Shannon McWeeney

Research output

Research output per year 1997 2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 2023 2024

• 175 Article
• 14 Review article
• 7 Comment/debate
• 5 Letter
• 8 More
  • 3 Chapter
  • 2 Conference contribution
  • 2 Conference article
  • 1 Short survey

Research output per year

Research output per year

Search results

• 2024

  Genetic loci regulate Sarbecovirus pathogenesis: A comparison across mice and humans

  Schäfer, A., Gralinski, L. E., Leist, S. R., Hampton, B. K., Mooney, M., Jensen, K. L., Graham, R. L., Agnihothram, S., Jeng, S., Chamberlin, S., Bell, T. A., Scobey, D. T., Linnertz, C. L., VanBlargan, L. A., Thackray, L. B., Hock, P., Miller, D. R., Shaw, G. D., Diamond, M. S., de Villena, F. P. M., & 5 othersMcWeeney, S. K., Heise, M. T., Menachery, V. D., Ferris, M. T. & Baric, R. S., Jun 2024, In: Virus Research. 344, 199357.

  Research output: Contribution to journal › Article › peer-review

  Open Access
• 2023

  Biology-inspired graph neural network encodes reactome and reveals biochemical reactions of disease

  Burkhart, J. G., Wu, G., Song, X., Raimondi, F., McWeeney, S., Wong, M. H. & Deng, Y., Jul 14 2023, In: Patterns. 4, 7, 100758.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Neural Networks 100%
  • Graph 79%
  • Future Studies 31%
  • Genotype 25%
  • Cancer 24%
  2 Scopus citations

• Clinical Correlates of Venetoclax-Based Combination Sensitivities to Augment Acute Myeloid Leukemia Therapy

  Eide, C. A., Kurtz, S. E., Kaempf, A., Long, N., Joshi, S. K., Nechiporuk, T., Huang, A., Dibb, C. A., Taylor, A., Bottomly, D., McWeeney, S. K., Minnier, J., Lachowiez, C. A., Saultz, J. N., Swords, R. T., Agarwal, A., Chang, B. H., Druker, B. J. & Tyner, J. W., 2023, In: Blood cancer discovery. 4, 6, p. 452-467 16 p.

  Research output: Contribution to journal › Article › peer-review

  • Venetoclax 100%
  • venetoclax 74%
  • Acute Myeloid Leukemia 44%
  • Ruxolitinib 15%
  • Cytogenetics 11%
  4 Scopus citations

• Comparison and validation of the 2022 European LeukemiaNet guidelines in acute myeloid leukemia

  Lachowiez, C. A., Long, N., Saultz, J., Gandhi, A., Newell, L. F., Hayes-Lattin, B., Maziarz, R. T., Leonard, J., Bottomly, D., McWeeney, S., Dunlap, J., Press, R., Meyers, G., Swords, R., Cook, R. J., Tyner, J. W., Druker, B. J. & Traer, E., May 9 2023, In: Blood Advances. 7, 9, p. 1899-1909 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Acute Myeloid Leukemia 100%
  • Guidelines 67%
  • Induction Chemotherapy 19%
  • Survival 17%
  • Mutation 9%
  23 Scopus citations

• Disruption of the MYC Superenhancer Complex by Dual Targeting of FLT3 and LSD1 in Acute Myeloid Leukemia

  Yashar, W. M., Curtiss, B. M., Coleman, D. J., VanCampen, J., Kong, G., Macaraeg, J., Estabrook, J., Demir, E., Long, N., Bottomly, D., McWeeney, S. K., Tyner, J. W., Druker, B. J., Maxson, J. E. & Braun, T. P., Jul 1 2023, In: Molecular Cancer Research. 21, 7, p. 631-647 17 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • fms-Like Tyrosine Kinase 3 100%
  • Lysine 58%
  • Acute Myeloid Leukemia 56%
  • Drug Combinations 26%
  • Phosphotransferases 13%
  2 Scopus citations

• Germ line variant GFI1-36N affects DNA repair and sensitizes AML cells to DNA damage and repair therapy

  Frank, D., Patnana, P. K., Vorwerk, J., Mao, L., Gopal, L. M., Jung, N., Hennig, T., Ruhnke, L., Frenz, J. M., Kuppusamy, M., Autry, R., Wei, L., Sun, K., Mohammed Ahmed, H. M., Künstner, A., Busch, H., Müller, H., Hutter, S., Hoermann, G., Liu, L., & 39 othersXie, X., Al-Matary, Y., Nimmagadda, S. C., Cano, F. C., Heuser, M., Thol, F., Göhring, G., Steinemann, D., Thomale, J., Leitner, T., Fischer, A., Rad, R., Röllig, C., Altmann, H., Kunadt, D., Berdel, W. E., Hüve, J., Neumann, F., Klingauf, J., Calderon, V., Opalka, B., Dührsen, U., Rosenbauer, F., Dugas, M., Varghese, J., Reinhardt, H. C., von Bubnoff, N., Möröy, T., Lenz, G., Batcha, A. M. N., Giorgi, M., Selvam, M., Wang, E., McWeeney, S. K., Tyner, J. W., Stölzel, F., Mann, M., Jayavelu, A. K. & Khandanpour, C., Dec 21 2023, In: Blood. 142, 25, p. 2175-2191 17 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Growth Factor 100%
  • Myeloid Cells 86%
  • Germ Cells 84%
  • Acute Myeloid Leukemia 81%
  • DNA Repair 78%

• How I read an article that uses machine learning methods

  American Society of Hematology Artificial Intelligence Taskforce, Aug 16 2023, In: Blood Advances. 7, 16, p. 4550-4554 5 p.

  Research output: Contribution to journal › Letter › peer-review

  Open Access

• Immune cell proportions correlate with clinicogenomic features and ex vivo drug responses in acute myeloid leukemia

  Romine, K. A., Bottomly, D., Yashar, W., Long, N., Viehdorfer, M., McWeeney, S. K. & Tyner, J. W., 2023, In: Frontiers in Oncology. 13, 1192829.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Acute Myeloid Leukemia 100%
  • Pharmaceutical Preparations 43%
  • Immunotherapy 39%
  • T-Lymphocytes 18%
  • Epigenomics 13%

• Impact of COVID-19 in patients on active melanoma therapy and with history of melanoma

  COVID-19 and Cancer Consortium, Dec 2023, In: BMC cancer. 23, 1, 265.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Melanoma 100%
  • Therapeutics 19%
  • Immunotherapy 19%
  • Troponin 13%
  • Second Primary Neoplasms 12%
  2 Scopus citations

• Proximity-dependent mapping of the HCMV US28 interactome identifies RhoGEF signaling as a requirement for efficient viral reactivation

  Medica, S., Crawford, L. B., Denton, M., Min, C. K., Jones, T. A., Alexander, T., Parkins, C. J., Diggins, N. L., Streblow, G. J., Mayo, A. T., Kreklywich, C. N., Smith, P., Jeng, S., McWeeney, S., Hancock, M. H., Yurochko, A., Cohen, M. S., Caposio, P. & Streblow, D. N., Oct 2023, In: PLoS pathogens. 19, 10 October, e1011682.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Rho Guanine Nucleotide Exchange Factors 100%
  • Human betaherpesvirus 5 97%
  • Cytomegalovirus 64%
  • hematopoietic stem cells 60%
  • Virus Latency 60%

• Secondary fusion proteins as a mechanism of BCR::ABL1 kinase-independent resistance in chronic myeloid leukaemia

  Barnes, E. J., Eide, C. A., Kaempf, A., Bottomly, D., Romine, K. A., Wilmot, B., Saunders, D., McWeeney, S. K., Tognon, C. E. & Druker, B. J., Feb 2023, In: British Journal of Haematology. 200, 3, p. 323-328 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive 100%
  • Phosphotransferases 73%
  • Preclinical Drug Evaluations 56%
  • Gene Fusion 53%
  • RNA Sequence Analysis 53%
  5 Scopus citations
• 2022

  A genome-wide CRISPR screen identifies regulators of MAPK and MTOR pathways that mediate resistance to sorafenib in acute myeloid leukemia

  Damnernsawad, A., Bottomly, D., Kurtz, S. E., Eide, C. A., McWeeney, S. K., Tyner, J. W. & Nechiporuk, T., Jan 2022, In: Haematologica. 107, 1, p. 77-85 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Sorafenib 100%
  • Clustered Regularly Interspaced Short Palindromic Repeats 93%
  • Acute Myeloid Leukemia 77%
  • Genome 55%
  • Mitogen-Activated Protein Kinase Kinases 35%
  15 Scopus citations

• Associating drug sensitivity with differentiation status identifies effective combinations for acute myeloid leukemia

  Kurtz, S. E., Eide, C. A., Kaempf, A., Long, N., Bottomly, D., Nikolova, O., Druker, B. J., McWeeney, S. K., Chang, B. H., Tyner, J. W. & Agarwal, A., May 24 2022, In: Blood Advances. 6, 10, p. 3062-3067 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • BIRB 796 100%
  • venetoclax 98%
  • Acute Myeloid Leukemia 59%
  • p38 Mitogen-Activated Protein Kinases 32%
  • Pharmaceutical Preparations 25%
  5 Scopus citations

• Author Correction: Myeloid lineage enhancers drive oncogene synergy in CEBPA/CSF3R mutant acute myeloid leukemia (Nature Communications, (2019), 10, 1, (5455), 10.1038/s41467-019-13364-2)

  Braun, T. P., Okhovat, M., Coblentz, C., Carratt, S. A., Foley, A., Schonrock, Z., Curtiss, B. M., Nevonen, K., Davis, B., Garcia, B., LaTocha, D., Weeder, B. R., Grzadkowski, M. R., Estabrook, J. C., Manning, H. G., Watanabe-Smith, K., Jeng, S., Smith, J. L., Leonti, A. R., Ries, R. E., & 8 othersMcWeeney, S., Di Genua, C., Drissen, R., Nerlov, C., Meshinchi, S., Carbone, L., Druker, B. J. & Maxson, J. E., Dec 2022, In: Nature communications. 13, 1, 3471.

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access

  • oncogenes 100%
  • leukemias 81%
  • Enhancer 66%
  • Acute Myeloid Leukemia 53%
  • Oncogenes 53%
  1 Scopus citations

• Biology and medicine in the landscape of quantum advantages

  Cordier, B. A., Sawaya, N. P. D., Guerreschi, G. G. & Mcweeney, S. K., Nov 30 2022, In: Journal of the Royal Society Interface. 19, 196, 20220541.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Medicine 100%
  • Biomolecules 46%
  • Machine Learning 37%
  • Application 31%
  • Machine learning 24%
  16 Scopus citations

• Community-Based SARS-CoV-2 Testing Using Saliva or Nasopharyngeal Swabs to Compare the Performance of Weekly COVID-19 Screening to Wastewater SARS-CoV-2 Signals

  Lu, Z., Brunton, A. E., Mohebnasab, M., Deloney, A., Williamson, K. J., Layton, B. A., Mansell, S., Brawley-Chesworth, A., Abrams, P., Wilcox, K. A., Franklin, F. A., McWeeney, S. K., Streblow, D. N., Fan, G. & Hansel, D. E., Oct 14 2022, In: ACS ES and T Water. 2, 10, p. 1667-1677 11 p.

  Research output: Contribution to journal › Article › peer-review

  • severe acute respiratory syndrome 100%
  • saliva 84%
  • Wastewater 69%
  • Screening 60%
  • screening 55%

• Comprehensive molecular characterization of a rare case of Philadelphia chromosome-positive acute myeloid leukemia

  Rosenberg, M. W., Savage, S. L., Eide, C. A., Reister Schultz, A., Cook, R., Press, R., Rempfer, C., Eickelberg, G., Wilmot, B., McWeeney, S. K., Tyner, J. W., Druker, B. J. & Tognon, C. E., Oct 1 2022, In: Cold Spring Harbor Molecular Case Studies. 8, 6

  Research output: Contribution to journal › Article › peer-review

  • Philadelphia Chromosome 100%
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive 81%
  • Acute Myeloid Leukemia 74%
  • Mutation 65%
  • Pathway Inhibitor 64%

• Dual BTK/SYK inhibition with CG-806 (luxeptinib) disrupts B-cell receptor and Bcl-2 signaling networks in mantle cell lymphoma

  Thieme, E., Liu, T., Bruss, N., Roleder, C., Lam, V., Wang, X., Nechiporuk, T., Shouse, G., Danilova, O. V., Bottomly, D., McWeeney, S. K., Tyner, J. W., Kurtz, S. E. & Danilov, A. V., Mar 2022, In: Cell Death and Disease. 13, 3, 246.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Agammaglobulinaemia Tyrosine Kinase 100%
  • Mantle-Cell Lymphoma 89%
  • B-Lymphocytes 52%
  • Signal Transduction 26%
  • PCI 32765 25%
  11 Scopus citations

• Functional proteomics of patient derived head and neck squamous cell carcinoma cells reveal novel applications of trametinib

  Vigoda, M., Mathieson, C., Evans, N., Hale, C., Jennings, J., Lucero, O., Jeng, S., Bottomly, D., Clayburgh, D., Andersen, P., Li, R., Petrisor, D., Tyner, J. W., McWeeney, S. & Kulesz-Martin, M., 2022, In: Cancer Biology and Therapy. 23, 1, p. 310-318 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • trametinib 100%
  • Squamous Cell Carcinoma of Head and Neck 71%
  • Proteomics 58%
  • glesatinib 25%
  • 6-(6-(1-methyl-1H-pyrazol-4-yl)-(1,2,4)triazolo(4,3-b)pyridazin-3-ylsulfanyl)quinoline 23%
  3 Scopus citations

• Identification and prioritization of myeloid malignancy germline variants in a large cohort of adult patients with AML

  Yang, F., Long, N., Anekpuritanang, T., Bottomly, D., Savage, J. C., Lee, T., Solis-Ruiz, J., Borate, U., Wilmot, B., Tognon, C., Bock, A. M., Pollyea, D. A., Radhakrishnan, S., Radhakrishnan, S., Patel, P., Collins, R. H., Tantravahi, S., Deininger, M. W., Fan, G., Druker, B., & 5 othersShinde, U., Tyner, J. W., Press, R., McWeeney, S. & Agarwal, A., Feb 24 2022, In: Blood. 139, 8, p. 1208-1221 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Haematological 100%
  • Acute Myeloid Leukemia 67%
  • Time 25%
  • Neoplasms 22%
  • Medical Genetics 18%
  43 Scopus citations

• Integrative analysis of drug response and clinical outcome in acute myeloid leukemia

  Bottomly, D., Long, N., Schultz, A. R., Kurtz, S. E., Tognon, C. E., Johnson, K., Abel, M., Agarwal, A., Avaylon, S., Benton, E., Blucher, A., Borate, U., Braun, T. P., Brown, J., Bryant, J., Burke, R., Carlos, A., Chang, B. H., Cho, H. J., Christy, S., & 74 othersCoblentz, C., Cohen, A. M., d'Almeida, A., Cook, R., Danilov, A., Dao, K. H. T., Degnin, M., Dibb, J., Eide, C. A., English, I., Hagler, S., Harrelson, H., Henson, R., Ho, H., Joshi, S. K., Junio, B., Kaempf, A., Kosaka, Y., Laderas, T., Lawhead, M., Lee, H., Leonard, J. T., Lin, C., Lind, E. F., Liu, S. Q., Lo, P., Loriaux, M. M., Luty, S., Maxson, J. E., Macey, T., Martinez, J., Minnier, J., Monteblanco, A., Mori, M., Morrow, Q., Nelson, D., Ramsdill, J., Rofelty, A., Rogers, A., Romine, K. A., Ryabinin, P., Saultz, J. N., Sampson, D. A., Savage, S. L., Schuff, R., Searles, R., Smith, R. L., Spurgeon, S. E., Sweeney, T., Swords, R. T., Thapa, A., Thiel-Klare, K., Traer, E., Wagner, J., Wilmot, B., Wolf, J., Wu, G., Yates, A., Zhang, H., Cogle, C. R., Collins, R. H., Deininger, M. W., Hourigan, C. S., Jordan, C. T., Lin, T. L., Martinez, M. E., Pallapati, R. R., Pollyea, D. A., Pomicter, A. D., Watts, J. M., Weir, S. J., Druker, B. J., McWeeney, S. K. & Tyner, J. W., Aug 8 2022, In: Cancer Cell. 40, 8, p. 850-864.e9

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Acute Myeloid Leukemia 100%
  • Myeloid Cells 53%
  • Pharmaceutical Preparations 43%
  • Drug Development 24%
  • Cell Differentiation 21%
  63 Scopus citations

• Luxeptinib (CG-806) Targets FLT3 and Clusters of Kinases Operative in Acute Myeloid Leukemia

  Rice, W. G., Howell, S. B., Zhang, H., Rastgoo, N., Local, A., Kurtz, S. E., Lo, P., Bottomly, D., Wilmot, B., McWeeney, S. K., Druker, B. J. & Tyner, J. W., Jul 2022, In: Molecular cancer therapeutics. 21, 7, p. 1125-1135 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Acute Myeloid Leukemia 100%
  • Phosphotransferases 81%
  • Heterografts 31%
  • Isocitrate Dehydrogenase 23%
  • Toxicology 16%
  3 Scopus citations

• MS4A3 promotes differentiation in chronic myeloid leukemia by enhancing common β-chain cytokine receptor endocytosis

  Zhao, H., Pomicter, A. D., Eiring, A. M., Franzini, A., Ahmann, J., Hwang, J. Y., Senina, A., Helton, B., Iyer, S., Yan, D., Khorashad, J. S., Zabriskie, M. S., Agarwal, A., Redwine, H. M., Bowler, A. D., Clair, P. M., McWeeney, S. K., Druker, B. J., Tyner, J. W., Stirewalt, D. L., & 8 othersOehler, V. G., Varambally, S., Berrett, K. C., Vahrenkamp, J. M., Gertz, J., Varley, K. E., Radich, J. P. & Deininger, M. W., Feb 3 2022, In: Blood. 139, 5, p. 761-778 18 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Tyrosine Kinase Inhibitor 100%
  • Cytokine Receptors 86%
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive 75%
  • Endocytosis 72%
  • Protein-Tyrosine Kinases 65%
  6 Scopus citations

• Revision of RUNX1 variant curation rules

  the Myeloid Malignancy Variant Curation Expert Panel, Aug 23 2022, In: Blood Advances. 6, 16, p. 4726-4730 5 p.

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access
  6 Scopus citations

• Targeted RNA editing in brainstem alleviates respiratory dysfunction in a mouse model of Rett syndrome

  Sinnamon, J. R., Jacobson, M. E., Yung, J. F., Fisk, J. R., Jeng, S., McWeeney, S. K., Chan, C. N., Yee, S. P., Mandel, G. & Parmelee, L. K., Aug 16 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 33, e2206053119.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • RNA Editing 100%
  • Rett Syndrome 97%
  • Methyl-CpG-Binding Protein 2 87%
  • Brain Stem 64%
  • Guide RNA 39%
  9 Scopus citations
• 2021

  A noncanonical FLT3 gatekeeper mutation disrupts gilteritinib binding and confers resistance

  Joshi, S. K., Sharzehi, S., Pittsenbarger, J., Bottomly, D., Tognon, C. E., McWeeney, S. K., Druker, B. J. & Traer, E., Jul 1 2021, In: American Journal of Hematology. 96, 7, p. E226-E229

  Research output: Contribution to journal › Letter › peer-review

  Open Access
  11 Scopus citations

• Antibody-Free Mass Spectrometry Identification of Vascular Integrity Markers in Major Trauma

  Hinson, H. E., Jacobs, J., McWeeney, S., Wachana, A., Shi, T., Martin, K. & Rodland, K., Jul 1 2021, In: Neurotrauma Reports. 2, 1, p. 322-329 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Mass Spectrometry 100%
  • Blood Vessels 65%
  • Antibodies 61%
  • Wounds and Injuries 53%
  • Proteins 40%
  3 Scopus citations

• Baseline T cell immune phenotypes predict virologic and disease control upon SARS-CoV infection in Collaborative Cross mice

  Graham, J. B., Swarts, J. L., Leist, S. R., Schäfer, A., Menachery, V. D., Gralinski, L. E., Jeng, S., Miller, D. R., Mooney, M. A., McWeeney, S. K., Ferris, M. T., de Villena, F. P. M., Heise, M. T., Baric, R. S. & Lund, J. M., Jan 29 2021, In: PLoS pathogens. 17, 1, e1009287.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Collaborative Cross Mice 100%
  • SARS Virus 78%
  • T-lymphocytes 48%
  • disease control 46%
  • phenotype 35%
  15 Scopus citations

• Correlation of Regulatory T Cell Numbers with Disease Tolerance upon Virus Infection

  Graham, J. B., Swarts, J. L., Edwards, K. R., Voss, K. M., Green, R., Jeng, S., Miller, D. R., Mooney, M. A., McWeeney, S. K., Ferris, M. T., de Villena, F. P. M., Gale, M. & Lund, J. M., Apr 1 2021, In: ImmunoHorizons. 5, 4, p. 157-169 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Regulatory T-Lymphocytes 100%
  • West Nile Fever 96%
  • Cell Count 75%
  • Virus Diseases 74%
  • Collaborative Cross Mice 63%

• Dopamine neuron-specific LRRK2 G2019S effects on gene expression revealed by translatome profiling

  Pallos, J., Jeng, S., McWeeney, S. & Martin, I., Jul 2021, In: Neurobiology of Disease. 155, 105390.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Dopaminergic Neurons 100%
  • Leucine 97%
  • Phosphotransferases 74%
  • Gene Expression 57%
  • Ribosomes 27%
  7 Scopus citations

• Incorporating immunoproteins in the development of classification models of progression of intracranial hemorrhage after traumatic brain injury

  Hinson, H. E., Li, P., Myers, L., Agarwal, C., Pollock, J. & McWeeney, S., Sep 2021, In: Journal of Head Trauma Rehabilitation. 36, 5, p. E322-E328

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Immunoproteins 100%
  • Intracranial Hemorrhages 62%
  • Traumatic Brain Injury 54%
  • Proteins 11%
  • Logistic Models 10%

• Lentiviral-driven discovery of cancer drug resistance mutations

  Yenerall, P., Kollipara, R. K., Avila, K., Peyton, M., Eide, C. A., Bottomly, D., McWeeney, S. K., Liu, Y., Westover, K. D., Druker, B. J., Minna, J. D. & Kittler, R., Sep 15 2021, In: Cancer Research. 81, 18, p. 4685-4695 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Drug Resistance 100%
  • Mutation 61%
  • Imatinib Mesylate 49%
  • Neoplasms 35%
  • Human immunodeficiency virus 1 reverse transcriptase 30%
  5 Scopus citations

• Monocytic Differentiation and AHR Signaling as Primary Nodes of BET Inhibitor Response in Acute Myeloid Leukemia

  Romine, K. A., Nechiporuk, T., Bottomly, D., Jeng, S., McWeeney, S. K., Kaempf, A., Corces, M. R., Majeti, R. & Tyner, J. W., Sep 1 2021, In: Blood cancer discovery. 2, 5, p. 518-531 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Acute Myeloid Leukemia 100%
  • venetoclax 83%
  • Aryl Hydrocarbon Receptors 33%
  • HL-60 Cells 30%
  • Clustered Regularly Interspaced Short Palindromic Repeats 30%
  20 Scopus citations

• Reporting guidelines for human microbiome research: the STORMS checklist

  Genomic Standards Consortium & Massive Analysis and Quality Control Society, Nov 2021, In: Nature medicine. 27, 11, p. 1885-1892 8 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Microbiota 100%
  • Checklist 98%
  • Organizations 84%
  • Guidelines 65%
  • Computational Biology 23%
  148 Scopus citations

• Serine-Threonine Kinase TAO3-Mediated Trafficking of Endosomes Containing the Invadopodia Scaffold TKS5a Promotes Cancer Invasion and Tumor Growth

  Iizuka, S., Quintavalle, M., Navarro, J. C., Gribbin, K. P., Ardecky, R. J., Abelman, M. M., Ma, C. T., Sergienko, E., Zeng, F. Y., Pass, I., Thomas, G. V., McWeeney, S. K., Hassig, C. A., Pinkerton, A. B. & Courtneidge, S. A., Mar 2021, In: Cancer Research. 81, 6, p. 1472-1485 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Podosomes 100%
  • Endosomes 75%
  • Protein-Serine-Threonine Kinases 75%
  • Growth 33%
  • GCK-like kinase 24%
  8 Scopus citations

• The AML microenvironment catalyzes a stepwise evolution to gilteritinib resistance

  Joshi, S. K., Nechiporuk, T., Bottomly, D., Piehowski, P. D., Reisz, J. A., Pittsenbarger, J., Kaempf, A., Gosline, S. J. C., Wang, Y. T., Hansen, J. R., Gritsenko, M. A., Hutchinson, C., Weitz, K. K., Moon, J., Cendali, F., Fillmore, T. L., Tsai, C. F., Schepmoes, A. A., Shi, T., Arshad, O. A., & 12 othersMcDermott, J. E., Babur, O., Watanabe-Smith, K., Demir, E., D'Alessandro, A., Liu, T., Tognon, C. E., Tyner, J. W., McWeeney, S. K., Rodland, K. D., Druker, B. J. & Traer, E., Jul 12 2021, In: Cancer Cell. 39, 7, p. 999-1014.e8

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • gilteritinib 100%
  • Acute Myeloid Leukemia 47%
  • Aurora Kinase B 46%
  • Leukemia 24%
  • Primary Cell Culture 12%
  53 Scopus citations
• 2020

  A Systematic Framework to Rapidly Obtain Data on Patients with Cancer and COVID-19: CCC19 Governance, Protocol, and Quality Assurance

  The COVID-19 and Cancer Consortium, Dec 14 2020, In: Cancer Cell. 38, 6, p. 761-766 6 p.

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access

  • Patient Participation 100%
  • Pandemics 93%
  • Electronic Health Records 90%
  • Neoplasms 85%
  • Eating 66%
  23 Scopus citations

• AZD4320, a dual inhibitor of bcl-2 and bcl-x_l, induces tumor regression in hematologic cancer models without dose-limiting thrombocytopenia

  Balachander, S. B., Criscione, S. W., Byth, K. F., Cidado, J., Adam, A., Lewis, P., Macintyre, T., Wen, S., Lawson, D., Burke, K., Lubinski, T., Tyner, J. W., Kurtz, S. E., McWeeney, S. K., Varnes, J., Diebold, R. B., Gero, T., Ioannidis, S., Hennessy, E. J., McCoull, W., & 18 othersSaeh, J. C., Tabatabai, A., Tavana, O., Su, N., Schuller, A., Garnett, M. J., Jaaks, P., Coker, E. A., Gregory, G. P., Newbold, A., Johnstone, R. W., Gangl, E., Wild, M., Zinda, M., Secrist, J. P., Davies, B. R., Fawell, S. E. & Gibbons, F. D., Dec 2020, In: Clinical Cancer Research. 26, 24, p. 6535-6549 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Thrombocytopenia 100%
  • venetoclax 72%
  • Neoplasms 34%
  • Acute Myeloid Leukemia 28%
  • Cell Line 17%
  37 Scopus citations

• Chronic Voluntary Ethanol Drinking in Cynomolgus Macaques Elicits Gene Expression Changes in Prefrontal Cortical Area 46

  Walter, N. A. R., Zheng, C. L., Searles, R. P., McWeeney, S. K., Grant, K. A. & Hitzemann, R., Feb 1 2020, In: Alcoholism: Clinical and Experimental Research. 44, 2, p. 470-478 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • MicroRNA 100%
  • Macaca 90%
  • Primates 75%
  • Drinking 74%
  • Ethanol 68%
  4 Scopus citations

• Circulating myeloid cells invade the central nervous system to mediate cachexia during pancreatic cancer

  Burfeind, K. G., Zhu, X., Norgard, M. A., Levasseur, P. R., Huisman, C., Buenafe, A. C., Olson, B., Michaelis, K. A., Torres, E. R. S., Jeng, S., McWeeney, S., Raber, J. & Marks, D. L., May 2020, In: eLife. 9, p. 1-27 27 p., e54095.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Intracerebroventricular 100%
  • Cachexia 76%
  • Myeloid Cells 63%
  • Pancreatic Neoplasms 59%
  • Anorexia 50%
  37 Scopus citations

• Clinical impact of COVID-19 on patients with cancer (CCC19): a cohort study

  COVID-19 and Cancer Consortium, Jun 20 2020, In: The Lancet. 395, 10241, p. 1907-1918 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Cohort Studies 100%
  • Neoplasms 47%
  • Mortality 31%
  • Canada 19%
  • Midwestern United States 16%
  1280 Scopus citations

• Complex Genetic Architecture Underlies Regulation of Influenza-A-Virus-Specific Antibody Responses in the Collaborative Cross

  Noll, K. E., Whitmore, A. C., West, A., McCarthy, M. K., Morrison, C. R., Plante, K. S., Hampton, B. K., Kollmus, H., Pilzner, C., Leist, S. R., Gralinski, L. E., Menachery, V. D., Schäfer, A., Miller, D., Shaw, G., Mooney, M., McWeeney, S., Pardo-Manuel de Villena, F., Schughart, K., Morrison, T. E., & 3 othersBaric, R. S., Ferris, M. T. & Heise, M. T., Apr 28 2020, In: Cell Reports. 31, 4, 107587.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Collaborative Cross Mice 100%
  • Population Genetics 65%
  • Genetic Loci 65%
  • Influenza A virus 58%
  • Orthomyxoviridae 53%
  19 Scopus citations

• Discovery and characterization of targetable NTRK point mutations in hematologic neoplasms

  Joshi, S. K., Qian, K., Bisson, W. H., Watanabe-Smith, K., Huang, A., Bottomly, D., Traer, E., Tyner, J. W., McWeeney, S. K., Davare, M. A., Druker, B. J. & Tognon, C. E., Jun 11 2020, In: Blood. 135, 24, p. 2159-2170 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Neurotrophic 100%
  • Receptor Protein-Tyrosine Kinases 67%
  • Hematologic Neoplasms 63%
  • Point Mutation 61%
  • Tyrosine 57%
  21 Scopus citations

• ERBB2/HER2 mutations are transforming and therapeutically targetable in leukemia

  Joshi, S. K., Keck, J. M., Eide, C. A., Bottomly, D., Traer, E., Tyner, J. W., McWeeney, S. K., Tognon, C. E. & Druker, B. J., Oct 1 2020, In: Leukemia. 34, 10, p. 2798-2804 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  13 Scopus citations

• Functional genomic analysis identifies drug targetable pathways in invasive and metastatic cutaneous squamous cell carcinoma

  Anderson, A. N., McClanahan, D., Jacobs, J., Jeng, S., Vigoda, M., Blucher, A. S., Zheng, C., Yoo, Y. J., Hale, C., Ouyang, X., Clayburgh, D., Andersen, P., Tyner, J. W., Bar, A., Lucero, O. M., Leitenberger, J. J., McWeeney, S. K. & Kulesz-Martin, M., Aug 2020, In: Cold Spring Harbor Molecular Case Studies. 6, 4, a005439.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Ephrins 100%
  • Biological Marker 92%
  • Squamous Cell Carcinoma 85%
  • Drug Target 58%
  • Skin 56%
  6 Scopus citations

• Immune Predictors of Mortality after Ribonucleic Acid Virus Infection

  Graham, J. B., Swarts, J. L., Menachery, V. D., Gralinski, L. E., Schäfer, A., Plante, K. S., Morrison, C. R., Voss, K. M., Green, R., Choonoo, G., Jeng, S., Miller, D. R., Mooney, M. A., McWeeney, S. K., Ferris, M. T., De Villena, F. P. M., Gale, M., Heise, M. T., Baric, R. S. & Lund, J. M., Mar 15 2020, In: Journal of Infectious Diseases. 221, 6, p. 882-889 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Collaborative Cross Mice 100%
  • Virus Diseases 78%
  • RNA 73%
  • Mortality 53%
  • Infections 50%
  6 Scopus citations

• Integrated analysis of patient samples identifies biomarkers for venetoclax efficacy and combination strategies in acute myeloid leukemia

  Zhang, H., Nakauchi, Y., Köhnke, T., Stafford, M., Bottomly, D., Thomas, R., Wilmot, B., McWeeney, S. K., Majeti, R. & Tyner, J. W., Aug 1 2020, In: Nature Cancer. 1, 8, p. 826-839 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • venetoclax 100%
  • Acute Myeloid Leukemia 60%
  • Biomarkers 40%
  • AZD5991 29%
  • Synthetic Lethal Mutations 18%
  100 Scopus citations

• In Vivo Repair of a Protein Underlying a Neurological Disorder by Programmable RNA Editing

  Sinnamon, J. R., Kim, S. Y., Fisk, J. R., Song, Z., Nakai, H., Jeng, S., McWeeney, S. K. & Mandel, G., Jul 14 2020, In: Cell Reports. 32, 2, 107878.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • RNA Editing 100%
  • Nervous System Diseases 67%
  • Disorder 61%
  • Mutation 60%
  • RNA 50%
  41 Scopus citations

• Reversible suppression of T cell function in the bone marrow microenvironment of acute myeloid leukemia

  Lamble, A. J., Kosaka, Y., Laderas, T., Maffit, A., Kaempf, A., Brady, L. K., Wang, W., Long, N., Saultz, J. N., Mori, M., Soong, D., LeFave, C. V., Huang, F., Adams, H., Loriaux, M. M., Tognon, C. E., Lo, P., Tyner, J. W., Fan, G., McWeeney, S. K., & 2 othersDruker, B. J. & Lind, E. F., Jun 23 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 25, p. 14331-14341 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Acute Myeloid Leukemia 100%
  • Bone Marrow 76%
  • T-Lymphocytes 64%
  • Induction Chemotherapy 20%
  • Survival 19%
  43 Scopus citations

• Subcellular localization of FANCD2 is associated with survival in ovarian carcinoma

  Joshi, S., Campbell, S., Lim, J. Y., McWeeney, S., Krieg, A., Bean, Y., Pejovic, N., Mhawech-Fauceglia, P. & Pejovic, T., Feb 25 2020, In: Oncotarget. 11, 8, p. 775-783 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Fanconi Anemia Complementation Group D2 Protein 100%
  • Carcinoma 35%
  • Survival 29%
  • Ovarian Neoplasms 19%
  • Epithelial Cells 5%
  4 Scopus citations