Rosalie Sears

Professor

  • 6080 Citations
  • 35 h-Index
1988 …2020
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  • 5 Similar Profiles
Protein Phosphatase 2 Medicine & Life Sciences
Proto-Oncogene Proteins c-myc Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
Phosphorylation Medicine & Life Sciences
Tumor Suppressor Proteins Medicine & Life Sciences
Proteins Medicine & Life Sciences
Oncogene Proteins Medicine & Life Sciences
Breast Neoplasms Medicine & Life Sciences

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Projects 1994 2020

Pancreatic Neoplasms
Serine
Adenocarcinoma
Phosphorylation
Neoplasms
Ubiquitination
Ubiquitin
Phosphorylation
Ligases
Carcinogenesis
Phosphorylation
Threonine
Serine
Proto-Oncogene Proteins c-myc
Neoplasms

Research Output 1988 2019

9 Citations (Scopus)

Activation of PP2A and inhibition of mTOR synergistically reduce MYC signaling and decrease tumor growth in pancreatic ductal adenocarcinoma

Allen-Petersen, B. L., Risom, T., Feng, Z., Wang, Z., Jenny, Z. P., Thoma, M. C., Pelz, K. R., Morton, J. P., Sansom, O. J., Lopez, C., Sheppard, B., Christensen, D. J., Ohlmeyer, M., Narla, G. & Sears, R., Jan 1 2019, In : Cancer Research. 79, 1, p. 209-219 11 p.

Research output: Contribution to journalArticle

Protein Phosphatase 2
Adenocarcinoma
Phosphoric Monoester Hydrolases
Phosphotransferases
Growth
5 Citations (Scopus)

A Stromal Lysolipid-Autotaxin Signaling Axis Promotes Pancreatic Tumor Progression

Auciello, F. R., Bulusu, V., Oon, C., Tait-Mulder, J., Berry, M., Bhattacharyya, S., Tumanov, S., Allen-Petersen, B. L., Link, J., Kendsersky, N. D., Vringer, E., Schug, M., Novo, D., Hwang, R. F., Evans, R. M., Nixon, C., Dorrell, C., Morton, J. P., Norman, J. C., Sears, R. & 2 others, Kamphorst, J. J. & Sherman, M., May 1 2019, In : Cancer discovery. 9, 5, p. 617-627 11 p.

Research output: Contribution to journalArticle

Open Access
Adenocarcinoma
Neoplasms
Wound Healing
Lipids
Pancreatic Stellate Cells

Erratum: Correction: Modeling differentiation-state transitions linked to therapeutic escape in triple-negative breast cancer (PLoS computational biology (2019) 15 3 (e1006840))

Chapman, M. P., Risom, T., Aswani, A. J., Langer, E. M., Sears, R. C. & Tomlin, C. J., Oct 1 2019, In : PLoS computational biology. 15, 10, p. e1007441

Research output: Contribution to journalComment/debate

Open Access
Triple Negative Breast Neoplasms
Computational Biology
State Transition
Breast Cancer
bioinformatics
1 Citation (Scopus)

GRB7 dependent proliferation of basal-like, HER-2 positive human breast cancer cell lines is mediated in part by HER-1 signaling

Luoh, S-W., Wagoner, W., Wang, X., Hu, Z., Lai, X., Chin, K-Y., Sears, R. & Ramsey, E., Jan 1 2019, In : Molecular Carcinogenesis.

Research output: Contribution to journalArticle

Breast Neoplasms
Cell Line
Small Interfering RNA
Growth
GRB7 Adaptor Protein

Mission Possible: Advances in MYC Therapeutic Targeting in Cancer

Allen-Petersen, B. L. & Sears, R., Jan 1 2019, (Accepted/In press) In : BioDrugs.

Research output: Contribution to journalReview article

Open Access
Neoplasms
G-Quadruplexes
Oncogene Proteins
Therapeutics
Epigenomics