Shannon McWeeney

Research output

Research output per year 1997 2013 2014 2015 2016 2017 2018 2019 2020 2022 2023

• 164 Article
• 14 Review article
• 7 Comment/debate
• 4 Letter
• 8 More
  • 3 Chapter
  • 2 Conference contribution
  • 2 Conference article
  • 1 Short survey

Research output per year

Research output per year

Search results

• 2023

  Secondary fusion proteins as a mechanism of BCR::ABL1 kinase-independent resistance in chronic myeloid leukaemia

  Barnes, E. J., Eide, C. A., Kaempf, A., Bottomly, D., Romine, K. A., Wilmot, B., Saunders, D., McWeeney, S. K., Tognon, C. E. & Druker, B. J., Feb 2023, In: British Journal of Haematology. 200, 3, p. 323-328 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive 100%
  • Phosphotransferases 73%
  • Preclinical Drug Evaluations 56%
  • Gene Fusion 53%
  • RNA Sequence Analysis 53%
• 2022

  A genome-wide CRISPR screen identifies regulators of MAPK and MTOR pathways that mediate resistance to sorafenib in acute myeloid leukemia

  Damnernsawad, A., Bottomly, D., Kurtz, S. E., Eide, C. A., McWeeney, S. K., Tyner, J. W. & Nechiporuk, T., Jan 2022, In: Haematologica. 107, 1, p. 77-85 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Sorafenib 100%
  • Clustered Regularly Interspaced Short Palindromic Repeats 93%
  • Acute Myeloid Leukemia 77%
  • Genome 55%
  • Mitogen-Activated Protein Kinase Kinases 35%
  11 Scopus citations

• Associating drug sensitivity with differentiation status identifies effective combinations for acute myeloid leukemia

  Kurtz, S., Eide, C. A., Kaempf, A., Long, N., Bottomly, D., Nikolova, O., Druker, B. J., McWeeney, S. K., Chang, B. H., Tyner, J. W. & Agarwal, A., May 24 2022, In: Blood Advances. 6, 10, p. 3062-3067 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • BIRB 796 100%
  • venetoclax 98%
  • Acute Myeloid Leukemia 59%
  • p38 Mitogen-Activated Protein Kinases 32%
  • Pharmaceutical Preparations 25%
  2 Scopus citations

• Community-Based SARS-CoV-2 Testing Using Saliva or Nasopharyngeal Swabs to Compare the Performance of Weekly COVID-19 Screening to Wastewater SARS-CoV-2 Signals

  Lu, Z., Brunton, A. E., Mohebnasab, M., Deloney, A., Williamson, K. J., Layton, B. A., Mansell, S., Brawley-Chesworth, A., Abrams, P., Wilcox, K. A., Franklin, F. A., McWeeney, S. K., Streblow, D. N., Fan, G. & Hansel, D. E., Oct 14 2022, In: ACS ES and T Water. 2, 10, p. 1667-1677 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • severe acute respiratory syndrome 100%
  • saliva 84%
  • Wastewater 69%
  • Screening 60%
  • screening 55%

• Comprehensive molecular characterization of a rare case of Philadelphia chromosome-positive acute myeloid leukemia

  Rosenberg, M. W., Savage, S. L., Eide, C. A., Reister Schultz, A., Cook, R., Press, R., Rempfer, C., Eickelberg, G., Wilmot, B., McWeeney, S. K., Tyner, J. W., Druker, B. J. & Tognon, C. E., Oct 1 2022, In: Cold Spring Harbor Molecular Case Studies. 8, 6

  Research output: Contribution to journal › Article › peer-review

  • Philadelphia Chromosome 100%
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive 81%
  • Acute Myeloid Leukemia 74%
  • Mutation 65%
  • Pathway Inhibitor 64%

• Dual BTK/SYK inhibition with CG-806 (luxeptinib) disrupts B-cell receptor and Bcl-2 signaling networks in mantle cell lymphoma

  Thieme, E., Liu, T., Bruss, N., Roleder, C., Lam, V., Wang, X., Nechiporuk, T., Shouse, G., Danilova, O. V., Bottomly, D., McWeeney, S. K., Tyner, J. W., Kurtz, S. E. & Danilov, A. V., Mar 2022, In: Cell Death and Disease. 13, 3, 246.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Agammaglobulinaemia Tyrosine Kinase 100%
  • Mantle-Cell Lymphoma 89%
  • B-Lymphocytes 52%
  • Signal Transduction 26%
  • PCI 32765 25%
  1 Scopus citations

• Functional proteomics of patient derived head and neck squamous cell carcinoma cells reveal novel applications of trametinib

  Vigoda, M., Mathieson, C., Evans, N., Hale, C., Jennings, J., Lucero, O., Jeng, S., Bottomly, D., Clayburgh, D., Andersen, P., Li, R., Petrisor, D., Tyner, J. W., McWeeney, S. & Kulesz-Martin, M., 2022, In: Cancer Biology and Therapy. 23, 1, p. 310-318 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • trametinib 100%
  • Squamous Cell Carcinoma of Head and Neck 71%
  • Proteomics 58%
  • glesatinib 25%
  • 6-(6-(1-methyl-1H-pyrazol-4-yl)-(1,2,4)triazolo(4,3-b)pyridazin-3-ylsulfanyl)quinoline 23%
  1 Scopus citations

• Identification and prioritization of myeloid malignancy germline variants in a large cohort of adult patients with AML

  Yang, F., Long, N., Anekpuritanang, T., Bottomly, D., Savage, J. C., Lee, T., Solis-Ruiz, J., Borate, U., Wilmot, B., Tognon, C., Bock, A. M., Pollyea, D. A., Radhakrishnan, S., Radhakrishnan, S., Patel, P., Collins, R. H., Tantravahi, S., Deininger, M. W., Fan, G., Druker, B., & 5 othersShinde, U., Tyner, J. W., Press, R. D., McWeeney, S. & Agarwal, A., Feb 24 2022, In: Blood. 139, 8, p. 1208-1221 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Haematological 100%
  • Acute Myeloid Leukemia 67%
  • Time 25%
  • Neoplasms 22%
  • Medical Genetics 18%
  18 Scopus citations

• Integrative analysis of drug response and clinical outcome in acute myeloid leukemia

  Bottomly, D., Long, N., Schultz, A. R., Kurtz, S., Tognon, C. E., Johnson, K., Abel, M., Agarwal, A., Avaylon, S., Benton, E., Blucher, A., Borate, U., Braun, T. P., Brown, J., Bryant, J., Burke, R., Carlos, A., Chang, B. H., Cho, H. J., Christy, S., & 74 othersCoblentz, C., Cohen, A. M., d'Almeida, A., Cook, R., Danilov, A., Dao, K-H., Degnin, M., Dibb, J., Eide, C. A., English, I., Hagler, S., Harrelson, H., Henson, R., Ho, H., Joshi, S. K., Junio, B., Kaempf, A., Kosaka, Y., Laderas, T., Lawhead, M., Lee, H., Leonard, J. T., Lin, C., Lind, E. F., Liu, S. Q., Lo, P., Loriaux, M. M., Luty, S., Maxson, J. E., Macey, T., Martinez, J., Minnier, J., Monteblanco, A., Mori, M., Morrow, Q., Nelson, D., Ramsdill, J., Rofelty, A., Rogers, A., Romine, K. A., Ryabinin, P., Saultz, J. N., Sampson, D. A., Savage, S. L., Schuff, R., Searles, R., Smith, R. L., Spurgeon, S. E., Sweeney, T., Swords, R. T., Thapa, A., Thiel-Klare, K., Traer, E., Wagner, J., Wilmot, B., Wolf, J., Wu, G., Yates, A., Zhang, H., Cogle, C. R., Collins, R. H., Deininger, M. W., Hourigan, C. S., Jordan, C. T., Lin, T. L., Martinez, M. E., Pallapati, R. R., Pollyea, D. A., Pomicter, A. D., Watts, J. M., Weir, S. J., Druker, B. J., McWeeney, S. K. & Tyner, J. W., Aug 8 2022, In: Cancer Cell. 40, 8, p. 850-864.e9

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Acute Myeloid Leukemia 100%
  • Myeloid Cells 53%
  • Pharmaceutical Preparations 43%
  • Drug Development 24%
  • Cell Differentiation 21%
  5 Scopus citations

• Luxeptinib (CG-806) Targets FLT3 and Clusters of Kinases Operative in Acute Myeloid Leukemia

  Rice, W. G., Howell, S. B., Zhang, H., Rastgoo, N., Local, A., Kurtz, S. E., Lo, P., Bottomly, D., Wilmot, B., McWeeney, S. K., Druker, B. J. & Tyner, J. W., Jul 2022, In: Molecular cancer therapeutics. 21, 7, p. 1125-1135 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Acute Myeloid Leukemia 100%
  • Phosphotransferases 81%
  • Heterografts 31%
  • Isocitrate Dehydrogenase 23%
  • Toxicology 16%

• MS4A3 promotes differentiation in chronic myeloid leukemia by enhancing common β-chain cytokine receptor endocytosis

  Zhao, H., Pomicter, A. D., Eiring, A. M., Franzini, A., Ahmann, J., Hwang, J. Y., Senina, A., Helton, B., Iyer, S., Yan, D., Khorashad, J. S., Zabriskie, M. S., Agarwal, A., Redwine, H. M., Bowler, A. D., Clair, P. M., McWeeney, S. K., Druker, B. J., Tyner, J. W., Stirewalt, D. L., & 8 othersOehler, V. G., Varambally, S., Berrett, K. C., Vahrenkamp, J. M., Gertz, J., Varley, K. E., Radich, J. P. & Deininger, M. W., Feb 3 2022, In: Blood. 139, 5, p. 761-778 18 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Tyrosine Kinase Inhibitor 100%
  • Cytokine Receptors 86%
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive 75%
  • Endocytosis 72%
  • Protein-Tyrosine Kinases 65%
  2 Scopus citations

• Targeted RNA editing in brainstem alleviates respiratory dysfunction in a mouse model of Rett syndrome

  Sinnamon, J. R., Jacobson, M. E., Yung, J. F., Fisk, J. R., Jeng, S., McWeeney, S. K., Chan, C. N., Yee, S. P., Mandel, G. & Parmelee, L. K., Aug 16 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 33, e2206053119.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • RNA Editing 100%
  • Rett Syndrome 97%
  • Methyl-CpG-Binding Protein 2 87%
  • Brain Stem 64%
  • Guide RNA 39%
• 2021

  Baseline T cell immune phenotypes predict virologic and disease control upon SARS-CoV infection in Collaborative Cross mice

  Graham, J. B., Swarts, J. L., Leist, S. R., Schäfer, A., Menachery, V. D., Gralinski, L. E., Jeng, S., Miller, D. R., Mooney, M. A., McWeeney, S. K., Ferris, M. T., de Villena, F. P. M., Heise, M. T., Baric, R. S. & Lund, J. M., Jan 29 2021, In: PLoS pathogens. 17, 1, e1009287.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Collaborative Cross Mice 100%
  • SARS Virus 78%
  • T-lymphocytes 48%
  • disease control 46%
  • phenotype 35%
  10 Scopus citations

• Correlation of Regulatory T Cell Numbers with Disease Tolerance upon Virus Infection

  Graham, J. B., Swarts, J. L., Edwards, K. R., Voss, K. M., Green, R., Jeng, S., Miller, D. R., Mooney, M. A., McWeeney, S. K., Ferris, M. T., de Villena, F. P. M., Gale, M. & Lund, J. M., Apr 1 2021, In: ImmunoHorizons. 5, 4, p. 157-169 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Regulatory T-Lymphocytes 100%
  • West Nile Fever 96%
  • Cell Count 75%
  • Virus Diseases 74%
  • Collaborative Cross Mice 63%

• Dopamine neuron-specific LRRK2 G2019S effects on gene expression revealed by translatome profiling

  Pallos, J., Jeng, S., McWeeney, S. & Martin, I., Jul 2021, In: Neurobiology of Disease. 155, 105390.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Dopaminergic Neurons 100%
  • Leucine 97%
  • Phosphotransferases 74%
  • Gene Expression 57%
  • Ribosomes 27%
  4 Scopus citations

• Incorporating immunoproteins in the development of classification models of progression of intracranial hemorrhage after traumatic brain injury

  Hinson, H. E., Li, P., Myers, L., Agarwal, C., Pollock, J. & McWeeney, S., Sep 2021, In: Journal of Head Trauma Rehabilitation. 36, 5, p. E322-E328

  Research output: Contribution to journal › Article › peer-review

  • Immunoproteins 100%
  • Intracranial Hemorrhages 62%
  • Traumatic Brain Injury 54%
  • Proteins 11%
  • Logistic Models 10%

• Lentiviral-driven discovery of cancer drug resistance mutations

  Yenerall, P., Kollipara, R. K., Avila, K., Peyton, M., Eide, C. A., Bottomly, D., McWeeney, S. K., Liu, Y., Westover, K. D., Druker, B. J., Minna, J. D. & Kittler, R., Sep 15 2021, In: Cancer Research. 81, 18, p. 4685-4695 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Drug Resistance 100%
  • Mutation 61%
  • Imatinib Mesylate 49%
  • Neoplasms 35%
  • Human immunodeficiency virus 1 reverse transcriptase 30%
  2 Scopus citations

• Serine-Threonine Kinase TAO3-Mediated Trafficking of Endosomes Containing the Invadopodia Scaffold TKS5a Promotes Cancer Invasion and Tumor Growth

  Iizuka, S., Quintavalle, M., Navarro, J. C., Gribbin, K. P., Ardecky, R. J., Abelman, M. M., Ma, C. T., Sergienko, E., Zeng, F. Y., Pass, I., Thomas, G. V., McWeeney, S. K., Hassig, C. A., Pinkerton, A. B. & Courtneidge, S. A., Mar 2021, In: Cancer Research. 81, 6, p. 1472-1485 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Podosomes 100%
  • Endosomes 75%
  • Protein-Serine-Threonine Kinases 75%
  • Growth 33%
  • GCK-like kinase 24%
  3 Scopus citations

• The AML microenvironment catalyzes a stepwise evolution to gilteritinib resistance

  Joshi, S. K., Nechiporuk, T., Bottomly, D., Piehowski, P. D., Reisz, J. A., Pittsenbarger, J., Kaempf, A., Gosline, S. J. C., Wang, Y. T., Hansen, J. R., Gritsenko, M. A., Hutchinson, C., Weitz, K. K., Moon, J., Cendali, F., Fillmore, T. L., Tsai, C. F., Schepmoes, A. A., Shi, T., Arshad, O. A., & 12 othersMcDermott, J. E., Babur, O., Watanabe-Smith, K., Demir, E., D'Alessandro, A., Liu, T., Tognon, C. E., Tyner, J. W., McWeeney, S. K., Rodland, K. D., Druker, B. J. & Traer, E., Jul 12 2021, In: Cancer Cell. 39, 7, p. 999-1014.e8

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • gilteritinib 100%
  • Acute Myeloid Leukemia 47%
  • Aurora Kinase B 46%
  • Leukemia 24%
  • Primary Cell Culture 12%
  23 Scopus citations
• 2020

  AZD4320, a dual inhibitor of bcl-2 and bcl-x_l, induces tumor regression in hematologic cancer models without dose-limiting thrombocytopenia

  Balachander, S. B., Criscione, S. W., Byth, K. F., Cidado, J., Adam, A., Lewis, P., Macintyre, T., Wen, S., Lawson, D., Burke, K., Lubinski, T., Tyner, J. W., Kurtz, S. E., McWeeney, S. K., Varnes, J., Diebold, R. B., Gero, T., Ioannidis, S., Hennessy, E. J., McCoull, W., & 18 othersSaeh, J. C., Tabatabai, A., Tavana, O., Su, N., Schuller, A., Garnett, M. J., Jaaks, P., Coker, E. A., Gregory, G. P., Newbold, A., Johnstone, R. W., Gangl, E., Wild, M., Zinda, M., Secrist, J. P., Davies, B. R., Fawell, S. E. & Gibbons, F. D., Dec 2020, In: Clinical Cancer Research. 26, 24, p. 6535-6549 15 p.

  Research output: Contribution to journal › Article › peer-review

  • Thrombocytopenia 100%
  • venetoclax 72%
  • Neoplasms 34%
  • Acute Myeloid Leukemia 28%
  • Cell Line 17%
  21 Scopus citations

• Chronic Voluntary Ethanol Drinking in Cynomolgus Macaques Elicits Gene Expression Changes in Prefrontal Cortical Area 46

  Walter, N. A. R., Zheng, C. L., Searles, R. P., McWeeney, S. K., Grant, K. A. & Hitzemann, R., Feb 1 2020, In: Alcoholism: Clinical and Experimental Research. 44, 2, p. 470-478 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • MicroRNA 100%
  • Macaca 90%
  • Primates 75%
  • Drinking 74%
  • Ethanol 68%
  3 Scopus citations

• Circulating myeloid cells invade the central nervous system to mediate cachexia during pancreatic cancer

  Burfeind, K. G., Zhu, X., Norgard, M. A., Levasseur, P. R., Huisman, C., Buenafe, A. C., Olson, B., Michaelis, K. A., Torres, E. R. S., Jeng, S., McWeeney, S., Raber, J. & Marks, D. L., May 2020, In: eLife. 9, p. 1-27 27 p., e54095.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Intracerebroventricular 100%
  • Cachexia 76%
  • Myeloid Cells 63%
  • Pancreatic Neoplasms 59%
  • Anorexia 50%
  21 Scopus citations

• Clinical impact of COVID-19 on patients with cancer (CCC19): a cohort study

  COVID-19 and Cancer Consortium, Jun 20 2020, In: The Lancet. 395, 10241, p. 1907-1918 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Cohort Studies 100%
  • Neoplasms 47%
  • Mortality 31%
  • Canada 19%
  • Midwestern United States 16%
  1020 Scopus citations

• Complex Genetic Architecture Underlies Regulation of Influenza-A-Virus-Specific Antibody Responses in the Collaborative Cross

  Noll, K. E., Whitmore, A. C., West, A., McCarthy, M. K., Morrison, C. R., Plante, K. S., Hampton, B. K., Kollmus, H., Pilzner, C., Leist, S. R., Gralinski, L. E., Menachery, V. D., Schäfer, A., Miller, D., Shaw, G., Mooney, M., McWeeney, S., Pardo-Manuel de Villena, F., Schughart, K., Morrison, T. E., & 3 othersBaric, R. S., Ferris, M. T. & Heise, M. T., Apr 28 2020, In: Cell Reports. 31, 4, 107587.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Collaborative Cross Mice 100%
  • Population Genetics 65%
  • Genetic Loci 65%
  • Influenza A virus 58%
  • Orthomyxoviridae 53%
  9 Scopus citations

• Discovery and characterization of targetable NTRK point mutations in hematologic neoplasms

  Joshi, S. K., Qian, K., Bisson, W. H., Watanabe-Smith, K., Huang, A., Bottomly, D., Traer, E., Tyner, J. W., McWeeney, S. K., Davare, M. A., Druker, B. J. & Tognon, C. E., Jun 11 2020, In: Blood. 135, 24, p. 2159-2170 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Neurotrophic 100%
  • Receptor Protein-Tyrosine Kinases 67%
  • Hematologic Neoplasms 63%
  • Point Mutation 61%
  • Tyrosine 57%
  13 Scopus citations

• ERBB2/HER2 mutations are transforming and therapeutically targetable in leukemia

  Joshi, S. K., Keck, J. M., Eide, C. A., Bottomly, D., Traer, E., Tyner, J. W., McWeeney, S. K., Tognon, C. E. & Druker, B. J., Oct 1 2020, In: Leukemia. 34, 10, p. 2798-2804 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  7 Scopus citations

• Functional genomic analysis identifies drug targetable pathways in invasive and metastatic cutaneous squamous cell carcinoma

  Anderson, A. N., McClanahan, D., Jacobs, J., Jeng, S., Vigoda, M., Blucher, A. S., Zheng, C., Yoo, Y. J., Hale, C., Ouyang, X., Clayburgh, D., Andersen, P., Tyner, J. W., Bar, A., Lucero, O. M., Leitenberger, J. J., McWeeney, S. K. & Kulesz-Martin, M., Aug 2020, In: Cold Spring Harbor Molecular Case Studies. 6, 4, a005439.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Ephrins 100%
  • Biological Marker 92%
  • Squamous Cell Carcinoma 85%
  • Drug Target 58%
  • Skin 56%
  4 Scopus citations

• Immune Predictors of Mortality after Ribonucleic Acid Virus Infection

  Graham, J. B., Swarts, J. L., Menachery, V. D., Gralinski, L. E., Schäfer, A., Plante, K. S., Morrison, C. R., Voss, K. M., Green, R., Choonoo, G., Jeng, S., Miller, D. R., Mooney, M. A., McWeeney, S. K., Ferris, M. T., De Villena, F. P. M., Gale, M., Heise, M. T., Baric, R. S. & Lund, J. M., Mar 15 2020, In: Journal of Infectious Diseases. 221, 6, p. 882-889 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Collaborative Cross Mice 100%
  • Virus Diseases 78%
  • RNA 73%
  • Mortality 53%
  • Infections 50%
  4 Scopus citations

• Integrated analysis of patient samples identifies biomarkers for venetoclax efficacy and combination strategies in acute myeloid leukemia

  Zhang, H., Nakauchi, Y., Köhnke, T., Stafford, M., Bottomly, D., Thomas, R., Wilmot, B., McWeeney, S. K., Majeti, R. & Tyner, J. W., Aug 1 2020, In: Nature Cancer. 1, 8, p. 826-839 14 p.

  Research output: Contribution to journal › Article › peer-review

  • venetoclax 100%
  • Acute Myeloid Leukemia 60%
  • Biomarkers 40%
  • AZD5991 29%
  • Synthetic Lethal Mutations 18%
  58 Scopus citations

• In Vivo Repair of a Protein Underlying a Neurological Disorder by Programmable RNA Editing

  Sinnamon, J. R., Kim, S. Y., Fisk, J. R., Song, Z., Nakai, H., Jeng, S., McWeeney, S. K. & Mandel, G., Jul 14 2020, In: Cell Reports. 32, 2, 107878.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • RNA Editing 100%
  • Nervous System Diseases 67%
  • Disorder 61%
  • Mutation 60%
  • RNA 50%
  33 Scopus citations

• Reversible suppression of T cell function in the bone marrow microenvironment of acute myeloid leukemia

  Lamble, A. J., Kosaka, Y., Laderas, T., Maffit, A., Kaempf, A., Brady, L. K., Wang, W., Long, N., Saultz, J. N., Mori, M., Soong, D., LeFave, C. V., Huang, F., Adams, H., Loriaux, M. M., Loriaux, M. M., Tognon, C. E., Lo, P., Tyner, J. W., Tyner, J. W., & 6 othersFan, G., McWeeney, S. K., Druker, B. J., Lind, E. F., Lind, E. F. & Lind, E. F., Jun 23 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 25, p. 14331-14341 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Acute Myeloid Leukemia 100%
  • Bone Marrow 76%
  • T-Lymphocytes 64%
  • Induction Chemotherapy 20%
  • Survival 19%
  27 Scopus citations

• Subcellular localization of FANCD2 is associated with survival in ovarian carcinoma

  Joshi, S., Campbell, S., Lim, J. Y., McWeeney, S., Krieg, A., Bean, Y., Pejovic, N., Mhawech-Fauceglia, P. & Pejovic, T., Feb 25 2020, In: Oncotarget. 11, 8, p. 775-783 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Fanconi Anemia Complementation Group D2 Protein 100%
  • Carcinoma 35%
  • Survival 29%
  • Ovarian Neoplasms 19%
  • Epithelial Cells 5%
  2 Scopus citations
• 2019

  Acute myeloid leukemia–induced T-cell suppression can be reversed by inhibition of the MAPK pathway

  Moshofsky, K. B., Cho, H. J., Wu, G., Romine, K. A., Newman, M. T., Kosaka, Y., McWeeney, S. K. & Lind, E. F., Oct 22 2019, In: Blood Advances. 3, 20, p. 3038-3051 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • trametinib 100%
  • T-Lymphocytes 39%
  • Acute Myeloid Leukemia 38%
  • Mitogen-Activated Protein Kinase Kinases 26%
  • Programmed Cell Death 1 Ligand 2 Protein 14%
  7 Scopus citations

• ClinGen Myeloid Malignancy Variant Curation Expert Panel recommendations for germline RUNX1 variants

  Luo, X., Feurstein, S., Mohan, S., Porter, C. C., Jackson, S. A., Keel, S., Chicka, M., Brown, A. L., Kesserwan, C., Agarwal, A., Luo, M., Li, Z., Ross, J. E., Baliakas, P., Pineda-Alvarez, D., DiNardo, C. D., Bertuch, A. A., Mehta, N., Vulliamy, T., Wang, Y., & 14 othersNichols, K. E., Malcovati, L., Walsh, M. F., Rawlings, L. H., McWeeney, S. K., Soulier, J., Raimbault, A., Routbort, M. J., Zhang, L., Ryan, G., Speck, N. A., Plon, S. E., Wu, D. & Godley, L. A., Oct 22 2019, In: Blood Advances. 3, 20, p. 2962-2979 18 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Medical Genetics 100%
  • Molecular Pathology 84%
  • Genomics 75%
  • Genome 50%
  • Blood Platelets 38%
  64 Scopus citations

• Clinical resistance to crenolanib in acute myeloid leukemia due to diverse molecular mechanisms

  Zhang, H., Savage, S., Schultz, A. R., Bottomly, D., White, L., Segerdell, E., Wilmot, B., McWeeney, S. K., Eide, C. A., Nechiporuk, T., Carlos, A., Henson, R., Lin, C., Searles, R., Ho, H., Lam, Y. L., Sweat, R., Follit, C., Jain, V., Lind, E., & 10 othersBorthakur, G., Garcia-Manero, G., Ravandi, F., Kantarjian, H. M., Cortes, J., Collins, R., Buelow, D. R., Baker, S. D., Druker, B. J. & Tyner, J. W., Dec 1 2019, In: Nature communications. 10, 1, 244.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • crenolanib 100%
  • leukemias 72%
  • mutations 58%
  • Acute Myeloid Leukemia 47%
  • Mutation 42%
  83 Scopus citations

• Controlling for contaminants in low-biomass 16S rRNA gene sequencing experiments

  Karstens, L., Asquith, M., Davin, S., Fair, D., Gregory, W. T., Wolfe, A. J., Braun, J. & McWeeney, S., Jul 2019, In: mSystems. 4, 4, e00290-19.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Biomass 100%
  • Sequencing 87%
  • rRNA Genes 76%
  • 16S Ribosomal RNA 76%
  • Microbiota 72%
  107 Scopus citations

• CSF1R inhibitors exhibit antitumor activity in acute myeloid leukemia by blocking paracrine signals from support cells

  Edwards, D. K., Watanabe-Smith, K., Rofelty, A., Damnernsawad, A., Laderas, T., Lamble, A., Lind, E. F., Kaempf, A., Mori, M., Rosenberg, M., d’Almeida, A., Long, N., Agarwal, A., Sweeney, D. T., Loriaux, M., McWeeney, S. K. & Tyner, J. W., Feb 7 2019, In: Blood. 133, 6, p. 588-599 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • 5-(3-methoxy-4-((4-methoxybenzyl)oxy)benzyl)pyrimidine-2,4-diamine 100%
  • Acute Myeloid Leukemia 54%
  • Antitumor 52%
  • Colony Stimulating Factor 50%
  • Hepatocyte Growth Factor 48%
  66 Scopus citations

• Genomic landscape of neutrophilic leukemias of ambiguous diagnosis

  Zhang, H., Wilmot, B., Bottomly, D., Dao, K-H., Stevens, E., Eide, C. A., Khanna, V., Rofelty, A., Savage, S., Schultz, A. R., Long, N., White, L., Carlos, A., Henson, R., Lin, C., Searles, R., Collins, R. H., DeAngelo, D. J., Deininger, M. W., Dunn, T., & 12 othersHein, T., Luskin, M. R., Medeiros, B. C., Oh, S. T., Pollyea, D. A., Steensma, D. P., Stone, R. M., Druker, B. J., McWeeney, S. K., Maxson, J. E., Gotlib, J. R. & Tyner, J. W., Sep 12 2019, In: Blood. 134, 11, p. 867-879 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • RNA Sequencing 100%
  • Leukemia 98%
  • Molecular Marker 90%
  • Molecular Cluster 78%
  • Leukemia, Neutrophilic, Chronic 53%
  39 Scopus citations

• Illuminating biological pathways for drug targeting in head and neck squamous cell carcinoma

  Choonoo, G., Blucher, A. S., Higgins, S., Boardman, M., Jeng, S., Zheng, C., Jacobs, J., Anderson, A., Chamberlin, S., Evans, N., Vigoda, M., Cordier, B., Tyner, J. W., Kulesz-Martin, M., McWeeney, S. K. & Laderas, T., Oct 1 2019, In: PloS one. 14, 10, e0223639.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • squamous cell carcinoma 100%
  • Squamous Cell Carcinoma of Head and Neck 79%
  • Drug Delivery Systems 70%
  • neck 68%
  • neoplasms 54%
  3 Scopus citations

• Myeloid lineage enhancers drive oncogene synergy in CEBPA/CSF3R mutant acute myeloid leukemia

  Braun, T. P., Okhovat, M., Coblentz, C., Carratt, S. A., Foley, A., Schonrock, Z., Smith, B. M., Nevonen, K., Davis, B., Garcia, B., LaTocha, D., Weeder, B. R., Grzadkowski, M. R., Estabrook, J. C., Manning, H. G., Watanabe-Smith, K., Jeng, S., Smith, J. L., Leonti, A. R., Ries, R. E., & 8 othersMcWeeney, S., Di Genua, C., Drissen, R., Nerlov, C., Meshinchi, S., Carbone, L., Druker, B. J. & Maxson, J. E., Dec 1 2019, In: Nature communications. 10, 1, 5455.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • oncogenes 100%
  • leukemias 81%
  • Enhancer 66%
  • mutations 65%
  • Acute Myeloid Leukemia 53%
  15 Scopus citations

• Natural product target network reveals potential for cancer combination therapies

  Chamberlin, S. R., Blucher, A., Wu, G., Shinto, L., Choonoo, G., Kulesz-Martin, M. & McWeeney, S., 2019, In: Frontiers in Pharmacology. 10, MAY, 557.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Biological Products 100%
  • Neoplasms 32%
  • Drug Interactions 19%
  • Therapeutics 16%
  • Pharmaceutical Preparations 12%
  33 Scopus citations

• Persistent Toll-like receptor 7 stimulation induces behavioral and molecular innate immune tolerance

  Michaelis, K. A., Norgard, M. A., Levasseur, P. R., Olson, B., Burfeind, K. G., Buenafe, A. C., Zhu, X., Jeng, S., McWeeney, S. K. & Marks, D. L., Nov 2019, In: Brain, Behavior, and Immunity. 82, p. 338-353 16 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • resiquimod 100%
  • Toll-Like Receptor 7 91%
  • Immune Tolerance 74%
  • Microglia 26%
  • Lipopolysaccharides 15%
  21 Scopus citations

• Predicting response to BET inhibitors using computational modeling: A BEAT AML project study

  Drusbosky, L. M., Vidva, R., Gera, S., Lakshminarayana, A. V., Shyamasundar, V. P., Agrawal, A. K., Talawdekar, A., Abbasi, T., Vali, S., Tognon, C. E., Kurtz, S., Tyner, J. W., McWeeney, S. K., Druker, B. J. & Cogle, C. R., Feb 2019, In: Leukemia Research. 77, p. 42-50 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Acute Myeloid Leukemia 100%
  • Genomics 79%
  • Computational Biology 73%
  • MAP Kinase Signaling System 28%
  • Chromosome Aberrations 25%
  11 Scopus citations

• Salt-sensitive transcriptome of isolated kidney distal tubule cells

  Swanson, E. A., Nelson, J. W., Jeng, S., Erspamer, K. J., Yang, C. L., McWeeney, S. & Ellison, D. H., Apr 2019, In: Physiological genomics. 51, 4, p. 125-135 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Distal Kidney Tubule 100%
  • Aldosterone 66%
  • Transcriptome 58%
  • Salts 56%
  • Diet 36%
  3 Scopus citations

• The TP53 apoptotic network is a primary mediator of resistance to BCL2 inhibition in AML cells

  Nechiporuk, T., Kurtz, S. E., Nikolova, O., Liu, T., Jones, C. L., D’alessandro, A., Culp-Hill, R., D’almeida, A., Joshi, S. K., Rosenberg, M., Tognon, C. E., Danilov, A. V., Druker, B. J., Chang, B. H., McWeeney, S. K. & Tyner, J. W., Jul 2019, In: Cancer discovery. 9, 7, p. 910-925 16 p.

  Research output: Contribution to journal › Article › peer-review

  • venetoclax 100%
  • Myeloid Cells 96%
  • Acute Myeloid Leukemia 90%
  • Psychological Inhibition 77%
  • Gene Silencing 33%
  133 Scopus citations
• 2018

  A single-cell approach to the elusive latent human cytomegalovirus transcriptome

  Goodrum, F. & McWeeney, S., May 1 2018, In: mBio. 9, 3, e01001-18.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • RNA Sequence Analysis 100%
  • Cytomegalovirus 88%
  • Transcriptome 82%
  • Single-Cell Analysis 39%
  • Gene Expression 35%
  4 Scopus citations

• Functional genomic landscape of acute myeloid leukaemia

  Tyner, J. W., Tognon, C. E., Bottomly, D., Wilmot, B., Kurtz, S., Savage, S. L., Long, N., Schultz, A. R., Traer, E., Abel, M., Agarwal, A., Blucher, A., Borate, U., Bryant, J., Burke, R., Carlos, A., Carpenter, R., Carroll, J., Chang, B. H., Coblentz, C., & 68 othersd’Almeida, A., Cook, R., Danilov, A., Dao, K-H., Degnin, M., Devine, D., Dibb, J., Edwards, D. K., Eide, C. A., English, I., Glover, J., Henson, R., Ho, H., Jemal, A., Johnson, K., Johnson, R., Junio, B., Kaempf, A., Leonard, J., Lin, C., Liu, S. Q., Lo, P., Loriaux, M. M., Luty, S., Macey, T., MacManiman, J., Martinez, J., Mori, M., Nelson, D., Nichols, C., Peters, J., Ramsdill, J., Rofelty, A., Schuff, R., Searles, R., Segerdell, E., Smith, R. L., Spurgeon, S. E., Sweeney, T., Thapa, A., Visser, C., Wagner, J., Watanabe-Smith, K., Werth, K., Wolf, J., White, L., Yates, A., Zhang, H., Cogle, C. R., Collins, R. H., Connolly, D. C., Deininger, M. W., Drusbosky, L., Hourigan, C. S., Jordan, C. T., Kropf, P., Lin, T. L., Martinez, M. E., Medeiros, B. C., Pallapati, R. R., Pollyea, D. A., Swords, R. T., Watts, J. M., Weir, S. J., Wiest, D. L., Winters, R. M., McWeeney, S. K. & Druker, B. J., Oct 25 2018, In: Nature. 562, 7728, p. 526-531 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Acute Myeloid Leukemia 100%
  • RNA Sequence Analysis 47%
  • Pharmaceutical Preparations 34%
  • Whole Exome Sequencing 24%
  • Gene Regulatory Networks 22%
  510 Scopus citations

• Gender-Specific Effects of Selection for Drinking in the Dark on the Network Roles of Coding and Noncoding RNAs

  Iancu, O., Colville, A. M., Wilmot, B., Searles, R., Darakjian, P., Zheng, C., McWeeney, S., Kawane, S., Crabbe, J. J., Metten, P., Oberbeck, D. & Hitzemann, R., Aug 2018, In: Alcoholism: Clinical and Experimental Research. 42, 8, p. 1454-1465 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Untranslated RNA 100%
  • Drinking 80%
  • Gene Expression 53%
  • Microarrays 47%
  • Transcriptome 40%
  11 Scopus citations

• Induction of anaplastic lymphoma kinase (ALK) as a novel mechanism of EGFR inhibitor resistance in head and neck squamous cell carcinoma patient-derived models

  Ouyang, X., Barling, A., Lesch, A., Tyner, J. W., Choonoo, G., Zheng, C., Jeng, S., West, T. M., Clayburgh, D., Courtneidge, S. A., McWeeney, S. K. & Kulesz-Martin, M., Oct 3 2018, In: Cancer Biology and Therapy. 19, 10, p. 921-933 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Anaplastic Lymphoma Kinase 100%
  • Squamous Cell Carcinoma of Head and Neck 83%
  • ErbB Receptors 71%
  • Gefitinib 23%
  • AP26113 11%
  9 Scopus citations

• Integrated functional and mass spectrometry-based flow cytometric phenotyping to describe the immune microenvironment in acute myeloid leukemia

  Lamble, A. J., Dietz, M., Laderas, T., McWeeney, S. & Lind, E. F., Feb 2018, In: Journal of Immunological Methods. 453, p. 44-52 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Acute Myeloid Leukemia 100%
  • Mass Spectrometry 94%
  • Flow Cytometry 53%
  • Immune Evasion 44%
  • Tumor Microenvironment 36%
  12 Scopus citations