• 8647 Citations
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1977 …2020

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Article
2007

Detoxification of olefinic epoxides and nucleotide excision repair of epoxide-mediated DNA damage: Insights from animal models examining human sensitivity to 1,3-butadiene

Wickliffe, J. K., Herring, S. M., Hallberg, L. M., Galbert, L. A., Masters, O. E., Ammenheuser, M. M., Xie, J., Friedberg, E. C., Lloyd, R. S., Abdel-Rahman, S. Z. & Ward, J. B., Mar 20 2007, In : Chemico-Biological Interactions. 166, 1-3, p. 226-231 6 p.

Research output: Contribution to journalArticle

12 Scopus citations

Human polymorphic variants of the NEIL1 DNA glycosylase

Roy, L. M., Jaruga, P., Wood, T. G., McCullough, A. K., Dizdaroglu, M. & Lloyd, R. S., May 25 2007, In : Journal of Biological Chemistry. 282, 21, p. 15790-15798 9 p.

Research output: Contribution to journalArticle

53 Scopus citations
4 Scopus citations

Structure of the 1,4-bis(2′-deoxyadenosin-N6-yl)-2S,3S- butanediol intrastrand DNA cross-link arising from butadiene diepoxide in the human N-ras codon 61 sequence

Xu, W., Merritt, W. K., Nechev, L. V., Harris, T. M., Harris, C. M., Lloyd, R. S. & Stone, M. P., Feb 1 2007, In : Chemical Research in Toxicology. 20, 2, p. 187-198 12 p.

Research output: Contribution to journalArticle

4 Scopus citations
2006

3,4-Epoxy-1-butene, a reactive metabolite of 1,3-butadiene, induces somatic mutations in Xpc-null mice

Wickliffe, J. K., Galbert, L. A., Ammenheuser, M. M., Herring, S. M., Xie, J., Masters, O. E., Friedberg, E. C., Lloyd, R. S. & Ward, J. B., Jan 1 2006, In : Environmental and Molecular Mutagenesis. 47, 1, p. 67-70 4 p.

Research output: Contribution to journalArticle

8 Scopus citations

Modulation of the turnover of formamidopyrimidine DNA glycosylase

Harbut, M. B., Meador, M., Dodson, M. L. & Lloyd, R. S., Jun 13 2006, In : Biochemistry. 45, 23, p. 7341-7346 6 p.

Research output: Contribution to journalArticle

2 Scopus citations

Orientation of the crotonaldehyde-derived N2[3-oxo-1(S)-methyl- propyl]-dG DNA adduct hinders interstrand cross-link formation in the 5′-CpG-3′ sequence

Cho, Y. J., Wang, H., Kozekov, I. D., Kozekova, A., Kurtz, A. J., Jacob, J., Voehler, M., Smith, J., Harris, T. M., Rizzo, C. J., Lloyd, R. S. & Stone, M. P., Aug 1 2006, In : Chemical Research in Toxicology. 19, 8, p. 1019-1029 11 p.

Research output: Contribution to journalArticle

18 Scopus citations

Replication past a trans-4-hydroxynonenal minor-groove adduct by the sequential action of human DNA polymerases ι and κ

Wolfle, W. T., Johnson, R. E., Minko, I. G., Lloyd, R. S., Prakash, S. & Prakash, L., Jan 2006, In : Molecular and cellular biology. 26, 1, p. 381-386 6 p.

Research output: Contribution to journalArticle

46 Scopus citations

Stereospecific formation of interstrand carbinolamine DNA cross-links by crotonaldehyde- and acetaldehyde-derived α-CH3-γ-OH-1, N2-propano-2′-deoxyguanosine adducts in the 5′-CpG-3′ sequence

Cho, Y. J., Wang, H., Kozekov, I. D., Kurtz, A. J., Jacob, J., Voehler, M., Smith, J., Harris, T. M., Lloyd, R. S., Rizzo, C. J. & Stone, M. P., Feb 2006, In : Chemical Research in Toxicology. 19, 2, p. 195-208 14 p.

Research output: Contribution to journalArticle

42 Scopus citations

Structure of T4 Pyrimidine Dimer Glycosylase in a Reduced Imine Covalent Complex with Abasic Site-containing DNA

Golan, G., Zharkov, D. O., Grollman, A. P., Dodson, M. L., McCullough, A. K., Lloyd, R. S. & Shoham, G., Sep 15 2006, In : Journal of molecular biology. 362, 2, p. 241-258 18 p.

Research output: Contribution to journalArticle

21 Scopus citations

Synthesis and mutagenesis of the butadiene-derived N3 2′-deoxyuridine adducts

Fernandes, P. H., Hackfeld, L. C., Kozekov, I. D., Hodge, R. P. & Lloyd, R. S., Jul 2006, In : Chemical Research in Toxicology. 19, 7, p. 968-976 9 p.

Research output: Contribution to journalArticle

12 Scopus citations

The forum theatre of Augusto boal: A dramatic model for dialogue and community-based environmental science

Sullivan, J. & Lloyd, R. S., Dec 1 2006, In : Local Environment. 11, 6, p. 627-646 20 p.

Research output: Contribution to journalArticle

12 Scopus citations

The metabolic syndrome resulting from a knockout of the NEIL1 DNA glycosylase

Vartanian, V., Lowell, B., Minko, I. G., Wood, T. G., Ceci, J. D., George, S., Ballinger, S. W., Corless, C. L., McCullough, A. K. & Lloyd, R. S., Feb 15 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 6, p. 1864-1869 6 p.

Research output: Contribution to journalArticle

165 Scopus citations

Uncoupling of nucleotide flipping and DNA bending by the T4 pyrimidine dimer DNA glycosylase

Walker, R. K., McCullough, A. K. & Lloyd, R. S., Nov 28 2006, In : Biochemistry. 45, 47, p. 14192-14200 9 p.

Research output: Contribution to journalArticle

8 Scopus citations
2005

Dual roles of glycosyl torsion angle conformation and stereochemical configuration in butadiene oxide-derived N1 β-hydroxyalkyl deoxyinosine adducts: A structural perspective

Merritt, W. K., Kowalczyk, A., Scholdberg, T. A., Dean, S. M., Harris, T. M., Harris, C. M., Lloyd, R. S. & Stone, M. P., Jul 2005, In : Chemical Research in Toxicology. 18, 7, p. 1098-1107 10 p.

Research output: Contribution to journalArticle

4 Scopus citations

Evidence for Escherichia coli polymerase II mutagenic bypass of intrastrand DNA crosslinks

Kanuri, M., Nechev, L. V., Kiehna, S. E., Tamura, P. J., Harris, C. M., Harris, T. M. & Lloyd, R. S., Dec 8 2005, In : DNA Repair. 4, 12, p. 1374-1380 7 p.

Research output: Contribution to journalArticle

12 Scopus citations

Formation of inter- and intrastrand imine type DNA-DNA cross-links through secondary reactions of aldehydic adducts

Sanchez, A. M., Kozekov, I. D., Harris, T. M. & Lloyd, R. S., Nov 1 2005, In : Chemical Research in Toxicology. 18, 11, p. 1683-1690 8 p.

Research output: Contribution to journalArticle

24 Scopus citations

Human DNA polymerase ι promotes replication through a ring-closed minor-groove adduct that adopts a syn conformation in DNA

Wolfle, W. T., Johnson, R. E., Minko, I. G., Lloyd, R. S., Prakash, S. & Prakash, L., Oct 1 2005, In : Molecular and cellular biology. 25, 19, p. 8748-8754 7 p.

Research output: Contribution to journalArticle

38 Scopus citations

Initiation of repair of DNA - Polypeptide cross-links by the UvrABC nuclease

Minko, I. G., Kurtz, A. J., Croteau, D. L., Van Houten, B., Harris, T. M. & Lloyd, R. S., Mar 1 2005, In : Biochemistry. 44, 8, p. 3000-3009 10 p.

Research output: Contribution to journalArticle

53 Scopus citations

Mammalian cell mutagenesis of the DNA adducts of vinyl chloride and crotonaldehyde

Fernandes, P. H., Kanuri, M., Nechev, L. V., Harris, T. M. & Lloyd, R. S., Jun 1 2005, In : Environmental and Molecular Mutagenesis. 45, 5, p. 455-459 5 p.

Research output: Contribution to journalArticle

49 Scopus citations

Mispairing of a site specific major groove (2S,3S)-N6-(2,3,4- trihydroxybutyl)-2′-deoxyadenosyl DNA adduct of butadiene diol epoxide with deoxyguanosine: Formation of a dA(anti)·dG(anti) pairing interaction

Scholdberg, T. A., Nechev, L. V., Merritt, W. K., Harris, T. M., Harris, C. M., Lloyd, R. S. & Stone, M. P., Feb 1 2005, In : Chemical Research in Toxicology. 18, 2, p. 145-153 9 p.

Research output: Contribution to journalArticle

11 Scopus citations

Spectroscopic characterization of interstrand carbinolamine cross-links formed in the 5′-CpG-3′ sequence by the acrolein-derived γ-OH-1,N2-propano-2′-deoxyguanosine DNA adduct

Cho, Y. J., Kim, H. Y., Huang, H., Slutsky, A., Minko, I. G., Wang, H., Nechev, L. V., Kozekov, I. D., Kozekova, A., Tamura, P., Jacob, J., Voehler, M., Harris, T. M., Lloyd, R. S., Rizzo, C. J. & Stone, M. P., Dec 21 2005, In : Journal of the American Chemical Society. 127, 50, p. 17686-17696 11 p.

Research output: Contribution to journalArticle

33 Scopus citations

Structure of an oligodeoxynucleotide containing a butadiene oxide-derived N1 beta-hydroxyalkyl deoxyinosine adduct in the human N-ras codon 61 sequence

Scholdberg, T. A., Merritt, W. K., Dean, S. M., Kowalcyzk, A., Harris, C. M., Harris, T. M., Rizzo, C. J., Lloyd, R. S. & Stone, M. P., Mar 8 2005, In : Biochemistry. 44, 9, p. 3327-3337 11 p.

Research output: Contribution to journalArticle

7 Scopus citations

Structure of the 1,4-Bis(2′-deoxyadenosin-N6-yl)-2R,3R- butanediol cross-link arising from alkylation of the human N-ras codon 61 by butadiene diepoxide

Merritt, W. K., Nechev, L. V., Scholdberg, T. A., Dean, S. M., Kiehna, S. E., Chang, J. C., Harris, T. M., Harris, C. M., Lloyd, R. S. & Stone, M. P., Aug 2 2005, In : Biochemistry. 44, 30, p. 10081-10092 12 p.

Research output: Contribution to journalArticle

4 Scopus citations
2004

A DNA Adenine Methyltransferase of Escherichia coli That Is Cell Cycle Regulated and Essential for Viability

Kossykh, V. G. & Lloyd, R. S., Apr 2004, In : Journal of bacteriology. 186, 7, p. 2061-2067 7 p.

Research output: Contribution to journalArticle

10 Scopus citations

A DNA adenine methyltransferase of Escherichia coli that is cell cycle regulated and essential for viability.

Kossykh, V. G. & Lloyd, R. S., Sep 2004, In : Journal of Bacteriology. 186, 18, p. 6340 1 p.

Research output: Contribution to journalArticle

DNA Damage Recognition of Mutated Forms of UvrB Proteins in Nucleotide Excision Repair

Zou, Y., Ma, H., Minko, I. G., Shell, S. M., Yang, Z., Qu, Y., Xu, Y., Geacintov, N. E. & Lloyd, R. S., Apr 13 2004, In : Biochemistry. 43, 14, p. 4196-4205 10 p.

Research output: Contribution to journalArticle

23 Scopus citations

Efficient and error-free replication past a minor-groove DNA adduct by the sequential action of human DNA polymerases ι and κ

Washington, M. T., Minko, I. G., Johnson, R. E., Wolfle, W. T., Harris, T. M., Lloyd, R. S., Prakash, S. & Prakash, L., Jul 2004, In : Molecular and cellular biology. 24, 13, p. 5687-5693 7 p.

Research output: Contribution to journalArticle

100 Scopus citations

Efficient and error-free replication past a minor-groove N 2-guanine adduct by the sequential action of yeast Rev1 and DNA polymerase

Washington, M. T., Minko, I. G., Johnson, R. E., Haracska, L., Harris, T. M., Lloyd, R. S., Prakash, S. & Prakash, L., Aug 2004, In : Molecular and cellular biology. 24, 16, p. 6900-6906 7 p.

Research output: Contribution to journalArticle

81 Scopus citations

Reaction intermediates in the catalytic mechanism of Escherichia coli MutY DNA glycosylase

Manuel, R. C., Hitomi, K., Arvai, A. S., House, P. G., Kurtz, A. J., Dodson, M. L., McCullough, A. K., Tainer, J. A. & Lloyd, R. S., Nov 5 2004, In : Journal of Biological Chemistry. 279, 45, p. 46930-46939 10 p.

Research output: Contribution to journalArticle

46 Scopus citations

Role of His-16 in Turnover of T4 Pyrimidine Dimer Glycosylase

Meador, M. G., Rajagopalan, L., Lloyd, R. S. & Dodson, M. L., Jan 30 2004, In : Journal of Biological Chemistry. 279, 5, p. 3348-3353 6 p.

Research output: Contribution to journalArticle

3 Scopus citations

Stereospecific structural perturbations arising from adenine N6 butadiene triol adducts in duplex DNA

Merritt, W. K., Scholdberg, T. A., Nechev, L. V., Harris, T. M., Harris, C. M., Lloyd, R. S. & Stone, M. P., Aug 1 2004, In : Chemical Research in Toxicology. 17, 8, p. 1007-1019 13 p.

Research output: Contribution to journalArticle

15 Scopus citations

Structure of a site specific major groove (2S,3S)-N6-(2,3,4- trihydroxybutyl)-2′-deoxyadenosyl DNA adduct of butadiene diol epoxide

Scholdberg, T. A., Nechev, L. V., Merritt, W. K., Harris, T. M., Harris, C. M., Lloyd, R. S. & Stone, M. P., Jun 1 2004, In : Chemical Research in Toxicology. 17, 6, p. 717-730 14 p.

Research output: Contribution to journalArticle

13 Scopus citations
2003
117 Scopus citations

A model of sensitivity: 1,3-Butadiene increases mutant frequencies and genomic damage in mice lacking a functional microsomal epoxide hydrolase gene

Wickliffe, J. K., Ammenheuser, M. M., Salazar, J. J., Abdel-Rahman, S. Z., Hastings-Smith, D. A., Postlethwait, E. M., Lloyd, R. S. & Ward, J. B., Sep 18 2003, In : Environmental and Molecular Mutagenesis. 42, 2, p. 106-110 5 p.

Research output: Contribution to journalArticle

18 Scopus citations

Community outreach as an iterative dialogue among scientists and communities in the Texas gulf coast region

Sullivan, J., Diamond, P. D., Kaplan, C. L., Mader, T. J., Santa, R. K. & Lloyd, R. S., Nov 2003, In : Mutation Research - Reviews in Mutation Research. 544, 2-3, p. 331-338 8 p.

Research output: Contribution to journalArticle

5 Scopus citations

Comparative evaluation of the bioreactivity and mutagenic spectra of acrolein-derived α-HOPdG and γ-HOPdG regioisomeric deoxyguanosine adducts

Sanchez, A. M., Minko, I. G., Kurtz, A. J., Kanuri, M., Moriya, M. & Lloyd, R. S., Aug 1 2003, In : Chemical Research in Toxicology. 16, 8, p. 1019-1028 10 p.

Research output: Contribution to journalArticle

58 Scopus citations

Initiation of repair of A/G mismatches is modulated by sequence context

Sanchez, A. M., Volk, D. E., Gorenstein, D. G. & Lloyd, R. S., Aug 12 2003, In : DNA Repair. 2, 8, p. 863-878 16 p.

Research output: Contribution to journalArticle

11 Scopus citations

Site-specific mutagenicity of stereochemically defined 1, N 2-deoxyguanosine adducts of trans-4-hydroxynonenal in mammalian cells

Fernandes, P. H., Wang, H., Rizzo, C. J. & Lloyd, R. S., Sep 18 2003, In : Environmental and Molecular Mutagenesis. 42, 2, p. 68-74 7 p.

Research output: Contribution to journalArticle

42 Scopus citations

Translesion synthesis past acrolein-derived DNA adduct, γ-hydroxypropanodeoxyguanosine, by yeast and human DNA polymerase η

Minko, I. G., Washington, M. T., Kanuri, M., Prakash, L., Prakash, S. & Lloyd, R. S., Jan 10 2003, In : Journal of Biological Chemistry. 278, 2, p. 784-790 7 p.

Research output: Contribution to journalArticle

74 Scopus citations

Workshop on DNA repair and related DNA transactions, a conference report

Spivak, G., Lloyd, R. S. & Sweder, K. S., Feb 3 2003, In : DNA Repair. 2, 2, p. 235-242 8 p.

Research output: Contribution to journalArticle

3 Scopus citations
2002
20 Scopus citations

Determination of active site residues in Escherichia coli endonuclease VIII

Burgess, S., Jaruga, P., Dodson, M. L., Dizdaroglu, M. & Stephen Lloyd, R., Jan 25 2002, In : Journal of Biological Chemistry. 277, 4, p. 2938-2944 7 p.

Research output: Contribution to journalArticle

42 Scopus citations

Error prone translesion synthesis past γ-hydroxypropano deoxyguanosine the primary acrolein-derived adduct in mammalian cells

Kanuri, M., Minko, I. G., Nechev, L. V., Harris, T. M., Harris, C. M. & Stephen Lloyd, R., May 24 2002, In : Journal of Biological Chemistry. 277, 21, p. 18257-18265 9 p.

Research output: Contribution to journalArticle

69 Scopus citations

Evidence for multiple imino intermediates and identification of reactive nucleophiles in peptide-catalyzed β-elimination at abasic sites

Kurtz, A. J., Dodson, M. L. & Lloyd, R. S., Jun 4 2002, In : Biochemistry. 41, 22, p. 7054-7064 11 p.

Research output: Contribution to journalArticle

32 Scopus citations
85 Scopus citations

Intrastrand DNA cross-links as tools for studying DNA replication and repair: Two-, three-, and four-carbon tethers between the N2 positions of adjacent guanines

Kowalczyk, A., Carmical, J. R., Zou, Y., Van Houten, B., Stephen Lloyd, R., Harris, C. M. & Harris, T. M., Mar 5 2002, In : Biochemistry. 41, 9, p. 3109-3118 10 p.

Research output: Contribution to journalArticle

18 Scopus citations

Mechanistic comparisons among base excision repair glycosylases

Dodson, M. L. & Lloyd, R. S., Apr 15 2002, In : Free Radical Biology and Medicine. 32, 8, p. 678-682 5 p.

Research output: Contribution to journalArticle

40 Scopus citations

Mutagenic spectrum of butadiene-derived N1-deoxyinosine adducts and N6,N6-deoxyadenosine intrastrand cross-links in mammalian cells

Kanuri, M., Nechev, L. V., Tamura, P. J., Harris, C. M., Harris, T. M. & Lloyd, R. S., Dec 1 2002, In : Chemical Research in Toxicology. 15, 12, p. 1572-1580 9 p.

Research output: Contribution to journalArticle

29 Scopus citations

Site-specific DNA cleavage by Chlorella virus topoisomerase II

Fortune, J. M., Dickey, J. S., Lavrukhin, O. V., Van Etten, J. L., Lloyd, R. S. & Osheroff, N., Oct 1 2002, In : Biochemistry. 41, 39, p. 11761-11769 9 p.

Research output: Contribution to journalArticle

20 Scopus citations