Research Output 1982 2017

2017

A case of severe acquired hypertriglyceridemia in a 7-year-old girl

Lilley, J. S., Linton, M. F., Kelley, J. C., Graham, T. B., Fazio, S. & Tavori, H. 2017 (Accepted/In press) In : Journal of Clinical Lipidology.

Research output: Research - peer-reviewArticle

Hypertriglyceridemia
Triglycerides
Lipoprotein Lipase
Pancreatitis
Hyperlipoproteinemia Type I
7 Citations

AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS AND AMERICAN COLLEGE OF ENDOCRINOLOGY GUIDELINES FOR MANAGEMENT OF DYSLIPIDEMIA AND PREVENTION OF CARDIOVASCULAR DISEASE - EXECUTIVE SUMMARYComplete Appendix to Guidelines available at http: //journals.aace.com

Jellinger, P. S., Handelsman, Y., Rosenblit, P. D., Bloomgarden, Z. T., Fonseca, V. A., Garber, A. J., Grunberger, G., Guerin, C. K., Bell, D. S. H., Mechanick, J. I., Pessah-Pollack, R., Wyne, K., Smith, D., Brinton, E. A., Fazio, S., Davidson, M., Zangeneh, F. & Bush, M. A. Apr 2 2017 In : Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists. 23, 4, p. 479-497 19 p.

Research output: Research - peer-reviewArticle

Hyperlipoproteinemia Type II
Endocrinology
Dyslipidemias
Practice Guidelines
Cardiovascular Diseases
Apolipoproteins B
Lipoproteins
Cardiovascular Diseases
Cholesterol
Foam Cells
1 Citations
Proprotein Convertase 9
Modern 1601-history
Clinical Medicine
Patient Care
Pharmacology
1 Citations
Lipoprotein(a)
LDL Cholesterol
Monoclonal Antibodies
Proprotein Convertase 9
LDL Lipoproteins
1 Citations

Dyslipidaemia: The PCSK9 adventure-humanizing extreme LDL lowering

Shapiro, M. D. & Fazio, S. Jun 1 2017 In : Nature Reviews Cardiology. 14, 6, p. 319-320 2 p.

Research output: Research - peer-reviewShort survey

Loss of SPRR3 in ApoE-/- mice leads to atheroma vulnerability through Akt dependent and independent effects in VSMCs

Lietman, C. D., Segedy, A. K., Li, B., Fazio, S., Atkinson, J. B., Linton, M. F. & Young, P. P. Sep 1 2017 In : PLoS ONE. 12, 9, e0184620

Research output: Research - peer-reviewArticle

blood vessels
smooth muscle
myocytes
mice
Apolipoproteins E
22 Citations

Low-density lipoproteins cause atherosclerotic cardiovascular disease. 1. Evidence from genetic, epidemiologic, and clinical studies. A consensus statement fromthe European Atherosclerosis Society Consensus Panel

Ference, B. A. , Ginsberg, H. N. , Graham, I. , Ray, K. K. , Packard, C. J. , Bruckert, E. , Hegele, R. A. , Krauss, R. M. , Raal, F. J. , Schunkert, H. , Watt, G. F. , Borén, J. , Fazio, S. , Horton, J. D. , Masana, L. , Nicholls, S. J. , Nordestgaard, B. G. , Van De Sluis, B. , Taskinen, M. R. , Tokgözoǧlu, L. & 6 others Landmesser, U., Laufs, U., Wiklund, O., Stock, J. K., Chapman, M. J. & Catapano, A. L. Aug 21 2017 In : European Heart Journal. 38, 32, p. 2459-2472 14 p.

Research output: Research - peer-reviewArticle

LDL Lipoproteins
Epidemiologic Studies
Cardiovascular Diseases
Clinical Studies
Random Allocation
1 Citations

PCSK9 and atherosclerosis - lipids and beyond

Shapiro, M. D. & Fazio, S. 2017 In : Journal of Atherosclerosis and Thrombosis. 24, 5, p. 462-472 11 p.

Research output: Research - peer-reviewReview article

Atherosclerosis
Lipids
Proprotein Convertase 9
Proprotein Convertases
Subtilisin

Setting the Agenda for Preventive Cardiology

Shapiro, M. D. & Fazio, S. Jul 21 2017 In : Circulation Research. 121, 3, p. 211-213 3 p.

Research output: Research - peer-reviewComment/debate

Threshold Effects of Circulating Angiopoietin-Like 3 Levels on Plasma Lipoproteins

Fazio, S., Minnier, J., Shapiro, M. D., Tsimikas, S., Tarugi, P., Averna, M. R., Arca, M. & Tavori, H. Sep 1 2017 In : The Journal of clinical endocrinology and metabolism. 102, 9, p. 3340-3348 9 p.

Research output: Research - peer-reviewArticle

Angiopoietins
Lipoproteins
Plasmas
LDL Lipoproteins
Proprotein Convertase 9
2016
7 Citations

A systematic review of PCSK9 inhibitors alirocumab and evolocumab

McDonagh, M., Peterson, K., Holzhammer, B. & Fazio, S. Jun 1 2016 In : Journal of managed care & specialty pharmacy. 22, 6, p. 641-653 13 p.

Research output: Research - peer-reviewArticle

Proprotein Convertases
Subtilisin
alirocumab
AMG 145
Proprotein Convertase 9
10 Citations

Biology of proprotein convertase subtilisin kexin 9: Beyond low-density lipoprotein cholesterol lowering

Norata, G. D., Tavori, H., Pirillo, A., Fazio, S. & Catapano, A. L. Oct 1 2016 In : Cardiovascular Research. 112, 1, p. 429-442 14 p.

Research output: Research - peer-reviewReview article

Proprotein Convertases
Subtilisin
LDL Cholesterol
Hypercholesterolemia
Cardiovascular Diseases
4 Citations

Effect of Drug Therapy on Net Cholesterol Efflux Capacity of High-Density Lipoprotein–Enriched Serum in Rheumatoid Arthritis

Ormseth, M. J. , Yancey, P. G. , Solus, J. F. , Louis Bridges, S. , Curtis, J. R. , Linton, M. F. , Fazio, S. , Davies, S. S. , Roberts, L. J. , Vickers, K. C. , Kon, V. , Michael Stein, C. , Bingham, C. O. , Cofield, S. S. , Furie, R. , Gregersen, P. K. , Genovese, M. C. , Robinson, W. H. , Levesque, M. C. , Moreland, L. W. & 7 others Nigrovic, P. A., Shadick, N. A., O'Dell, J. R., Thiele, G. M., St.Clair, E. W., Striebich, C. C. & the TETRAD Investigators Sep 1 2016 In : Arthritis and Rheumatology. 68, 9, p. 2099-2105 7 p.

Research output: Research - peer-reviewArticle

HDL Lipoproteins
Rheumatoid Arthritis
Cholesterol
Drug Therapy
Serum
37 Citations

From Lipids to Inflammation: New Approaches to Reducing Atherosclerotic Risk

Shapiro, M. D. & Fazio, S. Feb 19 2016 In : Circulation Research. 118, 4, p. 732-749 18 p.

Research output: Research - peer-reviewArticle

Hydroxymethylglutaryl-CoA Reductase Inhibitors
Cardiovascular Diseases
Inflammation
Lipids
Therapeutics
2 Citations

HDL particle size and functional heterogeneity

Fazio, S. & Pamir, N. Sep 2 2016 In : Circulation Research. 119, 6, p. 704-707 4 p.

Research output: Research - peer-reviewReview article

8 Citations

Human PCSK9 promotes hepatic lipogenesis and atherosclerosis development via apoE-and LDLR-mediated mechanisms

Tavori, H., Giunzioni, I., Predazzi, I. M., Plubell, D., Shivinsky, A., Miles, J., DeVay, R. M., Liang, H., Rashid, S., Linton, M. R. F. & Fazio, S. May 15 2016 In : Cardiovascular Research. 110, 2, p. 268-278 11 p.

Research output: Research - peer-reviewArticle

Low Density Lipoprotein Receptor-Related Protein-1
Lipogenesis
LDL Receptors
Atherosclerosis
Liver
10 Citations

Is isolated low high-density lipoprotein cholesterol a cardiovascular disease risk factor?

Bartlett, J., Predazzi, I. M., Williams, S. M., Bush, W. S., Kim, Y., Havas, S., Toth, P. P., Fazio, S. & Miller, M. May 1 2016 In : Circulation: Cardiovascular Quality and Outcomes. 9, 3, p. 206-212 7 p.

Research output: Research - peer-reviewArticle

LDL Cholesterol
HDL Cholesterol
Cardiovascular Diseases
Cohort Studies
low density lipoprotein triglyceride
8 Citations

Jnk1 Deficiency in Hematopoietic Cells Suppresses Macrophage Apoptosis and Increases Atherosclerosis in Low-Density Lipoprotein Receptor Null Mice

Babaev, V. R., Yeung, M., Erbay, E., Ding, L., Zhang, Y., May, J. M., Fazio, S., Hotamisligil, G. S. & Linton, M. R. F. Apr 21 2016 (Accepted/In press) In : Arteriosclerosis, Thrombosis, and Vascular Biology.

Research output: Research - peer-reviewArticle

JNK Mitogen-Activated Protein Kinases
LDL Receptors
Atherosclerosis
Macrophages
Apoptosis
19 Citations

Local effects of human PCSK9 on the atherosclerotic lesion

Giunzioni, I., Tavori, H., Covarrubias, R., Major, A. S., Ding, L., Zhang, Y., Devay, R. M., Hong, L., Fan, D., Predazzi, I. M., Rashid, S., Linton, M. F. & Fazio, S. Jan 1 2016 In : Journal of Pathology. 238, 1, p. 52-62 11 p.

Research output: Research - peer-reviewArticle

Proprotein Convertase 9
human PCSK9 protein
LDL Receptors
Macrophages
Apolipoproteins E
4 Citations

Loss of Macrophage Low-Density Lipoprotein Receptor–Related Protein 1 Confers Resistance to the Antiatherogenic Effects of Tumor Necrosis Factor-α Inhibition

Zhu, L., Giunzioni, I., Tavori, H., Covarrubias, R., Ding, L., Zhang, Y., Ormseth, M., Major, A. S., Stafford, J. M., Linton, M. R. F. & Fazio, S. Jun 30 2016 (Accepted/In press) In : Arteriosclerosis, Thrombosis, and Vascular Biology.

Research output: Research - peer-reviewArticle

Low Density Lipoprotein Receptor-Related Protein-1
Tumor Necrosis Factor-alpha
Macrophages
LDL Receptors
Apolipoproteins E
6 Citations

Macrophage IκB Kinase α Deficiency Suppresses Akt Phosphorylation, Reduces Cell Survival, and Decreases Early Atherosclerosis

Babaev, V. R., Ding, L., Zhang, Y., May, J. M., Lin, C. P., Fazio, S. & Linton, M. F. Feb 4 2016 (Accepted/In press) In : Arteriosclerosis, Thrombosis, and Vascular Biology.

Research output: Research - peer-reviewArticle

Cell Survival
Atherosclerosis
Phosphotransferases
Macrophages
Phosphorylation

Net cholesterol efflux capacity of HDL enriched serum and coronary atherosclerosis in rheumatoid arthritis

Ormseth, M. J., Yancey, P. G., Yamamoto, S., Oeser, A. M., Gebretsadik, T., Shintani, A., Linton, M. F., Fazio, S., Davies, S. S., Roberts, L. J., Vickers, K. C., Raggi, P., Kon, V. & Stein, C. M. Dec 1 2016 In : IJC Metabolic and Endocrine. 13, p. 6-11 6 p.

Research output: Research - peer-reviewArticle

Coronary Artery Disease
Rheumatoid Arthritis
Cholesterol
Serum
Calcium
18 Citations

PCSK9 Association With Lipoprotein(a)

Tavori, H., Christian, D., Minnier, J., Plubell, D., Shapiro, M. D., Yeang, C., Giunzioni, I., Croyal, M., Duell, P. B., Lambert, G., Tsimikas, S. & Fazio, S. Apr 29 2016 (Accepted/In press) In : Circulation Research.

Research output: Research - peer-reviewArticle

Lipoprotein(a)
Proprotein Convertase 9
Apoprotein(a)
LDL Lipoproteins
Apolipoproteins B

Polyunsaturated fat intake and mortality in non-statin users, is there an independent relationship? The authors reply

Kiage, J. N., Sampson, U. K. A., Lipworth, L., Fazio, S., Mensah, G. A., Yu, Q., Munro, H., Akwo, E. A., Dai, Q., Blot, W. J. & Kabagambe, E. K. Jan 1 2016 In : Nutrition, Metabolism and Cardiovascular Diseases. 26, 1, p. 78-79 2 p.

Research output: Research - peer-reviewArticle

74 Citations

Variation in PCSK9 and HMGCR and risk of cardiovascular disease and diabetes

Ference, B. A., Robinson, J. G., Brook, R. D., Catapano, A. L., Chapman, M. J., Neff, D. R., Voros, S., Giugliano, R. P., Smith, G. D., Fazio, S. & Sabatine, M. S. Dec 1 2016 In : New England Journal of Medicine. 375, 22, p. 2144-2153 10 p.

Research output: Research - peer-reviewArticle

Cardiovascular Diseases
Proprotein Convertase 9
LDL Cholesterol
Confidence Intervals
Odds Ratio
2015
4 Citations

Atherosclerosis following renal injury is ameliorated by pioglitazone and losartan via macrophage phenotype

Yamamoto, S., Zhong, J., Yancey, P. G., Zuo, Y., Linton, M. F., Fazio, S., Yang, H., Narita, I. & Kon, V. Sep 1 2015 In : Atherosclerosis. 242, 1, p. 56-64 9 p.

Research output: Research - peer-reviewArticle

pioglitazone
Losartan
Atherosclerosis
Macrophages
Phenotype
3 Citations

Carotid adventitial vasa vasorum and intima-media thickness in a primary prevention population

Sampson, U. K. A., Harrell, F. E., Fazio, S., Nwosu, S., Mercaldo, N., Mensah, G. A., Davidson, M. H., Coll, B. & Feinstein, S. B. Feb 1 2015 In : Echocardiography. 32, 2, p. 264-270 7 p.

Research output: Research - peer-reviewArticle

Vasa Vasorum
Adventitia
Carotid Intima-Media Thickness
Primary Prevention
Population
20 Citations

Dysfunctional high-density lipoproteins in children with chronic kidney disease

Kaseda, R., Jabs, K., Hunley, T. E., Jones, D., Bian, A., Allen, R. M., Vickers, K. C., Yancey, P. G., Linton, M. F., Fazio, S. & Kon, V. Feb 1 2015 In : Metabolism: Clinical and Experimental. 64, 2, p. 263-273 11 p.

Research output: Research - peer-reviewArticle

HDL Lipoproteins
Chronic Renal Insufficiency
Chronic Kidney Failure
Dialysis
Macrophages

Genetic disorders of hdl metabolism

Lilley, J. S., Linton, M. F. & Fazio, S. Jan 1 2015 Dyslipidemias: Pathophysiology, Evaluation and Management. Humana Press Inc., p. 221-233 13 p.

Research output: ResearchChapter

Inborn Genetic Diseases
HDL Lipoproteins
Lecithin Cholesterol Acyltransferase Deficiency
Cholesterol Ester Transfer Proteins
Heredity

Genetic disorders of HDL metabolism

Lilley, J. S., Linton, M. F. & Fazio, S. 2015 In : Contemporary Endocrinology. 1, p. 221-233 13 p.

Research output: Research - peer-reviewArticle

5 Citations

Intake of polyunsaturated fat in relation to mortality among statin users and non-users in the Southern Community Cohort Study

Kiage, J. N., Sampson, U. K. A., Lipworth, L., Fazio, S., Mensah, G. A., Yu, Q., Munro, H., Akwo, E. A., Dai, Q., Blot, W. J. & Kabagambe, E. K. 2015 In : Nutrition, Metabolism and Cardiovascular Diseases. 25, 11, p. 1016-1024 9 p.

Research output: Research - peer-reviewArticle

Hydroxymethylglutaryl-CoA Reductase Inhibitors
Unsaturated Fatty Acids
Cohort Studies
Fats
Mortality
8 Citations

Isolevuglandin-type lipid aldehydes induce the inflammatory response of macrophages by modifying phosphatidylethanolamines and activating the receptor for advanced glycation endproducts

Guo, L., Chen, Z., Amarnath, V., Yancey, P. G., Van Lenten, B. J., Savage, J. R., Fazio, S., Linton, M. F. & Davies, S. S. Jun 20 2015 In : Antioxidants and Redox Signaling. 22, 18, p. 1633-1645 13 p.

Research output: Research - peer-reviewArticle

Phosphatidylethanolamines
Aldehydes
Macrophages
Lipids
Advanced Glycosylation End Product-Specific Receptor
7 Citations

Macrophage apoAI protects against dyslipidemia-induced dermatitis and atherosclerosis without affecting HDL

Tavori, H., Su, Y. R., Yancey, P. G., Giunzioni, I., Wilhelm, A. J., Blakemore, J. L., Zabalawi, M., Linton, M. F., Sorci-Thomas, M. G. & Fazio, S. Mar 1 2015 In : Journal of Lipid Research. 56, 3, p. 635-643 9 p.

Research output: Research - peer-reviewArticle

Dermatitis
Dyslipidemias
Atherosclerosis
Macrophages
T-Lymphocytes
12 Citations

Macrophage SR-BI mediates efferocytosis via Src/PI3K/Rac1 signaling and reduces atherosclerotic lesion necrosis

Tao, H., Yancey, P. G., Babaev, V. R., Blakemore, J. L., Zhang, Y., Ding, L., Fazio, S. & Linton, M. F. Aug 1 2015 In : Journal of Lipid Research. 56, 8, p. 1449-1460 12 p.

Research output: Research - peer-reviewArticle

CD36 Antigens
Scavenger Receptors
Phosphatidylinositols
Phosphotransferases
1-Phosphatidylinositol 4-Kinase
25 Citations

On the function and homeostasis of PCSK9: Reciprocal interaction with LDLR and additional lipid effects

Tavori, H., Rashid, S. & Fazio, S. Feb 1 2015 In : Atherosclerosis. 238, 2, p. 264-270 7 p.

Research output: Research - peer-reviewArticle

LDL Receptors
Homeostasis
Lipids
Proprotein Convertase 9
LDL Lipoproteins
8 Citations
Proprotein Convertases
Subtilisin
Cardiovascular Diseases
Therapeutics
Lipoprotein(a)
7 Citations

Plasma lipid levels and colorectal adenoma risk

Coppola, J. A., Shrubsole, M. J., Cai, Q., Smalley, W. E., Dai, Q., Ness, R. M., Fazio, S., Zheng, W. & Murff, H. J. 2015 In : Cancer Causes and Control. 26, 4, p. 635-643 9 p.

Research output: Research - peer-reviewArticle

Adenoma
Lipids
Hydroxymethylglutaryl-CoA Reductase Inhibitors
HDL Cholesterol
Triglycerides
7 Citations

Residual Cardiovascular Risk in Chronic Kidney Disease: Role of High-density Lipoprotein

Kon, V., Yang, H. & Fazio, S. Jul 1 2015 In : Archives of Medical Research. 46, 5, p. 379-391 13 p.

Research output: Research - peer-reviewArticle

HDL Lipoproteins
Chronic Renal Insufficiency
Cardiovascular Diseases
Population
Therapeutics
4 Citations

Sex-Specific Parental Effects on Offspring Lipid Levels

Predazzi, I. M., Sobota, R. S., Sanna, S., Bush, W. S., Bartlett, J., Lilley, J. S., Linton, M. F., Schlessinger, D., Cucca, F., Fazio, S. & Williams, S. M. Jun 30 2015 In : Journal of the American Heart Association. 4, 7

Research output: Research - peer-reviewArticle

Lipids
Genetic Loci
Dyslipidemias
LDL Cholesterol
HDL Cholesterol
17 Citations

Smoking, sex, risk factors and abdominal aortic aneurysms: A prospective study of 18 782 persons aged above 65 years in the southern community cohort study

Jahangir, E., Lipworth, L., Edwards, T. L., Kabagambe, E. K., Mumma, M. T., Mensah, G. A., Fazio, S., Blot, W. J. & Sampson, U. K. A. 2015 In : Journal of Epidemiology and Community Health. 69, 5, p. 481-488 8 p.

Research output: Research - peer-reviewArticle

Sex Factors
Abdominal Aortic Aneurysm
Cohort Studies
Smoking
Prospective Studies
14 Citations

Targeting PCSK9 for Therapeutic Gains

Shapiro, M. D., Fazio, S. & Tavori, H. 2015 In : Current Atherosclerosis Reports. 17, 4

Research output: Research - peer-reviewArticle

Therapeutics
Proprotein Convertase 9
Cholesterol
Phase III Clinical Trials
Phase II Clinical Trials
1 Citations

The link between lipids, statins and cancer: Is there a role for cardio-oncology?

Jahangir, E., Polin, N. M., Lavie, C. J. & Fazio, S. Jul 1 2015 In : Future Cardiology. 11, 4, p. 389-393 5 p.

Research output: Research - peer-reviewArticle

5 Citations

The role of PCSK9 in intestinal lipoprotein metabolism: Synergism of statin and ezetimibe

Fazio, S. Feb 1 2015 In : Atherosclerosis Supplements. 17, p. 23-26 4 p.

Research output: Research - peer-reviewArticle

Hydroxymethylglutaryl-CoA Reductase Inhibitors
Lipoproteins
Cholesterol
Proprotein Convertase 9
Ezetimibe
2 Citations

Uric acid correlates to oxidation and inflammation in opposite directions in women

Wu, S. H., Shu, X. O., Milne, G., Xiang, Y. B., Zhang, X., Cai, Q., Fazio, S., Linton, M. F., Chen, H., Purdue, M., Rothman, N., Gao, Y. T., Zheng, W. & Yang, G. May 19 2015 In : Biomarkers. 20, 4, p. 225-231 7 p.

Research output: Research - peer-reviewArticle

Uric Acid
Oxidation
Direction compound
Inflammation
Oxidative stress
2014
7 Citations

Angiotensin-induced abdominal aortic aneurysms in hypercholesterolemic mice: Role of serum cholesterol and temporal effects of exposure

Prins, P. A., Hill, M. F., Airey, D., Nwosu, S., Perati, P. R., Tavori, H., Linton, M. F., Kon, V., Fazio, S. & Sampson, U. K. Jan 23 2014 In : PLoS One. 9, 1, e84517

Research output: Research - peer-reviewArticle

aneurysm
angiotensins
cholesterol
mice
Abdominal Aortic Aneurysm
11 Citations

Association of soy food intake with risk and biomarkers of coronary heart disease in Chinese men

Yu, D., Zhang, X., Xiang, Y. B., Yang, G., Li, H., Fazio, S., Linton, M., Cai, Q., Zheng, W., Gao, Y. T. & Shu, X. O. Mar 15 2014 In : International Journal of Cardiology. 172, 2

Research output: Research - peer-reviewArticle

10 Citations

Consuming a balanced high fat diet for 16 weeks improves body composition, inflammation and vascular function parameters in obese premenopausal women

Silver, H. J., Kang, H., Keil, C. D., Muldowney, J. A., Kocalis, H., Fazio, S., Vaughan, D. E. & Niswender, K. D. 2014 In : Metabolism: Clinical and Experimental. 63, 4, p. 562-573 12 p.

Research output: Research - peer-reviewArticle

High Fat Diet
Body Composition
Blood Vessels
Inflammation
Cardiovascular Diseases
20 Citations

Factors associated with the prevalence of hypertension in the southeastern united states insights from 69 211 blacks and whites in the southern community cohort study

Sampson, U. K. A., Edwards, T. L., Jahangir, E., Munro, H., Wariboko, M., Wassef, M. G., Fazio, S., Mensah, G. A., Kabagambe, E. K., Blot, W. J. & Lipworth, L. 2014 In : Circulation: Cardiovascular Quality and Outcomes. 7, 1, p. 33-54 22 p.

Research output: Research - peer-reviewArticle

Southeastern United States
Cohort Studies
Hypertension
hydroquinone
Odds Ratio