• 8665 Citations
  • 51 h-Index
1977 …2020

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Article
2001

Backbone dynamics of DNA containing 8-oxoguanine: Importance for substrate recognition by base excision repair glycosylases

Dodson, M. L. & Lloyd, R. S., Dec 19 2001, In : Mutation Research - DNA Repair. 487, 3-4, p. 93-108 16 p.

Research output: Contribution to journalArticle

7 Scopus citations

Efficient nonmutagenic replication bypass of DNAs containing β-adducts of styrene oxide at adenine N6

Kanuri, M., Finneman, J., Harris, C. M., Harris, T. M. & Lloyd, R. S., 2001, In : Environmental and Molecular Mutagenesis. 38, 4, p. 357-360 4 p.

Research output: Contribution to journalArticle

9 Scopus citations
Open Access
125 Scopus citations

Identification of a novel membrane protein, HP59, with therapeutic potential as a target of tumor angiogenesis

Fu, C., Bardhan, S., Cetateanu, N. D., Wamil, B. D., Wang, Y., Shi, E., Venkov, C., Yakes, F. M., Mernaugh, R. L., Hellerqvist, C. G., Yan, H. P., Carter, C., Page, D. L. & Lloyd, R. S., 2001, In : Clinical Cancer Research. 7, 12, p. 4182-4194 13 p.

Research output: Contribution to journalArticle

13 Scopus citations

Interchain cross-linking of DNA mediated by the principal adduct of acrolein

Kozekov, I. D., Nechev, L. V., Sanchez, A., Harris, C. M., Lloyd, R. S. & Harris, T. M., 2001, In : Chemical Research in Toxicology. 14, 11, p. 1482-1485 4 p.

Research output: Contribution to journalArticle

62 Scopus citations

Methylation by a mutant T2 DNA [N6-adenine] methyltransferase expands the usage of RecA-assisted endonuclease (RARE) cleavage

Minko, I., Hattman, S., Lloyd, R. S. & Kossykh, V., Apr 1 2001, In : Nucleic acids research. 29, 7, p. 1484-1490 7 p.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

Point mutations induced by 1,2-epoxy-3-butene N1 deoxyinosine adducts

Rodriguez, D. A., Kowalczyk, A., Ward, J. B., Harris, C. M., Harris, T. M. & Lloyd, R. S., 2001, In : Environmental and Molecular Mutagenesis. 38, 4, p. 292-296 5 p.

Research output: Contribution to journalArticle

18 Scopus citations

Repair of hydantoins, one electron oxidation product of 8-oxoguanine, by DNA glycosylases of Escherichia coli

Hazra, T. K., Muller, J. G., Manuel, R. C., Burrows, C. J., Lloyd, R. S. & Mitra, S., May 1 2001, In : Nucleic acids research. 29, 9, p. 1967-1974 8 p.

Research output: Contribution to journalArticle

Open Access
92 Scopus citations

Substrate specificity and excision kinetics of Escherichia coli endonuclease VIII (Nei) for modified bases in DNA damaged by free radicals

Dizdaroglu, M., Burgess, S. M., Jaruga, P., Hazra, T. K., Rodriguez, H. & Lloyd, R. S., Oct 9 2001, In : Biochemistry. 40, 40, p. 12150-12156 7 p.

Research output: Contribution to journalArticle

43 Scopus citations

The reaction mechanism of DNA glycosylase/AP lyases at abasic sites

McCullough, A. K., Sanchez, A., Dodson, M. L., Marapaka, P., Taylor, J. S. & Stephen Lloyd, R., Jan 16 2001, In : Biochemistry. 40, 2, p. 561-568 8 p.

Research output: Contribution to journalArticle

46 Scopus citations

Topoisomerase II from Chlorella Virus PBCV-1 Has an Exceptionally High DNA Cleavage Activity

Fortune, J. M., Lavrukhin, O. V., Gurnon, J. R., Van Etten, J. L., Lloyd, R. S. & Osheroff, N., Jun 29 2001, In : Journal of Biological Chemistry. 276, 26, p. 24401-24408 8 p.

Research output: Contribution to journalArticle

33 Scopus citations

Translesion DNA Synthesis by Yeast DNA Polymerase η on Templates Containing N2-Guanine Adducts of 1,3-Butadiene Metabolites

Minko, I. G., Washington, M. T., Prakash, L., Prakash, S. & Lloyd, R. S., Jan 26 2001, In : Journal of Biological Chemistry. 276, 4, p. 2517-2522 6 p.

Research output: Contribution to journalArticle

34 Scopus citations
2000

Active-site determination of a pyrimidine dimer glycosylase

Garvish, J. F. & Lloyd, R. S., Jan 21 2000, In : Journal of molecular biology. 295, 3, p. 479-488 10 p.

Research output: Contribution to journalArticle

13 Scopus citations

AP lyases and dRPases: Commonality of mechanism

Piersen, C. E., McCullough, A. K. & Lloyd, R. S., Feb 16 2000, In : Mutation Research - DNA Repair. 459, 1, p. 43-53 11 p.

Research output: Contribution to journalArticle

78 Scopus citations

Butadiene-induced intrastrand DNA cross-links: A possible role in deletion mutagenesis

Carmical, J. R., Kowalczyk, A., Zou, Y., Van Houten, B., Nechev, L. V., Harris, C. M., Harris, T. M. & Lloyd, R. S., Jun 30 2000, In : Journal of Biological Chemistry. 275, 26, p. 19482-19489 8 p.

Research output: Contribution to journalArticle

42 Scopus citations

Intron conservation in a UV-specific DNA repair gene encoded by chlorella viruses

Sun, L., Li, Y., McCullough, A. K., Wood, T. G., Lloyd, R. S., Adams, B., Gurnon, J. R. & Van Etten, J. L., 2000, In : Journal of Molecular Evolution. 50, 1, p. 82-92 11 p.

Research output: Contribution to journalArticle

16 Scopus citations

Involvement of phylogenetically conserved acidic amino acid residues in catalysis by an oxidative DNA damage enzyme formamidopyrimidine glycosylase

Lavrukhin, O. V. & Lloyd, R. S., Dec 12 2000, In : Biochemistry. 39, 49, p. 15266-15271 6 p.

Research output: Contribution to journalArticle

47 Scopus citations

Mutagenic potential of adenine N6 adducts of monoepoxide and diolepoxide derivatives of butadiene

Carmical, J. R., Nechev, L. V., Harris, C. M., Harris, T. M. & Lloyd, R. S., 2000, In : Environmental and Molecular Mutagenesis. 35, 1, p. 48-56 9 p.

Research output: Contribution to journalArticle

51 Scopus citations

Mutagenic potential of guanine N2 adducts of butadiene mono- and diolepoxide

Carmical, J. R., Zhang, M., Nechev, L., Harris, C. M., Harris, T. M. & Lloyd, R. S., 2000, In : Chemical Research in Toxicology. 13, 1, p. 18-25 8 p.

Research output: Contribution to journalArticle

35 Scopus citations

Purification and characterization of a novel UV lesion-specific DNA glycosylase/AP lyase from Bacillus sphaericus

Vasquez, D. A., Nyaga, S. G. & Lloyd, R. S., May 31 2000, In : Mutation Research - DNA Repair. 459, 4, p. 307-316 10 p.

Research output: Contribution to journalArticle

4 Scopus citations

Structural similarities between MutT and the C-terminal domain of MutY

Volk, D. E., House, P. G., Thiviyanathan, V., Luxon, B. A., Zhang, S., Lloyd, R. S. & Gorenstein, D. G., Jun 27 2000, In : Biochemistry. 39, 25, p. 7331-7336 6 p.

Research output: Contribution to journalArticle

44 Scopus citations

Structural similarities between MutT and the C-terminal Domain of MutY

Volk, D. E., House, P. G., Thiviyanathan, V., Luxon, B. A., Zhang, S., Lloyd, R. S. & Gorenstein, D. G., Apr 27 2000, In : Biochemistry. 39, 25, p. X-7336

Research output: Contribution to journalArticle

9 Scopus citations

Topoisomerase II from chlorella virus PBCV-1. Characterization of the smallest known type II topoisomerase

Lavrukhin, O. V., Fortune, J. M., Wood, T. G., Burbank, D. E., Van Etten, J. L., Osheroff, N. & Stephen Lloyd, R., Mar 10 2000, In : Journal of Biological Chemistry. 275, 10, p. 6915-6921 7 p.

Research output: Contribution to journalArticle

39 Scopus citations

Two glycosylase/abasic lyases from Neisseria mucosa that initiate DNA repair at sites of UV-induced photoproducts

Nyaga, S. G. & Lloyd, R. S., Aug 4 2000, In : Journal of Biological Chemistry. 275, 31, p. 23569-23576 8 p.

Research output: Contribution to journalArticle

8 Scopus citations

Vertical-scanning mutagenesis of a critical tryptophan in the 'minor groove binding track' of HIV-1 reverse transcriptase. Major groove DNA adducts identify specific protein interactions in the minor groove

Latham, G. J., Forgacs, E., Beard, W. A., Prasad, R., Bebenek, K., Kunkel, T. A., Wilson, S. H. & Lloyd, R. S., May 19 2000, In : Journal of Biological Chemistry. 275, 20, p. 15025-15033 9 p.

Research output: Contribution to journalArticle

30 Scopus citations
1999

The catalytic mechanism of a pyrimidine dimer-specific glycosylase (pdg)/abasic lyase, chlorella virus-pdg

Garvish, J. F. & Lloyd, R. S., Apr 2 1999, In : Journal of Biological Chemistry. 274, 14, p. 9786-9794 9 p.

Research output: Contribution to journalArticle

18 Scopus citations
1998

Base excision repair of cyclobutane pyrimidine dimers

Lloyd, R. S., Sep 11 1998, In : Mutation Research - DNA Repair. 408, 3, p. 159-170 12 p.

Research output: Contribution to journalArticle

19 Scopus citations

Characterization of a novel cis-syn and trans-syn-II pyrimidine dimer glycosylase/AP lyase from a eukaryotic algal virus, Paramecium bursaria chlorella virus-1

McCullough, A. K., Romberg, M. T., Nyaga, S., Wei, Y., Wood, T. G., Taylor, J. S., Van Etten, J. L., Dodson, M. L. & Lloyd, R. S., May 22 1998, In : Journal of Biological Chemistry. 273, 21, p. 13136-13142 7 p.

Research output: Contribution to journalArticle

42 Scopus citations

Multiple conformations of an intercalated (-)-(7S, 8R, 9S, 10R)-N6- [10-(7,8,9,10-tetrahydrobenzo[a]pyrenyl)]-2'-deoxyadenosyl adduct in the N- ras codon 61 sequence

Zegar, I. S., Chary, P., Jabil, R. J., Tamura, P. J., Johansen, T. N., Lloyd, R. S., Harris, C. M., Harris, T. M. & Stone, M. P., Nov 24 1998, In : Biochemistry. 37, 47, p. 16516-16528 13 p.

Research output: Contribution to journalArticle

45 Scopus citations
15 Scopus citations

MutY catalytic core, mutant and bound adenine structures define specificity for DNA repair enzyme superfamily

Guan, Y., Manuel, R. C., Arvai, A. S., Parikh, S. S., Mol, C. D., Miller, J. H., Lloyd, R. S. & Tainer, J. A., Dec 10 1998, In : Nature Structural Biology. 5, 12, p. 1058-1064 7 p.

Research output: Contribution to journalArticle

275 Scopus citations

The Initiation of DNA Base Excision Repair of Dipyrimidine Photoproducts

Lloyd, R. S., Jan 1 1998, In : Progress in nucleic acid research and molecular biology. 62, C, p. 155-175 21 p.

Research output: Contribution to journalArticle

29 Scopus citations
1997

Chlorella virus PBCV-1 encodes a homolog of the bacteriophage T4 UV damage repair gene denV

Furuta, M., Schrader, J. O., Schrader, H. S., Kokjohn, T. A., Nyaga, S., McCullough, A. K., Lloyd, R. S., Burbank, D. E., Landstein, D., Lane, L. & Van Etten, J. L., Apr 1997, In : Applied and Environmental Microbiology. 63, 4, p. 1551-1556 6 p.

Research output: Contribution to journalArticle

Open Access
53 Scopus citations

Cloning, overexpression, and biochemical characterization of the catalytic domain of MutY

Manuel, R. C. & Lloyd, R. S., Sep 16 1997, In : Biochemistry. 36, 37, p. 11140-11152 13 p.

Research output: Contribution to journalArticle

72 Scopus citations

Differential tolerance to DNA polymerization by HIV-1 reverse transcriptase on N6 adenine C10R and C10S benzo[a]pyrene-7,8-dihydrodiol 9,10-epoxide-adducted templates

Chary, P., Harris, C. M., Harris, T. M. & Lloyd, R. S., Feb 28 1997, In : Journal of Biological Chemistry. 272, 9, p. 5805-5813 9 p.

Research output: Contribution to journalArticle

11 Scopus citations

Kinetics of Repair of UV-induced DNA Damage in Repair-proficient and -deficient Cells as Determined by Quantitative Polymerase Chain Reaction

McCarthy, M. J., Rosenblatt, J. I. & Lloyd, R. S., Sep 1997, In : Photochemistry and photobiology. 66, 3, p. 356-362 7 p.

Research output: Contribution to journalArticle

10 Scopus citations

Lack of correlation between in vitro and in vivo replication of precisely defined benz[a]anthracene adducted DNAs

McNees, A. G., O'Donnell, M., Horton, P. H., Kim, H. Y., Kim, S. J., Harris, C. M., Harris, T. M. & Lloyd, R. S., Dec 26 1997, In : Journal of Biological Chemistry. 272, 52, p. 33211-33219 9 p.

Research output: Contribution to journalArticle

29 Scopus citations

Mechanistic link between DNA methyltransferases and DNA repair enzymes by base flipping

Lloyd, R. S. & Cheng, X., Dec 1 1997, In : Biopolymers. 44, 2, p. 139-151 13 p.

Research output: Contribution to journalArticle

19 Scopus citations

Probing structure/function relationships of HIV-1 reverse transcriptase with styrene oxide N2-guanine adducts

Forgacs, E., Latham, G., Beard, W. A., Prasad, R., Bebenek, K., Kunkel, T. A., Wilson, S. H. & Lloyd, R. S., Mar 28 1997, In : Journal of Biological Chemistry. 272, 13, p. 8525-8530 6 p.

Research output: Contribution to journalArticle

26 Scopus citations

Role of specific amino acid residues in T4 endonuclease V that alter nontarget DNA binding

Nyaga, S. G., Dodson, M. L. & Lloyd, R. S., Apr 8 1997, In : Biochemistry. 36, 14, p. 4080-4088 9 p.

Research output: Contribution to journalArticle

16 Scopus citations

The role of base flipping in damage recognition and catalysis by T4 endonuclease V

McCullough, A. K., Dodson, M. L., Schärer, O. D. & Lloyd, R. S., 1997, In : Journal of Biological Chemistry. 272, 43, p. 27210-27217 8 p.

Research output: Contribution to journalArticle

56 Scopus citations
1996

A modified quantitative polymerase chain reaction assay for measuring gene-specific repair of UV photoproducts in human cells

McCarthy, M. J., Rosenblatt, J. I. & Lloyd, R. S., May 15 1996, In : Mutation Research - DNA Repair. 363, 1, p. 57-66 10 p.

Research output: Contribution to journalArticle

29 Scopus citations

Analysis of t4 endonuclease v homologs from a variety of chlorella virus strains

Forgacs, E., Kodira, C., Van Elten, J. L. & Lloyd, R. S., Dec 1 1996, In : FASEB Journal. 10, 6, p. A965

Research output: Contribution to journalArticle

29 Scopus citations

Catalytic role of escherichia cou muty gene product in dna mismatch repair

Manuel, R. C. & Lloyd, R. S., Dec 1 1996, In : FASEB Journal. 10, 6, p. A964

Research output: Contribution to journalArticle

Comparison of the efficiency of synthesis past single bulky DNA adducts in vivo and in vitro by the polymerase III holoenzyme

Latham, G. J., McNees, A. G., De Corte, B., Harris, C. M., Harris, T. M., O'Donnell, M. & Stephen Lloyd, R., 1996, In : Chemical Research in Toxicology. 9, 7, p. 1167-1175 9 p.

Research output: Contribution to journalArticle

10 Scopus citations

Evidence for an imino intermediate in the dna polymerase beta deoxyribose phosphate excision reaction

Piersen, C., Prasad, R., Wilson, S. & Lloyd, R. S., 1996, In : FASEB Journal. 10, 6, p. A961

Research output: Contribution to journalArticle

Evidence for an imino intermediate in the DNA polymerase β deoxyribose phosphate excision reaction

Piersen, C. E., Prasad, R., Wilson, S. H. & Lloyd, R. S., 1996, In : Journal of Biological Chemistry. 271, 30, p. 17811-17815 5 p.

Research output: Contribution to journalArticle

146 Scopus citations

Identification of the structural and functional domains of MutY, an Escherichia coli DNA mismatch repair enzyme

Manuel, R. C., Czerwinski, E. W. & Stephen Lloyd, R., 1996, In : Journal of Biological Chemistry. 271, 27, p. 16218-16226 9 p.

Research output: Contribution to journalArticle

70 Scopus citations
18 Scopus citations