Sergio Fazio

Professor

  • 14984 Citations
  • 62 h-Index
1979 …2021
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Research Output 1982 2019

2019

A neutral lipid-enriched diet improves myelination and alleviates peripheral nerve pathology in neuropathic mice

Zhou, Y., Bazick, H., Miles, J. R., Fethiere, A. I., Salihi, M. O. A., Fazio, S., Tavori, H. & Notterpek, L., Nov 1 2019, In : Experimental Neurology. 321, 113031.

Research output: Contribution to journalArticle

Open Access
Peripheral Nerves
Pathology
Diet
Lipids
High Fat Diet
10 Citations (Scopus)

Application of PCSK9 Inhibitors in Practice

Kaufman, T., Warden, B. A., Minnier, J., Miles, J. R., Duell, P., Purnell, J., Wojcik, C., Fazio, S. & Shapiro, M., Jan 4 2019, In : Circulation Research. 124, 1, p. 32-37 6 p.

Research output: Contribution to journalArticle

Subtilisin
Proteins
Insurance
Therapeutics
Hydroxymethylglutaryl-CoA Reductase Inhibitors
1 Citation (Scopus)

Brief commentary: Marijuana and cardiovascular disease—what should we tell patients?

Kaufman, T., Fazio, S. & Shapiro, M., Jan 15 2019, In : Annals of Internal Medicine. 170, 2, p. 119-120 2 p.

Research output: Contribution to journalComment/debate

Cannabis
Cardiovascular Diseases
1 Citation (Scopus)
Coronary Angiography
Echocardiography
Coronary Artery Disease
Dilatation
Angiography

Elevated Lipoprotein(a) Levels Lower ABCA1 Cholesterol Efflux Capacity

Tavori, H., Fenton, A. M., Plubell, D. L., Rosario, S., Yerkes, E., Gasik, R., Miles, J., Bergstrom, P., Minnier, J., Fazio, S. & Pamir, N., Oct 1 2019, In : The Journal of clinical endocrinology and metabolism. 104, 10, p. 4793-4803 11 p.

Research output: Contribution to journalArticle

Lipoprotein(a)
Cholesterol
Plasminogen
Serum
Macrophages
2 Citations (Scopus)
Lipoprotein(a)
Niacin
Group Psychotherapy
Therapeutics
Proprotein Convertase 9
44 Citations (Scopus)

Lipoprotein(a), PCSK9 Inhibition, and Cardiovascular Risk

O'Donoghue, M. L., Fazio, S., Giugliano, R. P., Stroes, E. S. G., Kanevsky, E., Gouni-Berthold, I., Im, K. A., Lira Pineda, A., Wasserman, S. M., Češka, R., Ezhov, M. V., Jukema, J. W., Jensen, H. K., Tokgözoğlu, S. L., Mach, F., Huber, K., Sever, P. S., Keech, A. C., Pedersen, T. R. & Sabatine, M. S., Mar 19 2019, In : Circulation. 139, 12, p. 1483-1492 10 p.

Research output: Contribution to journalArticle

Proprotein Convertases
Subtilisin
Lipoprotein(a)
LDL Cholesterol
Numbers Needed To Treat
1 Citation (Scopus)

Overview of Therapeutic Approaches for Cholesterol Lowering and Attenuation of Thrombosis for Prevention of Atherothrombosis

Weitz, J. I. & Fazio, S., Feb 1 2019, In : Circulation Research. 124, 3, p. 351-353 3 p.

Research output: Contribution to journalEditorial

Plasminogen
Fibrinogen
Thrombosis
Collagen
Cholesterol

Preventive Cardiology as a Subspecialty of Cardiovascular Medicine: JACC Council Perspectives

Shapiro, M. D., Maron, D. J., Morris, P. B., Kosiborod, M., Sandesara, P. B., Virani, S. S., Khera, A., Ballantyne, C. M., Baum, S. J., Sperling, L. S., Bhatt, D. L. & Fazio, S., Oct 15 2019, In : Journal of the American College of Cardiology. 74, 15, p. 1926-1942 17 p.

Research output: Contribution to journalReview article

Cardiology
Medicine
Cardiovascular Diseases
Certification
Obesity
8 Citations (Scopus)
Open Access
Lipoprotein(a)
LDL Lipoproteins
LDL Cholesterol
Clinical Trials
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Low Density Lipoprotein Receptor-Related Protein-1
CC Chemokines
Chemokine Receptors
Atherosclerosis
Macrophages
7 Citations (Scopus)

The forgotten lipids: Triglycerides, remnant cholesterol, and atherosclerotic cardiovascular disease risk

Sandesara, P. B., Virani, S. S., Fazio, S. & Shapiro, M., Jan 1 2019, In : Endocrine reviews. 40, 2, p. 537-557 21 p.

Research output: Contribution to journalReview article

Triglycerides
Cardiovascular Diseases
Cholesterol
Lipids
Lipoproteins
1 Citation (Scopus)

The PCSK9 revolution: Current status, controversies, and future directions

Warden, B. A., Fazio, S. & Shapiro, M., Jan 1 2019, In : Trends in Cardiovascular Medicine.

Research output: Contribution to journalReview article

Open Access
LDL Cholesterol
Cardiovascular Diseases
Cholesterol
Hyperlipoproteinemia Type II
United States Food and Drug Administration
1 Citation (Scopus)

The Role of the Clinical Pharmacist in a Preventive Cardiology Practice

Warden, B. A., Shapiro, M. & Fazio, S., Jan 1 2019, (Accepted/In press) In : Annals of Pharmacotherapy.

Research output: Contribution to journalArticle

Cardiology
Pharmacists
Health Expenditures
Costs and Cost Analysis
Medication Adherence
2018
2 Citations (Scopus)

Balanced high fat diet reduces cardiovascular risk in obese women although changes in adipose tissue, lipoproteins, and insulin resistance differ by race

Niswender, K. D., Fazio, S., Gower, B. A. & Silver, H. J., May 1 2018, In : Metabolism: Clinical and Experimental. 82, p. 125-134 10 p.

Research output: Contribution to journalArticle

High Fat Diet
Lipoproteins
Insulin Resistance
Adipose Tissue
African Americans

Biologic bases of residual risk of cardiovascular events: A flawed concept

Shapiro, M. & Fazio, S., Nov 1 2018, In : European Journal of Preventive Cardiology. 25, 17, p. 1831-1835 5 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

CETP inhibition improves hdl function but leads to fatty liver and insulin resistance in CETP-expressing transgenic mice on a high-fat diet

Zhu, L., Luu, T., Emfinger, C. H., Parks, B. A., Shi, J., Trefts, E., Zeng, F., Kuklenyik, Z., Harris, R. C., Wasserman, D. H., Fazio, S. & Stafford, J. M., Dec 1 2018, In : Diabetes. 67, 12, p. 2494-2506 13 p.

Research output: Contribution to journalArticle

Cholesterol Ester Transfer Proteins
High Fat Diet
Fatty Liver
Transgenic Mice
Insulin Resistance
2 Citations (Scopus)

Chronic kidney disease alters lipid trafficking and inflammatory responses in macrophages: Effects of liver X receptor agonism

Kaseda, R., Tsuchida, Y., Yang, H. C., Yancey, P. G., Zhong, J., Tao, H., Bian, A., Fogo, A. B., Linton, M. R. F., Fazio, S., Ikizler, T. A. & Kon, V., Jan 27 2018, In : BMC Nephrology. 19, 1, 17.

Research output: Contribution to journalArticle

Chronic Renal Insufficiency
Macrophages
Lipids
Cholesterol
Mitogen-Activated Protein Kinase 3
1 Citation (Scopus)

Comparison of Medical Care Utilization and Costs Among Patients With Statin-Controlled Low-Density Lipoprotein Cholesterol With Versus Without Hypertriglyceridemia

Nichols, G. A., Philip, S., Reynolds, K., Granowitz, C. B., O'Keeffe-Rosetti, M. & Fazio, S., Jan 1 2018, (Accepted/In press) In : American Journal of Cardiology.

Research output: Contribution to journalArticle

Hydroxymethylglutaryl-CoA Reductase Inhibitors
Hypertriglyceridemia
Health Care Costs
LDL Cholesterol
Triglycerides
Hypertriglyceridemia
Estrogens
Xanthomatosis
Embryo Transfer
Triglycerides
10 Citations (Scopus)

Deletion of Macrophage Low-Density Lipoprotein Receptor-Related Protein 1 (LRP1) Accelerates Atherosclerosis Regression and Increases C-C Chemokine Receptor Type 7 (CCR7) Expression in Plaque Macrophages

Mueller, P. A., Zhu, L., Tavori, H., Huynh, K., Giunzioni, I., Stafford, J. M., Linton, M. F. & Fazio, S., Oct 23 2018, In : Circulation. 138, 17, p. 1850-1863 14 p.

Research output: Contribution to journalArticle

Low Density Lipoprotein Receptor-Related Protein-1
CC Chemokines
Chemokine Receptors
Atherosclerosis
Macrophages
8 Citations (Scopus)

Diagnosing resistance to a proprotein convertase subtilisin/kexin type 9 inhibitor

Shapiro, M., Miles, J., Tavori, H. & Fazio, S., Mar 6 2018, In : Annals of Internal Medicine. 168, 5, p. 376-379 4 p.

Research output: Contribution to journalLetter

Proprotein Convertase 9
1 Citation (Scopus)

Exercise is Associated with Increased Small HDL Particle Concentration and Decreased Vascular Stiffness in Rheumatoid Arthritis

Byram, K. W., Oeser, A. M., Linton, M. F., Fazio, S., Stein, C. M. & Ormseth, M. J., Dec 1 2018, In : Journal of Clinical Rheumatology. 24, 8, p. 417-421 5 p.

Research output: Contribution to journalArticle

Vascular Stiffness
Rheumatoid Arthritis
Exercise
Metabolic Equivalent
Waist-Hip Ratio
15 Citations (Scopus)

Increased cardiovascular risk in hypertriglyceridemic patients with statin-controlled LDL cholesterol

Nichols, G. A., Philip, S., Reynolds, K., Granowitz, C. B. & Fazio, S., Jan 1 2018, In : Journal of Clinical Endocrinology and Metabolism. 103, 8, p. 3019-3027 9 p.

Research output: Contribution to journalArticle

Hydroxymethylglutaryl-CoA Reductase Inhibitors
LDL Cholesterol
Triglycerides
Composite materials
Myocardial Infarction
13 Citations (Scopus)

Increased residual cardiovascular risk in patients with diabetes and high versus normal triglycerides despite statin-controlled LDL cholesterol

Nichols, G. A., Philip, S., Reynolds, K., Granowitz, C. B. & Fazio, S., Jan 1 2018, (Accepted/In press) In : Diabetes, Obesity and Metabolism.

Research output: Contribution to journalArticle

Hydroxymethylglutaryl-CoA Reductase Inhibitors
LDL Cholesterol
Triglycerides
Cardiovascular Diseases
Unstable Angina
3 Citations (Scopus)

Lipoprotein Apheresis Acutely Reverses Coronary Microvascular Dysfunction in Patients With Severe Hypercholesterolemia

Wu, M. D., Moccetti, F., Brown, E., Davidson, B. P., Atkinson, T. T., Belcik, J. T., Giraud, G., Duell, P., Fazio, S., Tavori, H., Tsimikas, S. & Lindner, J., Jan 1 2018, (Accepted/In press) In : JACC: Cardiovascular Imaging.

Research output: Contribution to journalArticle

Blood Component Removal
Hypercholesterolemia
Lipoproteins
Perfusion
Femoral Artery
1 Citation (Scopus)

Medication-based versus target-based lipid management

Fazio, S. & Shapiro, M., Jan 1 2018, (Accepted/In press) In : Journal of Diabetes.

Research output: Contribution to journalArticle

Lipids
58 Citations (Scopus)

NHLBI Working Group Recommendations to Reduce Lipoprotein(a)-Mediated Risk of Cardiovascular Disease and Aortic Stenosis

Tsimikas, S., Fazio, S., Ferdinand, K. C., Ginsberg, H. N., Koschinsky, M. L., Marcovina, S. M., Moriarty, P. M., Rader, D. J., Remaley, A. T., Reyes-Soffer, G., Santos, R. D., Thanassoulis, G., Witztum, J. L., Danthi, S., Olive, M. & Liu, L., Jan 16 2018, In : Journal of the American College of Cardiology. 71, 2, p. 177-192 16 p.

Research output: Contribution to journalReview article

National Heart, Lung, and Blood Institute (U.S.)
Lipoprotein(a)
Aortic Valve Stenosis
Cardiovascular Diseases
Aortic Diseases
19 Citations (Scopus)

PCSK9 from basic science discoveries to clinical trials

Shapiro, M., Tavori, H. & Fazio, S., May 1 2018, In : Circulation research. 122, 10, p. 1420-1438 19 p.

Research output: Contribution to journalReview article

Clinical Trials
Cardiovascular Diseases
Drug Discovery
Lipoproteins
Therapeutics

Predicting hypertriglyceridemic pancreatitis - Not so fast!

Shapiro, M. & Fazio, S., May 1 2018, In : Endocrine Practice. 24, 5, p. 495-497 3 p.

Research output: Contribution to journalComment/debate

Pancreatitis

Raising the Bar by Lowering the Target: Integrating PCSK9 Inhibitors Into Hypercholesterolemia Management

Ballantyne, C. M., Bhatt, D. L., Cannon, C. P., Fazio, S. & Sabatine, M. S., Jan 1 2018, (Accepted/In press) In : American Journal of Cardiology.

Research output: Contribution to journalArticle

Subtilisin
Hypercholesterolemia
Enzyme Inhibitors
LDL Cholesterol
Proteins
6 Citations (Scopus)

Relationship of lipoprotein(a) molar concentrations and mass according to lipoprotein(a) thresholds and apolipoprotein(a) isoform size

Tsimikas, S., Fazio, S., Viney, N. J., Xia, S., Witztum, J. L. & Marcovina, S. M., Jan 1 2018, (Accepted/In press) In : Journal of Clinical Lipidology.

Research output: Contribution to journalArticle

Apoprotein(a)
Lipoprotein(a)
Protein Isoforms
Lipid Metabolism
Research
23 Citations (Scopus)

The Evolving Future of PCSK9 Inhibitors

Rosenson, R. S., Hegele, R. A., Fazio, S. & Cannon, C. P., Jul 17 2018, In : Journal of the American College of Cardiology. 72, 3, p. 314-329 16 p.

Research output: Contribution to journalReview article

LDL Lipoproteins
Cardiovascular Diseases
Monoclonal Antibodies
Clinical Trials
Hydroxymethylglutaryl-CoA Reductase Inhibitors
1 Citation (Scopus)
Hyperlipoproteinemia Type II
Hyperlipoproteinemia Type II
2017
3 Citations (Scopus)

A case of severe acquired hypertriglyceridemia in a 7-year-old girl

Lilley, J. S., Linton, M. F., Kelley, J. C., Graham, T. B., Fazio, S. & Tavori, H., 2017, (Accepted/In press) In : Journal of Clinical Lipidology.

Research output: Contribution to journalArticle

Hypertriglyceridemia
Lipoprotein Lipase
Triglycerides
Hyperlipoproteinemia Type I
Pancreatitis
266 Citations (Scopus)

AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS AND AMERICAN COLLEGE OF ENDOCRINOLOGY GUIDELINES FOR MANAGEMENT OF DYSLIPIDEMIA AND PREVENTION OF CARDIOVASCULAR DISEASE

Jellinger, P. S., Handelsman, Y., Rosenblit, P. D., Bloomgarden, Z. T., Fonseca, V. A., Garber, A. J., Grunberger, G., Guerin, C. K., Bell, D. S. H., Mechanick, J. I., Pessah-Pollack, R., Wyne, K., Smith, D., Brinton, E. A., Fazio, S. & Davidson, M., Apr 1 2017, In : Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists. 23, p. 1-87 87 p.

Research output: Contribution to journalArticle

Endocrinology
Dyslipidemias
Hyperlipoproteinemia Type II
Cardiovascular Diseases
Guidelines
50 Citations (Scopus)

AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS AND AMERICAN COLLEGE OF ENDOCRINOLOGY GUIDELINES FOR MANAGEMENT OF DYSLIPIDEMIA AND PREVENTION OF CARDIOVASCULAR DISEASE - EXECUTIVE SUMMARYComplete Appendix to Guidelines available at http: //journals.aace.com

Jellinger, P. S., Handelsman, Y., Rosenblit, P. D., Bloomgarden, Z. T., Fonseca, V. A., Garber, A. J., Grunberger, G., Guerin, C. K., Bell, D. S. H., Mechanick, J. I., Pessah-Pollack, R., Wyne, K., Smith, D., Brinton, E. A., Fazio, S., Davidson, M., Zangeneh, F. & Bush, M. A., Apr 2 2017, In : Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists. 23, 4, p. 479-497 19 p.

Research output: Contribution to journalArticle

Hyperlipoproteinemia Type II
Endocrinology
Dyslipidemias
Practice Guidelines
Cardiovascular Diseases
8 Citations (Scopus)

Apolipoprotein B-containing lipoproteins and atherosclerotic cardiovascular disease

Fazio, S. & Shapiro, M., 2017, In : F1000Research. 6, 134.

Research output: Contribution to journalReview article

Apolipoproteins B
Lipoproteins
Cardiovascular Diseases
Cholesterol
Cardiovascular Agents
11 Citations (Scopus)

Application of PCSK9 inhibitors in practice: Challenges and opportunities

Kaufman, T., Duell, P., Purnell, J., Wojcik, C., Fazio, S. & Shapiro, M., Aug 1 2017, In : Circulation Research. 121, 5, p. 499-501 3 p.

Research output: Contribution to journalReview article

Modern 1601-history
Clinical Medicine
Patient Care
Pharmacology
Proprotein Convertase 9
15 Citations (Scopus)
Lipoprotein(a)
LDL Cholesterol
Monoclonal Antibodies
LDL Lipoproteins
LDL Receptors
2 Citations (Scopus)

Dyslipidaemia: The PCSK9 adventure-humanizing extreme LDL lowering

Shapiro, M. & Fazio, S., Jun 1 2017, In : Nature Reviews Cardiology. 14, 6, p. 319-320 2 p.

Research output: Contribution to journalShort survey

4 Citations (Scopus)

Effects of 12 weeks of treatment with intravenously administered bococizumab, a humanized monoclonal antibody blocking proprotein convertase subtilisin/kexin type 9, in hypercholesterolemic subjects on high-dose statin

Fazio, S., Robertson, D. G., Joh, T., Wan, H., Riel, T., Forgues, P., Baum, C. M., Garzone, P. D. & Gumbiner, B., Jan 1 2017, (Accepted/In press) In : Cardiovascular Therapeutics.

Research output: Contribution to journalArticle

Antibodies, Monoclonal, Humanized
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Blocking Antibodies
Placebos
Therapeutics

Loss of SPRR3 in ApoE-/- mice leads to atheroma vulnerability through Akt dependent and independent effects in VSMCs

Lietman, C. D., Segedy, A. K., Li, B., Fazio, S., Atkinson, J. B., Linton, M. F. & Young, P. P., Sep 1 2017, In : PLoS One. 12, 9, e0184620.

Research output: Contribution to journalArticle

Cornified Envelope Proline-Rich Proteins
Apolipoproteins E
Atherosclerotic Plaques
Vascular Smooth Muscle
blood vessels
352 Citations (Scopus)

Low-density lipoproteins cause atherosclerotic cardiovascular disease. 1. Evidence from genetic, epidemiologic, and clinical studies. A consensus statement fromthe European Atherosclerosis Society Consensus Panel

Ference, B. A., Ginsberg, H. N., Graham, I., Ray, K. K., Packard, C. J., Bruckert, E., Hegele, R. A., Krauss, R. M., Raal, F. J., Schunkert, H., Watt, G. F., Borén, J., Fazio, S., Horton, J. D., Masana, L., Nicholls, S. J., Nordestgaard, B. G., Van De Sluis, B., Taskinen, M. R., Tokgözoǧlu, L. & 6 others, Landmesser, U., Laufs, U., Wiklund, O., Stock, J. K., Chapman, M. J. & Catapano, A. L., Aug 21 2017, In : European Heart Journal. 38, 32, p. 2459-2472 14 p.

Research output: Contribution to journalArticle

LDL Lipoproteins
Epidemiologic Studies
Cardiovascular Diseases
Random Allocation
Clinical Studies
21 Citations (Scopus)

PCSK9 and atherosclerosis - lipids and beyond

Shapiro, M. & Fazio, S., 2017, In : Journal of Atherosclerosis and Thrombosis. 24, 5, p. 462-472 11 p.

Research output: Contribution to journalReview article

Proprotein Convertases
Subtilisin
Atherosclerosis
Lipids
Cholesterol
4 Citations (Scopus)

Setting the Agenda for Preventive Cardiology

Shapiro, M. & Fazio, S., Jul 21 2017, In : Circulation Research. 121, 3, p. 211-213 3 p.

Research output: Contribution to journalComment/debate

Cardiology
Atherosclerosis
Cardiovascular Diseases
Myocardial Infarction
Cholesterol
6 Citations (Scopus)

Threshold Effects of Circulating Angiopoietin-Like 3 Levels on Plasma Lipoproteins

Fazio, S., Minnier, J., Shapiro, M., Tsimikas, S., Tarugi, P., Averna, M. R., Arca, M. & Tavori, H., Sep 1 2017, In : The Journal of clinical endocrinology and metabolism. 102, 9, p. 3340-3348 9 p.

Research output: Contribution to journalArticle

Angiopoietins
Lipoproteins
Proprotein Convertases
Subtilisin
Plasmas
2016
20 Citations (Scopus)

A systematic review of PCSK9 inhibitors alirocumab and evolocumab

McDonagh, M., Peterson, K., Holzhammer, B. & Fazio, S., Jun 1 2016, In : Journal of managed care & specialty pharmacy. 22, 6, p. 641-653 13 p.

Research output: Contribution to journalArticle

Proprotein Convertases
Subtilisin
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Hyperlipoproteinemia Type II
Health
50 Citations (Scopus)

Biology of proprotein convertase subtilisin kexin 9: Beyond low-density lipoprotein cholesterol lowering

Norata, G. D., Tavori, H., Pirillo, A., Fazio, S. & Catapano, A. L., Oct 1 2016, In : Cardiovascular Research. 112, 1, p. 429-442 14 p.

Research output: Contribution to journalReview article

Proprotein Convertases
Subtilisin
LDL Cholesterol
Hypercholesterolemia
Cardiovascular Diseases