Shoukhrat Mitalipov

Professor

  • 5341 Citations
  • 37 h-Index
1978 …2019

Research output per year

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Research Output

2019

Author Correction: Mitochondrial replacement in human oocytes carrying pathogenic mitochondrial DNA mutations (Nature, (2016), 540, 7632, (270-275), 10.1038/nature20592)

Kang, E., Wu, J., Gutierrez, N. M., Koski, A., Tippner-Hedges, R., Agaronyan, K., Platero-Luengo, A., Martinez-Redondo, P., Ma, H., Lee, Y., Hayama, T., Van Dyken, C., Wang, X., Luo, S., Ahmed, R., Li, Y., Ji, D., Kayali, R., Cinnioglu, C., Olson, S. & 10 others, Jensen, J., Battaglia, D., Lee, D., Wu, D., Huang, T., Wolf, D. P., Temiakov, D., Belmonte, J. C. I., Amato, P. & Mitalipov, S., Mar 14 2019, In : Nature. 567, 7747, p. E5-E9

Research output: Contribution to journalComment/debate

Open Access
2 Scopus citations

Human cleaving embryos enable robust homozygotic nucleotide substitutions by base editors

Zhang, M., Zhou, C., Wei, Y., Xu, C., Pan, H., Ying, W., Sun, Y., Sun, Y., Xiao, Q., Yao, N., Zhong, W., Li, Y., Wu, K., Yuan, G., Mitalipov, S., Chen, Z. J. & Yang, H., May 22 2019, In : Genome biology. 20, 1, 101.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Principles of and strategies for germline gene therapy

Wolf, D. P., Mitalipov, P. A. & Mitalipov, S. M., Jan 1 2019, In : Nature medicine.

Research output: Contribution to journalReview article

2 Scopus citations

Reply to: Reversion after replacement of mitochondrial DNA

Kang, E., Koski, A., Amato, P., Temiakov, D. & Mitalipov, S., Oct 17 2019, In : Nature. 574, 7778, p. E12-E13

Research output: Contribution to journalLetter

Therapeutic Genome Editing in Cardiovascular Diseases

German, D. M., Mitalipov, S., Mishra, A. & Kaul, S., Feb 1 2019, In : JACC: Basic to Translational Science. 4, 1, p. 122-131 10 p.

Research output: Contribution to journalReview article

Open Access
6 Scopus citations
2018

Allogeneic iPSC-derived RPE cell graft failure following transplantation into the subretinal space in nonhuman primates

McGill, T., Stoddard, J., Renner, A. M., Messaoudi, I., Bharti, K., Mitalipov, S., Lauer, A. A., Wilson, D. & Neuringer, M., Mar 1 2018, In : Investigative Ophthalmology and Visual Science. 59, 3, p. 1374-1383 10 p.

Research output: Contribution to journalArticle

10 Scopus citations

Germline and somatic mtDNA mutations in mouse aging

Ma, H., Lee, Y., Hayama, T., Van Dyken, C., Marti-Gutierrez, N., Li, Y., Ahmed, R., Koski, A., Kang, E., Darby, H., Gonmanee, T., Park, Y., Wolf, D. P., Kim, C. J. & Mitalipov, S., Jul 1 2018, In : PLoS One. 13, 7, e0201304.

Research output: Contribution to journalArticle

3 Scopus citations

Ma et al. reply

Ma, H., Marti-Gutierrez, N., Park, S. W., Wu, J., Hayama, T., Darby, H., Van Dyken, C., Li, Y., Koski, A., Liang, D., Suzuki, K., Gu, Y., Gong, J., Xu, X., Ahmed, R., Lee, Y., Kang, E., Ji, D., Park, A. R., Kim, D. & 12 others, Kim, S. T., Heitner, S. B., Battaglia, D., Krieg, S. A., Lee, D. M., Wu, D. H., Wolf, D. P., Amato, P., Kaul, S., Belmonte, J. C. I., Kim, J. S. & Mitalipov, S., Aug 9 2018, In : Nature. 560, 7717, p. E10-E23

Research output: Contribution to journalArticle

12 Scopus citations

Sarcomere Gene Mutation correction

Kaul, S., Heitner, S. B. & Mitalipov, S., May 1 2018, In : European heart journal. 39, 17, p. 1506-1507 2 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
1 Scopus citations
2017

Correction of a pathogenic gene mutation in human embryos

Ma, H., Marti-Gutierrez, N., Park, S. W., Wu, J., Lee, Y., Suzuki, K., Koski, A., Ji, D., Hayama, T., Ahmed, R., Darby, H., Van Dyken, C., Li, Y., Kang, E., Park, A. R., Kim, D., Kim, S. T., Gong, J., Gu, Y., Xu, X. & 11 others, Battaglia, D., Krieg, S. A., Lee, D. M., Wu, D. H., Wolf, D. P., Heitner, S. B., Belmonte, J. C. I., Amato, P., Kim, J. S., Kaul, S. & Mitalipov, S., Aug 24 2017, In : Nature. 548, 7668, p. 413-419 7 p.

Research output: Contribution to journalArticle

390 Scopus citations

Corrigendum to: Mitochondrial genome inheritance and replacement in the human germline (The EMBO Journal, (2017), 36, 15, (2177-2181), 10.15252/embj.201797606)

Wolf, D. P., Hayama, T. & Mitalipov, S., Sep 1 2017, In : EMBO Journal. 36, 17, p. 2659 1 p.

Research output: Contribution to journalComment/debate

4 Scopus citations

Functional Human Oocytes Generated by Transfer of Polar Body Genomes

Ma, H., O'Neil, R. C., Marti Gutierrez, N., Hariharan, M., Zhang, Z. Z., He, Y., Cinnioglu, C., Kayali, R., Kang, E., Lee, Y., Hayama, T., Koski, A., Nery, J., Castanon, R., Tippner-Hedges, R., Ahmed, R., Van Dyken, C., Li, Y., Olson, S., Battaglia, D. & 6 others, Lee, D. M., Wu, D. H., Amato, P., Wolf, D. P., Ecker, J. R. & Mitalipov, S., Jan 5 2017, In : Cell Stem Cell. 20, 1, p. 112-119 8 p.

Research output: Contribution to journalArticle

27 Scopus citations

Mitochondrial genome inheritance and replacement in the human germline

Wolf, D. P., Hayama, T. & Mitalipov, S., 2017, (Accepted/In press) In : EMBO Journal.

Research output: Contribution to journalArticle

14 Scopus citations

Molecular and functional resemblance of differentiated cells derived from isogenic human iPSCs and SCNT-derived ESCs

Zhao, M. T., Chen, H., Liu, Q., Shao, N. Y., Sayed, N., Wo, H. T., Zhang, J. Z., Ong, S. G., Liu, C., Kim, Y., Yang, H., Chour, T., Ma, H., Gutierrez, N. M., Karakikes, I., Mitalipov, S., Snyder, M. P. & Wu, J. C., Dec 26 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 52, p. E11111-E11120

Research output: Contribution to journalArticle

23 Scopus citations
2016

Age-related accumulation of somatic mitochondrial DNA mutations in adult-derived human ipscs

Kang, E., Wang, X., Tippner-Hedges, R., Ma, H., Folmes, C. D. L., Gutierrez, N. M., Lee, Y., Van Dyken, C., Ahmed, R., Li, Y., Koski, A., Hayama, T., Luo, S., Harding, C. O., Amato, P., Jensen, J., Battaglia, D., Lee, D., Wu, D., Terzic, A. & 3 others, Wolf, D. P., Huang, T. & Mitalipov, S., May 5 2016, In : Cell Stem Cell. 18, 5, p. 625-636 12 p.

Research output: Contribution to journalArticle

102 Scopus citations

Embryonic Stem Cells Derived by Somatic Cell Nuclear Transfer: A Horse in the Race?

Wolf, D. P., Morey, R., Kang, E., Ma, H., Hayama, T., Laurent, L. C. & Mitalipov, S., 2016, (Accepted/In press) In : Stem Cells.

Research output: Contribution to journalArticle

17 Scopus citations

Incompatibility between Nuclear and Mitochondrial Genomes Contributes to an Interspecies Reproductive Barrier

Ma, H., Marti Gutierrez, N., Morey, R., Van Dyken, C., Kang, E., Hayama, T., Lee, Y., Li, Y., Tippner-Hedges, R., Wolf, D. P., Laurent, L. C. & Mitalipov, S., Aug 9 2016, In : Cell Metabolism. 24, 2, p. 283-294 12 p.

Research output: Contribution to journalArticle

38 Scopus citations

Mitochondria in pluripotent stem cells: Stemness regulators and disease targets

Folmes, C. D. L., Ma, H., Mitalipov, S. & Terzic, A., Jun 1 2016, In : Current Opinion in Genetics and Development. 38, p. 1-7 7 p.

Research output: Contribution to journalArticle

23 Scopus citations

Mitochondrial replacement in human oocytes carrying pathogenic mitochondrial DNA mutations

Kang, E., Wu, J., Gutierrez, N. M., Koski, A., Tippner-Hedges, R., Agaronyan, K., Platero-Luengo, A., Martinez-Redondo, P., Ma, H., Lee, Y., Hayama, T., Van Dyken, C., Wang, X., Luo, S., Ahmed, R., Li, Y., Ji, D., Kayali, R., Cinnioglu, C., Olson, S. & 10 others, Jensen, J., Battaglia, D., Lee, D., Wu, D., Huang, T., Wolf, D. P., Temiakov, D., Belmonte, J. C. I., Amato, P. & Mitalipov, S., Dec 8 2016, In : Nature. 540, 7632, p. 270-275 6 p.

Research output: Contribution to journalArticle

92 Scopus citations
2015

Brains, Genes, and Primates

Izpisua Belmonte, J. C., Callaway, E. M., Churchland, P., Caddick, S. J., Feng, G., Homanics, G. E., Lee, K. F., Leopold, D. A., Miller, C. T., Mitchell, J. F., Mitalipov, S., Moutri, A. R., Movshon, J. A., Okano, H., Reynolds, J. H., Ringach, D., Sejnowski, T. J., Silva, A. C., Strick, P. L., Wu, J. & 1 others, Zhang, F., May 6 2015, In : Neuron. 86, 3, p. 617-631 15 p.

Research output: Contribution to journalReview article

116 Scopus citations

Corrigendum to Brains, Genes, and Primates [Neuron 86, 617-631; May 6, 2015]

Belmonte, J. C. I., Callaway, E. M., Caddick, S. J., Churchland, P., Feng, G., Homanics, G. E., Lee, K. F., Leopold, D. A., Miller, C. T., Mitchell, J. F., Mitalipov, S., Moutri, A. R., Movshon, J. A., Okano, H., Reynolds, J. H., Ringach, D. L., Sejnowski, T. J., Silva, A. C., Strick, P. L., Wu, J. & 1 others, Zhang, F., Aug 5 2015, In : Neuron. 87, 3, 1 p.

Research output: Contribution to journalComment/debate

Metabolic rescue in pluripotent cells from patients with mtDNA disease

Ma, H., Folmes, C. D. L., Wu, J., Morey, R., Mora-Castilla, S., Ocampo, A., Ma, L., Poulton, J., Wang, X., Ahmed, R., Kang, E., Lee, Y., Hayama, T., Li, Y., Van Dyken, C., Gutierrez, N. M., Tippner-Hedges, R., Koski, A., Mitalipov, N., Amato, P. & 6 others, Wolf, D. P., Huang, T., Terzic, A., Laurent, L. C., Belmonte, J. C. I. & Mitalipov, S., Aug 13 2015, In : Nature. 524, 7564, p. 234-238 5 p.

Research output: Contribution to journalArticle

93 Scopus citations

Mitochondrial replacement therapy in reproductive medicine

Wolf, D. P., Mitalipov, N. & Mitalipov, S., Feb 1 2015, In : Trends in Molecular Medicine. 21, 2, p. 68-76 9 p.

Research output: Contribution to journalReview article

74 Scopus citations
2014

Abnormalities in human pluripotent cells due to reprogramming mechanisms

Ma, H., Morey, R., O'Neil, R. C., He, Y., Daughtry, B., Schultz, M. D., Hariharan, M., Nery, J. R., Castanon, R., Sabatini, K., Thiagarajan, R. D., Tachibana, M., Kang, E., Tippner-Hedges, R., Ahmed, R., Gutierrez, N. M., Van Dyken, C., Polat, A., Sugawara, A., Sparman, M. & 6 others, Gokhale, S., Amato, P., Wolf, D. P., Ecker, J. R., Laurent, L. C. & Mitalipov, S., Jan 1 2014, In : Nature. 511, 7508, p. 177-183 7 p.

Research output: Contribution to journalArticle

200 Scopus citations

Clinical and ethical implications of mitochondrial gene transfer

Mitalipov, S. & Wolf, D. P., Jan 1 2014, In : Trends in Endocrinology and Metabolism. 25, 1, p. 5-7 3 p.

Research output: Contribution to journalComment/debate

37 Scopus citations

Comparable frequencies of coding mutations and loss of imprinting in human pluripotent cells derived by nuclear transfer and defined factors

Johannesson, B., Sagi, I., Gore, A., Paull, D., Yamada, M., Golan-Lev, T., Li, Z., LeDuc, C., Shen, Y., Stern, S., Xu, N., Ma, H., Kang, E., Mitalipov, S., Sauer, M. V., Zhang, K., Benvenisty, N. & Egli, D., Jan 1 2014, In : Cell Stem Cell. 15, 5, p. 634-642 9 p.

Research output: Contribution to journalArticle

75 Scopus citations
28 Scopus citations

Erratum: Nuclear reprogramming by interphase cytoplasm of two-cell mouse embryos (Nature (2014) 509 (101-104) DOI:10.1038/nature13134)

Kang, E., Wu, G., Ma, H., Li, Y., Tippner-Hedges, R., Tachibana, M., Sparman, M., Wolf, D. P., Schöler, H. R. & Mitalipov, S., Dec 11 2014, In : Nature. 516, 7530, 1 p.

Research output: Contribution to journalComment/debate

Erratum: Producing primate embryonic stem cells by somatic cell nuclear transfer (Nature (2007) 450 (497-502) DOI:10.1038/nature06357)

Byrne, J. A., Pedersen, D. A., Clepper, L. L., Nelson, M., Sanger, W. G., Gokhale, S., Wolf, D. P. & Mitalipov, S. M., Dec 11 2014, In : Nature. 516, 7530, 1 p.

Research output: Contribution to journalComment/debate

Erratum: Mitochondrial gene replacement in primate offspring and embryonic stem cells (Nature (2009) 461 367-372 DOI:10.1038/nature08368)

Tachibana, M., Sparman, M., Sritanaudomchai, H., Ma, H., Clepper, L., Woodward, J., Li, Y., Ramsey, C., Kolotushkina, O. & Mitalipov, S., Dec 11 2014, In : Nature. 516, 7530, 1 p.

Research output: Contribution to journalComment/debate

Limitations of preimplantation genetic diagnosis for mitochondrial DNA diseases

Mitalipov, S., Amato, P., Parry, S. & Falk, M. J., May 22 2014, In : Cell Reports. 7, 4, p. 935-937 3 p.

Research output: Contribution to journalLetter

35 Scopus citations

Mitochondrial replacement therapies can circumvent mtDNA-based disease transmission

Wolf, D. P. & Mitalipov, S., Jul 1 2014, In : Cell Metabolism. 20, 1, p. 6-8 3 p.

Research output: Contribution to journalShort survey

7 Scopus citations

Nuclear reprogramming by interphase cytoplasm of two-cell mouse embryos

Kang, E., Wu, G., Ma, H., Li, Y., Tippner-Hedges, R., Tachibana, M., Sparman, M., Wolf, D. P., Schöler, H. R. & Mitalipov, S., Jan 1 2014, In : Nature. 508, 7498, p. 101-104 4 p.

Research output: Contribution to journalArticle

27 Scopus citations

The Challenges of Mitochondrial Replacement

Chinnery, P. F., Craven, L., Mitalipov, S., Stewart, J. B., Herbert, M. & Turnbull, D. M., Apr 2014, In : PLoS genetics. 10, 4, e1004315.

Research output: Contribution to journalArticle

44 Scopus citations

Three-parent in vitro fertilization: Gene replacement for the prevention of inherited mitochondrial diseases

Amato, P., Tachibana, M., Sparman, M. & Mitalipov, S., Jan 2014, In : Fertility and sterility. 101, 1, p. 31-35 5 p.

Research output: Contribution to journalReview article

70 Scopus citations
2013

Cloning Primates

Simerly, C., Tachibana, M., Mitalipov, S. & Schatten, G., Oct 1 2013, Principles of Cloning: Second Edition. Elsevier Inc., p. 299-310 12 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Erratum: Human embryonic stem cells derived by somatic cell nuclear transfer (Cell (2013) 153 (1228-1238))

Tachibana, M., Amato, P., Sparman, M., Gutierrez, N. M., Tippner-Hedges, R., Ma, H., Kang, E., Fulati, A., Lee, H. S., Sritanaudomchai, H., Masterson, K., Larson, J., Eaton, D., Sadler-Fredd, K., Battaglia, D., Lee, D., Wu, D., Jensen, J., Patton, P., Gokhale, S. & 3 others, Stouffer, R. L., Wolf, D. & Mitalipov, S., Jul 18 2013, In : Cell. 154, 2, p. 465-466 2 p.

Research output: Contribution to journalComment/debate

2 Scopus citations

Foreword to the Second Edition

Trounson, A. & Mitalipov, S., Oct 1 2013, Principles of Cloning: Second Edition. Elsevier Inc., p. xi-xii

Research output: Chapter in Book/Report/Conference proceedingForeword/postscript

Human embryonic stem cells derived by somatic cell nuclear transfer

Tachibana, M., Amato, P., Sparman, M., Gutierrez, N. M., Tippner-Hedges, R., Ma, H., Kang, E., Fulati, A., Lee, H. S., Sritanaudomchai, H., Masterson, K., Larson, J., Eaton, D., Sadler-Fredd, K., Battaglia, D., Lee, D., Wu, D., Jensen, J., Patton, P., Gokhale, S. & 3 others, Stouffer, R. L., Wolf, D. & Mitalipov, S., Jun 6 2013, In : Cell. 153, 6, p. 1228-1238 11 p.

Research output: Contribution to journalArticle

456 Scopus citations

Restoration of testis function in hypogonadotropic hypogonadal mice harboring a misfolded GnRHR mutant by pharmacoperone drug therapy

Janovick, J. A., Stewart, M. D., Jacob, D., Martin, L. D., Deng, J. M., Stewart, C. A., Wang, Y., Cornea, A., Chavali, L., Lopez, S., Mitalipov, S., Kang, E., Lee, H. S., Manna, P. R., Stocco, D. M., Behringer, R. R. & Conn, P. M., Dec 24 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 52, p. 21030-21035 6 p.

Research output: Contribution to journalArticle

46 Scopus citations

Stem cell potency and the ability to contribute to chimeric organisms

Polejaeva, I. & Mitalipov, S., Mar 1 2013, In : Reproduction. 145, 3, p. R81-R88

Research output: Contribution to journalReview article

12 Scopus citations

Towards germline gene therapy of inherited mitochondrial diseases

Tachibana, M., Amato, P., Sparman, M., Woodward, J., Sanchis, D. M., Ma, H., Gutierrez, N. M., Tippner-Hedges, R., Kang, E., Lee, H. S., Ramsey, C., Masterson, K., Battaglia, D., Lee, D., Wu, D., Jensen, J., Patton, P., Gokhale, S., Stouffer, R. & Mitalipov, S., Feb 7 2013, In : Nature. 494, 7435, p. 627-631 5 p.

Research output: Contribution to journalArticle

Towards germline gene therapy of inherited mitochondrial diseases

Tachibana, M., Amato, P., Sparman, M., Woodward, J., Sanchis, D. M., Ma, H., Gutierrez, N. M., Tippner-Hedges, R., Kang, E., Lee, H. S., Ramsey, C., Masterson, K., Battaglia, D., Lee, D., Wu, D., Jensen, J., Patton, P., Gokhale, S., Stouffer, R. & Mitalipov, S., Jan 31 2013, In : Nature. 493, 7434, p. 627-631 5 p.

Research output: Contribution to journalArticle

234 Scopus citations
2012

Chromosome transfer in mature oocytes.

Tachibana, M., Sparman, M. & Mitalipov, S., May 2012, In : Fertility and sterility. 97, 5, p. e16

Research output: Contribution to journalArticle

6 Scopus citations

Generation of chimeric rhesus monkeys

Tachibana, M., Sparman, M., Ramsey, C., Ma, H., Lee, H. S., Penedo, M. C. T. & Mitalipov, S., Jan 20 2012, In : Cell. 148, 1-2, p. 285-295 11 p.

Research output: Contribution to journalArticle

105 Scopus citations

Primate and human somatic cell nuclear transfer

Cervera, R. P. & Mitalipov, S., Jan 1 2012, Biology and Pathology of the Oocyte: Role in Fertility, Medicine, and Nuclear Reprogramming, Second Edition. Cambridge University Press, p. 274-284 11 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Rapid Mitochondrial DNA Segregation in Primate Preimplantation Embryos Precedes Somatic and Germline Bottleneck

Lee, H. S., Ma, H., Juanes, R. C., Tachibana, M., Sparman, M., Woodward, J., Ramsey, C., Xu, J., Kang, E. J., Amato, P., Mair, G., Steinborn, R. & Mitalipov, S., May 31 2012, In : Cell Reports. 1, 5, p. 506-515 10 p.

Research output: Contribution to journalArticle

68 Scopus citations

Spermatogonial stem cell transplantation into rhesus testes regenerates spermatogenesis producing functional sperm

Hermann, B. P., Sukhwani, M., Winkler, F., Pascarella, J. N., Peters, K. A., Sheng, Y., Valli, H., Rodriguez, M., Ezzelarab, M., Dargo, G., Peterson, K., Masterson, K., Ramsey, C., Ward, T., Lienesch, M., Volk, A., Cooper, D. K., Thomson, A. W., Kiss, J. E., Penedo, M. C. T. & 3 others, Schatten, G. P., Mitalipov, S. & Orwig, K. E., Nov 2 2012, In : Cell Stem Cell. 11, 5, p. 715-726 12 p.

Research output: Contribution to journalArticle

196 Scopus citations

X-chromosome inactivation in monkey embryos and pluripotent stem cells

Tachibana, M., Ma, H., Sparman, M. L., Lee, H. S., Ramsey, C. M., Woodward, J. S., Sritanaudomchai, H., Masterson, K. R., Wolff, E. E., Jia, Y. & Mitalipov, S. M., Nov 15 2012, In : Developmental Biology. 371, 2, p. 146-155 10 p.

Research output: Contribution to journalArticle

15 Scopus citations