Sergio Fazio

Professor

  • 13276 Citations
  • 59 h-Index
1979 …2021
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Research Output 1982 2018

2018

Balanced high fat diet reduces cardiovascular risk in obese women although changes in adipose tissue, lipoproteins, and insulin resistance differ by race

Niswender, K. D., Fazio, S., Gower, B. A. & Silver, H. J., May 1 2018, In : Metabolism: Clinical and Experimental. 82, p. 125-134 10 p.

Research output: Contribution to journalArticle

High Fat Diet
Lipoproteins
Insulin Resistance
Adipose Tissue
African Americans
2 Citations

Chronic kidney disease alters lipid trafficking and inflammatory responses in macrophages: Effects of liver X receptor agonism

Kaseda, R., Tsuchida, Y., Yang, H. C., Yancey, P. G., Zhong, J., Tao, H., Bian, A., Fogo, A. B., Linton, M. R. F., Fazio, S., Ikizler, T. A. & Kon, V., Jan 27 2018, In : BMC Nephrology. 19, 1, 17.

Research output: Contribution to journalArticle

Chronic Renal Insufficiency
Macrophages
Lipids
Cholesterol
Mitogen-Activated Protein Kinase 3

Comparison of Medical Care Utilization and Costs Among Patients With Statin-Controlled Low-Density Lipoprotein Cholesterol With Versus Without Hypertriglyceridemia

Nichols, G. A., Philip, S., Reynolds, K., Granowitz, C. B., O'Keeffe-Rosetti, M. & Fazio, S., Jan 1 2018, (Accepted/In press) In : American Journal of Cardiology.

Research output: Contribution to journalArticle

Hydroxymethylglutaryl-CoA Reductase Inhibitors
Hypertriglyceridemia
Health Care Costs
LDL Cholesterol
Triglycerides
Hypertriglyceridemia
Estrogens
Xanthomatosis
Embryo Transfer
Triglycerides
3 Citations

Diagnosing resistance to a proprotein convertase subtilisin/kexin type 9 inhibitor

Shapiro, M. D., Miles, J., Tavori, H. & Fazio, S., Mar 6 2018, In : Annals of Internal Medicine. 168, 5, p. 376-379 4 p.

Research output: Contribution to journalLetter

Proprotein Convertase 9

Increased cardiovascular risk in hypertriglyceridemic patients with statin-controlled LDL cholesterol

Nichols, G. A., Philip, S., Reynolds, K., Granowitz, C. B. & Fazio, S., Jan 1 2018, In : Journal of Clinical Endocrinology and Metabolism. 103, 8, p. 3019-3027 9 p.

Research output: Contribution to journalArticle

Hydroxymethylglutaryl-CoA Reductase Inhibitors
LDL Cholesterol
Triglycerides
Composite materials
Myocardial Infarction

Increased residual cardiovascular risk in patients with diabetes and high versus normal triglycerides despite statin-controlled LDL cholesterol

Nichols, G. A., Philip, S., Reynolds, K., Granowitz, C. B. & Fazio, S., Jan 1 2018, (Accepted/In press) In : Diabetes, Obesity and Metabolism.

Research output: Contribution to journalArticle

Hydroxymethylglutaryl-CoA Reductase Inhibitors
LDL Cholesterol
Triglycerides
Cardiovascular Diseases
Unstable Angina

Lipoprotein Apheresis Acutely Reverses Coronary Microvascular Dysfunction in Patients With Severe Hypercholesterolemia

Wu, M. D., Moccetti, F., Brown, E., Davidson, B. P., Atkinson, T., Belcik, J. T., Giraud, G., Duell, P. B., Fazio, S., Tavori, H., Tsimikas, S. & Lindner, J. R., Jan 1 2018, (Accepted/In press) In : JACC: Cardiovascular Imaging.

Research output: Contribution to journalArticle

Blood Component Removal
Hypercholesterolemia
Lipoproteins
Perfusion
Femoral Artery
1 Citations

Medication-based versus target-based lipid management

Fazio, S. & Shapiro, M. D., Jan 1 2018, (Accepted/In press) In : Journal of Diabetes.

Research output: Contribution to journalArticle

Lipids
14 Citations

NHLBI Working Group Recommendations to Reduce Lipoprotein(a)-Mediated Risk of Cardiovascular Disease and Aortic Stenosis

Tsimikas, S., Fazio, S., Ferdinand, K. C., Ginsberg, H. N., Koschinsky, M. L., Marcovina, S. M., Moriarty, P. M., Rader, D. J., Remaley, A. T., Reyes-Soffer, G., Santos, R. D., Thanassoulis, G., Witztum, J. L., Danthi, S., Olive, M. & Liu, L., Jan 16 2018, In : Journal of the American College of Cardiology. 71, 2, p. 177-192 16 p.

Research output: Contribution to journalReview article

National Heart, Lung, and Blood Institute (U.S.)
Lipoprotein(a)
Aortic Valve Stenosis
Cardiovascular Diseases
Aortic Diseases

Predicting hypertriglyceridemic pancreatitis - Not so fast!

Shapiro, M. D. & Fazio, S., May 1 2018, In : Endocrine Practice. 24, 5, p. 495-497 3 p.

Research output: Contribution to journalComment/debate

Pancreatitis

Relationship of lipoprotein(a) molar concentrations and mass according to lipoprotein(a) thresholds and apolipoprotein(a) isoform size

Tsimikas, S., Fazio, S., Viney, N. J., Xia, S., Witztum, J. L. & Marcovina, S. M., Jan 1 2018, (Accepted/In press) In : Journal of Clinical Lipidology.

Research output: Contribution to journalArticle

Apoprotein(a)
Lipoprotein(a)
Protein Isoforms
Lipid Metabolism
Research
3 Citations

The Evolving Future of PCSK9 Inhibitors

Rosenson, R. S., Hegele, R. A., Fazio, S. & Cannon, C. P., Jul 17 2018, In : Journal of the American College of Cardiology. 72, 3, p. 314-329 16 p.

Research output: Contribution to journalReview article

LDL Lipoproteins
Cardiovascular Diseases
Monoclonal Antibodies
Clinical Trials
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Hyperlipoproteinemia Type II
Hyperlipoproteinemia Type II
2017
1 Citations

A case of severe acquired hypertriglyceridemia in a 7-year-old girl

Lilley, J. S., Linton, M. F., Kelley, J. C., Graham, T. B., Fazio, S. & Tavori, H., 2017, (Accepted/In press) In : Journal of Clinical Lipidology.

Research output: Contribution to journalArticle

Hypertriglyceridemia
Lipoprotein Lipase
Triglycerides
Hyperlipoproteinemia Type I
Pancreatitis
26 Citations

AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS AND AMERICAN COLLEGE OF ENDOCRINOLOGY GUIDELINES FOR MANAGEMENT OF DYSLIPIDEMIA AND PREVENTION OF CARDIOVASCULAR DISEASE - EXECUTIVE SUMMARYComplete Appendix to Guidelines available at http: //journals.aace.com

Jellinger, P. S., Handelsman, Y., Rosenblit, P. D., Bloomgarden, Z. T., Fonseca, V. A., Garber, A. J., Grunberger, G., Guerin, C. K., Bell, D. S. H., Mechanick, J. I., Pessah-Pollack, R., Wyne, K., Smith, D., Brinton, E. A., Fazio, S., Davidson, M., Zangeneh, F. & Bush, M. A., Apr 2 2017, In : Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists. 23, 4, p. 479-497 19 p.

Research output: Contribution to journalArticle

Hyperlipoproteinemia Type II
Endocrinology
Dyslipidemias
Practice Guidelines
Cardiovascular Diseases
2 Citations

Apolipoprotein B-containing lipoproteins and atherosclerotic cardiovascular disease

Fazio, S. & Shapiro, M. D., 2017, In : F1000Research. 6, 134.

Research output: Contribution to journalReview article

Apolipoproteins B
Lipoproteins
Cardiovascular Diseases
Cholesterol
Cardiovascular Agents
2 Citations

Application of PCSK9 inhibitors in practice: Challenges and opportunities

Kaufman, T. M., Duell, P. B., Purnell, J. Q., Wójcik, C., Fazio, S. & Shapiro, M. D., Aug 1 2017, In : Circulation Research. 121, 5, p. 499-501 3 p.

Research output: Contribution to journalReview article

Modern 1601-history
Clinical Medicine
Patient Care
Pharmacology
Proprotein Convertase 9
7 Citations
Lipoprotein(a)
LDL Cholesterol
Monoclonal Antibodies
LDL Lipoproteins
LDL Receptors
2 Citations

Dyslipidaemia: The PCSK9 adventure-humanizing extreme LDL lowering

Shapiro, M. D. & Fazio, S., Jun 1 2017, In : Nature Reviews Cardiology. 14, 6, p. 319-320 2 p.

Research output: Contribution to journalShort survey

1 Citations

Effects of 12 weeks of treatment with intravenously administered bococizumab, a humanized monoclonal antibody blocking proprotein convertase subtilisin/kexin type 9, in hypercholesterolemic subjects on high-dose statin

Fazio, S., Robertson, D. G., Joh, T., Wan, H., Riel, T., Forgues, P., Baum, C. M., Garzone, P. D. & Gumbiner, B., Jan 1 2017, (Accepted/In press) In : Cardiovascular Therapeutics.

Research output: Contribution to journalArticle

Antibodies, Monoclonal, Humanized
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Blocking Antibodies
Placebos
Therapeutics

Loss of SPRR3 in ApoE-/- mice leads to atheroma vulnerability through Akt dependent and independent effects in VSMCs

Lietman, C. D., Segedy, A. K., Li, B., Fazio, S., Atkinson, J. B., Linton, M. F. & Young, P. P., Sep 1 2017, In : PLoS One. 12, 9, e0184620.

Research output: Contribution to journalArticle

Cornified Envelope Proline-Rich Proteins
Apolipoproteins E
Atherosclerotic Plaques
Vascular Smooth Muscle
blood vessels
144 Citations

Low-density lipoproteins cause atherosclerotic cardiovascular disease. 1. Evidence from genetic, epidemiologic, and clinical studies. A consensus statement fromthe European Atherosclerosis Society Consensus Panel

Ference, B. A., Ginsberg, H. N., Graham, I., Ray, K. K., Packard, C. J., Bruckert, E., Hegele, R. A., Krauss, R. M., Raal, F. J., Schunkert, H., Watt, G. F., Borén, J., Fazio, S., Horton, J. D., Masana, L., Nicholls, S. J., Nordestgaard, B. G., Van De Sluis, B., Taskinen, M. R., Tokgözoǧlu, L. & 6 othersLandmesser, U., Laufs, U., Wiklund, O., Stock, J. K., Chapman, M. J. & Catapano, A. L., Aug 21 2017, In : European Heart Journal. 38, 32, p. 2459-2472 14 p.

Research output: Contribution to journalArticle

LDL Lipoproteins
Epidemiologic Studies
Cardiovascular Diseases
Random Allocation
Clinical Studies
7 Citations

PCSK9 and atherosclerosis - lipids and beyond

Shapiro, M. D. & Fazio, S., 2017, In : Journal of Atherosclerosis and Thrombosis. 24, 5, p. 462-472 11 p.

Research output: Contribution to journalReview article

Proprotein Convertases
Subtilisin
Atherosclerosis
Lipids
Cholesterol
1 Citations

Setting the Agenda for Preventive Cardiology

Shapiro, M. D. & Fazio, S., Jul 21 2017, In : Circulation Research. 121, 3, p. 211-213 3 p.

Research output: Contribution to journalComment/debate

Cardiology
Atherosclerosis
Cardiovascular Diseases
Myocardial Infarction
Cholesterol
2 Citations

Threshold Effects of Circulating Angiopoietin-Like 3 Levels on Plasma Lipoproteins

Fazio, S., Minnier, J., Shapiro, M. D., Tsimikas, S., Tarugi, P., Averna, M. R., Arca, M. & Tavori, H., Sep 1 2017, In : The Journal of clinical endocrinology and metabolism. 102, 9, p. 3340-3348 9 p.

Research output: Contribution to journalArticle

Angiopoietins
Lipoproteins
Proprotein Convertases
Subtilisin
Plasmas
2016
13 Citations

A systematic review of PCSK9 inhibitors alirocumab and evolocumab

McDonagh, M., Peterson, K., Holzhammer, B. & Fazio, S., Jun 1 2016, In : Journal of managed care & specialty pharmacy. 22, 6, p. 641-653 13 p.

Research output: Contribution to journalArticle

Proprotein Convertases
Subtilisin
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Hyperlipoproteinemia Type II
Health
31 Citations

Biology of proprotein convertase subtilisin kexin 9: Beyond low-density lipoprotein cholesterol lowering

Norata, G. D., Tavori, H., Pirillo, A., Fazio, S. & Catapano, A. L., Oct 1 2016, In : Cardiovascular Research. 112, 1, p. 429-442 14 p.

Research output: Contribution to journalReview article

Proprotein Convertases
Subtilisin
LDL Cholesterol
Hypercholesterolemia
Cardiovascular Diseases
9 Citations

Effect of Drug Therapy on Net Cholesterol Efflux Capacity of High-Density Lipoprotein–Enriched Serum in Rheumatoid Arthritis

the TETRAD Investigators, Sep 1 2016, In : Arthritis and Rheumatology. 68, 9, p. 2099-2105 7 p.

Research output: Contribution to journalArticle

HDL Lipoproteins
Rheumatoid Arthritis
Cholesterol
Drug Therapy
Serum
57 Citations

From Lipids to Inflammation: New Approaches to Reducing Atherosclerotic Risk

Shapiro, M. D. & Fazio, S., Feb 19 2016, In : Circulation Research. 118, 4, p. 732-749 18 p.

Research output: Contribution to journalArticle

Hydroxymethylglutaryl-CoA Reductase Inhibitors
Cardiovascular Diseases
Inflammation
Lipids
Atherosclerosis
3 Citations

HDL particle size and functional heterogeneity

Fazio, S. & Pamir, N., Sep 2 2016, In : Circulation Research. 119, 6, p. 704-707 4 p.

Research output: Contribution to journalReview article

Particle Size
HDL Cholesterol
21 Citations

Human PCSK9 promotes hepatic lipogenesis and atherosclerosis development via apoE-and LDLR-mediated mechanisms

Tavori, H., Giunzioni, I., Predazzi, I. M., Plubell, D., Shivinsky, A., Miles, J., DeVay, R. M., Liang, H., Rashid, S., Linton, M. R. F. & Fazio, S., May 15 2016, In : Cardiovascular Research. 110, 2, p. 268-278 11 p.

Research output: Contribution to journalArticle

Low Density Lipoprotein Receptor-Related Protein-1
Lipogenesis
LDL Receptors
Apolipoproteins E
Atherosclerosis
18 Citations

Is isolated low high-density lipoprotein cholesterol a cardiovascular disease risk factor?

Bartlett, J., Predazzi, I. M., Williams, S. M., Bush, W. S., Kim, Y., Havas, S., Toth, P. P., Fazio, S. & Miller, M., May 1 2016, In : Circulation: Cardiovascular Quality and Outcomes. 9, 3, p. 206-212 7 p.

Research output: Contribution to journalArticle

LDL Cholesterol
HDL Cholesterol
Cardiovascular Diseases
Cohort Studies
10 Citations

Jnk1 Deficiency in Hematopoietic Cells Suppresses Macrophage Apoptosis and Increases Atherosclerosis in Low-Density Lipoprotein Receptor Null Mice

Babaev, V. R., Yeung, M., Erbay, E., Ding, L., Zhang, Y., May, J. M., Fazio, S., Hotamisligil, G. S. & Linton, M. R. F., Apr 21 2016, (Accepted/In press) In : Arteriosclerosis, Thrombosis, and Vascular Biology.

Research output: Contribution to journalArticle

JNK Mitogen-Activated Protein Kinases
LDL Receptors
Atherosclerosis
Macrophages
Apoptosis
41 Citations

Local effects of human PCSK9 on the atherosclerotic lesion

Giunzioni, I., Tavori, H., Covarrubias, R., Major, A. S., Ding, L., Zhang, Y., Devay, R. M., Hong, L., Fan, D., Predazzi, I. M., Rashid, S., Linton, M. F. & Fazio, S., Jan 1 2016, In : Journal of Pathology. 238, 1, p. 52-62 11 p.

Research output: Contribution to journalArticle

LDL Receptors
Macrophages
Bone Marrow
Apolipoproteins E
Transgenic Mice
9 Citations

Loss of Macrophage Low-Density Lipoprotein Receptor–Related Protein 1 Confers Resistance to the Antiatherogenic Effects of Tumor Necrosis Factor-α Inhibition

Zhu, L., Giunzioni, I., Tavori, H., Covarrubias, R., Ding, L., Zhang, Y., Ormseth, M., Major, A. S., Stafford, J. M., Linton, M. R. F. & Fazio, S., Jun 30 2016, (Accepted/In press) In : Arteriosclerosis, Thrombosis, and Vascular Biology.

Research output: Contribution to journalArticle

Low Density Lipoprotein Receptor-Related Protein-1
LDL Receptors
Apolipoproteins E
Tumor Necrosis Factor-alpha
Macrophages
12 Citations

Macrophage IκB Kinase α Deficiency Suppresses Akt Phosphorylation, Reduces Cell Survival, and Decreases Early Atherosclerosis

Babaev, V. R., Ding, L., Zhang, Y., May, J. M., Lin, C. P., Fazio, S. & Linton, M. F., Feb 4 2016, (Accepted/In press) In : Arteriosclerosis, Thrombosis, and Vascular Biology.

Research output: Contribution to journalArticle

Cell Survival
Atherosclerosis
Phosphotransferases
Macrophages
Phosphorylation

Net cholesterol efflux capacity of HDL enriched serum and coronary atherosclerosis in rheumatoid arthritis

Ormseth, M. J., Yancey, P. G., Yamamoto, S., Oeser, A. M., Gebretsadik, T., Shintani, A., Linton, M. F., Fazio, S., Davies, S. S., Roberts, L. J., Vickers, K. C., Raggi, P., Kon, V. & Stein, C. M., Dec 1 2016, In : IJC Metabolic and Endocrine. 13, p. 6-11 6 p.

Research output: Contribution to journalArticle

Coronary Artery Disease
Rheumatoid Arthritis
Cholesterol
Serum
Calcium
33 Citations

PCSK9 Association With Lipoprotein(a)

Tavori, H., Christian, D., Minnier, J., Plubell, D., Shapiro, M. D., Yeang, C., Giunzioni, I., Croyal, M., Duell, P. B., Lambert, G., Tsimikas, S. & Fazio, S., Apr 29 2016, (Accepted/In press) In : Circulation Research.

Research output: Contribution to journalArticle

Lipoprotein(a)
Apoprotein(a)
LDL Lipoproteins
Proprotein Convertase 9
Apolipoproteins B

Polyunsaturated fat intake and mortality in non-statin users, is there an independent relationship? The authors reply

Kiage, J. N., Sampson, U. K. A., Lipworth, L., Fazio, S., Mensah, G. A., Yu, Q., Munro, H., Akwo, E. A., Dai, Q., Blot, W. J. & Kabagambe, E. K., Jan 1 2016, In : Nutrition, Metabolism and Cardiovascular Diseases. 26, 1, p. 78-79 2 p.

Research output: Contribution to journalArticle

Hydroxymethylglutaryl-CoA Reductase Inhibitors
Fats
Mortality
155 Citations

Variation in PCSK9 and HMGCR and risk of cardiovascular disease and diabetes

Ference, B. A., Robinson, J. G., Brook, R. D., Catapano, A. L., Chapman, M. J., Neff, D. R., Voros, S., Giugliano, R. P., Smith, G. D., Fazio, S. & Sabatine, M. S., Dec 1 2016, In : New England Journal of Medicine. 375, 22, p. 2144-2153 10 p.

Research output: Contribution to journalArticle

Cardiovascular Diseases
LDL Cholesterol
Confidence Intervals
Odds Ratio
Proprotein Convertase 9
2015
9 Citations

Atherosclerosis following renal injury is ameliorated by pioglitazone and losartan via macrophage phenotype

Yamamoto, S., Zhong, J., Yancey, P. G., Zuo, Y., Linton, M. F., Fazio, S., Yang, H., Narita, I. & Kon, V., Sep 1 2015, In : Atherosclerosis. 242, 1, p. 56-64 9 p.

Research output: Contribution to journalArticle

pioglitazone
Losartan
Atherosclerosis
Macrophages
Phenotype
5 Citations

Carotid adventitial vasa vasorum and intima-media thickness in a primary prevention population

Sampson, U. K. A., Harrell, F. E., Fazio, S., Nwosu, S., Mercaldo, N., Mensah, G. A., Davidson, M. H., Coll, B. & Feinstein, S. B., Feb 1 2015, In : Echocardiography. 32, 2, p. 264-270 7 p.

Research output: Contribution to journalArticle

Vasa Vasorum
Adventitia
Carotid Intima-Media Thickness
Primary Prevention
Population
28 Citations

Dysfunctional high-density lipoproteins in children with chronic kidney disease

Kaseda, R., Jabs, K., Hunley, T. E., Jones, D., Bian, A., Allen, R. M., Vickers, K. C., Yancey, P. G., Linton, M. F., Fazio, S. & Kon, V., Feb 1 2015, In : Metabolism: Clinical and Experimental. 64, 2, p. 263-273 11 p.

Research output: Contribution to journalArticle

HDL Lipoproteins
Chronic Renal Insufficiency
E-Selectin
Vascular Cell Adhesion Molecule-1
Macrophages

Genetic disorders of hdl metabolism

Lilley, J. S., Linton, M. F. & Fazio, S., Jan 1 2015, Dyslipidemias: Pathophysiology, Evaluation and Management. Humana Press Inc., p. 221-233 13 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Inborn Genetic Diseases
HDL Lipoproteins
Lecithin Cholesterol Acyltransferase Deficiency
Cholesterol Ester Transfer Proteins
Heredity

Genetic disorders of HDL metabolism

Lilley, J. S., Linton, M. F. & Fazio, S., 2015, In : Contemporary Endocrinology. 1, p. 221-233 13 p.

Research output: Contribution to journalArticle

Inborn Genetic Diseases
7 Citations

Intake of polyunsaturated fat in relation to mortality among statin users and non-users in the Southern Community Cohort Study

Kiage, J. N., Sampson, U. K. A., Lipworth, L., Fazio, S., Mensah, G. A., Yu, Q., Munro, H., Akwo, E. A., Dai, Q., Blot, W. J. & Kabagambe, E. K., 2015, In : Nutrition, Metabolism and Cardiovascular Diseases. 25, 11, p. 1016-1024 9 p.

Research output: Contribution to journalArticle

Hydroxymethylglutaryl-CoA Reductase Inhibitors
Unsaturated Fatty Acids
Cohort Studies
Fats
Omega-3 Fatty Acids
10 Citations

Isolevuglandin-type lipid aldehydes induce the inflammatory response of macrophages by modifying phosphatidylethanolamines and activating the receptor for advanced glycation endproducts

Guo, L., Chen, Z., Amarnath, V., Yancey, P. G., Van Lenten, B. J., Savage, J. R., Fazio, S., Linton, M. F. & Davies, S. S., Jun 20 2015, In : Antioxidants and Redox Signaling. 22, 18, p. 1633-1645 13 p.

Research output: Contribution to journalArticle

Phosphatidylethanolamines
Macrophages
Aldehydes
Lipids
High Fat Diet
12 Citations

Macrophage apoAI protects against dyslipidemia-induced dermatitis and atherosclerosis without affecting HDL

Tavori, H., Su, Y. R., Yancey, P. G., Giunzioni, I., Wilhelm, A. J., Blakemore, J. L., Zabalawi, M., Linton, M. F., Sorci-Thomas, M. G. & Fazio, S., Mar 1 2015, In : Journal of Lipid Research. 56, 3, p. 635-643 9 p.

Research output: Contribution to journalArticle

Dermatitis
Macrophages
Dyslipidemias
Atherosclerosis
T-cells