Sergio Ojeda

Professor

  • 17488 Citations
  • 72 h-Index
1969 …2020

Research output per year

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Research Output

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Article
2019

EAP1 regulation of GnRH promoter activity is important for human pubertal timing

Mancini, A., Howard, S. R., Cabrera, C. P., Barnes, M. R., David, A., Wehkalampi, K., Heger, S., Lomniczi, A., Guasti, L., Ojeda, S. & Dunkel, L., Apr 15 2019, In : Human molecular genetics. 28, 8, p. 1357-1368 12 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations
2018

Correcting deregulated Fxyd1 expression rescues deficits in neuronal arborization and potassium homeostasis in MeCP2 deficient male mice

Matagne, V., Wondolowski, J., Frerking, M., Shahidullah, M., Delamere, N. A., Sandau, U. S., Budden, S. & Ojeda, S., Oct 15 2018, In : Brain Research. 1697, p. 45-52 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

Elucidating the genetic architecture of reproductive ageing in the Japanese population

Horikoshi, M., Day, F. R., Akiyama, M., Hirata, M., Kamatani, Y., Matsuda, K., Ishigaki, K., Kanai, M., Wright, H., Toro, C. A., Ojeda, S. R., Lomniczi, A., Kubo, M., Ong, K. K. & Perry, J. R. B., Dec 1 2018, In : Nature communications. 9, 1, 1977.

Research output: Contribution to journalArticle

5 Scopus citations

Methylome profiling of healthy and central precocious puberty girls

Bessa, D. S., Maschietto, M., Aylwin, C. F., Canton, A. P. M., Brito, V. N., Macedo, D. B., Cunha-Silva, M., Palhares, H. M. C., de Resende, E. A. M. R., Borges, M. D. F., Mendonca, B. B., Netchine, I., Krepischi, A. C. V., Lomniczi, A., Ojeda, S. R. & Latronico, A. C., Nov 22 2018, In : Clinical epigenetics. 10, 1, 1 p.

Research output: Contribution to journalArticle

2 Scopus citations

SIRT1 mediates obesity- and nutrient-dependent perturbation of pubertal timing by epigenetically controlling Kiss1 expression

Vazquez, M. J., Toro, C. A., Castellano, J. M., Ruiz-Pino, F., Roa, J., Beiroa, D., Heras, V., Velasco, I., Dieguez, C., Pinilla, L., Gaytan, F., Nogueiras, R., Bosch, M. A., Ronnekleiv, O., Lomniczi, A., Ojeda, S. & Tena-Sempere, M., Dec 1 2018, In : Nature Communications. 9, 1, 4194.

Research output: Contribution to journalArticle

11 Scopus citations

Trithorax dependent changes in chromatin landscape at enhancer and promoter regions drive female puberty

Toro, C. A., Wright, H., Aylwin, C. F., Ojeda, S. & Lomniczi, A., Dec 1 2018, In : Nature Communications. 9, 1, 02512.

Research output: Contribution to journalArticle

12 Scopus citations
2016

Engineering a gene silencing viral construct that targets the cat hypothalamus to induce permanent sterility: An update

Dissen, G., Adachi, K., Lomniczi, A., Chatkupt, T., Davidson, B., Nakai, H. & Ojeda, S., 2016, (Accepted/In press) In : Reproduction in Domestic Animals.

Research output: Contribution to journalArticle

3 Scopus citations

Seminal plasma induces ovulation in llamas in the absence of a copulatory stimulus: Role of nerve growth factor as an ovulation-inducing factor

Berland, M. A., Ulloa-Leal, C., Barría, M., Wright, H., Dissen, G., Silva, M. E., Ojeda, S. & Ratto, M. H., Aug 1 2016, In : Endocrinology. 157, 8, p. 3224-3232 9 p.

Research output: Contribution to journalArticle

18 Scopus citations

The emerging role of epigenetics in the regulation of female puberty

Lomniczi, A. & Ojeda, S., 2016, In : Endocrine Development. 29, p. 1-16 16 p.

Research output: Contribution to journalArticle

29 Scopus citations
2015

Epigenetic regulation of puberty via Zinc finger protein-mediated transcriptional repression

Lomniczi, A., Wright, H., Castellano, J. M., Matagne, V., Toro, C. A., Ramaswamy, S., Plant, T. M. & Ojeda, S., Dec 16 2015, In : Nature Communications. 6, 10195.

Research output: Contribution to journalArticle

36 Scopus citations

Expression of the beta-2 adrenergic receptor (ADRB-2) in human and monkey ovarian follicles: A marker of growing follicles?

Merz, C., Saller, S., Kunz, L., Xu, J., Yeoman, R. R., Ting, A. Y., Lawson, M. S., Stouffer, R. L., Hennebold, J. D., Pau, F., Dissen, G. A., Ojeda, S. R., Zelinski, M. B. & Mayerhofer, A., 2015, In : Journal of Ovarian Research. 8, 1, 8.

Research output: Contribution to journalArticle

8 Scopus citations

FBXW12, a novel F box protein-encoding gene, is deleted or methylated in some cases of epithelial ovarian cancer

De La Chesnaye, E., Méndez, J. P., López-Romero, R., Romero-Tlalolini, M. D. L. A., Vergara, M. D., Salcedo, M. & Ojeda, S. R., Jan 1 2015, In : International Journal of Clinical and Experimental Pathology. 8, 9, p. 10192-10203 12 p.

Research output: Contribution to journalArticle

4 Scopus citations

Gene networks, epigenetics and the control of female puberty

Lomniczi, A., Castellano, J. M., Wright, H., Selcuk, B., Sonmez, K. & Ojeda, S. R., Jan 1 2015, In : Research and Perspectives in Endocrine Interactions. 13, p. 97-119 23 p.

Research output: Contribution to journalArticle

1 Scopus citations

Pro-nerve growth factor in the ovary and human granulosa cells

Meinel, S., Blohberger, J., Berg, D., Berg, U., Dissen, G., Ojeda, S. & Mayerhofer, A., Nov 1 2015, In : Hormone Molecular Biology and Clinical Investigation. 24, 2, p. 91-99 9 p.

Research output: Contribution to journalArticle

2 Scopus citations

Readthrough acetylcholinesterase (AChE-R) and regulated necrosis: pharmacological targets for the regulation of ovarian functions?

Blohberger, J., Kunz, L., Einwang, D., Berg, U., Berg, D., Ojeda, S., Dissen, G., Fröhlich, T., Arnold, G. J., Soreq, H., Lara, H. & Mayerhofer, A., 2015, In : Cell Death and Disease. 6, p. e1685

Research output: Contribution to journalArticle

23 Scopus citations
2014

An alternative transcription start site yields estrogen-unresponsive kiss1 mRNA transcripts in the hypothalamus of prepubertal female rats

Castellano, J. M., Wright, H., Ojeda, S. R. & Lomniczi, A., Jul 2014, In : Neuroendocrinology. 99, 2, p. 94-107 14 p.

Research output: Contribution to journalArticle

5 Scopus citations

Excess of nerve growth factor in the ovary causes a polycystic ovary-like syndrome in mice, which closely resembles both reproductive and metabolic aspects of the human syndrome

Wilson, J. L., Chen, W., Dissen, G. A., Ojeda, S. R., Cowley, M. A., Garcia-Rudaz, C. & Enriori, P. J., Nov 1 2014, In : Endocrinology. 155, 11, p. 4494-4506 13 p.

Research output: Contribution to journalArticle

9 Scopus citations

Kisspeptin receptor haplo-insufficiency causes premature ovarian failure despite preserved gonadotropin secretion

Gaytan, F., Garcia-Galiano, D., Dorfman, M. D., Manfredi-Lozano, M., Castellano, J. M., Dissen, G. A., Ojeda, S. R. & Tena-Sempere, M., Aug 2014, In : Endocrinology. 155, 8, p. 3088-3097 10 p.

Research output: Contribution to journalArticle

53 Scopus citations

Loss-of-function mutations in PNPLA6 encoding neuropathy target esterase underlie pubertal failure and neurological deficits in Gordon Holmes syndrome

Topaloglu, A. K., Lomniczi, A., Kretzschmar, D., Dissen, G. A., Kotan, L. D., McArdle, C. A., Koc, A. F., Hamel, B. C., Guclu, M., Papatya, E. D., Eren, E., Mengen, E., Gurbuz, F., Cook, M., Castellano, J. M., Kekil, M. B., Mungan, N. O., Yuksel, B. & Ojeda, S. R., Oct 1 2014, In : Journal of Clinical Endocrinology and Metabolism. 99, 10, p. E2067-E2075

Research output: Contribution to journalArticle

45 Scopus citations

Loss of NTRK2/KISS1R signaling in oocytes causes premature Ovarian failure

Dorfman, M. D., Garcia-Rudaz, C., Alderman, Z., Kerr, B., Lomniczi, A., Dissen, G. A., Castellano, J. M., Garcia-Galiano, D., Gaytan, F., Xu, B., Tena-Sempere, M. & Ojeda, S. R., Aug 2014, In : Endocrinology. 155, 8, p. 3098-3111 14 p.

Research output: Contribution to journalArticle

41 Scopus citations
2013

Changes in hypothalamic expression of the Lin28/let-7 system and related MicroRNAs during postnatal maturation and after experimental manipulations of puberty

Sangiao-Alvarellos, S., Manfredi-Lozano, M., Ruiz-Pino, F., Navarro, V. M., Sánchez-Garrido, M. A., Leon, S., Dieguez, C., Cordido, F., Matagne, V., Dissen, G. A., Ojeda, S. R., Pinilla, L. & Tena-Sempere, M., Feb 1 2013, In : Endocrinology. 154, 2, p. 942-955 14 p.

Research output: Contribution to journalArticle

66 Scopus citations

Correcting deregulated Fxyd1 expression ameliorates a behavioral impairment in a mouse model of Rett syndrome

Matagne, V., Budden, S., Ojeda, S. R. & Raber, J., Feb 16 2013, In : Brain research. 1496, p. 104-114 11 p.

Research output: Contribution to journalArticle

7 Scopus citations

Epigenetic control of female puberty

Lomniczi, A., Loche, A., Castellano, J. M., Ronnekleiv, O. K., Bosch, M., Kaidar, G., Knoll, J. G., Wright, H., Pfeifer, G. P. & Ojeda, S. R., Mar 1 2013, In : Nature Neuroscience. 16, 3, p. 281-289 9 p.

Research output: Contribution to journalArticle

143 Scopus citations

Molecular and gene network analysis of thyroid transcription factor 1 (TTF1) and enhanced at puberty (EAP1) genes in patients with GnRH-dependent pubertal disorders

Cukier, P., Wright, H., Rulfs, T., Silveira, L. F. G., Teles, M. G., Mendonca, B. B., Arnhold, I. J. P., Heger, S., Latronico, A. C., Ojeda, S. R. & Brito, V. N., Oct 1 2013, In : Hormone Research in Paediatrics. 80, 4, p. 257-266 10 p.

Research output: Contribution to journalArticle

15 Scopus citations
2012

Applying Gene Silencing Technology to Contraception

Dissen, G. A., Lomniczi, A., Boudreau, R. L., Chen, Y. H., Davidson, B. L. & Ojeda, S. R., Dec 1 2012, In : Reproduction in Domestic Animals. 47, SUPPL. 6, p. 381-386 6 p.

Research output: Contribution to journalArticle

6 Scopus citations

A single-nucleotide polymorphism in the EAP1 gene is associated with amenorrhea/oligomenorrhea in nonhuman primates

Lomniczi, A., Garcia-Rudaz, C., Ramakrishnan, R., Wilmot, B., Khouangsathiene, S., Ferguson, B., Dissen, G. A. & Ojeda, S. R., Jan 1 2012, In : Endocrinology. 153, 1, p. 339-349 11 p.

Research output: Contribution to journalArticle

20 Scopus citations

Astrocyte-specific disruption of SynCAM1 signaling results in ADHD-like behavioral manifestations

Sandau, U. S., Alderman, Z., Corfas, G., Ojeda, S. R. & Raber, J., Apr 30 2012, In : PloS one. 7, 4, e36424.

Research output: Contribution to journalArticle

16 Scopus citations

Decorin is a part of the ovarian extracellular matrix in primates and may act as a signaling molecule

Adam, M., Saller, S., Ströbl, S., Hennebold, J. D., Dissen, G. A., Ojeda, S. R., Stouffer, R. L., Berg, D., Berg, U. & Mayerhofer, A., Nov 2012, In : Human Reproduction. 27, 11, p. 3249-3258 10 p.

Research output: Contribution to journalArticle

16 Scopus citations

Hypothalamic EAP1 (Enhanced at Puberty 1) is required for menstrual cyclicity in nonhuman primates

Dissen, G. A., Lomniczi, A., Heger, S., Neff, T. L. & Ojeda, S. R., Jan 1 2012, In : Endocrinology. 153, 1, p. 350-361 12 p.

Research output: Contribution to journalArticle

27 Scopus citations

Targeted gene silencing to induce permanent sterility

Dissen, G. A., Lomniczi, A., Boudreau, R. L., Chen, Y. H., Davidson, B. L. & Ojeda, S. R., Aug 1 2012, In : Reproduction in Domestic Animals. 47, SUPPL.4, p. 228-232 5 p.

Research output: Contribution to journalArticle

5 Scopus citations

Thyroid Transcription Factor 1, a Homeodomain Containing Transcription Factor, Contributes to Regulating Periodic Oscillations in GnRH Gene Expression

Matagne, V., Kim, J. G., Ryu, B. J., Hur, M. K., Kim, M. S., Kim, K., Park, B. S., Damante, G., Smiley, G., Lee, B. J. & Ojeda, S. R., Jun 1 2012, In : Journal of Neuroendocrinology. 24, 6, p. 916-929 14 p.

Research output: Contribution to journalArticle

12 Scopus citations

Transcription of the human EAP1 gene is regulated by upstream components of a puberty-controlling Tumor Suppressor Gene network

Mueller, J. K., Koch, I., Lomniczi, A., Loche, A., Rulfs, T., Castellano, J. M., Kiess, W., Ojeda, S. & Heger, S., Apr 4 2012, In : Molecular and Cellular Endocrinology. 351, 2, p. 184-198 15 p.

Research output: Contribution to journalArticle

19 Scopus citations
2011

A novel transcription complex that selectively modulates apoptosis of breast cancer cells through regulation of FASTKD2

Yeung, K. T., Das, S., Zhang, J., Lomniczi, A., Ojeda, S. R., Xu, C. F., Neubert, T. A. & Samuels, H. H., Jun 1 2011, In : Molecular and Cellular Biology. 31, 11, p. 2287-2298 12 p.

Research output: Contribution to journalArticle

32 Scopus citations
11 Scopus citations

Excessive ovarian production of nerve growth factor elicits granulosa cell apoptosis by setting in motion a tumor necrosis factor α/stathmin-mediated death signaling pathway

Garcia-Rudaz, C., Dorfman, M., Nagalla, S., Svechnikov, K., Söder, O., Ojeda, S. R. & Dissen, G. A., Aug 1 2011, In : Reproduction. 142, 2, p. 319-331 13 p.

Research output: Contribution to journalArticle

8 Scopus citations

Neurotrophins acting via TRKB receptors activate the JAGGED1-NOTCH2 cell-cell communication pathway to facilitate early ovarian development

Dorfman, M. D., Kerr, B., Garcia-Rudaz, C., Paredes, A. H., Dissen, G. A. & Ojeda, S. R., Dec 1 2011, In : Endocrinology. 152, 12, p. 5005-5016 12 p.

Research output: Contribution to journalArticle

13 Scopus citations

Preclinical differences of intravascular aav9 delivery to neurons and glia: A comparative study of adult mice and nonhuman primates

Gray, S. J., Matagne, V., Bachaboina, L., Yadav, S., Ojeda, S. R. & Samulski, R. J., Jun 2011, In : Molecular Therapy. 19, 6, p. 1058-1069 12 p.

Research output: Contribution to journalArticle

245 Scopus citations

Preclinical safety of RNAi-mediated HTT suppression in the rhesus macaque as a potential therapy for Huntington's disease

McBride, J. L., Pitzer, M. R., Boudreau, R. L., Dufour, B., Hobbs, T., Ojeda, S. R. & Davidson, B. L., Dec 1 2011, In : Molecular Therapy. 19, 12, p. 2152-2162 11 p.

Research output: Contribution to journalArticle

141 Scopus citations

Prostaglandin E 2 release from astrocytes triggers gonadotropin-releasing hormone (GnRH) neuron firing via EP2 receptor activation

Clasadonte, J., Poulain, P., Hanchate, N. K., Corfas, G., Ojeda, S. R. & Prevot, V., Oct 20 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 38, p. 16104-16109 6 p.

Research output: Contribution to journalArticle

56 Scopus citations

SynCAM1, a synaptic adhesion molecule, is expressed in astrocytes and contributes to erbB4 receptor-mediated control of female sexual development

Sandau, U. S., Mungenast, A. E., Alderman, Z., Sardi, S. P., Fogel, A. I., Taylor, B., Parent, A. S., Biederer, T., Corfas, G. & Ojeda, S. R., Jun 1 2011, In : Endocrinology. 152, 6, p. 2364-2376 13 p.

Research output: Contribution to journalArticle

24 Scopus citations

The synaptic cell adhesion molecule, SynCAM1, mediates astrocyte-to- astrocyte and astrocyte-to-GnRH neuron adhesiveness in the mouse hypothalamus

Sandau, U. S., Mungenast, A. E., McCarthy, J., Biederer, T., Corfas, G. & Ojeda, S. R., Jun 1 2011, In : Endocrinology. 152, 6, p. 2353-2363 11 p.

Research output: Contribution to journalArticle

26 Scopus citations

Transcriptional regulation of the human KiSS1 gene

Mueller, J. K., Dietzel, A., Lomniczi, A., Loche, A., Tefs, K., Kiess, W., Danne, T., Ojeda, S. R. & Heger, S., Aug 6 2011, In : Molecular and Cellular Endocrinology. 342, 1-2, p. 8-19 12 p.

Research output: Contribution to journalArticle

46 Scopus citations
2010

Contribution of glial-neuronal interactions to the neuroendocrine control of female puberty

Ojeda, S. R., Lomniczi, A. & Sandau, U., Dec 1 2010, In : European Journal of Neuroscience. 32, 12, p. 2003-2010 8 p.

Research output: Contribution to journalArticle

35 Scopus citations

Estrogen-dependent transcription of the NEL-like 2 (NELL2) gene and its role in protection from cell death

Choi, E. J., Kim, D. H., Kim, J. G., Kim, D. Y., Kim, J. D., Seol, O. J., Jeong, C. S., Park, J. W., Choi, M. Y., Kang, S. G., Costa, M. E., Ojeda, S. R. & Lee, B. J., Aug 6 2010, In : Journal of Biological Chemistry. 285, 32, p. 25074-25084 11 p.

Research output: Contribution to journalArticle

21 Scopus citations

Oxytocin receptors in the primate ovary: Molecular identity and link to apoptosis in human granulosa cells

Saller, S., Kunz, L., Dissen, G. A., Stouffer, R., Ojeda, S. R., Berg, D., Berg, U. & Mayerhofer, A., Apr 2010, In : Human Reproduction. 25, 4, p. 969-976 8 p.

Research output: Contribution to journalArticle

22 Scopus citations

Role of Estradiol in the Dynamic Control of Tanycyte Plasticity Mediated by Vascular Endothelial Cells in the Median Eminence

De Seranno, S., D'Anglemont De Tassigny, X., Estrella, C., Loyens, A., Kasparov, S., Leroy, D., Ojeda, S. R., Beauvillain, J. C. & Prevot, V., Apr 1 2010, In : Endocrinology. 151, 4, p. 1760-1772 13 p.

Research output: Contribution to journalArticle

47 Scopus citations
2009

Differential erbB signaling in astrocytes from the cerebral cortex and the hypothalamus of the human brain

Sharif, A., Duhem-Tonnelle, V., Allet, C., Baroncini, M., Loyens, A., Kerr-Conte, J., Collier, F., Blond, S., Ojeda, S. R., Junier, M. P. & Prevot, V., Jan 1 2009, In : GLIA. 57, 4, p. 362-379 18 p.

Research output: Contribution to journalArticle

39 Scopus citations

Excessive ovarian production of nerve growth factor facilitates development of cystic ovarian morphology in mice and is a feature of polycystic ovarian syndrome in humans

Dissen, G. A., Garcia-Rudaz, C., Paredes, A., Mayer, C., Mayerhofer, A. & Ojeda, S. R., Jun 1 2009, In : Endocrinology. 150, 6, p. 2906-2914 9 p.

Research output: Contribution to journalArticle

72 Scopus citations

FXYD1, a modulator of Na+, K+-ATPase activity, facilitates female sexual development by maintaining gonadotrophin-releasing hormone neuronal excitability

Garcia-rudaz, C., Deng, V., Matagne, V., Ronnekleiv, O. K., Bosch, M., Han, V., Percy, A. K. & Ojeda, S. R., Jan 27 2009, In : Journal of Neuroendocrinology. 21, 2, p. 108-122 15 p.

Research output: Contribution to journalArticle

14 Scopus citations

Hypothalamic expression of Eap1 is not directly controlled by ovarian steroids

Matagne, V., Mastronardi, C., Shapiro, R. A., Dorsa, D. M. & Ojeda, S. R., Apr 1 2009, In : Endocrinology. 150, 4, p. 1870-1878 9 p.

Research output: Contribution to journalArticle

7 Scopus citations