• 2375 Citations
  • 27 h-Index
1978 …2020

Research output per year

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Research Output

  • 2375 Citations
  • 27 h-Index
  • 62 Article
  • 3 Comment/debate
  • 3 Review article
  • 2 Chapter
2020

Molecular analysis of lymphoid tissue from rhesus macaque rhadinovirus-infected monkeys identifies alterations in host genes associated with oncogenesis

Estep, R. D., Govindan, A. N., Manoharan, M., Li, H., Fei, S. S., Park, B. S., Axthelm, M. K. & Wong, S. W., Jan 1 2020, In : PloS one. 15, 2, e0228484.

Research output: Contribution to journalArticle

Open Access
2019

Rhesus macaque rhadinovirus encodes a viral interferon regulatory factor to disrupt promyelocytic leukemia nuclear bodies and antagonize type I interferon signaling

Springgay, L. K., Fitzpatrick, K., Park, B., Estep, R. D. & Wong, S. W., Mar 1 2019, In : Journal of virology. 93, 6, e02147-18.

Research output: Contribution to journalArticle

2 Scopus citations

Role of IL-15 signaling in the pathogenesis of simian immunodeficiency virus infection in rhesus macaques

Okoye, A. A., DeGottardi, M. Q., Fukazawa, Y., Vaidya, M., Abana, C. O., Konfe, A. L., Fachko, D. N., Duell, D. M., Li, H., Lum, R., Gao, L., Park, B. S., Skalsky, R. L., Lewis, A. D., Axthelm, M. K., Lifson, J. D., Wong, S. W. & Picker, L. J., Dec 1 2019, In : Journal of Immunology. 203, 11, p. 2928-2943 16 p.

Research output: Contribution to journalArticle

2018

Gammaherpesvirus infection and malignant disease in rhesus macaques experimentally infected with SIV or SHIV

Marshall, V. A., Labo, N., Hao, X. P., Holdridge, B., Thompson, M., Miley, W., Brands, C., Coalter, V., Kiser, R., Anver, M., Golubeva, Y., Warner, A., Jaffe, E. S., Piatak, M., Wong, S., Ohlen, C., MacAllister, R., Smedley, J., Deleage, C., Del Prete, G. Q. & 3 others, Lifson, J. D., Estes, J. & Whitby, D., Jul 1 2018, In : PLoS Pathogens. 14, 7, e1007130.

Research output: Contribution to journalArticle

4 Scopus citations

Nonhuman primate models of human viral infections

Estes, J., Wong, S. & Brenchley, J. M., Mar 19 2018, (Accepted/In press) In : Nature Reviews Immunology. p. 1-15 15 p.

Research output: Contribution to journalArticle

18 Scopus citations
2016

Immunopathology of Japanese macaque encephalomyelitis is similar to multiple sclerosis

Blair, T. C., Manoharan, M., Rawlings-Rhea, S. D., Tagge, I., Kohama, S., Hollister-Smith, J., Ferguson, B., Woltjer, R. R., Frederick, M. C., Pollaro, J., Rooney, W., Sherman, L. L., Bourdette, D. & Wong, S., Feb 15 2016, In : Journal of Neuroimmunology. 291, p. 1-10 10 p.

Research output: Contribution to journalArticle

6 Scopus citations

Japanese macaque rhadinovirus encodes a viral microRNA mimic of the miR-17 family

Skalsky, R., Barr, S. A., Jeffery, A. J., Blair, T., Estep, R. & Wong, S., 2016, In : Journal of Virology. 90, 20, p. 9350-9363 14 p.

Research output: Contribution to journalArticle

5 Scopus citations
2015

A rhesus rhadinovirus viral interferon (IFN) regulatory factor is virion associated and inhibits the early IFN antiviral response

Morin, G., Robinson, B. A., Rogers, K. S. & Wong, S. W., Jan 1 2015, In : Journal of virology. 89, 15, p. 7707-7721 15 p.

Research output: Contribution to journalArticle

8 Scopus citations

A simian hemorrhagic fever virus isolate from persistently infected baboons efficiently induces hemorrhagic fever disease in Japanese macaques

Vatter, H. A., Donaldson, E. F., Huynh, J., Rawlings, S., Manoharan, M., Legasse, A., Planer, S., Dickerson, M. F., Lewis, A. D., Colgin, L. M. A., Axthelm, M. K., Pecotte, J. K., Baric, R. S., Wong, S. W. & Brinton, M. A., Jan 1 2015, In : Virology. 474, p. 186-198 13 p.

Research output: Contribution to journalArticle

10 Scopus citations

BoHV-4-based vector single heterologous antigen delivery protects STAT1(-/-) mice from monkeypoxvirus lethal challenge

Franceschi, V., Parker, S., Jacca, S., Crump, R. W., Doronin, K., Hembrador, E., Pompilio, D., Tebaldi, G., Estep, R. D., Wong, S. W., Buller, M. R. & Donofrio, G., Jun 18 2015, In : PLoS neglected tropical diseases. 9, 6, e0003850.

Research output: Contribution to journalArticle

10 Scopus citations
2014

T Cell Inactivation by Poxviral B22 Family Proteins Increases Viral Virulence

Alzhanova, D., Hammarlund, E., Reed, J., Meermeier, E., Rawlings, S., Ray, C. A., Edwards, D. M., Bimber, B., Legasse, A., Planer, S., Sprague, J., Axthelm, M. K., Pickup, D. J., Lewinsohn, D. M., Gold, M. C., Wong, S. W., Sacha, J. B., Slifka, M. K. & Früh, K., May 2014, In : PLoS pathogens. 10, 5, e1004123.

Research output: Contribution to journalArticle

14 Scopus citations

The rhesus rhadinovirus CD200 homologue affects immune responses and viral loads during in vivo infection

Estep, R. D., Rawlings, S. D., Li, H., Manoharan, M., Blaine, E. T., O'Connor, M. A., Messaoudi, I., Axthelm, M. K. & Wong, S. W., 2014, In : Journal of virology. 88, 18, p. 10635-10654 20 p.

Research output: Contribution to journalArticle

12 Scopus citations
2013

Erratum: Comparative proteomics of human monkeypox and vaccinia intracellular mature and extracellular enveloped virions (Journal of Proteome Research (2008) 7:3 (960-968) DOI: 10.1021/pr070432+)

Manes, N. P., Estep, R. D., Mottaz, H. M., Moore, R. J., Clauss, T. R. W., Monroe, M. E., Du, X., Adkins, J. N., Wong, S. W. & Smith, R. D., Jan 4 2013, In : Journal of Proteome Research. 12, 1, 1 p.

Research output: Contribution to journalComment/debate

10 Scopus citations

Neisseria infection of rhesus macaques as a model to study colonization, transmission, persistence, and horizontal gene transfer

Weyand, N. J., Wertheimer, A. M., Hobbs, T. R., Sisko, J. L., Taku, N. A., Gregston, L. D., Clary, S., Higashi, D. L., Biais, N., Brown, L. M., Planer, S. L., Legasse, A. W., Axthelm, M. K., Wong, S. W. & So, M., Feb 19 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 8, p. 3059-3064 6 p.

Research output: Contribution to journalArticle

12 Scopus citations

Rhesus macaque rhadinovirus-associated disease

Estep, R. D. & Wong, S. W., Jun 2013, In : Current Opinion in Virology. 3, 3, p. 245-250 6 p.

Research output: Contribution to journalReview article

11 Scopus citations
2012

Author's correction: Viral interferon regulatory factors decrease the induction of type I and type II interferon during rhesus macaque rhadinovirus infection

Robinson, B. A., Estep, R. D., Messaoudi, I., Rogers, K. S. & Wong, S. W., Apr 1 2012, In : Journal of virology. 86, 8, 1 p.

Research output: Contribution to journalComment/debate

Nonhuman primate gamma-herpesviruses and their role in cancer

Estep, R. D. & Wong, S. W., Dec 13 2012, Cancer Associated Viruses. Robertson, E., Jasmin, J-F. & Lisanti, M. (eds.). p. 201-214 14 p. (Current Cancer Research; vol. 8).

Research output: Chapter in Book/Report/Conference proceedingChapter

Viral interferon regulatory factors are critical for delay of the host immune response against rhesus macaque rhadinovirus infection

Robinson, B. A., O'connor, M. A., Li, H., Engelmann, F., Poland, B., Grant, R., Defilippis, V., Estep, R. D., Axthelm, M. K., Messaoudi, I. & Wong, S. W., Mar 1 2012, In : Journal of virology. 86, 5, p. 2769-2779 11 p.

Research output: Contribution to journalArticle

14 Scopus citations

Viral interferon regulatory factors decrease the induction of type I and type II interferon during rhesus macaque rhadinovirus infection

Robinson, B. A., Estep, R. D., Messaoudi, I., Rogers, K. S. & Wong, S. W., Feb 1 2012, In : Journal of virology. 86, 4, p. 2197-2211 15 p.

Research output: Contribution to journalArticle

20 Scopus citations
2011

Deletion of the monkeypox virus inhibitor of complement enzymes locus impacts the adaptive immune response to monkeypox virus in a nonhuman primate model of infection

Estep, R. D., Messaoudi, I., O'Connor, M. A., Li, H., Sprague, J., Barron, A., Engelmann, F., Yen, B., Powers, M. F., Jones, J. M., Robinson, B. A., Orzechowska, B. U., Manoharan, M., Legasse, A., Planer, S., Wilk, J., Axthelm, M. K. & Wong, S. W., Sep 1 2011, In : Journal of virology. 85, 18, p. 9527-9542 16 p.

Research output: Contribution to journalArticle

14 Scopus citations

Japanese macaque encephalomyelitis: A spontaneous multiple sclerosis-like disease in a nonhuman primate

Axthelm, M. K., Bourdette, D. N., Marracci, G. H., Su, W., Mullaney, E. T., Manoharan, M., Kohama, S. G., Pollaro, J., Witkowski, E., Wang, P., Rooney, W. D., Sherman, L. S. & Wong, S. W., Sep 1 2011, In : Annals of Neurology. 70, 3, p. 362-373 12 p.

Research output: Contribution to journalArticle

30 Scopus citations

Nonhuman primate models of human immunology

Messaoudi, I., Estep, R., Robinson, B. & Wong, S. W., Jan 15 2011, In : Antioxidants and Redox Signaling. 14, 2, p. 261-273 13 p.

Research output: Contribution to journalReview article

65 Scopus citations
2010

Analysis of rhesus rhadinovirus microRNAs expressed in virus-induced tumors from infected rhesus macaques

Umbach, J. L., Strelow, L. I., Wong, S. W. & Cullen, B. R., Sep 30 2010, In : Virology. 405, 2, p. 592-599 8 p.

Research output: Contribution to journalArticle

33 Scopus citations
16 Scopus citations

Characterization of macaque pulmonary fluid proteome during monkeypox infection: Dynamics of host response

Brown, J. N., Estep, R. D., Lopez-Ferrer, D., Brewer, H. M., Clauss, T. R., Manes, N. P., O'Connor, M., Li, H., Adkins, J. N., Wong, S. W. & Smith, R. D., Dec 1 2010, In : Molecular and Cellular Proteomics. 9, 12, p. 2760-2771 12 p.

Research output: Contribution to journalArticle

6 Scopus citations

Immune response to the West Nile virus in aged non- human primates

Wertheimer, A. M., Uhrlaub, J. L., Hirsch, A., Medigeshi, G., Sprague, J., Legasse, A., Wilk, J., Wiley, C. A., Didier, P., Tesh, R. B., Murray, K. O., Axthelm, M. K., Wong, S. W. & Nikolich-Žugich, J., Dec 15 2010, In : PloS one. 5, 12, e15514.

Research output: Contribution to journalArticle

16 Scopus citations
2009

Characterization of the complement inhibitory function of rhesus rhadinovirus complement control protein (RCP)

Okroj, M., Mark, L., Stokowska, A., Wong, S. W., Rose, N., Blackbourn, D. J., Villoutreix, B. O., Brad Spiller, O. & Blom, A. M., Jan 2 2009, In : Journal of Biological Chemistry. 284, 1, p. 505-514 10 p.

Research output: Contribution to journalArticle

20 Scopus citations

Mutations in the highly conserved SLQYLA motif of Vif in a simian-human immunodeficiency virus result in a less pathogenic virus and are associated with G-to-A mutations in the viral genome

Schmitt, K., Hill, M. S., Ruiz, A., Culley, N., Pinson, D. M., Wong, S. W. & Stephens, E. B., Jan 20 2009, In : Virology. 383, 2, p. 362-372 11 p.

Research output: Contribution to journalArticle

12 Scopus citations

Prevalence of viremia and oral shedding of rhesus rhadinovirus and retroperitoneal fibromatosis herpesvirus in large age-structured breeding groups of rhesus macaques (Macaca mulatta)

White, J. A., Todd, P. A., Yee, J. A. L., Kalman-Bowlus, A., Rodgers, K. S., Xiaowei, Y., Wong, S. W., Barry, P. & Lerche, N. W., Aug 1 2009, In : Comparative Medicine. 59, 4, p. 383-390 8 p.

Research output: Contribution to journalArticle

18 Scopus citations

Primate models for gammaherpesvirus-associated malignancies

Messaoudi, I., Damania, B. & Wong, S. W., Jan 1 2009, DNA Tumor Viruses. Springer US, p. 703-733 31 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Viral interleukin-6 encoded by rhesus macaque rhadinovirus is associated with lymphoproliferative disorder (LPD)

Orzechowska, B. U., Manoharan, M., Sprague, J., Estep, R. D., Axthelm, M. K. & Wong, S. W., Oct 1 2009, In : Journal of medical primatology. 38, SUPPL. 1, p. 2-7 6 p.

Research output: Contribution to journalArticle

9 Scopus citations
2008

Comparative proteomics of human monkeypox and vaccinia intracellular mature and extracellular enveloped virions

Manes, N. P., Estep, R. D., Mottaz, H. M., Moore, R. J., Clauss, T. R. W., Monroe, M. E., Du, X., Adkins, J. N., Wong, S. W. & Smith, R. D., Mar 2008, In : Journal of Proteome Research. 7, 3, p. 960-968 9 p.

Research output: Contribution to journalArticle

44 Scopus citations

Modulation of the severe CD4+ T-cell loss caused by a pathogenic simian-human immunodeficiency virus by replacement of the subtype B vpu with the vpu from a subtype C HIV-1 clinical isolate

Hill, M. S., Ruiz, A., Pacyniak, E., Pinson, D. M., Culley, N., Yen, B., Wong, S. W. & Stephens, E. B., Feb 5 2008, In : Virology. 371, 1, p. 86-97 12 p.

Research output: Contribution to journalArticle

17 Scopus citations

Monkeypox virus viral chemokine inhibitor (MPV vCCI), a potent inhibitor of rhesus macrophage inflammatory protein-1

Jones, J. M., Messauodi, I., Estep, R. D., Orzechowska, B. & Wong, S. W., Aug 1 2008, In : Cytokine. 43, 2, p. 220-228 9 p.

Research output: Contribution to journalArticle

8 Scopus citations

Optimization of proteomic sample preparation procedures for comprehensive protein characterization of pathogenic systems

Mottaz-Brewer, H. M., Norbeck, A. D., Adkins, J. N., Manes, N. P., Ansong, C., Shi, L., Rikihisa, Y., Kikuchi, T., Wong, S. W., Estep, R. D., Heffron, F., Pasa-Tolic, L. & Smith, R. D., Dec 1 2008, In : Journal of Biomolecular Techniques. 19, 5, p. 285-295 11 p.

Research output: Contribution to journalArticle

13 Scopus citations

Rhesus macaque rhadinovirus-associated non-Hodgkin lymphoma: animal model for KSHV-associated malignancies

Orzechowska, B. U., Powers, M. F., Sprague, J., Li, H., Yen, B., Searles, R. P., Axthelm, M. K. & Wong, S. W., Nov 15 2008, In : Blood. 112, 10, p. 4227-4234 8 p.

Research output: Contribution to journalArticle

56 Scopus citations

Serologic evidence for novel poxvirus in endangered red colobus monkeys, Western Uganda

Goldberg, T. L., Chapman, C. A., Cameron, K., Saj, T., Karesh, W. B., Wolfe, N. D., Wong, S. W., Dubois, M. E. & Slifka, M. K., May 2008, In : Emerging infectious diseases. 14, 5, p. 801-803 3 p.

Research output: Contribution to journalArticle

Open Access
17 Scopus citations
2007

Construction of an infectious rhesus rhadinovirus bacterial artificial chromosome for the analysis of Kaposi's sarcoma-associated herpesvirus-related disease development

Estep, R. D., Powers, M. F., Yen, B. K., Li, H. & Wong, S. W., Mar 1 2007, In : Journal of virology. 81, 6, p. 2957-2969 13 p.

Research output: Contribution to journalArticle

37 Scopus citations

Molecular characterization of the Rhesus rhadinovirus (RRV) ORF4 gene and the RRV complement control protein it encodes

Mark, L., Spiller, O. B., Okroj, M., Chanas, S., Aitken, J. A., Wong, S. W., Damania, B., Blom, A. M. & Blackbourn, D. J., Apr 1 2007, In : Journal of virology. 81, 8, p. 4166-4176 11 p.

Research output: Contribution to journalArticle

15 Scopus citations
2006

Anti-OX40 (CD134) administration to nonhuman primates: Immunostimulatory effects and toxicokinetic study

Weinberg, A. D., Thalhofer, C., Morris, N., Walker, J. M., Seiss, D., Wong, S., Axthelm, M. K., Picker, L. J. & Urba, W. J., Nov 1 2006, In : Journal of Immunotherapy. 29, 6, p. 575-585 11 p.

Research output: Contribution to journalArticle

42 Scopus citations

Rhesus rhadinovirus R15 encodes a functional homologue of human CD200

Langlais, C. L., Jones, J. M., Estep, R. D. & Wong, S. W., Mar 1 2006, In : Journal of virology. 80, 6, p. 3098-3103 6 p.

Research output: Contribution to journalArticle

28 Scopus citations

Substitution of the transmembrane domain of Vpu in simian-human immunodeficiency virus (SHIVKU1bMC33) with that of M2 of influenza A results in a virus that is sensitive to inhibitors of the M2 ion channel and is pathogenic for pig-tailed macaques

Hout, D. R., Gomez, M. L., Pacyniak, E., Gomez, L. M., Fegley, B., Mulcahy, E. R., Hill, M. S., Culley, N., Pinson, D. M., Nothnick, W., Powers, M. F., Wong, S. W. & Stephens, E. B., Jan 20 2006, In : Virology. 344, 2, p. 541-559 19 p.

Research output: Contribution to journalArticle

28 Scopus citations
2005

Multiple diagnostic techniques identify previously vaccinated individuals with protective immunity against monkeypox

Hammarlund, E., Lewis, M. W., Carter, S. V., Amanna, I., Hansen, S. G., Strelow, L. I., Wong, S. W., Yoshihara, P., Hanifin, J. M. & Slifka, M. K., Sep 1 2005, In : Nature medicine. 11, 9, p. 1005-1011 7 p.

Research output: Contribution to journalArticle

75 Scopus citations

Scrambling of the amino acids within the transmembrane domain of Vpu results in a simian-human immunodeficiency virus (SHIVTM) that is less pathogenic for pig-tailed macaques

Hout, D. R., Gomez, M. L., Pacyniak, E., Gomez, L. M., Inbody, S. H., Mulcahy, E. R., Culley, N., Pinson, D. M., Powers, M. F., Wong, S. W. & Stephens, E. B., Aug 15 2005, In : Virology. 339, 1, p. 56-69 14 p.

Research output: Contribution to journalArticle

36 Scopus citations

Splicing of rhesus rhadinovirus R15 and ORF74 bicistronic transcripts during lytic infection and analysis of effects on production of vCD200 and vGPCR

Pratt, C. L., Estep, R. D. & Wong, S. W., Mar 1 2005, In : Journal of virology. 79, 6, p. 3878-3882 5 p.

Research output: Contribution to journalArticle

9 Scopus citations
2004

A cyclooxygenase-2 homologue encoded by rhesus cytomegalovirus is a determinant for endothelial cell tropism

Rue, C. A., Jarvis, M. A., Knoche, A. J., Meyers, H. L., DeFilippis, V. R., Hansen, S. G., Wagner, M., Früh, K., Anders, D. G., Wong, S. W., Barry, P. A. & Nelson, J. A., Nov 1 2004, In : Journal of virology. 78, 22, p. 12529-12536 8 p.

Research output: Contribution to journalArticle

38 Scopus citations

Fusion of the upstream vpu sequences to the env of simian human immunodeficiency virus (SHIVKU-1bMC33) results in the synthesis of two envelope precursor proteins, increased numbers of virus particles associated with the cell surface and is pathogenic for pig-tailed macaques

Hout, D. R., Gomez, M. L., Pacyniak, E., Mulcahy, E. R., Gomez, L. M., Jackson, M., Flick, M., Fegley, B., McCormick, C., Wisdom, B. J., Culley, N., Pinson, D. M., Powers, M., Wong, S. W. & Stephens, E. B., May 20 2004, In : Virology. 323, 1, p. 91-107 17 p.

Research output: Contribution to journalArticle

4 Scopus citations
2003

A G protein-coupled receptor encoded by rhesus rhadinovirus is similar to ORF74 of Kaposi's sarcoma-associated herpesvirus

Estep, R. D., Axthelm, M. K. & Wong, S. W., Feb 1 2003, In : Journal of virology. 77, 3, p. 1738-1746 9 p.

Research output: Contribution to journalArticle

25 Scopus citations

Complete sequence and genomic analysis of rhesus cytomegalovirus

Hansen, S. G., Strelow, L. I., Franchi, D. C., Anders, D. G. & Wong, S. W., Jun 1 2003, In : Journal of virology. 77, 12, p. 6620-6636 17 p.

Research output: Contribution to journalArticle

134 Scopus citations