Sean Speese

Assistant Professor

Assistant Professor, Neurology

Emailspeese@ohsu.edu

1374 Citations
12 h-Index

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Drosophila Medicine & Life Sciences

Neuroglia Medicine & Life Sciences

Axons Medicine & Life Sciences

Synapses Medicine & Life Sciences

Lamin Type A Medicine & Life Sciences

Ribonucleoproteins Chemical Compounds

Lamins Medicine & Life Sciences

Wounds and Injuries Medicine & Life Sciences

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Research Output 2000 2017

1374 Citations
12 h-Index
17 Article

5 Citations (Scopus)

A novel Drosophila injury model reveals severed axons are cleared through a draper/MMP-1 signaling cascade

Purice, M. D., Ray, A., Münzel, E. J., Pope, B. J., Park, D. J., Speese, S. & Logan, M., Aug 21 2017, In : eLife. 6, e23611.

Research output: Contribution to journal › Article

Matrix Metalloproteinase 1

Neuroglia

Drosophila

Axons

Wounds and Injuries

11 Citations (Scopus)

Glial draper rescues Aβ toxicity in a Drosophila model of Alzheimer’s disease

Ray, A., Speese, S. & Logan, M., Dec 6 2017, In : Journal of Neuroscience. 37, 49, p. 11881-11893 13 p.

Research output: Contribution to journal › Article

Neuroglia

Drosophila

Alzheimer Disease

Diptera

Mitogen-Activated Protein Kinase 8

3 Citations (Scopus)

Protein phosphatase 4 coordinates glial membrane recruitment and phagocytic clearance of degenerating axons in Drosophila

Winfree, L. M., Speese, S. & Logan, M., Feb 23 2017, In : Cell death & disease. 8, 2, p. e2623

Research output: Contribution to journal › Article

Neuroglia

Drosophila

Axons

Membranes

Wounds and Injuries

13 Citations (Scopus)

Delayed glial clearance of degenerating axons in aged Drosophila is due to reduced PI3K/Draper activity

Purice, M. D., Speese, S. & Logan, M., Sep 20 2016, In : Nature Communications. 7, 12871.

Research output: Contribution to journal › Article

Drosophila

axons

1-Phosphatidylinositol 4-Kinase

clearances

Phosphatidylinositols

7 Citations (Scopus)

Insulin-like Signaling Promotes Glial Phagocytic Clearance of Degenerating Axons through Regulation of Draper

Musashe, D. T., Purice, M. D., Speese, S., Doherty, J. & Logan, M., Aug 16 2016, In : Cell Reports. 16, 7, p. 1838-1850 13 p.

Research output: Contribution to journal › Article

Neuroglia

Axons

Insulin

Insulin Receptor

Wounds and Injuries