Sherman, L. S., Apr 2012, In : Neurobiology of Aging. 33, 4, p. 830.e13-830.e24

Research output: Contribution to journalArticle

30 Scopus citations

Cell therapy for neonatal hypoxia-ischemia and cerebral palsy

Bennet, L., Tan, S., Van Den Heuij, L., Derrick, M., Groenendaal, F., Van Bel, F., Juul, S., Back, S. A., Northington, F., Robertson, N. J., Mallard, C. & Gunn, A. J., May 1 2012, In : Annals of Neurology. 71, 5, p. 589-600 12 p.

Research output: Contribution to journalArticle

101 Scopus citations

Central axons preparing to myelinate are highly sensitivity to ischemic injury

Alix, J. J. P., Zammit, C., Riddle, A., Meshul, C. K., Back, S. A., Valentino, M. & Fern, R., Dec 2012, In : Annals of Neurology. 72, 6, p. 936-951 16 p.

Research output: Contribution to journalArticle

32 Scopus citations

Congenital Malformations of the Central Nervous System

Back, S. A. & Plawner, L. L., Dec 1 2012, Avery's Diseases of the Newborn (Ninth Edition). Elsevier Inc., p. 844-868 25 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Developmental Physiology of the Central Nervous System

Gleason, C. A., Hohimer, A. R. & Back, S. A., Dec 1 2012, Avery's Diseases of the Newborn (Ninth Edition). Elsevier Inc., p. 811-815 5 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Differential susceptibility to axonopathy in necrotic and non-necrotic perinatal white matter injury

Riddle, A., Maire, J., Gong, X., Chen, K. X., Kroenke, C. D., Hohimer, A. R. & Back, S. A., Jan 1 2012, In : Stroke. 43, 1, p. 178-184 7 p.

Research output: Contribution to journalArticle

46 Scopus citations

Human neural stem cells induce functional myelination in mice with severe dysmyelination

Uchida, N., Chen, K., Dohse, M., Hansen, K. D., Dean, J., Buser, J. R., Riddle, A., Beardsley, D. J., Wan, Y., Gong, X., Nguyen, T., Cummings, B. J., Anderson, A. J., Tamaki, S. J., Tsukamoto, A., Weissman, I. L., Matsumoto, S. G., Sherman, L. S., Kroenke, C. D. & Back, S. A., Oct 10 2012, In : Science translational medicine. 4, 155, 155ra136.

Research output: Contribution to journalArticle

80 Scopus citations

Human neural stem cells induce functional myelination in mice with severe dysmyelination (Science Translational Medicine (2012) 4, (165er7))

Uchida, N., Chen, K., Dohse, M., Hansen, K. D., Dean, J., Buser, J. R., Riddle, A., Beardsley, D. J., Wan, Y., Gong, X., Nguyen, T., Cummings, B. J., Anderson, A. J., Tamaki, S. J., Tsukamoto, A., Weissman, I. L., Matsumoto, S. G., Sherman, L. S., Kroenke, C. D. & Back, S. A., Dec 19 2012, In : Science translational medicine. 4, 165, 165er7.

Research output: Contribution to journalComment/debate

Isoflurane-induced apoptosis of oligodendrocytes in the neonatal primate brain

Brambrink, A. M., Back, S. A., Riddle, A., Gong, X., Moravec, M. D., Dissen, G. A., Creeley, C. E., Dikranian, K. T. & Olney, J. W., Oct 1 2012, In : Annals of Neurology. 72, 4, p. 525-535 11 p.

Research output: Contribution to journalArticle

167 Scopus citations

The Instrumented Fetal Sheep as a Model of Cerebral White Matter Injury in the Premature Infant

Back, S. A., Riddle, A., Dean, J. & Hohimer, A. R., Apr 1 2012, In : Neurotherapeutics. 9, 2, p. 359-370 12 p.

Research output: Contribution to journalReview article

84 Scopus citations

Which neuroprotective agents are ready for bench to bedside translation in the newborn infant?

Robertson, N. J., Tan, S., Groenendaal, F., Van Bel, F., Juul, S. E., Bennet, L., Derrick, M., Back, S. A., Chavez Valdez, R., Northington, F., Gunn, A. J. & Mallard, C., Apr 2012, In : Journal of Pediatrics. 160, 4, p. 544-552.e4

Research output: Contribution to journalComment/debate

103 Scopus citations
2011

An organotypic slice culture model of chronic white matter injury with maturation arrest of oligodendrocyte progenitors

Dean, J. M., Riddle, A., Maire, J., Hansen, K. D., Preston, M., Barnes, A. P., Sherman, L. S. & Back, S. A., Jul 7 2011, In : Molecular Neurodegeneration. 6, 1, 46.

Research output: Contribution to journalArticle

21 Scopus citations

Diffusion characteristics associated with neuronal injury and glial activation following hypoxia-ischemia in the immature brain

Lodygensky, G. A., West, T., Moravec, M. D., Back, S. A., Dikranian, K., Holtzman, D. M. & Neil, J. J., Sep 1 2011, In : Magnetic Resonance in Medicine. 66, 3, p. 839-845 7 p.

Research output: Contribution to journalArticle

29 Scopus citations

Histopathological correlates of magnetic resonance imaging-defined chronic perinatal white matter injury

Riddle, A., Dean, J., Buser, J. R., Gong, X., Maire, J., Chen, K., Ahmad, T., Cai, V., Nguyen, T., Kroenke, C. D., Hohimer, A. R. & Back, S. A., Sep 1 2011, In : Annals of Neurology. 70, 3, p. 493-507 15 p.

Research output: Contribution to journalArticle

95 Scopus citations

Strain-specific differences in perinatal rodent oligodendrocyte lineage progression and its correlation with human

Dean, J. M., Moravec, M. D., Grafe, M., Abend, N., Ren, J., Gong, X., Volpe, J. J., Jensen, F. E., Hohimer, A. R. & Back, S. A., Oct 1 2011, In : Developmental Neuroscience. 33, 3-4, p. 251-260 10 p.

Research output: Contribution to journalArticle

52 Scopus citations

White matter lesions defined by diffusion tensor imaging in older adults

Back, S. A., Kroenke, C. D., Sherman, L. S., Lawrence, G., Gong, X., Taber, E. N., Sonnen, J. A., Larson, E. B. & Montine, T. J., Sep 1 2011, In : Annals of Neurology. 70, 3, p. 465-476 12 p.

Research output: Contribution to journalArticle

74 Scopus citations
2010

Timing of appearance of late oligodendrocyte progenitors coincides with enhanced susceptibility of preterm rabbit cerebral white matter to hypoxia-ischemia

Buser, J. R., Segovia, K. N., Dean, J. M., Nelson, K., Beardsley, D., Gong, X., Luo, N. L., Ren, J., Wan, Y., Riddle, A., McClure, M. M., Ji, X., Derrick, M., Hohimer, A. R., Back, S. A. & Tan, S., May 1 2010, In : Journal of Cerebral Blood Flow and Metabolism. 30, 5, p. 1053-1065 13 p.

Research output: Contribution to journalArticle

57 Scopus citations