Shawn Chavez

Assistant Scientist

  • 1185 Citations
  • 13 h-Index
20072021
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Research Output 2007 2019

  • 1185 Citations
  • 13 h-Index
  • 18 Article
  • 3 Chapter
  • 1 Editorial
  • 1 Short survey
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Article
2019
Granulosa Cells
Primates
Androgens
Oocytes
Diet
1 Citation (Scopus)

Single-cell sequencing of primate preimplantation embryos reveals chromosome elimination via cellular fragmentation and blastomere exclusion

Daughtry, B. L., Rosenkrantz, J. L., Lazar, N. H., Fei, S. S., Redmayne, N., Torkenczy, K. A., Adey, A., Yan, M., Gao, L., Park, B., Nevonen, K. A., Carbone, L. & Chavez, S., Mar 1 2019, In : Genome Research. 29, 3, p. 367-382 16 p.

Research output: Contribution to journalArticle

Open Access
Blastomeres
Blastocyst
Primates
Chromosomes
Aneuploidy
2017
8 Citations (Scopus)

GATA2/3-TFAP2A/C transcription factor network couples human pluripotent stem cell differentiation to trophectoderm with repression of pluripotency

Krendl, C., Shaposhnikov, D., Rishko, V., Ori, C., Ziegenhain, C., Sass, S., Simon, L., Müller, N. S., Straub, T., Brooks, K. E., Chavez, S., Enard, W., Theis, F. J. & Drukker, M., Nov 7 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 45, p. E9579-E9588

Research output: Contribution to journalArticle

Pluripotent Stem Cells
Trophoblasts
Transcriptome
GATA3 Transcription Factor
GATA2 Transcription Factor
2016
23 Citations (Scopus)

Chromosomal instability in mammalian pre-implantation embryos: potential causes, detection methods, and clinical consequences

Daughtry, B. L. & Chavez, S., Jan 1 2016, In : Cell and Tissue Research. 363, 1, p. 201-225 25 p.

Research output: Contribution to journalArticle

Chromosomal Instability
Embryonic Structures
Aneuploidy
Blastocyst
Fertilization in Vitro
1 Citation (Scopus)

IFPA meeting 2016 workshop report I: Genomic communication, bioinformatics, trophoblast biology and transport systems

Albrecht, C., Baker, J. C., Blundell, C., Chavez, S., Carbone, L., Chamley, L., Hannibal, R. L., Illsley, N., Kurre, P., Laurent, L. C., McKenzie, C., Morales-Prieto, D., Pantham, P., Paquette, A., Powell, K., Price, N., Rao, B. M., Sadovsky, Y., Salomon, C., Tuteja, G. & 2 others, Wilson, S. & O'Tierney-Ginn, P. F., Dec 12 2016, (Accepted/In press) In : Placenta.

Research output: Contribution to journalArticle

Systems Biology
Trophoblasts
Computational Biology
Education
Pathology
2015
179 Citations (Scopus)

Intrinsic retroviral reactivation in human preimplantation embryos and pluripotent cells

Grow, E. J., Flynn, R. A., Chavez, S., Bayless, N. L., Wossidlo, M., Wesche, D. J., Martin, L., Ware, C. B., Blish, C. A., Chang, H. Y., Pera, R. A. R. & Wysocka, J., Jun 11 2015, In : Nature. 522, 7555, p. 221-246 26 p.

Research output: Contribution to journalArticle

Blastocyst
Endogenous Retroviruses
Human Development
Virus Diseases
Integration Host Factors
13 Citations (Scopus)
Chromosomal Instability
Embryonic Development
Embryonic Structures
Germ Cells
Mammals
54 Citations (Scopus)

Prediction model for aneuploidy in early human embryo development revealed by single-cell analysis

Vera-Rodriguez, M., Chavez, S., Rubio, C., Reijo Pera, R. A. & Simon, C., Jul 7 2015, In : Nature Communications. 6, 7601.

Research output: Contribution to journalArticle

Single-Cell Analysis
embryos
Human Development
Aneuploidy
Embryonic Development
14 Citations (Scopus)

Single-cell XIST expression in human preimplantation embryos and newly reprogrammed female induced pluripotent stem cells

Briggs, S. F., Dominguez, A. A., Chavez, S. & Reijo Pera, R. A., Jun 1 2015, In : Stem Cells. 33, 6, p. 1771-1781 11 p.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
X Chromosome
Blastocyst
X Chromosome Inactivation
Embryonic Structures
2014
22 Citations (Scopus)

Comparison of epigenetic mediator expression and function in mouse and human embryonic blastomeres

Chavez, S., McElroy, S. L., Bossert, N. L., De Jonge, C. J., Rodriguez, M. V., Leong, D. E., Behr, B., Westphal, L. M. & Reijo Pera, R. A., 2014, In : Human Molecular Genetics. 23, 18, p. 4970-4984 15 p., ddu212.

Research output: Contribution to journalArticle

Blastomeres
Epigenomics
Histone Code
Embryonic Structures
Intercellular Signaling Peptides and Proteins
2013
7 Citations (Scopus)

Generation of human induced pluripotent stem cells using epigenetic regulators reveals a germ cell-like identity in partially reprogrammed colonies

Goyal, A., Chavez, S. & Reijo Pera, R. A., Dec 12 2013, In : PLoS One. 8, 12, e82838.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Stem cells
Epigenomics
epigenetics
Germ Cells
2012
153 Citations (Scopus)

Dynamic blastomere behaviour reflects human embryo ploidy by the four-cell stage

Chavez, S., Loewke, K. E., Han, J., Moussavi, F., Colls, P., Munne, S., Behr, B. & Reijo Pera, R. A., 2012, In : Nature Communications. 3, 1251.

Research output: Contribution to journalArticle

human behavior
Blastomeres
Ploidies
embryos
Chromosomes
2011
240 Citations (Scopus)

An antibody against SSEA-5 glycan on human pluripotent stem cells enables removal of teratoma-forming cells

Tang, C., Lee, A. S., Volkmer, J. P., Sahoo, D., Nag, D., Mosley, A. R., Inlay, M. A., Ardehali, R., Chavez, S., Pera, R. R., Behr, B., Wu, J. C., Weissman, I. L. & Drukker, M., Sep 2011, In : Nature Biotechnology. 29, 9, p. 829-834 6 p.

Research output: Contribution to journalArticle

Stage-Specific Embryonic Antigens
Pluripotent Stem Cells
Teratoma
Antigens
Stem cells
2010
22 Citations (Scopus)

Parthenogenic blastocysts derived from cumulus-free In Vitro matured human oocytes

McElroy, S. L., Byrne, J. A., Chavez, S., Behr, B., Hsueh, A. J., Westphal, L. M. & Reijo Pera, R. A., 2010, In : PLoS One. 5, 6, e10979.

Research output: Contribution to journalArticle

Glial Cell Line-Derived Neurotrophic Factor
Brain-Derived Neurotrophic Factor
Blastocyst
Fibroblast Growth Factor 2
Leptin
2009
38 Citations (Scopus)

Instructing an embryonic stem cell-derived oocyte fate: Lessons from endogenous oogenesis

Nicholas, C. R., Chavez, S., Baker, V. L. & Reijo Pera, R. A., May 2009, In : Endocrine Reviews. 30, 3, p. 264-283 20 p.

Research output: Contribution to journalArticle

Oogenesis
Embryonic Stem Cells
Oocytes
Stem Cells
Human Development
211 Citations (Scopus)

Isolation and characterization of pluripotent human spermatogonial stem cell-derived cells

Kossack, N., Meneses, J., Shefi, S., Ha, N. N., Chavez, S., Nicholas, C., Gromoll, J., Turek, P. J. & Reijo-Pera, R. A., Jan 2009, In : Stem Cells. 27, 1, p. 138-149 12 p.

Research output: Contribution to journalArticle

Multipotent Stem Cells
Stem Cells
Testis
Germ Layers
Spermatogonia
2008
30 Citations (Scopus)

Characterization of six new human embryonic stem cell lines (HSF7, -8, -9, -10, -12, and -13) derived under minimal-animal component conditions

Chavez, S., Meneses, J. J., Nguyen, H. N., Kim, S. K. & Pera, R. A. R., Jun 1 2008, In : Stem Cells and Development. 17, 3, p. 535-546 12 p.

Research output: Contribution to journalArticle

Cell Line
Cell- and Tissue-Based Therapy
Human Embryonic Stem Cells
CD15 Antigens
Embryoid Bodies
2007
143 Citations (Scopus)

Trophoblast-macrophage interactions: A regulatory network for the protection of pregnancy

Fest, S., Aldo, P. B., Abrahams, V. M., Visintin, I., Alvero, A., Chen, R., Chavez, S., Romero, R. & Mor, G., Jan 2007, In : American Journal of Reproductive Immunology. 57, 1, p. 55-66 12 p.

Research output: Contribution to journalArticle

Trophoblasts
Monocytes
Macrophages
Pregnancy
Cytokines