Shoukhrat Mitalipov

Professor

  • 5287 Citations
  • 37 h-Index
1978 …2019

Research output per year

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Research Output

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2019

Human cleaving embryos enable robust homozygotic nucleotide substitutions by base editors

Zhang, M., Zhou, C., Wei, Y., Xu, C., Pan, H., Ying, W., Sun, Y., Sun, Y., Xiao, Q., Yao, N., Zhong, W., Li, Y., Wu, K., Yuan, G., Mitalipov, S., Chen, Z. J. & Yang, H., May 22 2019, In : Genome biology. 20, 1, 101.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2018

Allogeneic iPSC-derived RPE cell graft failure following transplantation into the subretinal space in nonhuman primates

McGill, T., Stoddard, J., Renner, A. M., Messaoudi, I., Bharti, K., Mitalipov, S., Lauer, A. A., Wilson, D. & Neuringer, M., Mar 1 2018, In : Investigative Ophthalmology and Visual Science. 59, 3, p. 1374-1383 10 p.

Research output: Contribution to journalArticle

10 Scopus citations

Germline and somatic mtDNA mutations in mouse aging

Ma, H., Lee, Y., Hayama, T., Van Dyken, C., Marti-Gutierrez, N., Li, Y., Ahmed, R., Koski, A., Kang, E., Darby, H., Gonmanee, T., Park, Y., Wolf, D. P., Kim, C. J. & Mitalipov, S., Jul 1 2018, In : PLoS One. 13, 7, e0201304.

Research output: Contribution to journalArticle

3 Scopus citations

Ma et al. reply

Ma, H., Marti-Gutierrez, N., Park, S. W., Wu, J., Hayama, T., Darby, H., Van Dyken, C., Li, Y., Koski, A., Liang, D., Suzuki, K., Gu, Y., Gong, J., Xu, X., Ahmed, R., Lee, Y., Kang, E., Ji, D., Park, A. R., Kim, D. & 12 others, Kim, S. T., Heitner, S. B., Battaglia, D., Krieg, S. A., Lee, D. M., Wu, D. H., Wolf, D. P., Amato, P., Kaul, S., Belmonte, J. C. I., Kim, J. S. & Mitalipov, S., Aug 9 2018, In : Nature. 560, 7717, p. E10-E23

Research output: Contribution to journalArticle

11 Scopus citations

Sarcomere Gene Mutation correction

Kaul, S., Heitner, S. B. & Mitalipov, S., May 1 2018, In : European heart journal. 39, 17, p. 1506-1507 2 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2017

Correction of a pathogenic gene mutation in human embryos

Ma, H., Marti-Gutierrez, N., Park, S. W., Wu, J., Lee, Y., Suzuki, K., Koski, A., Ji, D., Hayama, T., Ahmed, R., Darby, H., Van Dyken, C., Li, Y., Kang, E., Park, A. R., Kim, D., Kim, S. T., Gong, J., Gu, Y., Xu, X. & 11 others, Battaglia, D., Krieg, S. A., Lee, D. M., Wu, D. H., Wolf, D. P., Heitner, S. B., Belmonte, J. C. I., Amato, P., Kim, J. S., Kaul, S. & Mitalipov, S., Aug 24 2017, In : Nature. 548, 7668, p. 413-419 7 p.

Research output: Contribution to journalArticle

380 Scopus citations

Functional Human Oocytes Generated by Transfer of Polar Body Genomes

Ma, H., O'Neil, R. C., Marti Gutierrez, N., Hariharan, M., Zhang, Z. Z., He, Y., Cinnioglu, C., Kayali, R., Kang, E., Lee, Y., Hayama, T., Koski, A., Nery, J., Castanon, R., Tippner-Hedges, R., Ahmed, R., Van Dyken, C., Li, Y., Olson, S., Battaglia, D. & 6 others, Lee, D. M., Wu, D. H., Amato, P., Wolf, D. P., Ecker, J. R. & Mitalipov, S., Jan 5 2017, In : Cell Stem Cell. 20, 1, p. 112-119 8 p.

Research output: Contribution to journalArticle

26 Scopus citations

Mitochondrial genome inheritance and replacement in the human germline

Wolf, D. P., Hayama, T. & Mitalipov, S., 2017, (Accepted/In press) In : EMBO Journal.

Research output: Contribution to journalArticle

14 Scopus citations

Molecular and functional resemblance of differentiated cells derived from isogenic human iPSCs and SCNT-derived ESCs

Zhao, M. T., Chen, H., Liu, Q., Shao, N. Y., Sayed, N., Wo, H. T., Zhang, J. Z., Ong, S. G., Liu, C., Kim, Y., Yang, H., Chour, T., Ma, H., Gutierrez, N. M., Karakikes, I., Mitalipov, S., Snyder, M. P. & Wu, J. C., Dec 26 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 52, p. E11111-E11120

Research output: Contribution to journalArticle

22 Scopus citations
2016

Age-related accumulation of somatic mitochondrial DNA mutations in adult-derived human ipscs

Kang, E., Wang, X., Tippner-Hedges, R., Ma, H., Folmes, C. D. L., Gutierrez, N. M., Lee, Y., Van Dyken, C., Ahmed, R., Li, Y., Koski, A., Hayama, T., Luo, S., Harding, C. O., Amato, P., Jensen, J., Battaglia, D., Lee, D., Wu, D., Terzic, A. & 3 others, Wolf, D. P., Huang, T. & Mitalipov, S., May 5 2016, In : Cell Stem Cell. 18, 5, p. 625-636 12 p.

Research output: Contribution to journalArticle

98 Scopus citations

Embryonic Stem Cells Derived by Somatic Cell Nuclear Transfer: A Horse in the Race?

Wolf, D. P., Morey, R., Kang, E., Ma, H., Hayama, T., Laurent, L. C. & Mitalipov, S., 2016, (Accepted/In press) In : Stem Cells.

Research output: Contribution to journalArticle

17 Scopus citations

Incompatibility between Nuclear and Mitochondrial Genomes Contributes to an Interspecies Reproductive Barrier

Ma, H., Marti Gutierrez, N., Morey, R., Van Dyken, C., Kang, E., Hayama, T., Lee, Y., Li, Y., Tippner-Hedges, R., Wolf, D. P., Laurent, L. C. & Mitalipov, S., Aug 9 2016, In : Cell Metabolism. 24, 2, p. 283-294 12 p.

Research output: Contribution to journalArticle

37 Scopus citations

Mitochondria in pluripotent stem cells: Stemness regulators and disease targets

Folmes, C. D. L., Ma, H., Mitalipov, S. & Terzic, A., Jun 1 2016, In : Current Opinion in Genetics and Development. 38, p. 1-7 7 p.

Research output: Contribution to journalArticle

22 Scopus citations

Mitochondrial replacement in human oocytes carrying pathogenic mitochondrial DNA mutations

Kang, E., Wu, J., Gutierrez, N. M., Koski, A., Tippner-Hedges, R., Agaronyan, K., Platero-Luengo, A., Martinez-Redondo, P., Ma, H., Lee, Y., Hayama, T., Van Dyken, C., Wang, X., Luo, S., Ahmed, R., Li, Y., Ji, D., Kayali, R., Cinnioglu, C., Olson, S. & 10 others, Jensen, J., Battaglia, D., Lee, D., Wu, D., Huang, T., Wolf, D. P., Temiakov, D., Belmonte, J. C. I., Amato, P. & Mitalipov, S., Dec 8 2016, In : Nature. 540, 7632, p. 270-275 6 p.

Research output: Contribution to journalArticle

87 Scopus citations
2015

Metabolic rescue in pluripotent cells from patients with mtDNA disease

Ma, H., Folmes, C. D. L., Wu, J., Morey, R., Mora-Castilla, S., Ocampo, A., Ma, L., Poulton, J., Wang, X., Ahmed, R., Kang, E., Lee, Y., Hayama, T., Li, Y., Van Dyken, C., Gutierrez, N. M., Tippner-Hedges, R., Koski, A., Mitalipov, N., Amato, P. & 6 others, Wolf, D. P., Huang, T., Terzic, A., Laurent, L. C., Belmonte, J. C. I. & Mitalipov, S., Aug 13 2015, In : Nature. 524, 7564, p. 234-238 5 p.

Research output: Contribution to journalArticle

92 Scopus citations
2014

Abnormalities in human pluripotent cells due to reprogramming mechanisms

Ma, H., Morey, R., O'Neil, R. C., He, Y., Daughtry, B., Schultz, M. D., Hariharan, M., Nery, J. R., Castanon, R., Sabatini, K., Thiagarajan, R. D., Tachibana, M., Kang, E., Tippner-Hedges, R., Ahmed, R., Gutierrez, N. M., Van Dyken, C., Polat, A., Sugawara, A., Sparman, M. & 6 others, Gokhale, S., Amato, P., Wolf, D. P., Ecker, J. R., Laurent, L. C. & Mitalipov, S., Jan 1 2014, In : Nature. 511, 7508, p. 177-183 7 p.

Research output: Contribution to journalArticle

200 Scopus citations

Comparable frequencies of coding mutations and loss of imprinting in human pluripotent cells derived by nuclear transfer and defined factors

Johannesson, B., Sagi, I., Gore, A., Paull, D., Yamada, M., Golan-Lev, T., Li, Z., LeDuc, C., Shen, Y., Stern, S., Xu, N., Ma, H., Kang, E., Mitalipov, S., Sauer, M. V., Zhang, K., Benvenisty, N. & Egli, D., Jan 1 2014, In : Cell Stem Cell. 15, 5, p. 634-642 9 p.

Research output: Contribution to journalArticle

75 Scopus citations
28 Scopus citations

Nuclear reprogramming by interphase cytoplasm of two-cell mouse embryos

Kang, E., Wu, G., Ma, H., Li, Y., Tippner-Hedges, R., Tachibana, M., Sparman, M., Wolf, D. P., Schöler, H. R. & Mitalipov, S., Jan 1 2014, In : Nature. 508, 7498, p. 101-104 4 p.

Research output: Contribution to journalArticle

26 Scopus citations

The Challenges of Mitochondrial Replacement

Chinnery, P. F., Craven, L., Mitalipov, S., Stewart, J. B., Herbert, M. & Turnbull, D. M., Apr 2014, In : PLoS genetics. 10, 4, e1004315.

Research output: Contribution to journalArticle

44 Scopus citations
2013

Human embryonic stem cells derived by somatic cell nuclear transfer

Tachibana, M., Amato, P., Sparman, M., Gutierrez, N. M., Tippner-Hedges, R., Ma, H., Kang, E., Fulati, A., Lee, H. S., Sritanaudomchai, H., Masterson, K., Larson, J., Eaton, D., Sadler-Fredd, K., Battaglia, D., Lee, D., Wu, D., Jensen, J., Patton, P., Gokhale, S. & 3 others, Stouffer, R. L., Wolf, D. & Mitalipov, S., Jun 6 2013, In : Cell. 153, 6, p. 1228-1238 11 p.

Research output: Contribution to journalArticle

454 Scopus citations

Restoration of testis function in hypogonadotropic hypogonadal mice harboring a misfolded GnRHR mutant by pharmacoperone drug therapy

Janovick, J. A., Stewart, M. D., Jacob, D., Martin, L. D., Deng, J. M., Stewart, C. A., Wang, Y., Cornea, A., Chavali, L., Lopez, S., Mitalipov, S., Kang, E., Lee, H. S., Manna, P. R., Stocco, D. M., Behringer, R. R. & Conn, P. M., Dec 24 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 52, p. 21030-21035 6 p.

Research output: Contribution to journalArticle

46 Scopus citations

Towards germline gene therapy of inherited mitochondrial diseases

Tachibana, M., Amato, P., Sparman, M., Woodward, J., Sanchis, D. M., Ma, H., Gutierrez, N. M., Tippner-Hedges, R., Kang, E., Lee, H. S., Ramsey, C., Masterson, K., Battaglia, D., Lee, D., Wu, D., Jensen, J., Patton, P., Gokhale, S., Stouffer, R. & Mitalipov, S., Jan 31 2013, In : Nature. 493, 7434, p. 627-631 5 p.

Research output: Contribution to journalArticle

233 Scopus citations

Towards germline gene therapy of inherited mitochondrial diseases

Tachibana, M., Amato, P., Sparman, M., Woodward, J., Sanchis, D. M., Ma, H., Gutierrez, N. M., Tippner-Hedges, R., Kang, E., Lee, H. S., Ramsey, C., Masterson, K., Battaglia, D., Lee, D., Wu, D., Jensen, J., Patton, P., Gokhale, S., Stouffer, R. & Mitalipov, S., Feb 7 2013, In : Nature. 494, 7435, p. 627-631 5 p.

Research output: Contribution to journalArticle

2012

Chromosome transfer in mature oocytes.

Tachibana, M., Sparman, M. & Mitalipov, S., May 2012, In : Fertility and sterility. 97, 5, p. e16

Research output: Contribution to journalArticle

6 Scopus citations

Generation of chimeric rhesus monkeys

Tachibana, M., Sparman, M., Ramsey, C., Ma, H., Lee, H. S., Penedo, M. C. T. & Mitalipov, S., Jan 20 2012, In : Cell. 148, 1-2, p. 285-295 11 p.

Research output: Contribution to journalArticle

105 Scopus citations

Rapid Mitochondrial DNA Segregation in Primate Preimplantation Embryos Precedes Somatic and Germline Bottleneck

Lee, H. S., Ma, H., Juanes, R. C., Tachibana, M., Sparman, M., Woodward, J., Ramsey, C., Xu, J., Kang, E. J., Amato, P., Mair, G., Steinborn, R. & Mitalipov, S., May 31 2012, In : Cell Reports. 1, 5, p. 506-515 10 p.

Research output: Contribution to journalArticle

67 Scopus citations

Spermatogonial stem cell transplantation into rhesus testes regenerates spermatogenesis producing functional sperm

Hermann, B. P., Sukhwani, M., Winkler, F., Pascarella, J. N., Peters, K. A., Sheng, Y., Valli, H., Rodriguez, M., Ezzelarab, M., Dargo, G., Peterson, K., Masterson, K., Ramsey, C., Ward, T., Lienesch, M., Volk, A., Cooper, D. K., Thomson, A. W., Kiss, J. E., Penedo, M. C. T. & 3 others, Schatten, G. P., Mitalipov, S. & Orwig, K. E., Nov 2 2012, In : Cell Stem Cell. 11, 5, p. 715-726 12 p.

Research output: Contribution to journalArticle

192 Scopus citations

X-chromosome inactivation in monkey embryos and pluripotent stem cells

Tachibana, M., Ma, H., Sparman, M. L., Lee, H. S., Ramsey, C. M., Woodward, J. S., Sritanaudomchai, H., Masterson, K. R., Wolff, E. E., Jia, Y. & Mitalipov, S. M., Nov 15 2012, In : Developmental Biology. 371, 2, p. 146-155 10 p.

Research output: Contribution to journalArticle

15 Scopus citations
2010

A purified population of multipotent cardiovascular progenitors derived from primate pluripotent stem cells engrafts in postmyocardial infarcted nonhuman primates

Blin, G., Nury, D., Stefanovic, S., Neri, T., Guillevic, O., Brinon, B., Bellamy, V., Rücker-Martin, C., Barbry, P., Bel, A., Bruneval, P., Cowan, C., Pouly, J., Mitalipov, S., Gouadon, E., Binder, P., Hagège, A., Desnos, M., Renaud, J. F., Menasché, P. & 1 others, Pucéat, M., Apr 1 2010, In : Journal of Clinical Investigation. 120, 4, p. 1125-1139 15 p.

Research output: Contribution to journalArticle

235 Scopus citations

Chromosome transfer in mature oocytes

Tachibana, M., Sparman, M. & Mitalipov, S., May 27 2010, In : Nature protocols. 5, 6, p. 1138-1147 10 p.

Research output: Contribution to journalArticle

25 Scopus citations

Discovery of a novel imprinted gene by transcriptional analysis of parthenogenetic embryonic stem cells

Sritanaudomchai, H., Ma, H., Clepper, L., Gokhale, S., Bogan, R., Hennebold, J., Wolf, D. & Mitalipov, S., Aug 2010, In : Human Reproduction. 25, 8, p. 1927-1941 15 p.

Research output: Contribution to journalArticle

23 Scopus citations
2009

CDX2 in the formation of the trophectoderm lineage in primate embryos

Sritanaudomchai, H., Sparman, M., Tachibana, M., Clepper, L., Woodward, J., Gokhale, S., Wolf, D., Hennebold, J., Hurlbut, W., Grompe, M. & Mitalipov, S., Nov 1 2009, In : Developmental Biology. 335, 1, p. 179-187 9 p.

Research output: Contribution to journalArticle

28 Scopus citations

DNA methylation programming and reprogramming in primate embryonic stem cells

Cohen, N. M., Dighe, V., Landan, G., Reynisdóttir, S., Palsson, A., Mitalipov, S. & Tanay, A., Dec 1 2009, In : Genome Research. 19, 12, p. 2193-2201 9 p.

Research output: Contribution to journalArticle

12 Scopus citations

Epigenetic reprogramming by somatic cell nuclear transfer in primates

Sparman, M., Dighe, V., Sritanaudomchai, H., Ma, H., Ramsey, C., Pedersen, D., Clepper, L., Nighot, P., Wolf, D., Hennebold, J. & Mitalipov, S., Jun 1 2009, In : Stem Cells. 27, 6, p. 1255-1264 10 p.

Research output: Contribution to journalArticle

34 Scopus citations

Mitochondrial gene replacement in primate offspring and embryonic stem cells

Tachibana, M., Sparman, M., Sritanaudomchai, H., Ma, H., Clepper, L., Woodward, J., Li, Y., Ramsey, C., Kolotushkina, O. & Mitalipov, S., Sep 17 2009, In : Nature. 461, 7262, p. 367-372 6 p.

Research output: Contribution to journalArticle

351 Scopus citations
2008

Gene targeting in adult rhesus macaque fibroblasts

Meehan, D. T., Zink, M. A., Mahlen, M., Nelson, M., Sanger, W. G., Mitalipov, S. M., Wolf, D. P., Ouellette, M. M. & Norgren, R. B., Mar 26 2008, In : BMC Biotechnology. 8, 31.

Research output: Contribution to journalArticle

4 Scopus citations

Heterozygous embryonic stem cell lines derived from nonhuman primate parthenotes

Dighe, V., Clepper, L., Pedersen, D., Byrne, J., Ferguson, B., Gokhale, S., Penedo, M. C. T., Wolf, D. & Mitalipov, S., Mar 1 2008, In : Stem Cells. 26, 3, p. 756-766 11 p.

Research output: Contribution to journalArticle

56 Scopus citations

Pluripotent stem cells: Maintenance of genetic and epigenetic stability and prospects of cell technologies

Gordeeva, O. F. & Mitalipov, S. M., Nov 1 2008, In : Russian Journal of Developmental Biology. 39, 6, p. 325-336 12 p.

Research output: Contribution to journalArticle

7 Scopus citations
2007

Characterization and multilineage differentiation of embryonic stem cells derived from a buffalo parthenogenetic embryo

Sritanaudomchai, H., Pavasuthipaisit, K., Kitiyanant, Y., Kupradinun, P., Mitalipov, S. & Kusamran, T., Oct 1 2007, In : Molecular Reproduction and Development. 74, 10, p. 1295-1302 8 p.

Research output: Contribution to journalArticle

49 Scopus citations

Differential requirements for hematopoietic commitment between human and rhesus embryonic stem cells

Rajesh, D., Chinnasamy, N., Mitalipov, S. M., Wolf, D. P., Slukvin, I., Thomson, J. A. & Shaaban, A. F., Feb 1 2007, In : Stem Cells. 25, 2, p. 490-499 10 p.

Research output: Contribution to journalArticle

18 Scopus citations

Evaluation of the vervet (Clorocebus aethiops) as a model for the assisted reproductive technologies

Sparman, M. L., Ramsey, C. M., Thomas, C. M., Mitalipov, S. M., Fanton, J. W., Maginnis, G. M., Stouffer, R. L. & Wolf, D. P., Aug 1 2007, In : American Journal of Primatology. 69, 8, p. 917-929 13 p.

Research output: Contribution to journalArticle

8 Scopus citations

Methylation status of imprinting centers for H19/IGF2 and SNURF/SNRPN in primate embryonic stem cells

Mitalipov, S., Clepper, L., Sritanaudomchai, H., Fujimoto, A. & Wolf, D., Mar 1 2007, In : Stem Cells. 25, 3, p. 581-588 8 p.

Research output: Contribution to journalArticle

38 Scopus citations

Producing primate embryonic stem cells by somatic cell nuclear transfer

Byrne, J. A., Pedersen, D. A., Clepper, L. L., Nelson, M., Sanger, W. G., Gokhale, S., Wolf, D. P. & Mitalipov, S. M., Nov 21 2007, In : Nature. 450, 7169, p. 497-502 6 p.

Research output: Contribution to journalArticle

440 Scopus citations

Reprogramming following somatic cell nuclear transfer in primates is dependent upon nuclear remodeling

Mitalipov, S. M., Zhou, Q., Byrne, J. A., Ji, W. Z., Norgren, R. B. & Wolf, D. P., Aug 2007, In : Human Reproduction. 22, 8, p. 2232-2242 11 p.

Research output: Contribution to journalArticle

90 Scopus citations
2006

Aberrant genomic imprinting in rhesus monkey embryonic stem cells

Fujimoto, A., Mitalipov, S. M., Kuo, H. C. & Wolf, D. P., Mar 1 2006, In : Stem Cells. 24, 3, p. 595-603 9 p.

Research output: Contribution to journalArticle

27 Scopus citations

A comparative approach to somatic cell nuclear transfer in the rhesus monkey

Zhou, Q., Yang, S. H., Ding, C. H., He, X. C., Xie, Y. H., Hildebrandt, T. B., Mitalipov, S. M., Tang, X. H., Wolf, D. P. & Ji, W. Z., Oct 2006, In : Human Reproduction. 21, 10, p. 2564-2571 8 p.

Research output: Contribution to journalArticle

36 Scopus citations

Cell cycle features of primate embryonic stem cells

Fluckiger, A. C., Marcy, G., Marchand, M., Négre, D., Cosset, F. L., Mitalipov, S., Wolf, D., Savatier, P. & Dehay, C., Mar 2006, In : Stem Cells. 24, 3, p. 547-556 10 p.

Research output: Contribution to journalArticle

144 Scopus citations

Genomic imprinting in primate embryos and embryonic stem cells

Mitalipov, S. M., Nov 29 2006, In : Reproduction, Fertility and Development. 18, 8, p. 817-821 5 p.

Research output: Contribution to journalArticle

19 Scopus citations