• 8647 Citations
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1977 …2020

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Article
2004

Efficient and error-free replication past a minor-groove N 2-guanine adduct by the sequential action of yeast Rev1 and DNA polymerase

Washington, M. T., Minko, I. G., Johnson, R. E., Haracska, L., Harris, T. M., Lloyd, R. S., Prakash, S. & Prakash, L., Aug 2004, In : Molecular and cellular biology. 24, 16, p. 6900-6906 7 p.

Research output: Contribution to journalArticle

81 Scopus citations

Reaction intermediates in the catalytic mechanism of Escherichia coli MutY DNA glycosylase

Manuel, R. C., Hitomi, K., Arvai, A. S., House, P. G., Kurtz, A. J., Dodson, M. L., McCullough, A. K., Tainer, J. A. & Lloyd, R. S., Nov 5 2004, In : Journal of Biological Chemistry. 279, 45, p. 46930-46939 10 p.

Research output: Contribution to journalArticle

46 Scopus citations

Role of His-16 in Turnover of T4 Pyrimidine Dimer Glycosylase

Meador, M. G., Rajagopalan, L., Lloyd, R. S. & Dodson, M. L., Jan 30 2004, In : Journal of Biological Chemistry. 279, 5, p. 3348-3353 6 p.

Research output: Contribution to journalArticle

3 Scopus citations

Stereospecific structural perturbations arising from adenine N6 butadiene triol adducts in duplex DNA

Merritt, W. K., Scholdberg, T. A., Nechev, L. V., Harris, T. M., Harris, C. M., Lloyd, R. S. & Stone, M. P., Aug 1 2004, In : Chemical Research in Toxicology. 17, 8, p. 1007-1019 13 p.

Research output: Contribution to journalArticle

15 Scopus citations

Structure of a site specific major groove (2S,3S)-N6-(2,3,4- trihydroxybutyl)-2′-deoxyadenosyl DNA adduct of butadiene diol epoxide

Scholdberg, T. A., Nechev, L. V., Merritt, W. K., Harris, T. M., Harris, C. M., Lloyd, R. S. & Stone, M. P., Jun 1 2004, In : Chemical Research in Toxicology. 17, 6, p. 717-730 14 p.

Research output: Contribution to journalArticle

13 Scopus citations
2005

Dual roles of glycosyl torsion angle conformation and stereochemical configuration in butadiene oxide-derived N1 β-hydroxyalkyl deoxyinosine adducts: A structural perspective

Merritt, W. K., Kowalczyk, A., Scholdberg, T. A., Dean, S. M., Harris, T. M., Harris, C. M., Lloyd, R. S. & Stone, M. P., Jul 2005, In : Chemical Research in Toxicology. 18, 7, p. 1098-1107 10 p.

Research output: Contribution to journalArticle

4 Scopus citations

Evidence for Escherichia coli polymerase II mutagenic bypass of intrastrand DNA crosslinks

Kanuri, M., Nechev, L. V., Kiehna, S. E., Tamura, P. J., Harris, C. M., Harris, T. M. & Lloyd, R. S., Dec 8 2005, In : DNA Repair. 4, 12, p. 1374-1380 7 p.

Research output: Contribution to journalArticle

12 Scopus citations

Formation of inter- and intrastrand imine type DNA-DNA cross-links through secondary reactions of aldehydic adducts

Sanchez, A. M., Kozekov, I. D., Harris, T. M. & Lloyd, R. S., Nov 1 2005, In : Chemical Research in Toxicology. 18, 11, p. 1683-1690 8 p.

Research output: Contribution to journalArticle

24 Scopus citations

Human DNA polymerase ι promotes replication through a ring-closed minor-groove adduct that adopts a syn conformation in DNA

Wolfle, W. T., Johnson, R. E., Minko, I. G., Lloyd, R. S., Prakash, S. & Prakash, L., Oct 1 2005, In : Molecular and cellular biology. 25, 19, p. 8748-8754 7 p.

Research output: Contribution to journalArticle

38 Scopus citations

Initiation of repair of DNA - Polypeptide cross-links by the UvrABC nuclease

Minko, I. G., Kurtz, A. J., Croteau, D. L., Van Houten, B., Harris, T. M. & Lloyd, R. S., Mar 1 2005, In : Biochemistry. 44, 8, p. 3000-3009 10 p.

Research output: Contribution to journalArticle

53 Scopus citations

Mammalian cell mutagenesis of the DNA adducts of vinyl chloride and crotonaldehyde

Fernandes, P. H., Kanuri, M., Nechev, L. V., Harris, T. M. & Lloyd, R. S., Jun 1 2005, In : Environmental and Molecular Mutagenesis. 45, 5, p. 455-459 5 p.

Research output: Contribution to journalArticle

49 Scopus citations

Mispairing of a site specific major groove (2S,3S)-N6-(2,3,4- trihydroxybutyl)-2′-deoxyadenosyl DNA adduct of butadiene diol epoxide with deoxyguanosine: Formation of a dA(anti)·dG(anti) pairing interaction

Scholdberg, T. A., Nechev, L. V., Merritt, W. K., Harris, T. M., Harris, C. M., Lloyd, R. S. & Stone, M. P., Feb 1 2005, In : Chemical Research in Toxicology. 18, 2, p. 145-153 9 p.

Research output: Contribution to journalArticle

11 Scopus citations

Spectroscopic characterization of interstrand carbinolamine cross-links formed in the 5′-CpG-3′ sequence by the acrolein-derived γ-OH-1,N2-propano-2′-deoxyguanosine DNA adduct

Cho, Y. J., Kim, H. Y., Huang, H., Slutsky, A., Minko, I. G., Wang, H., Nechev, L. V., Kozekov, I. D., Kozekova, A., Tamura, P., Jacob, J., Voehler, M., Harris, T. M., Lloyd, R. S., Rizzo, C. J. & Stone, M. P., Dec 21 2005, In : Journal of the American Chemical Society. 127, 50, p. 17686-17696 11 p.

Research output: Contribution to journalArticle

33 Scopus citations

Structure of an oligodeoxynucleotide containing a butadiene oxide-derived N1 beta-hydroxyalkyl deoxyinosine adduct in the human N-ras codon 61 sequence

Scholdberg, T. A., Merritt, W. K., Dean, S. M., Kowalcyzk, A., Harris, C. M., Harris, T. M., Rizzo, C. J., Lloyd, R. S. & Stone, M. P., Mar 8 2005, In : Biochemistry. 44, 9, p. 3327-3337 11 p.

Research output: Contribution to journalArticle

7 Scopus citations

Structure of the 1,4-Bis(2′-deoxyadenosin-N6-yl)-2R,3R- butanediol cross-link arising from alkylation of the human N-ras codon 61 by butadiene diepoxide

Merritt, W. K., Nechev, L. V., Scholdberg, T. A., Dean, S. M., Kiehna, S. E., Chang, J. C., Harris, T. M., Harris, C. M., Lloyd, R. S. & Stone, M. P., Aug 2 2005, In : Biochemistry. 44, 30, p. 10081-10092 12 p.

Research output: Contribution to journalArticle

4 Scopus citations
2006

3,4-Epoxy-1-butene, a reactive metabolite of 1,3-butadiene, induces somatic mutations in Xpc-null mice

Wickliffe, J. K., Galbert, L. A., Ammenheuser, M. M., Herring, S. M., Xie, J., Masters, O. E., Friedberg, E. C., Lloyd, R. S. & Ward, J. B., Jan 1 2006, In : Environmental and Molecular Mutagenesis. 47, 1, p. 67-70 4 p.

Research output: Contribution to journalArticle

8 Scopus citations

Modulation of the turnover of formamidopyrimidine DNA glycosylase

Harbut, M. B., Meador, M., Dodson, M. L. & Lloyd, R. S., Jun 13 2006, In : Biochemistry. 45, 23, p. 7341-7346 6 p.

Research output: Contribution to journalArticle

2 Scopus citations

Orientation of the crotonaldehyde-derived N2[3-oxo-1(S)-methyl- propyl]-dG DNA adduct hinders interstrand cross-link formation in the 5′-CpG-3′ sequence

Cho, Y. J., Wang, H., Kozekov, I. D., Kozekova, A., Kurtz, A. J., Jacob, J., Voehler, M., Smith, J., Harris, T. M., Rizzo, C. J., Lloyd, R. S. & Stone, M. P., Aug 1 2006, In : Chemical Research in Toxicology. 19, 8, p. 1019-1029 11 p.

Research output: Contribution to journalArticle

18 Scopus citations

Replication past a trans-4-hydroxynonenal minor-groove adduct by the sequential action of human DNA polymerases ι and κ

Wolfle, W. T., Johnson, R. E., Minko, I. G., Lloyd, R. S., Prakash, S. & Prakash, L., Jan 2006, In : Molecular and cellular biology. 26, 1, p. 381-386 6 p.

Research output: Contribution to journalArticle

46 Scopus citations

Stereospecific formation of interstrand carbinolamine DNA cross-links by crotonaldehyde- and acetaldehyde-derived α-CH3-γ-OH-1, N2-propano-2′-deoxyguanosine adducts in the 5′-CpG-3′ sequence

Cho, Y. J., Wang, H., Kozekov, I. D., Kurtz, A. J., Jacob, J., Voehler, M., Smith, J., Harris, T. M., Lloyd, R. S., Rizzo, C. J. & Stone, M. P., Feb 2006, In : Chemical Research in Toxicology. 19, 2, p. 195-208 14 p.

Research output: Contribution to journalArticle

42 Scopus citations

Structure of T4 Pyrimidine Dimer Glycosylase in a Reduced Imine Covalent Complex with Abasic Site-containing DNA

Golan, G., Zharkov, D. O., Grollman, A. P., Dodson, M. L., McCullough, A. K., Lloyd, R. S. & Shoham, G., Sep 15 2006, In : Journal of molecular biology. 362, 2, p. 241-258 18 p.

Research output: Contribution to journalArticle

21 Scopus citations

Synthesis and mutagenesis of the butadiene-derived N3 2′-deoxyuridine adducts

Fernandes, P. H., Hackfeld, L. C., Kozekov, I. D., Hodge, R. P. & Lloyd, R. S., Jul 2006, In : Chemical Research in Toxicology. 19, 7, p. 968-976 9 p.

Research output: Contribution to journalArticle

12 Scopus citations

The forum theatre of Augusto boal: A dramatic model for dialogue and community-based environmental science

Sullivan, J. & Lloyd, R. S., Dec 1 2006, In : Local Environment. 11, 6, p. 627-646 20 p.

Research output: Contribution to journalArticle

12 Scopus citations

The metabolic syndrome resulting from a knockout of the NEIL1 DNA glycosylase

Vartanian, V., Lowell, B., Minko, I. G., Wood, T. G., Ceci, J. D., George, S., Ballinger, S. W., Corless, C. L., McCullough, A. K. & Lloyd, R. S., Feb 15 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 6, p. 1864-1869 6 p.

Research output: Contribution to journalArticle

165 Scopus citations

Uncoupling of nucleotide flipping and DNA bending by the T4 pyrimidine dimer DNA glycosylase

Walker, R. K., McCullough, A. K. & Lloyd, R. S., Nov 28 2006, In : Biochemistry. 45, 47, p. 14192-14200 9 p.

Research output: Contribution to journalArticle

8 Scopus citations
2007

Detoxification of olefinic epoxides and nucleotide excision repair of epoxide-mediated DNA damage: Insights from animal models examining human sensitivity to 1,3-butadiene

Wickliffe, J. K., Herring, S. M., Hallberg, L. M., Galbert, L. A., Masters, O. E., Ammenheuser, M. M., Xie, J., Friedberg, E. C., Lloyd, R. S., Abdel-Rahman, S. Z. & Ward, J. B., Mar 20 2007, In : Chemico-Biological Interactions. 166, 1-3, p. 226-231 6 p.

Research output: Contribution to journalArticle

12 Scopus citations

Human polymorphic variants of the NEIL1 DNA glycosylase

Roy, L. M., Jaruga, P., Wood, T. G., McCullough, A. K., Dizdaroglu, M. & Lloyd, R. S., May 25 2007, In : Journal of Biological Chemistry. 282, 21, p. 15790-15798 9 p.

Research output: Contribution to journalArticle

53 Scopus citations
4 Scopus citations

Structure of the 1,4-bis(2′-deoxyadenosin-N6-yl)-2S,3S- butanediol intrastrand DNA cross-link arising from butadiene diepoxide in the human N-ras codon 61 sequence

Xu, W., Merritt, W. K., Nechev, L. V., Harris, T. M., Harris, C. M., Lloyd, R. S. & Stone, M. P., Feb 1 2007, In : Chemical Research in Toxicology. 20, 2, p. 187-198 12 p.

Research output: Contribution to journalArticle

4 Scopus citations
2008

Interstrand DNA cross-links induced by α,β-unsaturated aldehydes derived from lipid peroxidation and environmental sources

Stonez, M. P., Cho, Y. J., Huang, H., Kim, H. Y., Kozekov, I. D., Kozekova, A., Wang, H., Minko, I. G., Lloyd, R. S., Harris, T. M. & Rizzo, C. J., Jul 2008, In : Accounts of Chemical Research. 41, 7, p. 793-804 12 p.

Research output: Contribution to journalArticle

115 Scopus citations

Mutagenic potential of DNA-peptide crosslinks mediated by acrolein-derived DNA adducts

Minko, I. G., Kozekov, I. D., Kozekova, A., Harris, T. M., Rizzo, C. J. & Lloyd, R. S., Jan 1 2008, In : Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 637, 1-2, p. 161-172 12 p.

Research output: Contribution to journalArticle

44 Scopus citations

Replication bypass of interstrand cross-link intermediates by Escherichia coli DNA polymerase IV

Kumari, A., Minko, I. G., Harbut, M. B., Finkel, S. E., Goodman, M. F. & Lloyd, R. S., Oct 10 2008, In : Journal of Biological Chemistry. 283, 41, p. 27433-27437 5 p.

Research output: Contribution to journalArticle

41 Scopus citations

Replication bypass of the acrolein-mediated deoxyguanine DNA-peptide cross-links by DNA polymerases of the DinB family

Minko, I. G., Yamanaka, K., Kozekov, I. D., Kozekova, A., Indiani, C., O'Donnell, M. E., Jiang, Q., Goodman, M. F., Rizzo, C. J. & Lloyd, R. S., Oct 2008, In : Chemical Research in Toxicology. 21, 10, p. 1983-1990 8 p.

Research output: Contribution to journalArticle

49 Scopus citations

Role for DNA polymerase κ in the processing of N2-N 2-guanine interstrand cross-links

Minko, I. G., Harbut, M. B., Kozekov, I. D., Kozekova, A., Jakobs, P. M., Olson, S. B., Moses, R. E., Harris, T. M., Rizzo, C. J. & Lloyd, R. S., Jun 20 2008, In : Journal of Biological Chemistry. 283, 25, p. 17075-17082 8 p.

Research output: Contribution to journalArticle

107 Scopus citations

The stereochemistry of trans-4-hydroxynonenal-derived exocyclic 1,N 2-2′-deoxyguanosine adducts modulates formation of interstrand cross-links in the 5′-CpG-3′ sequence

Huang, H., Wang, H., Qi, N., Lloyd, R. S., Rizzo, C. J. & Stone, M. P., Nov 4 2008, In : Biochemistry. 47, 44, p. 11457-11472 16 p.

Research output: Contribution to journalArticle

15 Scopus citations
2009

Conformational interconversion of the trans-4-hydroxynonenal-derived (6S,8R,11S) l,N 2-deoxyguanosine adduct when mismatched with deoxyadenosine in DNA

Huang, H., Wang, H., Lloyd, R. S., Rizzo, C. J. & Stone, M. P., Jan 2009, In : Chemical Research in Toxicology. 22, 1, p. 187-200 14 p.

Research output: Contribution to journalArticle

11 Scopus citations

Deficiency of the oxidative damage-specific DNA glycosylase NEIL1 leads to reduced germinal center B cell expansion

Mori, H., Ouchida, R., Hijikata, A., Kitamura, H., Ohara, O., Li, Y., Gao, X., Yasui, A., Lloyd, R. S. & Wang, J. Y., Nov 2 2009, In : DNA Repair. 8, 11, p. 1328-1332 5 p.

Research output: Contribution to journalArticle

19 Scopus citations

Targeted deletion of the genes encoding NTH1 and NEIL1 DNA N-glycosylases reveals the existence of novel carcinogenic oxidative damage to DNA

Chan, M. K., Ocampo-Hafalla, M. T., Vartanian, V., Jaruga, P., Kirkali, G., Koenig, K. L., Brown, S., Lloyd, R. S., Dizdaroglu, M. & Teebor, G. W., Jul 4 2009, In : DNA Repair. 8, 7, p. 786-794 9 p.

Research output: Contribution to journalArticle

81 Scopus citations
2010

Evidence for the involvement of DNA repair enzyme NEIL1 in nucleotide excision repair of (5′R)- and (5′S)-8,5′-Cyclo-2′- deoxyadenosines

Jaruga, P., Xiao, Y., Vartanian, V., Lloyd, R. S. & Dizdaroglu, M., Feb 16 2010, In : Biochemistry. 49, 6, p. 1053-1055 3 p.

Research output: Contribution to journalArticle

41 Scopus citations

Minor groove orientation of the KWKK peptide tethered via the N-terminal amine to the acrolein-derived 1, N 2-γ- hydroxypropanodeoxyguanosine lesion with a trimethylene linkage

Huang, H., Kozekov, I. D., Kozekova, A., Rizzo, C. J., McCullough, A. K., Lloyd, R. S. & Stone, M. P., Jul 27 2010, In : Biochemistry. 49, 29, p. 6155-6164 10 p.

Research output: Contribution to journalArticle

11 Scopus citations

Modulation of UvrD helicase activity by covalent DNA-protein cross-links

Kumari, A., Minko, I. G., Smith, R. L., Lloyd, R. S. & McCullough, A. K., Jul 9 2010, In : Journal of Biological Chemistry. 285, 28, p. 21313-21322 10 p.

Research output: Contribution to journalArticle

20 Scopus citations

Novel enzymatic function of DNA Polymerase v in translesion DNA synthesis past major groove DNA-peptide and DNA-DNA cross-links

Yamanaka, K., Minko, I. G., Takata, K. I., Kolbanovskiy, A., Kozekov, I. D., Wood, R. D., Rizzo, C. J. & Lloyd, R. S., Mar 15 2010, In : Chemical Research in Toxicology. 23, 3, p. 689-695 7 p.

Research output: Contribution to journalArticle

43 Scopus citations
2011

Modulation of the processive abasic site lyase activity of a pyrimidine dimer glycosylase

Ryabinina, O. P., Minko, I. G., Lasarev, M. R., McCullough, A. K. & Lloyd, R. S., Oct 10 2011, In : DNA Repair. 10, 10, p. 1014-1022 9 p.

Research output: Contribution to journalArticle

4 Scopus citations

Role of high-fidelity Escherichia coli DNA polymerase I in replication bypass of a deoxyadenosine DNA-peptide cross-link

Yamanaka, K., Minko, I. G., Finkel, S. E., Goodman, M. F. & Lloyd, R. S., Aug 2011, In : Journal of bacteriology. 193, 15, p. 3815-3821 7 p.

Research output: Contribution to journalArticle

14 Scopus citations

TAT-mediated delivery of a DNA repair enzyme to skin cells rapidly initiates repair of UV-induced DNA damage

Johnson, J. L., Lowell, B. C., Ryabinina, O. P., Lloyd, R. S. & McCullough, A. K., Mar 2011, In : Journal of Investigative Dermatology. 131, 3, p. 753-761 9 p.

Research output: Contribution to journalArticle

15 Scopus citations

The base excision repair pathway is required for efficient lentivirus integration

Yoder, K. E., Espeseth, A., Wang, X. H., Fang, Q., Russo, M. T., Lloyd, R. S., Hazuda, D., Sobol, R. W. & Fishel, R., 2011, In : PloS one. 6, 3, e17862.

Research output: Contribution to journalArticle

22 Scopus citations

Variable penetrance of metabolic phenotypes and development of high-fat diet-induced adiposity in NEIL1-deficient mice.

Sampath, H., Batra, A. K., Vartanian, V., Carmical, J. R., Prusak, D., King, I. B., Lowell, B., Earley, L. F., Wood, T. G., Marks, D. L., McCullough, A. K. & R Stephen, L., Apr 2011, In : American journal of physiology. Endocrinology and metabolism. 300, 4, p. E724-734

Research output: Contribution to journalArticle

27 Scopus citations

γ-Hydroxy-1, N 2-propano-2′-deoxyguanosine DNA adduct conjugates the N-terminal amine of the KWKK peptide via a carbinolamine linkage

Huang, H., Wang, H., Voehler, M. W., Kozekova, A., Rizzo, C. J., McCullough, A. K., Lloyd, R. S. & Stone, M. P., Jul 18 2011, In : Chemical Research in Toxicology. 24, 7, p. 1123-1133 11 p.

Research output: Contribution to journalArticle

5 Scopus citations
2012

8-Oxoguanine DNA Glycosylase (OGG1) Deficiency Increases Susceptibility to Obesity and Metabolic Dysfunction

Sampath, H., Vartanian, V., Rollins, M. R., Sakumi, K., Nakabeppu, Y. & Lloyd, R. S., Dec 17 2012, In : PloS one. 7, 12, e51697.

Research output: Contribution to journalArticle

68 Scopus citations

A Comprehensive Strategy to Discover Inhibitors of the Translesion Synthesis DNA Polymerase κ

Yamanaka, K., Dorjsuren, D., Eoff, R. L., Egli, M., Maloney, D. J., Jadhav, A., Simeonov, A. & Lloyd, R. S., Oct 8 2012, In : PloS one. 7, 10, e45032.

Research output: Contribution to journalArticle

25 Scopus citations