• 8581 Citations
  • 51 h-Index
1977 …2020

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1977

Bleomycin-induced alkaline-labile damage and direct strand breakage in covalent-circular DNA

Lloyd, R. S., Hewitt, R. R. & Haidle, C. W., Jan 1 1977, In : Federation Proceedings. 36, 3, p. No. 2229

Research output: Contribution to journalArticle

1 Scopus citations

Bleomycin-induced breakage of closed-circular DNA

Bearden, J. C., Lloyd, R. S. & Haidle, C. W., Mar 21 1977, In : Biochemical and Biophysical Research Communications. 75, 2, p. 442-448 7 p.

Research output: Contribution to journalArticle

6 Scopus citations
1978

A physical map of belomycin-specific fragmentation sites on PM2 bacteriophage DNA

Lloyd, R. S., Haidle, C. W., Robberson, D. L. & Dodson, M. L., Jan 1978, In : Current Microbiology: An International Journal. 1, 1, p. 45-50 6 p.

Research output: Contribution to journalArticle

13 Scopus citations

Bleomycin-induced Alkaline-labile Damage and Direct Strand Breakage of PM2 DNA

Lloyd, R. S., Haidle, C. W. & Hewitt, R. R., Oct 1978, In : Cancer Research. 38, 10, p. 3191-3196 6 p.

Research output: Contribution to journalArticle

60 Scopus citations

Bleomycin-Specific Fragmentation of Double-Stranded DNA

Lloyd, R. S., Haidle, C. W. & Robberson, D. L., Jan 1 1978, In : Biochemistry. 17, 10, p. 1890-1896 7 p.

Research output: Contribution to journalArticle

172 Scopus citations
1979

Bleomycin fragmentation of duplex DNA occurs as staggered single-strand scissions

Lloyd, R. S., Haidle, C. W. & Robberson, D. L., Nov 1979, In : Gene. 7, 3-4, p. 303-316 14 p.

Research output: Contribution to journalArticle

10 Scopus citations

Noncovalent intermolecular crosslinks are produced by bleomycin reaction with duplex DNA

Lloyd, R. S., Haidle, C. W. & Robberson, D. L., Jan 1 1979, In : Proceedings of the National Academy of Sciences of the United States of America. 76, 6, p. 2674-2678 5 p.

Research output: Contribution to journalArticle

Open Access
17 Scopus citations

Site specific bleomycin-mediated single-strand breaks and alkali-labile damage on covalently closed-circular DNA

Lloyd, R. S., Haidle, C. W. & Robberson, D. L., Jan 1 1979, In : Federation Proceedings. 38, 3 I, p. No. 1443

Research output: Contribution to journalArticle

Site specificity of bleomycin-mediated single-strand scissions and alkali-labile damage in duplex DNA

Lloyd, R. S., Haidle, C. W. & Robberson, D. L., Nov 1979, In : Gene. 7, 3-4, p. 289-302 14 p.

Research output: Contribution to journalArticle

16 Scopus citations
1980

Processive action of T4 endonuclease V on ultraviolet-irradiated DNA

Lloyd, R. S., Hanawalt, P. C. & Dodson, M. L., Nov 11 1980, In : Nucleic acids research. 8, 21, p. 5113-5127 15 p.

Research output: Contribution to journalArticle

67 Scopus citations
1981

Bleomycin-mediated DNA cross-links are dependent on closed-circular molecules with superhelical turns

Lloyd, R. S., Robberson, D. L. & Haidle, C. W., Feb 1981, In : Chemico-Biological Interactions. 34, 1, p. 39-46 8 p.

Research output: Contribution to journalArticle

2 Scopus citations

Expression of the denV gene of bacteriophage T4 cloned in Escherichia coli.

Lloyd, R. S. & Hanawalt, P. C., May 1981, In : Proceedings of the National Academy of Sciences of the United States of America. 78, 5, p. 2796-2800 5 p.

Research output: Contribution to journalArticle

Open Access
14 Scopus citations
1985

Immunoinhibition of catalytic activities and cDNA cloning using antibodies to human liver cytochromes P-450

Umbenhauer, D. R., Wolff, T. & Lloyd, R. S., Jan 1 1985, In : Federation Proceedings. 44, 5, p. No. 6175

Research output: Contribution to journalArticle

1986

Cloning and expression of the 3′ portion of the T4 denV gene as a lacZ fusion gene

Stephen Lloyd, R. & Augustine, M. L., Mar 1986, In : Mutation Research DNA Repair Reports. 165, 2, p. 89-100 12 p.

Research output: Contribution to journalArticle

7 Scopus citations
14 Scopus citations

Expression of the bacteriophage T4 denV structural gene in Escherichia coli

Recinos, A., Augustine, M. L., Higgins, K. M. & Lloyd, R. S., Jan 1 1986, In : Journal of bacteriology. 168, 2, p. 1014-1018 5 p.

Research output: Contribution to journalArticle

Open Access
23 Scopus citations

Isolation and sequence determination of a cDNA clone related to human cytochrome P-450 nifedipine oxidase

Beaune, P. H., Umbenhauer, D. R., Bork, R. W., Lloyd, R. S. & Guengerich, F. P., Dec 1 1986, In : Proceedings of the National Academy of Sciences of the United States of America. 83, 21, p. 8064-8068 5 p.

Research output: Contribution to journalArticle

179 Scopus citations

The DNA scanning mechanism of T4 endonuclease V. Effect of NaCl concentration on processive nicking activity

Gruskin, E. A. & Lloyd, R. S., Dec 1 1986, In : Journal of Biological Chemistry. 261, 21, p. 9607-9613 7 p.

Research output: Contribution to journalArticle

69 Scopus citations
1987

Cloning and Sequence Determination of a Complementary DNA Related to Human Liver Microsomal Cytochrome P-450 S-Mephenytoin 4-Hydroxylase

Umbenhauer, D. R., Martin, M. V., Lloyd, R. S. & Guengerich, F. P., Jan 1 1987, In : Biochemistry. 26, 4, p. 1094-1099 6 p.

Research output: Contribution to journalArticle

99 Scopus citations

Cytochrome P-450 enzymes involved in genetic polymorphism of drug oxidation in humans

Guengerich, F. P., Beaune, P. H., Umbenhauer, D. R., Churchill, P. F., Bork, R. W., Dannan, G. A., Knodell, R. G., Lloyd, R. S. & Martin, M. V., Jan 1 1987, In : Biochemical Society transactions. 15, 4, p. 576-578 3 p.

Research output: Contribution to journalArticle

16 Scopus citations
2 Scopus citations

Polymorphism of human cytochrome p-450

Guengerich, F. P., Umbenhauer, D. R., Churchill, P. F., Beaune, P. H., Böcker, R., Knodell, R. G., Martin, M. V. & Lloyd, R. S., Jan 1 1987, In : Xenobiotica. 17, 3, p. 311-316 6 p.

Research output: Contribution to journalArticle

30 Scopus citations

Purification of the T4 endonuclease V

Higgins, K. M. & Lloyd, R. S., Mar 1987, In : Mutation Research DNA Repair Reports. 183, 2, p. 117-121 5 p.

Research output: Contribution to journalArticle

11 Scopus citations
37 Scopus citations

T4 endonuclease V promotes the formation of multimeric DNA structures

Lloyd, R. S., Dodson, M. L., Gruskin, E. A. & Robberson, D. L., Mar 1987, In : Mutation Research DNA Repair Reports. 183, 2, p. 109-115 7 p.

Research output: Contribution to journalArticle

8 Scopus citations
1988

Characterization of Cdnas, Mrnas, and Proteins Related to Human Liver Microsomal Cytochrome P-450 (s)-mephenytoin 4′-Hydroxylase

Ged, C., Umbenhauer, D. R., Bellew, T. M., Bork, R. W., Srivastava, P. K., Shinriki, N., Lloyd, R. S. & Guengerich, F. P., Sep 1 1988, In : Biochemistry. 27, 18, p. 6929-6940 12 p.

Research output: Contribution to journalArticle

122 Scopus citations

Gene Cloning Using cDNA Libraries in a Differential Competition Hybridization Strategy: Application to Cloning XP-A Related Genes

Rinaldy, A., Dodson, M. L., Darling, T. L. & Lloyd, R. S., Oct 1988, In : DNA. 7, 8, p. 563-570 8 p.

Research output: Contribution to journalArticle

6 Scopus citations

Modulation of expression of the human gamma interferon gene in E. coli by site-directed mutagenesis

Lee, S. G., Ricca, G. A., Crumley, G., Lloyd, R. S. & Drohan, W., Feb 29 1988, In : Biochemical and Biophysical Research Communications. 151, 1, p. 598-607 10 p.

Research output: Contribution to journalArticle

3 Scopus citations
45 Scopus citations
27 Scopus citations

Site-Directed Mutagenesis of the T4 Endonuclease V Gene: Role of Tyrosine-129 and -131 in Pyrimidine Dimer-Specific Binding

Stump, D. G. & Lloyd, R. S., Mar 1 1988, In : Biochemistry. 27, 6, p. 1839-1843 5 p.

Research output: Contribution to journalArticle

19 Scopus citations

Site-Directed Mutagenesis of the T4 Endonuclease V Gene: Role of Lysine-130

Recinos, A. & Lloyd, R. S., Mar 1 1988, In : Biochemistry. 27, 6, p. 1832-1838 7 p.

Research output: Contribution to journalArticle

21 Scopus citations
1989

Characterization of mRNA species related to human liver cytochrome P-450 nifedipine oxidase and the regulation of catalytic activity

Bork, R. W., Muto, T., Beaune, P. H., Srivastava, P. K., Lloyd, R. S. & Guengerich, F. P., Jan 1 1989, In : Journal of Biological Chemistry. 264, 2, p. 910-919 10 p.

Research output: Contribution to journalArticle

122 Scopus citations

Expression of a Human Liver Cytochrome P-450 Protein with Tolbutamide Hydroxylase Activity in Saccharomyces cerevisiae

Brian, W. R., Srivastava, P. K., Umbenhauer, D. R., Lloyd, R. S. & Guengerich, F. P., Jun 1 1989, In : Biochemistry. 28, 12, p. 4993-4999 7 p.

Research output: Contribution to journalArticle

150 Scopus citations

Human liver mephenytoin 4 -hydroxylase cytochrome p-450 proteins and genes

Brian, W. R., Gedt, C., Bellew, T. M., Srivastava, P. K., Bork, R. W., Umbenhauer, D. R., Lloyd, R. S. & Guengerich, F. P., Jan 1 1989, In : Drug Metabolism Reviews. 20, 2-4, p. 449-465 17 p.

Research output: Contribution to journalArticle

6 Scopus citations

Modulation of the DNA scanning activity of the Micrococcus luteus UV endonuclease.

Hamilton, R. W. & Lloyd, R. S., Oct 15 1989, In : The Journal of biological chemistry. 264, 29, p. 17422-17427 6 p.

Research output: Contribution to journalArticle

28 Scopus citations

Site-Directed Mutagenesis of the T4 Endonuclease V Gene: The Role of Arginine-3 in the Target Search

Dowd, D. R. & Lloyd, R. S., Jan 1 1989, In : Biochemistry. 28, 22, p. 8699-8705 7 p.

Research output: Contribution to journalArticle

30 Scopus citations
7 Scopus citations

Structure-function studies of the T4 endonuclease V repair enzyme

Dodson, M. L. & Lloyd, R. S., Sep 1989, In : Mutation Research-DNA Repair. 218, 2, p. 49-65 17 p.

Research output: Contribution to journalArticle

50 Scopus citations
1990
59 Scopus citations
13 Scopus citations
1991

Inhibition of eukaryotic topoisomerase II by ultraviolet-induced cyclobutane pyrimidine dimers

Corbett, A. H., Zechiedrich, E. L., Lloyd, R. S. & Osheroff, N., Jan 1 1991, In : Journal of Biological Chemistry. 266, 29, p. 19666-19671 6 p.

Research output: Contribution to journalArticle

28 Scopus citations

Isolation and characterization of cDNA clones for rat liver 10-formyltetrahydrofolate dehydrogenase

Cook, R. J., Lloyd, R. S. & Wagner, C., Jul 11 1991, In : Journal of Biological Chemistry. 266, 8, p. 4965-4973 9 p.

Research output: Contribution to journalArticle

84 Scopus citations

Mutations in Endonuclease V That Affect both Protein-Protein Association and Target Site Location

Nickell, C. & Lloyd, R. S., Sep 1 1991, In : Biochemistry. 30, 35, p. 8638-8648 11 p.

Research output: Contribution to journalArticle

19 Scopus citations

Oligonucleotide Site Directed Mutagenesis of All Histidine Residues within the T4 Endonuclease V Gene: Role in Enzyme-Nontarget DNA Binding

Augustine, M. L., Hamilton, R. W., Dodson, M. L. & Lloyd, R. S., Aug 1 1991, In : Biochemistry. 30, 32, p. 8052-8059 8 p.

Research output: Contribution to journalArticle

13 Scopus citations
70 Scopus citations

Selective metal binding to cys-78 within endonuclease V causes an inhibition of catalytic activities without altering nontarget and target DNA binding

Prince, M. A., Friedman, B., Gruskin, E. A., Schrock, R. D. & Lloyd, R. S., Aug 16 1991, In : Journal of Biological Chemistry. 266, 16, p. 10686-10693 8 p.

Research output: Contribution to journalArticle

19 Scopus citations

Site-directed deletion mutagenesis within the T4 endonuclease V gene: dispensable sequences within putative loop regions

Dodson, M. L., Prince, M. A., Anderson, W. F. & Lloyd, R. S., Jul 1991, In : Mutation Research-DNA Repair. 255, 1, p. 19-29 11 p.

Research output: Contribution to journalArticle

4 Scopus citations
30 Scopus citations

Substitution of basic amino acids within endonuclease V enhances nontarget DNA binding

Nickell, C., Anderson, W. F. & Lloyd, R. S., Oct 22 1991, In : Journal of Biological Chemistry. 266, 9, p. 5634-5642 9 p.

Research output: Contribution to journalArticle

15 Scopus citations