• 8647 Citations
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1977 …2020

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Pyrosequencing: Applicability for studying DNA damage-induced mutagenesis

Minko, I. G., Earley, L. F., Larlee, K. E., Lin, Y. C. & Lloyd, R. S., Oct 1 2014, In : Environmental and Molecular Mutagenesis. 55, 8, p. 601-608 8 p.

Research output: Contribution to journalArticle

2 Scopus citations
37 Scopus citations

Reaction intermediates in the catalytic mechanism of Escherichia coli MutY DNA glycosylase

Manuel, R. C., Hitomi, K., Arvai, A. S., House, P. G., Kurtz, A. J., Dodson, M. L., McCullough, A. K., Tainer, J. A. & Lloyd, R. S., Nov 5 2004, In : Journal of Biological Chemistry. 279, 45, p. 46930-46939 10 p.

Research output: Contribution to journalArticle

46 Scopus citations

Recognition of DNA adducts by edited and unedited forms of DNA glycosylase NEIL1

Minko, I. G., Vartanian, V. L., Tozaki, N. N., Coskun, E., Coskun, S. H., Jaruga, P., Yeo, J., David, S. S., Stone, M. P., Egli, M., Dizdaroglu, M., McCullough, A. K. & Lloyd, R. S., Jan 2020, In : DNA Repair. 85, 102741.

Research output: Contribution to journalArticle

2 Scopus citations
70 Scopus citations

Repair of hydantoins, one electron oxidation product of 8-oxoguanine, by DNA glycosylases of Escherichia coli

Hazra, T. K., Muller, J. G., Manuel, R. C., Burrows, C. J., Lloyd, R. S. & Mitra, S., May 1 2001, In : Nucleic acids research. 29, 9, p. 1967-1974 8 p.

Research output: Contribution to journalArticle

Open Access
92 Scopus citations

Replication bypass of interstrand cross-link intermediates by Escherichia coli DNA polymerase IV

Kumari, A., Minko, I. G., Harbut, M. B., Finkel, S. E., Goodman, M. F. & Lloyd, R. S., Oct 10 2008, In : Journal of Biological Chemistry. 283, 41, p. 27433-27437 5 p.

Research output: Contribution to journalArticle

41 Scopus citations

Replication bypass of N 2-deoxyguanosine interstrand cross-links by human DNA polymerases η and ι

Klug, A. R., Harbut, M. B., Lloyd, R. S. & Minko, I. G., Mar 19 2012, In : Chemical Research in Toxicology. 25, 3, p. 755-762 8 p.

Research output: Contribution to journalArticle

17 Scopus citations

Replication bypass of the acrolein-mediated deoxyguanine DNA-peptide cross-links by DNA polymerases of the DinB family

Minko, I. G., Yamanaka, K., Kozekov, I. D., Kozekova, A., Indiani, C., O'Donnell, M. E., Jiang, Q., Goodman, M. F., Rizzo, C. J. & Lloyd, R. S., Oct 2008, In : Chemical Research in Toxicology. 21, 10, p. 1983-1990 8 p.

Research output: Contribution to journalArticle

49 Scopus citations

Replication of the 2,6-diamino-4-hydroxy- N 5-(methyl)- formamidopyrimidine (MeFapy-dGuo) adduct by eukaryotic DNA polymerases

Christov, P. P., Yamanaka, K., Choi, J. Y., Takata, K. I., Wood, R. D., Guengerich, F. P., Lloyd, R. S. & Rizzo, C. J., Aug 20 2012, In : Chemical Research in Toxicology. 25, 8, p. 1652-1661 10 p.

Research output: Contribution to journalArticle

11 Scopus citations

Replication past a trans-4-hydroxynonenal minor-groove adduct by the sequential action of human DNA polymerases ι and κ

Wolfle, W. T., Johnson, R. E., Minko, I. G., Lloyd, R. S., Prakash, S. & Prakash, L., Jan 2006, In : Molecular and cellular biology. 26, 1, p. 381-386 6 p.

Research output: Contribution to journalArticle

46 Scopus citations

Ring-opening of the γ-OH-PdG adduct promotes error-free bypass by the sulfolobus solfataricus DNA polymerase Dpo4

Shanmugam, G., Minko, I. G., Banerjee, S., Christov, P. P., Kozekov, I. D., Rizzo, C. J., Lloyd, R. S., Egli, M. & Stone, M. P., Sep 16 2013, In : Chemical Research in Toxicology. 26, 9, p. 1348-1360 13 p.

Research output: Contribution to journalArticle

2 Scopus citations

Role for DNA polymerase κ in the processing of N2-N 2-guanine interstrand cross-links

Minko, I. G., Harbut, M. B., Kozekov, I. D., Kozekova, A., Jakobs, P. M., Olson, S. B., Moses, R. E., Harris, T. M., Rizzo, C. J. & Lloyd, R. S., Jun 20 2008, In : Journal of Biological Chemistry. 283, 25, p. 17075-17082 8 p.

Research output: Contribution to journalArticle

107 Scopus citations

Role of high-fidelity Escherichia coli DNA polymerase I in replication bypass of a deoxyadenosine DNA-peptide cross-link

Yamanaka, K., Minko, I. G., Finkel, S. E., Goodman, M. F. & Lloyd, R. S., Aug 2011, In : Journal of bacteriology. 193, 15, p. 3815-3821 7 p.

Research output: Contribution to journalArticle

14 Scopus citations

Role of His-16 in Turnover of T4 Pyrimidine Dimer Glycosylase

Meador, M. G., Rajagopalan, L., Lloyd, R. S. & Dodson, M. L., Jan 30 2004, In : Journal of Biological Chemistry. 279, 5, p. 3348-3353 6 p.

Research output: Contribution to journalArticle

3 Scopus citations

Role of specific amino acid residues in T4 endonuclease V that alter nontarget DNA binding

Nyaga, S. G., Dodson, M. L. & Lloyd, R. S., Apr 8 1997, In : Biochemistry. 36, 14, p. 4080-4088 9 p.

Research output: Contribution to journalArticle

16 Scopus citations

Selective metal binding to cys-78 within endonuclease V causes an inhibition of catalytic activities without altering nontarget and target DNA binding

Prince, M. A., Friedman, B., Gruskin, E. A., Schrock, R. D. & Lloyd, R. S., Aug 16 1991, In : Journal of Biological Chemistry. 266, 16, p. 10686-10693 8 p.

Research output: Contribution to journalArticle

19 Scopus citations

Sequence context modulation of polycyclic aromatic hydrocarbon-induced mutagenesis

Chary, P., Stone, M. P. & Lloyd, R. S., Oct 1 2013, In : Environmental and Molecular Mutagenesis. 54, 8, p. 652-658 7 p.

Research output: Contribution to journalArticle

1 Scopus citations

Site-directed deletion mutagenesis within the T4 endonuclease V gene: dispensable sequences within putative loop regions

Dodson, M. L., Prince, M. A., Anderson, W. F. & Lloyd, R. S., Jul 1991, In : Mutation Research-DNA Repair. 255, 1, p. 19-29 11 p.

Research output: Contribution to journalArticle

4 Scopus citations
30 Scopus citations
58 Scopus citations

Site-Directed Mutagenesis of the T4 Endonuclease V Gene: Role of Tyrosine-129 and -131 in Pyrimidine Dimer-Specific Binding

Stump, D. G. & Lloyd, R. S., Mar 1 1988, In : Biochemistry. 27, 6, p. 1839-1843 5 p.

Research output: Contribution to journalArticle

19 Scopus citations

Site-Directed Mutagenesis of the T4 Endonuclease V Gene: Role of Lysine-130

Recinos, A. & Lloyd, R. S., Mar 1 1988, In : Biochemistry. 27, 6, p. 1832-1838 7 p.

Research output: Contribution to journalArticle

21 Scopus citations

Site-Directed Mutagenesis of the T4 Endonuclease V Gene: The Role of Arginine-3 in the Target Search

Dowd, D. R. & Lloyd, R. S., Jan 1 1989, In : Biochemistry. 28, 22, p. 8699-8705 7 p.

Research output: Contribution to journalArticle

30 Scopus citations
7 Scopus citations

Site specific bleomycin-mediated single-strand breaks and alkali-labile damage on covalently closed-circular DNA

Lloyd, R. S., Haidle, C. W. & Robberson, D. L., Jan 1 1979, In : Federation Proceedings. 38, 3 I, p. No. 1443

Research output: Contribution to journalArticle

Site-specific DNA cleavage by Chlorella virus topoisomerase II

Fortune, J. M., Dickey, J. S., Lavrukhin, O. V., Van Etten, J. L., Lloyd, R. S. & Osheroff, N., Oct 1 2002, In : Biochemistry. 41, 39, p. 11761-11769 9 p.

Research output: Contribution to journalArticle

20 Scopus citations

Site specificity of bleomycin-mediated single-strand scissions and alkali-labile damage in duplex DNA

Lloyd, R. S., Haidle, C. W. & Robberson, D. L., Nov 1979, In : Gene. 7, 3-4, p. 289-302 14 p.

Research output: Contribution to journalArticle

16 Scopus citations

Site-specific mutagenicity of stereochemically defined 1, N 2-deoxyguanosine adducts of trans-4-hydroxynonenal in mammalian cells

Fernandes, P. H., Wang, H., Rizzo, C. J. & Lloyd, R. S., Sep 18 2003, In : Environmental and Molecular Mutagenesis. 42, 2, p. 68-74 7 p.

Research output: Contribution to journalArticle

42 Scopus citations

Small Molecule Inhibitors of 8-Oxoguanine DNA Glycosylase-1 (OGG1)

Donley, N., Jaruga, P., Coskun, E., Dizdaroglu, M., McCullough, A. K. & Lloyd, R. S., Oct 16 2015, In : ACS chemical biology. 10, 10, p. 2334-2343 10 p.

Research output: Contribution to journalArticle

30 Scopus citations

Specific interactions of t4 endonuclease v with a proposed transition state analogue for dna glycosylases

McCullough, A. K., Verdine, G. L. & Stephen Lloyd, R., Dec 1 1996, In : FASEB Journal. 10, 6, p. A966

Research output: Contribution to journalArticle

Spectroscopic characterization of interstrand carbinolamine cross-links formed in the 5′-CpG-3′ sequence by the acrolein-derived γ-OH-1,N2-propano-2′-deoxyguanosine DNA adduct

Cho, Y. J., Kim, H. Y., Huang, H., Slutsky, A., Minko, I. G., Wang, H., Nechev, L. V., Kozekov, I. D., Kozekova, A., Tamura, P., Jacob, J., Voehler, M., Harris, T. M., Lloyd, R. S., Rizzo, C. J. & Stone, M. P., Dec 21 2005, In : Journal of the American Chemical Society. 127, 50, p. 17686-17696 11 p.

Research output: Contribution to journalArticle

33 Scopus citations

Stereospecific formation of interstrand carbinolamine DNA cross-links by crotonaldehyde- and acetaldehyde-derived α-CH3-γ-OH-1, N2-propano-2′-deoxyguanosine adducts in the 5′-CpG-3′ sequence

Cho, Y. J., Wang, H., Kozekov, I. D., Kurtz, A. J., Jacob, J., Voehler, M., Smith, J., Harris, T. M., Lloyd, R. S., Rizzo, C. J. & Stone, M. P., Feb 2006, In : Chemical Research in Toxicology. 19, 2, p. 195-208 14 p.

Research output: Contribution to journalArticle

42 Scopus citations

Stereospecific structural perturbations arising from adenine N6 butadiene triol adducts in duplex DNA

Merritt, W. K., Scholdberg, T. A., Nechev, L. V., Harris, T. M., Harris, C. M., Lloyd, R. S. & Stone, M. P., Aug 1 2004, In : Chemical Research in Toxicology. 17, 8, p. 1007-1019 13 p.

Research output: Contribution to journalArticle

15 Scopus citations

Structural determinants for specific recognition by T4 endonuclease V

McCullough, A. K., Schärer, O., Verdine, G. L. & Stephen Lloyd, R., 1996, In : Journal of Biological Chemistry. 271, 50, p. 32147-32152 6 p.

Research output: Contribution to journalArticle

27 Scopus citations

Structural similarities between MutT and the C-terminal domain of MutY

Volk, D. E., House, P. G., Thiviyanathan, V., Luxon, B. A., Zhang, S., Lloyd, R. S. & Gorenstein, D. G., Jun 27 2000, In : Biochemistry. 39, 25, p. 7331-7336 6 p.

Research output: Contribution to journalArticle

44 Scopus citations

Structural similarities between MutT and the C-terminal Domain of MutY

Volk, D. E., House, P. G., Thiviyanathan, V., Luxon, B. A., Zhang, S., Lloyd, R. S. & Gorenstein, D. G., Apr 27 2000, In : Biochemistry. 39, 25, p. X-7336

Research output: Contribution to journalArticle

9 Scopus citations

Structure-function studies of the T4 endonuclease V repair enzyme

Dodson, M. L. & Lloyd, R. S., Sep 1989, In : Mutation Research-DNA Repair. 218, 2, p. 49-65 17 p.

Research output: Contribution to journalArticle

50 Scopus citations

Structure of an oligodeoxynucleotide containing a butadiene oxide-derived N1 beta-hydroxyalkyl deoxyinosine adduct in the human N-ras codon 61 sequence

Scholdberg, T. A., Merritt, W. K., Dean, S. M., Kowalcyzk, A., Harris, C. M., Harris, T. M., Rizzo, C. J., Lloyd, R. S. & Stone, M. P., Mar 8 2005, In : Biochemistry. 44, 9, p. 3327-3337 11 p.

Research output: Contribution to journalArticle

7 Scopus citations

Structure of a site specific major groove (2S,3S)-N6-(2,3,4- trihydroxybutyl)-2′-deoxyadenosyl DNA adduct of butadiene diol epoxide

Scholdberg, T. A., Nechev, L. V., Merritt, W. K., Harris, T. M., Harris, C. M., Lloyd, R. S. & Stone, M. P., Jun 1 2004, In : Chemical Research in Toxicology. 17, 6, p. 717-730 14 p.

Research output: Contribution to journalArticle

13 Scopus citations

Structure of T4 Pyrimidine Dimer Glycosylase in a Reduced Imine Covalent Complex with Abasic Site-containing DNA

Golan, G., Zharkov, D. O., Grollman, A. P., Dodson, M. L., McCullough, A. K., Lloyd, R. S. & Shoham, G., Sep 15 2006, In : Journal of molecular biology. 362, 2, p. 241-258 18 p.

Research output: Contribution to journalArticle

21 Scopus citations

Structure of the 1,4-Bis(2′-deoxyadenosin-N6-yl)-2R,3R- butanediol cross-link arising from alkylation of the human N-ras codon 61 by butadiene diepoxide

Merritt, W. K., Nechev, L. V., Scholdberg, T. A., Dean, S. M., Kiehna, S. E., Chang, J. C., Harris, T. M., Harris, C. M., Lloyd, R. S. & Stone, M. P., Aug 2 2005, In : Biochemistry. 44, 30, p. 10081-10092 12 p.

Research output: Contribution to journalArticle

4 Scopus citations

Structure of the 1,4-bis(2′-deoxyadenosin-N6-yl)-2S,3S- butanediol intrastrand DNA cross-link arising from butadiene diepoxide in the human N-ras codon 61 sequence

Xu, W., Merritt, W. K., Nechev, L. V., Harris, T. M., Harris, C. M., Lloyd, R. S. & Stone, M. P., Feb 1 2007, In : Chemical Research in Toxicology. 20, 2, p. 187-198 12 p.

Research output: Contribution to journalArticle

4 Scopus citations

Studies on the catalytic mechanism of five DNA glycosylases: Probing for enzyme-DNA imino intermediates

Sun, B., Latham, K. A., Dodson, M. L. & Lloyd, R. S., Aug 18 1995, In : Journal of Biological Chemistry. 270, 33, p. 19501-19508 8 p.

Research output: Contribution to journalArticle

Open Access
128 Scopus citations

Substitution of basic amino acids within endonuclease V enhances nontarget DNA binding

Nickell, C., Anderson, W. F. & Lloyd, R. S., Oct 22 1991, In : Journal of Biological Chemistry. 266, 9, p. 5634-5642 9 p.

Research output: Contribution to journalArticle

15 Scopus citations

Substrate specificity and excision kinetics of Escherichia coli endonuclease VIII (Nei) for modified bases in DNA damaged by free radicals

Dizdaroglu, M., Burgess, S. M., Jaruga, P., Hazra, T. K., Rodriguez, H. & Lloyd, R. S., Oct 9 2001, In : Biochemistry. 40, 40, p. 12150-12156 7 p.

Research output: Contribution to journalArticle

43 Scopus citations

Synthesis and mutagenesis of the butadiene-derived N3 2′-deoxyuridine adducts

Fernandes, P. H., Hackfeld, L. C., Kozekov, I. D., Hodge, R. P. & Lloyd, R. S., Jul 2006, In : Chemical Research in Toxicology. 19, 7, p. 968-976 9 p.

Research output: Contribution to journalArticle

12 Scopus citations

T4 Endonuclease V: Perspectives on Catalysis

LATHAM, K. ATKINS. & LLOYD, R. STEPHEN., Jul 1994, In : Annals of the New York Academy of Sciences. 726, 1, p. 181-197 17 p.

Research output: Contribution to journalArticle

21 Scopus citations

T4 endonuclease V exists in solution as a monomer and binds to target sites as a monomer

Latham, K. A., Rajendran, S., Carmical, J. R., Lee, J. C. & Lloyd, R. S., Feb 8 1996, In : Biochimica et Biophysica Acta - Protein Structure and Molecular Enzymology. 1292, 2, p. 324-334 11 p.

Research output: Contribution to journalArticle

3 Scopus citations

T4 endonuclease V promotes the formation of multimeric DNA structures

Lloyd, R. S., Dodson, M. L., Gruskin, E. A. & Robberson, D. L., Mar 1987, In : Mutation Research DNA Repair Reports. 183, 2, p. 109-115 7 p.

Research output: Contribution to journalArticle

8 Scopus citations