Research Output 1977 2017

  • 7868 Citations
  • 47 h-Index
  • 235 Article
  • 2 Chapter
  • 1 Conference contribution
  • 1 Review article
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2017

8-oxoguanine DNA glycosylase (OGG1) deficiency elicits coordinated changes in lipid and mitochondrial metabolism in muscle

Vartanian, V., Tumova, J., Dobrzyn, P., Dobrzyn, A., Nakabeppu, Y., Lloyd, R. S. & Sampath, H. Jul 1 2017 In : PLoS ONE. 12, 7, e0181687

Research output: Research - peer-reviewArticle

glycosylases
skeletal muscle
muscles
metabolism
mice
2 Citations

Error-prone replication bypass of the imidazole ring-opened formamidopyrimidine deoxyguanosine adduct

Sha, Y., Minko, I. G., Malik, C. K., Rizzo, C. J. & Lloyd, R. S. May 1 2017 In : Environmental and Molecular Mutagenesis. 58, 4, p. 182-189 8 p.

Research output: Research - peer-reviewArticle

Deoxyguanosine
imidazole
N6-(2-deoxy-erythro-pentofuranosyl)-2,6-diamino-4-hydroxy-5-formamidopyrimidine
Mutation
Nucleotides
1 Citations

NEIL1 protects against aflatoxin-induced hepatocellular carcinoma in mice

Vartanian, V., Minko, I. G., Chawanthayatham, S., Egner, P. A., Lin, Y. C., Earley, L. F., Makar, R., Eng, J. R., Camp, M. T., Li, L., Stone, M. P., Lasarev, M. R., Groopman, J. D., Croy, R. G., Essigmann, J. M., McCullough, A. K. & Lloyd, R. S. Apr 18 2017 In : Proceedings of the National Academy of Sciences of the United States of America. 114, 16, p. 4207-4212 6 p.

Research output: Research - peer-reviewArticle

Aflatoxins
Hepatocellular Carcinoma
DNA Glycosylases
DNA Repair
DNA
2016
1 Citations

Catalysts of DNA Strand Cleavage at Apurinic/Apyrimidinic Sites

Minko, I. G., Jacobs, A. C., De Leon, A. R., Gruppi, F., Donley, N., Harris, T. M., Rizzo, C. J., McCullough, A. K. & Lloyd, R. S. Jul 1 2016 In : Scientific Reports. 6, 28894

Research output: Research - peer-reviewArticle

Catalysts
DNA
DNA Glycosylases
Deoxyribose
Purines

DNA polymerase ζ limits chromosomal damage and promotes cell survival following aflatoxin exposure

Lin, Y. C., Owen, N., Minko, I. G., Lange, S. S., Li, L., Stone, M. P., Wood, R. D., McCullough, A. K. & Lloyd, R. S. Nov 29 2016 In : Proceedings of the National Academy of Sciences of the United States of America. 113, 48, p. 13774-13779 6 p.

Research output: Research - peer-reviewArticle

Aflatoxins
Cell Survival
DNA polymerase zeta
N6-(2-deoxy-erythro-pentofuranosyl)-2,6-diamino-4-hydroxy-5-formamidopyrimidine
Aflatoxin B1
1 Citations

Enhanced sensitivity of Neil1−/− mice to chronic UVB exposure

Calkins, M. J., Vartanian, V., Owen, N., Kirkali, G., Jaruga, P., Dizdaroglu, M., McCullough, A. K. & Lloyd, R. S. Dec 1 2016 In : DNA Repair. 48, p. 43-50 8 p.

Research output: Research - peer-reviewArticle

Reactive Oxygen Species
DNA
Repair
Deoxyribonuclease (Pyrimidine Dimer)
Skin
2015
8 Citations

Small Molecule Inhibitors of 8-Oxoguanine DNA Glycosylase-1 (OGG1)

Donley, N., Jaruga, P., Coskun, E., Dizdaroglu, M., McCullough, A. K. & Lloyd, R. S. Oct 16 2015 In : ACS Chemical Biology. 10, 10, p. 2334-2343 10 p.

Research output: Research - peer-reviewArticle

DNA Glycosylases
Molecules
8-hydroxyguanine
Repair
DNA
2014
11 Citations

Error-prone replication bypass of the primary aflatoxin B1 DNA adduct, AFB1-N7-Gua

Lin, Y. C., Li, L., Makarova, A. V., Burgers, P. M., Stone, M. P. & Lloyd, R. S. Jun 27 2014 In : Journal of Biological Chemistry. 289, 26, p. 18497-18506 10 p.

Research output: Research - peer-reviewArticle

Hepatocellular Carcinoma
aflatoxin B1-DNA adduct
DNA Adducts
Mutation
Geographical regions
11 Citations

Molecular basis of aflatoxin-induced mutagenesis-role of the aflatoxin B1-formamidopyrimidine adduct

Lin, Y. C., Li, L., Makarova, A. V., Burgers, P. M., Stone, M. P. & Stephen Lloyd, R. 2014 In : Carcinogenesis. 35, 7, p. 1461-1468 8 p., bgu003

Research output: Research - peer-reviewArticle

Aflatoxin B1
Aflatoxins
Genomic Instability
Site-Directed Mutagenesis
Mutagenesis
2 Citations

Pyrosequencing: Applicability for studying DNA damage-induced mutagenesis

Minko, I. G., Earley, L. F., Larlee, K. E., Lin, Y. C. & Lloyd, R. S. Oct 1 2014 In : Environmental and Molecular Mutagenesis. 55, 8, p. 601-608 8 p.

Research output: Research - peer-reviewArticle

Mutagenesis
DNA Damage
DNA
Primates
Mutation
2013
12 Citations

Inhibition of DNA glycosylases via small molecule purine analogs

Jacobs, A. C., Calkins, M. J., Jadhav, A., Dorjsuren, D., Maloney, D., Simeonov, A., Jaruga, P., Dizdaroglu, M., McCullough, A. K. & Stephen Lloyd, R. Dec 9 2013 In : PLoS One. 8, 12, e81667

Research output: Research - peer-reviewArticle

DNA Glycosylases
Molecules
purine
glycosylases
purines

Inhibition of HIV-1 Reverse Transcriptase-Catalyzed Synthesis by Intercalated DNA Benzo[a]Pyrene 7,8-Dihydrodiol-9,10-Epoxide Adducts

Chary, P., Beard, W. A., Wilson, S. H. & Lloyd, R. S. Sep 19 2013 In : PLoS One. 8, 9, e72131

Research output: Research - peer-reviewArticle

RNA-directed DNA polymerase
Human immunodeficiency virus 1
epoxides
synthesis
DNA
9 Citations

Leukotriene biosynthesis inhibitor MK886 impedes DNA polymerase activity

Ketkar, A., Zafar, M. K., Maddukuri, L., Yamanaka, K., Banerjee, S., Egli, M., Choi, J. Y., Lloyd, R. S. & Eoff, R. L. Feb 18 2013 In : Chemical Research in Toxicology. 26, 2, p. 221-232 12 p.

Research output: Research - peer-reviewArticle

Leukotrienes
DNA-Directed DNA Polymerase
Biosynthesis
Inhibition (Psychology)
DNA
8 Citations

Mutagenic spectra arising from replication bypass of the 2,6-diamino-4-hydroxy-N5-methyl formamidopyrimidine adduct in primate cells

Earley, L. F., Minko, I. G., Christov, P. P., Rizzo, C. J. & Lloyd, R. S. Jul 15 2013 In : Chemical Research in Toxicology. 26, 7, p. 1108-1114 7 p.

Research output: Research - peer-reviewArticle

Primates
N6-(2-deoxypentofuranosyl)-2,6-diamino-3,4-dihydro-4-oxo-5-N-methylformamidopyrimidine
Nucleotides
DNA
Genetic Vectors
2 Citations

Ring-opening of the γ-OH-PdG adduct promotes error-free bypass by the sulfolobus solfataricus DNA polymerase Dpo4

Shanmugam, G., Minko, I. G., Banerjee, S., Christov, P. P., Kozekov, I. D., Rizzo, C. J., Lloyd, R. S., Egli, M. & Stone, M. P. Sep 16 2013 In : Chemical Research in Toxicology. 26, 9, p. 1348-1360 13 p.

Research output: Research - peer-reviewArticle

Sulfolobus solfataricus
DNA-Directed DNA Polymerase
hydroxide ion
Nucleotides
DNA
1 Citations

Sequence context modulation of polycyclic aromatic hydrocarbon-induced mutagenesis

Chary, P., Stone, M. P. & Lloyd, R. S. Oct 2013 In : Environmental and Molecular Mutagenesis. 54, 8, p. 652-658 7 p.

Research output: Research - peer-reviewArticle

7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
Polycyclic Aromatic Hydrocarbons
Mutagenesis
Codon
Mutation
14 Citations

Translesion synthesis past acrolein-derived DNA adducts by human mitochondrial DNA polymerase γ

Kasiviswanathan, R., Minko, I. G., Lloyd, R. S. & Copeland, W. C. May 17 2013 In : Journal of Biological Chemistry. 288, 20, p. 14247-14255 9 p.

Research output: Research - peer-reviewArticle

Acrolein
Deoxyguanosine
DNA Adducts
Mitochondrial DNA
DNA polymerase gamma
2012
35 Citations

8-Oxoguanine DNA Glycosylase (OGG1) Deficiency Increases Susceptibility to Obesity and Metabolic Dysfunction

Sampath, H., Vartanian, V., Rollins, M. R., Sakumi, K., Nakabeppu, Y. & Lloyd, R. S. Dec 17 2012 In : PLoS One. 7, 12, e51697

Research output: Research - peer-reviewArticle

glycosylases
obesity
mice
DNA
DNA Glycosylases
15 Citations

A Comprehensive Strategy to Discover Inhibitors of the Translesion Synthesis DNA Polymerase κ

Yamanaka, K., Dorjsuren, D., Eoff, R. L., Egli, M., Maloney, D. J., Jadhav, A., Simeonov, A. & Lloyd, R. S. Oct 8 2012 In : PLoS One. 7, 10, e45032

Research output: Research - peer-reviewArticle

DNA-directed DNA polymerase
synthesis
DNA
DNA-Directed DNA Polymerase
assays

Carbinolamine formation and dehydration in a dna repair enzyme active site

Dodson, M. L., Walker, R. C. & Lloyd, R. S. Feb 22 2012 In : PLoS One. 7, 2, e31377

Research output: Research - peer-reviewArticle

Dehydration
Repair
Water
Enzymes
Mechanics
11 Citations

DNA polymerase β gap-filling translesion DNA synthesis

Chary, P., Beard, W. A., Wilson, S. H. & Lloyd, R. S. Dec 17 2012 In : Chemical Research in Toxicology. 25, 12, p. 2744-2754 11 p.

Research output: Research - peer-reviewArticle

DNA Polymerase beta
DNA
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
Substrates
Direction compound
21 Citations

Regulation of DNA glycosylases and their role in limiting disease

Sampath, H., McCullough, A. K. & Stephen Lloyd, R. Apr 2012 In : Free Radical Research. 46, 4, p. 460-478 19 p.

Research output: Research - peer-reviewArticle

DNA Glycosylases
DNA Repair
DNA Damage
Enzymes
Population
14 Citations

Replication bypass of N 2-deoxyguanosine interstrand cross-links by human DNA polymerases η and ι

Klug, A. R., Harbut, M. B., Lloyd, R. S. & Minko, I. G. Mar 19 2012 In : Chemical Research in Toxicology. 25, 3, p. 755-762 8 p.

Research output: Research - peer-reviewArticle

DNA-Directed DNA Polymerase
DNA
8-nitro-2'-deoxyguanosine
DNA polymerase iota
Rad30 protein
4 Citations

Replication of the 2,6-diamino-4-hydroxy- N 5-(methyl)- formamidopyrimidine (MeFapy-dGuo) adduct by eukaryotic DNA polymerases

Christov, P. P., Yamanaka, K., Choi, J. Y., Takata, K. I., Wood, R. D., Guengerich, F. P., Lloyd, R. S. & Rizzo, C. J. Aug 20 2012 In : Chemical Research in Toxicology. 25, 8, p. 1652-1661 10 p.

Research output: Research - peer-reviewArticle

DNA-Directed DNA Polymerase
N6-(2-deoxypentofuranosyl)-2,6-diamino-3,4-dihydro-4-oxo-5-N-methylformamidopyrimidine
DNA
Nucleotides
DNA Adducts
2011
4 Citations

Modulation of the processive abasic site lyase activity of a pyrimidine dimer glycosylase

Ryabinina, O. P., Minko, I. G., Lasarev, M. R., McCullough, A. K. & Lloyd, R. S. Oct 10 2011 In : DNA Repair. 10, 10, p. 1014-1022 9 p.

Research output: Research - peer-reviewArticle

Pyrimidine Dimers
Lyases
Modulation
Enzymes
DNA
9 Citations

Role of high-fidelity Escherichia coli DNA polymerase I in replication bypass of a deoxyadenosine DNA-peptide cross-link

Yamanaka, K., Minko, I. G., Finkel, S. E., Goodman, M. F. & Lloyd, R. S. Aug 2011 In : Journal of Bacteriology. 193, 15, p. 3815-3821 7 p.

Research output: Research - peer-reviewArticle

DNA Polymerase I
Escherichia coli
Peptides
DNA
2'-deoxyadenosine
10 Citations

TAT-mediated delivery of a DNA repair enzyme to skin cells rapidly initiates repair of UV-induced DNA damage

Johnson, J. L., Lowell, B. C., Ryabinina, O. P., Lloyd, R. S. & McCullough, A. K. Mar 2011 In : Journal of Investigative Dermatology. 131, 3, p. 753-761 9 p.

Research output: Research - peer-reviewArticle

DNA Repair Enzymes
Trans-Activators
DNA Repair
DNA Damage
Skin
18 Citations

The base excision repair pathway is required for efficient lentivirus integration

Yoder, K. E., Espeseth, A., Wang, X. H., Fang, Q., Russo, M. T., Lloyd, R. S., Hazuda, D., Sobol, R. W. & Fishel, R. 2011 In : PLoS One. 6, 3, e17862

Research output: Research - peer-reviewArticle

Lentivirus
DNA Repair
DNA repair
Repair
Proteins
15 Citations

Variable penetrance of metabolic phenotypes and development of high-fat diet-induced adiposity in NEIL1-deficient mice.

Sampath, H., Batra, A. K., Vartanian, V., Carmical, J. R., Prusak, D., King, I. B., Lowell, B., Earley, L. F., Wood, T. G., Marks, D. L., McCullough, A. K. & R Stephen, L. Apr 2011 In : American journal of physiology. Endocrinology and metabolism. 300, 4

Research output: Research - peer-reviewArticle

Penetrance
Adiposity
High Fat Diet
Phenotype
Oxidative Stress
4 Citations

γ-Hydroxy-1, N 2-propano-2′-deoxyguanosine DNA adduct conjugates the N-terminal amine of the KWKK peptide via a carbinolamine linkage

Huang, H., Wang, H., Voehler, M. W., Kozekova, A., Rizzo, C. J., McCullough, A. K., Lloyd, R. S. & Stone, M. P. Jul 18 2011 In : Chemical Research in Toxicology. 24, 7, p. 1123-1133 11 p.

Research output: Research - peer-reviewArticle

Deoxyguanosine
DNA Adducts
Amines
Peptides
DNA
2010
26 Citations

DNA cross-link induced by trans-4-hydroxynonenal

Huang, H., Kozekov, I. D., Kozekova, A., Wang, H., Lloyd, R. S., Rizzo, C. J. & Stone, M. P. Jul 2010 In : Environmental and Molecular Mutagenesis. 51, 6, p. 625-634 10 p.

Research output: Research - peer-reviewArticle

Aldehydes
DNA
4-hydroxy-2-nonenal
Direction compound
2-butenal
39 Citations

Evidence for the involvement of DNA repair enzyme NEIL1 in nucleotide excision repair of (5′R)- and (5′S)-8,5′-Cyclo-2′- deoxyadenosines

Jaruga, P., Xiao, Y., Vartanian, V., Lloyd, R. S. & Dizdaroglu, M. Feb 16 2010 In : Biochemistry. 49, 6, p. 1053-1055 3 p.

Research output: Research - peer-reviewArticle

DNA Repair Enzymes
Repair
Nucleotides
S(8)
2'-deoxyadenosine
11 Citations

Minor groove orientation of the KWKK peptide tethered via the N-terminal amine to the acrolein-derived 1, N 2-γ- hydroxypropanodeoxyguanosine lesion with a trimethylene linkage

Huang, H., Kozekov, I. D., Kozekova, A., Rizzo, C. J., McCullough, A. K., Lloyd, R. S. & Stone, M. P. Jul 27 2010 In : Biochemistry. 49, 29, p. 6155-6164 10 p.

Research output: Research - peer-reviewArticle

Acrolein
Amines
Peptides
DNA
cyclopropane
18 Citations

Modulation of UvrD helicase activity by covalent DNA-protein cross-links

Kumari, A., Minko, I. G., Smith, R. L., Lloyd, R. S. & McCullough, A. K. Jul 9 2010 In : Journal of Biological Chemistry. 285, 28, p. 21313-21322 10 p.

Research output: Research - peer-reviewArticle

Modulation
DNA
Proteins
link protein
DNA Replication
37 Citations

Novel enzymatic function of DNA Polymerase v in translesion DNA synthesis past major groove DNA-peptide and DNA-DNA cross-links

Yamanaka, K., Minko, I. G., Takata, K. I., Kolbanovskiy, A., Kozekov, I. D., Wood, R. D., Rizzo, C. J. & Lloyd, R. S. Mar 15 2010 In : Chemical Research in Toxicology. 23, 3, p. 689-695 7 p.

Research output: Research - peer-reviewArticle

DNA-Directed DNA Polymerase
Peptides
DNA
Nucleotides
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
2009
107 Citations

Chemistry and biology of DNA containing 1,N2-deoxyguanosine adducts of the α,β-unsaturated aldehydes acrolein, crotonaldehyde, and 4-hydroxynonenal

Minko, I. G., Kozekov, I. D., Harris, T. M., Rizzo, C. J., Lloyd, R. S. & Stone, M. P. May 18 2009 In : Chemical Research in Toxicology. 22, 5, p. 759-778 20 p.

Research output: Research - peer-reviewArticle

2-butenal
Acrolein
Deoxyguanosine
Aldehydes
DNA
9 Citations

Conformational interconversion of the trans-4-hydroxynonenal-derived (6S,8R,11S) l,N 2-deoxyguanosine adduct when mismatched with deoxyadenosine in DNA

Huang, H., Wang, H., Lloyd, R. S., Rizzo, C. J. & Stone, M. P. Jan 2009 In : Chemical Research in Toxicology. 22, 1, p. 187-200 14 p.

Research output: Research - peer-reviewArticle

Deoxyguanosine
DNA
2'-deoxyadenosine
4-hydroxy-2-nonenal
8-nitro-2'-deoxyguanosine
15 Citations

Deficiency of the oxidative damage-specific DNA glycosylase NEIL1 leads to reduced germinal center B cell expansion

Mori, H., Ouchida, R., Hijikata, A., Kitamura, H., Ohara, O., Li, Y., Gao, X., Yasui, A., Lloyd, R. S. & Wang, J. Y. Nov 2 2009 In : DNA Repair. 8, 11, p. 1328-1332 5 p.

Research output: Research - peer-reviewArticle

DNA Glycosylases
Germinal Center
B-Lymphocytes
Cells
DNA
65 Citations

Targeted deletion of the genes encoding NTH1 and NEIL1 DNA N-glycosylases reveals the existence of novel carcinogenic oxidative damage to DNA

Chan, M. K., Ocampo-Hafalla, M. T., Vartanian, V., Jaruga, P., Kirkali, G., Koenig, K. L., Brown, S., Lloyd, R. S., Dizdaroglu, M. & Teebor, G. W. Jul 4 2009 In : DNA Repair. 8, 7, p. 786-794 9 p.

Research output: Research - peer-reviewArticle

DNA Glycosylases
Gene Deletion
DNA Damage
Neoplasms
Gene encoding
2008
96 Citations

Interstrand DNA cross-links induced by α,β-unsaturated aldehydes derived from lipid peroxidation and environmental sources

Stonez, M. P., Cho, Y. J., Huang, H., Kim, H. Y., Kozekov, I. D., Kozekova, A., Wang, H., Minko, I. G., Lloyd, R. S., Harris, T. M. & Rizzo, C. J. Jul 2008 In : Accounts of Chemical Research. 41, 7, p. 793-804 12 p.

Research output: Research - peer-reviewArticle

Aldehydes
Lipids
DNA
2-butenal
Acrolein
37 Citations

Mutagenic potential of DNA-peptide crosslinks mediated by acrolein-derived DNA adducts

Minko, I. G., Kozekov, I. D., Kozekova, A., Harris, T. M., Rizzo, C. J. & Lloyd, R. S. Jan 1 2008 In : Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 637, 1-2, p. 161-172 12 p.

Research output: Research - peer-reviewArticle

Acrolein
DNA Adducts
Peptides
DNA
Lysine
37 Citations

Replication bypass of interstrand cross-link intermediates by Escherichia coli DNA polymerase IV

Kumari, A., Minko, I. G., Harbut, M. B., Finkel, S. E., Goodman, M. F. & Lloyd, R. S. Oct 10 2008 In : Journal of Biological Chemistry. 283, 41, p. 27433-27437 5 p.

Research output: Research - peer-reviewArticle

DNA Polymerase beta
Escherichia coli
DNA
Repair
Nucleotides
42 Citations

Replication bypass of the acrolein-mediated deoxyguanine DNA-peptide cross-links by DNA polymerases of the DinB family

Minko, I. G., Yamanaka, K., Kozekov, I. D., Kozekova, A., Indiani, C., O'Donnell, M. E., Jiang, Q., Goodman, M. F., Rizzo, C. J. & Lloyd, R. S. Oct 2008 In : Chemical Research in Toxicology. 21, 10, p. 1983-1990 8 p.

Research output: Research - peer-reviewArticle

Acrolein
DNA-Directed DNA Polymerase
Peptides
DNA
Escherichia coli
96 Citations

Role for DNA polymerase κ in the processing of N2-N 2-guanine interstrand cross-links

Minko, I. G., Harbut, M. B., Kozekov, I. D., Kozekova, A., Jakobs, P. M., Olson, S. B., Moses, R. E., Harris, T. M., Rizzo, C. J. & Lloyd, R. S. Jun 20 2008 In : Journal of Biological Chemistry. 283, 25, p. 17075-17082 8 p.

Research output: Research - peer-reviewArticle

Guanine
DNA-Directed DNA Polymerase
Processing
Oligodeoxyribonucleotides
Mitomycin
14 Citations

The stereochemistry of trans-4-hydroxynonenal-derived exocyclic 1,N 2-2′-deoxyguanosine adducts modulates formation of interstrand cross-links in the 5′-CpG-3′ sequence

Huang, H., Wang, H., Qi, N., Lloyd, R. S., Rizzo, C. J. & Stone, M. P. Nov 4 2008 In : Biochemistry. 47, 44, p. 11457-11472 16 p.

Research output: Research - peer-reviewArticle

Stereochemistry
Deoxyguanosine
Aldehydes
4-hydroxy-2-nonenal
Direction compound
2007
10 Citations

Detoxification of olefinic epoxides and nucleotide excision repair of epoxide-mediated DNA damage: Insights from animal models examining human sensitivity to 1,3-butadiene

Wickliffe, J. K., Herring, S. M., Hallberg, L. M., Galbert, L. A., Masters, O. E., Ammenheuser, M. M., Xie, J., Friedberg, E. C., Lloyd, R. S., Abdel-Rahman, S. Z. & Ward, J. B. Mar 20 2007 In : Chemico-Biological Interactions. 166, 1-3, p. 226-231 6 p.

Research output: Research - peer-reviewArticle

Detoxification
Epoxy Compounds
Animals
Repair
Nucleotides
46 Citations

Human polymorphic variants of the NEIL1 DNA glycosylase

Roy, L. M., Jaruga, P., Wood, T. G., McCullough, A. K., Dizdaroglu, M. & Lloyd, R. S. May 25 2007 In : Journal of Biological Chemistry. 282, 21, p. 15790-15798 9 p.

Research output: Research - peer-reviewArticle

DNA Glycosylases
Oligonucleotides
Gas Chromatography-Mass Spectrometry
DNA
thymine glycol
4 Citations
Deoxyuridine
Nucleotides
1,3-butadiene
Environmental Carcinogens
DNA Adducts
4 Citations

Structure of the 1,4-bis(2′-deoxyadenosin-N6-yl)-2S,3S- butanediol intrastrand DNA cross-link arising from butadiene diepoxide in the human N-ras codon 61 sequence

Xu, W., Merritt, W. K., Nechev, L. V., Harris, T. M., Harris, C. M., Lloyd, R. S. & Stone, M. P. Feb 2007 In : Chemical Research in Toxicology. 20, 2, p. 187-198 12 p.

Research output: Research - peer-reviewArticle

Butylene Glycols
Conformations
DNA
erythritol anhydride
Codon
2006
8 Citations

3,4-Epoxy-1-butene, a reactive metabolite of 1,3-butadiene, induces somatic mutations in Xpc-null mice

Wickliffe, J. K., Galbert, L. A., Ammenheuser, M. M., Herring, S. M., Xie, J., Masters, O. E., Friedberg, E. C., Lloyd, R. S. & Ward, J. B. Jan 2006 In : Environmental and Molecular Mutagenesis. 47, 1, p. 67-70 4 p.

Research output: Research - peer-reviewArticle

Metabolites
Repair
DNA
1,3-butadiene
3,4-epoxy-1-butene