• 8636 Citations
  • 51 h-Index
1977 …2020

Research output per year

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Article
1996

Modulation of interleukin-12 mRNA expression in leukocytes of cancer patients treated with CM101

Hellerqvist, C. G., Lloyd, R. S., Wang, E. & Bardhan, S., Jan 1 1996, In : Annals of the New York Academy of Sciences. 795, p. 346-348 3 p.

Research output: Contribution to journalArticle

3 Scopus citations

Partial purification and characterization of a novel dna glycosylase from neisseria mucosa

Nyaga, S. G. & Stephen Lloyd, R., Dec 1 1996, In : FASEB Journal. 10, 6, p. A966

Research output: Contribution to journalArticle

1 Scopus citations

Specific interactions of t4 endonuclease v with a proposed transition state analogue for dna glycosylases

McCullough, A. K., Verdine, G. L. & Stephen Lloyd, R., Dec 1 1996, In : FASEB Journal. 10, 6, p. A966

Research output: Contribution to journalArticle

Structural determinants for specific recognition by T4 endonuclease V

McCullough, A. K., Schärer, O., Verdine, G. L. & Stephen Lloyd, R., 1996, In : Journal of Biological Chemistry. 271, 50, p. 32147-32152 6 p.

Research output: Contribution to journalArticle

27 Scopus citations

T4 endonuclease V exists in solution as a monomer and binds to target sites as a monomer

Latham, K. A., Rajendran, S., Carmical, J. R., Lee, J. C. & Lloyd, R. S., Feb 8 1996, In : Biochimica et Biophysica Acta - Protein Structure and Molecular Enzymology. 1292, 2, p. 324-334 11 p.

Research output: Contribution to journalArticle

3 Scopus citations
1995
51 Scopus citations

In vivo and in vitro replication consequences of stereoisomeric benzo[a]pyrene-7,8-dihydrodiol 9,10-epoxide adducts on adenine N6 at the second position of N-ras codon 61

Chary, P., Latham, G. J., Robberson, D. L., Kim, S. J., Han, S., Harris, C. M., Harris, T. M. & Lloyd, R. S., Jan 1 1995, In : Journal of Biological Chemistry. 270, 10, p. 4990-5000 11 p.

Research output: Contribution to journalArticle

91 Scopus citations

Involvement of glutamic acid 23 in the catalytic mechanism of T4 endonuclease V

Manuel, R. C., Latham, K. A., Dodson, M. L. & Lloyd, R. S., Jan 1 1995, In : Journal of Biological Chemistry. 270, 6, p. 2652-2661 10 p.

Research output: Contribution to journalArticle

32 Scopus citations

Purification and cloning of Micrococcus luteus ultraviolet endonuclease, an N-glycosylase/abasic lyase that proceeds via an imino enzyme-DNA intermediate

Piersen, C. E., Prince, M. A., Augustine, M. L., Dodson, M. L. & Lloyd, R. S., Jan 1 1995, In : Journal of Biological Chemistry. 270, 40, p. 23475-23484 10 p.

Research output: Contribution to journalArticle

56 Scopus citations

Studies on the catalytic mechanism of five DNA glycosylases: Probing for enzyme-DNA imino intermediates

Sun, B., Latham, K. A., Dodson, M. L. & Lloyd, R. S., Aug 18 1995, In : Journal of Biological Chemistry. 270, 33, p. 19501-19508 8 p.

Research output: Contribution to journalArticle

Open Access
128 Scopus citations

T4 endonuclease V protects the DNA strand opposite a thymine dimer from cleavage by the footprinting reagents DNase I and 1,10-phenanthroline-copper

Latham, K. A., Taylor, J. S. & Lloyd, R. S., Jan 1 1995, In : Journal of Biological Chemistry. 270, 8, p. 3765-3771 7 p.

Research output: Contribution to journalArticle

13 Scopus citations

The Efficiency of Translesion Synthesis Past Single Styrene Oxide DNA Adducts In Vitro Is Polymerase-Specific

Latham, G. J., Harris, C. M., Harris, T. M. & Lloyd, R. S., Apr 1995, In : Chemical Research in Toxicology. 8, 3, p. 422-430 9 p.

Research output: Contribution to journalArticle

31 Scopus citations

The interaction of T4 endonuclease V E23Q mutant with thymine dimer- and tetrahydrofuran-containing DNA

Latham, K. A., Manuel, R. C. & Lloyd, R. S., Jan 1 1995, In : Journal of bacteriology. 177, 17, p. 5166-5168 3 p.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations

δ-Elimination by T4 Endonuclease V at a Thymine Dimer Site Requires a Secondary Binding Event and Amino Acid Glu-23

Latham, K. A. & Stephen Lloyd, R., Jul 1995, In : Biochemistry. 34, 27, p. 8796-8803 8 p.

Research output: Contribution to journalArticle

22 Scopus citations
1994
4 Scopus citations
37 Scopus citations

Mutation of Tryptophan 128 in T4 Endonuclease V Does Not Affect Glycosylase or Abasic Site Lyase Activity

Latham, K. A., Carmical, J. R. & Lloyd, R. S., Aug 1 1994, In : Biochemistry. 33, 30, p. 9024-9031 8 p.

Research output: Contribution to journalArticle

8 Scopus citations

T4 Endonuclease V: Perspectives on Catalysis

LATHAM, K. ATKINS. & LLOYD, R. STEPHEN., Jul 1994, In : Annals of the New York Academy of Sciences. 726, 1, p. 181-197 17 p.

Research output: Contribution to journalArticle

21 Scopus citations
1993

A xeroderma pigmentosum complementation group A related gene: confirmation using monoclonal antibodies against the cyclobutane dimer and (6-4) photoproduct

Mori, T., Rinaldy, T. L., Athwal, R. S., Kaur, G. P., Nikaido, O., Lloyd, R. S. & Rinaldy, A., Jan 1993, In : Mutation Research-DNA Repair. 293, 2, p. 143-150 8 p.

Research output: Contribution to journalArticle

13 Scopus citations

Conserved features of selenoprotein P cDNA

Hill, K. E., Lloyd, R. S. & Burk, R. F., Jan 1 1993, In : Biochemical Society transactions. 21, 4, p. 832-835 4 p.

Research output: Contribution to journalArticle

7 Scopus citations
Open Access
151 Scopus citations

Evidence for an Imino Intermediate in the T4 Endonuclease V Reaction

Dodson, M. L., Lloyd, R. S. & Schrock, R. D., Jan 1 1993, In : Biochemistry. 32, 32, p. 8284-8290 7 p.

Research output: Contribution to journalArticle

133 Scopus citations

Processivity of uracil DNA glycosylase

Higley, M. & Stephen Lloyd, R., Aug 1993, In : Mutation Research-DNA Repair. 294, 2, p. 109-116 8 p.

Research output: Contribution to journalArticle

56 Scopus citations
58 Scopus citations

The replication fate of R- and S-styrene oxide adducts on adenine N6 is dependent on both the chirality of the lesion and the local sequence context

Latham, G. J., Zhou, L., Harris, C. M., Harris, T. M. & Lloyd, R. S., Jan 1 1993, In : Journal of Biological Chemistry. 268, 31, p. 23427-23434 8 p.

Research output: Contribution to journalArticle

75 Scopus citations
1992

A gene that partially complements xeroderma pigmentosum group A cells maps to human chromosome 8

Kaur, G. P., Rinaldy, A., Lloyd, R. S. & Athwal, R. S., Jul 1 1992, In : Somatic Cell and Molecular Genetics. 18, 4, p. 371-379 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

Consequences of Molecular Engineering Enhanced DNA Binding in a DNA Repair Enzyme

Nickell, C., Prince, M. A. & Lloyd, R. S., Jan 1 1992, In : Biochemistry. 31, 17, p. 4189-4198 10 p.

Research output: Contribution to journalArticle

12 Scopus citations
57 Scopus citations
1991

Inhibition of eukaryotic topoisomerase II by ultraviolet-induced cyclobutane pyrimidine dimers

Corbett, A. H., Zechiedrich, E. L., Lloyd, R. S. & Osheroff, N., Jan 1 1991, In : Journal of Biological Chemistry. 266, 29, p. 19666-19671 6 p.

Research output: Contribution to journalArticle

29 Scopus citations

Isolation and characterization of cDNA clones for rat liver 10-formyltetrahydrofolate dehydrogenase

Cook, R. J., Lloyd, R. S. & Wagner, C., Jul 11 1991, In : Journal of Biological Chemistry. 266, 8, p. 4965-4973 9 p.

Research output: Contribution to journalArticle

86 Scopus citations

Mutations in Endonuclease V That Affect both Protein-Protein Association and Target Site Location

Nickell, C. & Lloyd, R. S., Sep 1 1991, In : Biochemistry. 30, 35, p. 8638-8648 11 p.

Research output: Contribution to journalArticle

19 Scopus citations

Oligonucleotide Site Directed Mutagenesis of All Histidine Residues within the T4 Endonuclease V Gene: Role in Enzyme-Nontarget DNA Binding

Augustine, M. L., Hamilton, R. W., Dodson, M. L. & Lloyd, R. S., Aug 1 1991, In : Biochemistry. 30, 32, p. 8052-8059 8 p.

Research output: Contribution to journalArticle

13 Scopus citations
70 Scopus citations

Selective metal binding to cys-78 within endonuclease V causes an inhibition of catalytic activities without altering nontarget and target DNA binding

Prince, M. A., Friedman, B., Gruskin, E. A., Schrock, R. D. & Lloyd, R. S., Aug 16 1991, In : Journal of Biological Chemistry. 266, 16, p. 10686-10693 8 p.

Research output: Contribution to journalArticle

19 Scopus citations

Site-directed deletion mutagenesis within the T4 endonuclease V gene: dispensable sequences within putative loop regions

Dodson, M. L., Prince, M. A., Anderson, W. F. & Lloyd, R. S., Jul 1991, In : Mutation Research-DNA Repair. 255, 1, p. 19-29 11 p.

Research output: Contribution to journalArticle

4 Scopus citations
30 Scopus citations

Substitution of basic amino acids within endonuclease V enhances nontarget DNA binding

Nickell, C., Anderson, W. F. & Lloyd, R. S., Oct 22 1991, In : Journal of Biological Chemistry. 266, 9, p. 5634-5642 9 p.

Research output: Contribution to journalArticle

15 Scopus citations

The cDNA for rat selenoprotein P contains 10 TGA codons in the open reading frame

Hill, K. E., Lloyd, R. S., Yang, J. G., Read, R. & Burk, R. F., Aug 16 1991, In : Journal of Biological Chemistry. 266, 16, p. 10050-10053 4 p.

Research output: Contribution to journalArticle

186 Scopus citations
1990
59 Scopus citations
13 Scopus citations
1989

Characterization of mRNA species related to human liver cytochrome P-450 nifedipine oxidase and the regulation of catalytic activity

Bork, R. W., Muto, T., Beaune, P. H., Srivastava, P. K., Lloyd, R. S. & Guengerich, F. P., Jan 1 1989, In : Journal of Biological Chemistry. 264, 2, p. 910-919 10 p.

Research output: Contribution to journalArticle

123 Scopus citations

Expression of a Human Liver Cytochrome P-450 Protein with Tolbutamide Hydroxylase Activity in Saccharomyces cerevisiae

Brian, W. R., Srivastava, P. K., Umbenhauer, D. R., Lloyd, R. S. & Guengerich, F. P., Jun 1 1989, In : Biochemistry. 28, 12, p. 4993-4999 7 p.

Research output: Contribution to journalArticle

151 Scopus citations

Human liver mephenytoin 4 -hydroxylase cytochrome p-450 proteins and genes

Brian, W. R., Gedt, C., Bellew, T. M., Srivastava, P. K., Bork, R. W., Umbenhauer, D. R., Lloyd, R. S. & Guengerich, F. P., Jan 1 1989, In : Drug Metabolism Reviews. 20, 2-4, p. 449-465 17 p.

Research output: Contribution to journalArticle

6 Scopus citations

Modulation of the DNA scanning activity of the Micrococcus luteus UV endonuclease.

Hamilton, R. W. & Lloyd, R. S., Oct 15 1989, In : The Journal of biological chemistry. 264, 29, p. 17422-17427 6 p.

Research output: Contribution to journalArticle

28 Scopus citations

Site-Directed Mutagenesis of the T4 Endonuclease V Gene: The Role of Arginine-3 in the Target Search

Dowd, D. R. & Lloyd, R. S., Jan 1 1989, In : Biochemistry. 28, 22, p. 8699-8705 7 p.

Research output: Contribution to journalArticle

30 Scopus citations
7 Scopus citations

Structure-function studies of the T4 endonuclease V repair enzyme

Dodson, M. L. & Lloyd, R. S., Sep 1989, In : Mutation Research-DNA Repair. 218, 2, p. 49-65 17 p.

Research output: Contribution to journalArticle

50 Scopus citations
1988

Characterization of Cdnas, Mrnas, and Proteins Related to Human Liver Microsomal Cytochrome P-450 (s)-mephenytoin 4′-Hydroxylase

Ged, C., Umbenhauer, D. R., Bellew, T. M., Bork, R. W., Srivastava, P. K., Shinriki, N., Lloyd, R. S. & Guengerich, F. P., Sep 1 1988, In : Biochemistry. 27, 18, p. 6929-6940 12 p.

Research output: Contribution to journalArticle

122 Scopus citations

Gene Cloning Using cDNA Libraries in a Differential Competition Hybridization Strategy: Application to Cloning XP-A Related Genes

Rinaldy, A., Dodson, M. L., Darling, T. L. & Lloyd, R. S., Oct 1988, In : DNA. 7, 8, p. 563-570 8 p.

Research output: Contribution to journalArticle

6 Scopus citations

Modulation of expression of the human gamma interferon gene in E. coli by site-directed mutagenesis

Lee, S. G., Ricca, G. A., Crumley, G., Lloyd, R. S. & Drohan, W., Feb 29 1988, In : Biochemical and Biophysical Research Communications. 151, 1, p. 598-607 10 p.

Research output: Contribution to journalArticle

3 Scopus citations