• 8540 Citations
  • 51 h-Index
1977 …2020

Research output per year

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Research Output

2020

OGG1 deficiency alters the intestinal microbiome and increases intestinal inflammation in a mouse model

Simon, H., Vartanian, V., Wong, M. H., Nakabeppu, Y., Sharma, P., Stephen Lloyd, R. & Sampath, H., Jan 1 2020, In : PloS one. 15, 1, e0227501.

Research output: Contribution to journalArticle

Open Access

Recognition of DNA adducts by edited and unedited forms of DNA glycosylase NEIL1

Minko, I. G., Vartanian, V. L., Tozaki, N. N., Coskun, E., Coskun, S. H., Jaruga, P., Yeo, J., David, S. S., Stone, M. P., Egli, M., Dizdaroglu, M., McCullough, A. K. & Lloyd, R. S., Jan 2020, In : DNA Repair. 85, 102741.

Research output: Contribution to journalArticle

1 Scopus citations
2019

Characterization of rare NEIL1 variants found in East Asian populations

Minko, I. G., Vartanian, V. L., Tozaki, N. N., Linde, O. K., Jaruga, P., Coskun, S. H., Coskun, E., Qu, C., He, H., Xu, C., Chen, T., Song, Q., Jiao, Y., Stone, M. P., Egli, M., Dizdaroglu, M., McCullough, A. K. & Lloyd, R. S., Jul 2019, In : DNA Repair. 79, p. 32-39 8 p.

Research output: Contribution to journalArticle

2 Scopus citations

Mechanisms underlying aflatoxin-associated mutagenesis – Implications in carcinogenesis

McCullough, A. & Lloyd, R. S., May 1 2019, In : DNA Repair. 77, p. 76-86 11 p.

Research output: Contribution to journalReview article

7 Scopus citations

Processing of N5-substituted formamidopyrimidine DNA adducts by DNA glycosylases NEIL1 and NEIL3

Minko, I. G., Christov, P. P., Li, L., Stone, M. P., McCullough, A. K. & Lloyd, R. S., Jan 2019, In : DNA Repair. 73, p. 49-54 6 p.

Research output: Contribution to journalArticle

4 Scopus citations

Roles of OGG1 in transcriptional regulation and maintenance of metabolic homeostasis

Sampath, H. & Lloyd, R. S., Jan 1 2019, In : DNA Repair. 102667.

Research output: Contribution to journalReview article

2 Scopus citations
2018

Aflatoxin-Guanine DNA Adducts and Oxidatively Induced DNA Damage in Aflatoxin-Treated Mice in Vivo as Measured by Liquid Chromatography-Tandem Mass Spectrometry with Isotope Dilution

Coskun, E., Jaruga, P., Vartanian, V., Erdem, O., Egner, P. A., Groopman, J. D., Lloyd, R. S. & Dizdaroglu, M., Jan 1 2018, (Accepted/In press) In : Chemical Research in Toxicology.

Research output: Contribution to journalArticle

7 Scopus citations

Modulation of UVB-induced Carcinogenesis by Activation of Alternative DNA Repair Pathways

Sha, Y., Vartanian, V., Owen, N., Mengden Koon, S. J., Calkins, M. J., Thompson, C. S., Mirafzali, Z., Mir, S., Goldsmith, L. E., He, H., Luo, C., Brown, S. M., Doetsch, P. W., Kaempf, A., Lim, J. Y., McCullough, A. & Lloyd, R. S., Dec 1 2018, In : Scientific Reports. 8, 1, 705.

Research output: Contribution to journalArticle

4 Scopus citations

The DNA Repair Protein OGG1 Protects Against Obesity by Altering Mitochondrial Energetics in White Adipose Tissue

Komakula, S. S. B., Tumova, J., Kumaraswamy, D., Burchat, N., Vartanian, V., Ye, H., Dobrzyn, A., Lloyd, R. S. & Sampath, H., Dec 1 2018, In : Scientific Reports. 8, 1, 14886.

Research output: Contribution to journalArticle

9 Scopus citations
2017

8-oxoguanine DNA glycosylase (OGG1) deficiency elicits coordinated changes in lipid and mitochondrial metabolism in muscle

Vartanian, V., Tumova, J., Dobrzyn, P., Dobrzyn, A., Nakabeppu, Y., Lloyd, R. S. & Sampath, H., Jul 1 2017, In : PLoS One. 12, 7, e0181687.

Research output: Contribution to journalArticle

11 Scopus citations

Error-prone replication bypass of the imidazole ring-opened formamidopyrimidine deoxyguanosine adduct

Sha, Y., Minko, I., Malik, C. K., Rizzo, C. J. & Lloyd, R. S., May 1 2017, In : Environmental and Molecular Mutagenesis. 58, 4, p. 182-189 8 p.

Research output: Contribution to journalArticle

3 Scopus citations

Mutagenic potential of nitrogen mustard-induced formamidopyrimidine DNA adduct: Contribution of the non-canonical α-anomer

Minko, I., Rizzo, C. J. & Lloyd, R. S., Jan 1 2017, In : Journal of Biological Chemistry. 292, 46, p. 18790-18799 10 p.

Research output: Contribution to journalArticle

5 Scopus citations

NEIL1 protects against aflatoxin-induced hepatocellular carcinoma in mice

Vartanian, V., Minko, I. G., Chawanthayatham, S., Egner, P. A., Lin, Y. C., Earley, L. F., Makar, R., Eng, J. R., Camp, M. T., Li, L., Stone, M. P., Lasarev, M. R., Groopman, J. D., Croy, R. G., Essigmann, J. M., McCullough, A. K. & Lloyd, R. S., Apr 18 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 16, p. 4207-4212 6 p.

Research output: Contribution to journalArticle

16 Scopus citations
2016

Catalysts of DNA Strand Cleavage at Apurinic/Apyrimidinic Sites

Minko, I., Jacobs, A. C., De Leon, A. R., Gruppi, F., Donley, N., Harris, T. M., Rizzo, C. J., McCullough, A. & Lloyd, R. S., Jul 1 2016, In : Scientific Reports. 6, 28894.

Research output: Contribution to journalArticle

6 Scopus citations

DNA polymerase ζ limits chromosomal damage and promotes cell survival following aflatoxin exposure

Lin, Y. C., Owen, N., Minko, I. G., Lange, S. S., Li, L., Stone, M. P., Wood, R. D., McCullough, A. K. & Lloyd, R. S., Nov 29 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 48, p. 13774-13779 6 p.

Research output: Contribution to journalArticle

6 Scopus citations

Enhanced sensitivity of Neil1−/− mice to chronic UVB exposure

Calkins, M. J., Vartanian, V., Owen, N., Kirkali, G., Jaruga, P., Dizdaroglu, M., McCullough, A. & Lloyd, R. S., Dec 1 2016, In : DNA Repair. 48, p. 43-50 8 p.

Research output: Contribution to journalArticle

2 Scopus citations
2015

Small Molecule Inhibitors of 8-Oxoguanine DNA Glycosylase-1 (OGG1)

Donley, N., Jaruga, P., Coskun, E., Dizdaroglu, M., McCullough, A. K. & Lloyd, R. S., Oct 16 2015, In : ACS chemical biology. 10, 10, p. 2334-2343 10 p.

Research output: Contribution to journalArticle

26 Scopus citations
2014

Error-prone replication bypass of the primary aflatoxin B1 DNA adduct, AFB1-N7-Gua

Lin, Y. C., Li, L., Makarova, A. V., Burgers, P. M., Stone, M. P. & Lloyd, R. S., Jun 27 2014, In : Journal of Biological Chemistry. 289, 26, p. 18497-18506 10 p.

Research output: Contribution to journalArticle

23 Scopus citations

Molecular basis of aflatoxin-induced mutagenesis-role of the aflatoxin B1-formamidopyrimidine adduct

Lin, Y. C., Li, L., Makarova, A. V., Burgers, P. M., Stone, M. P. & Stephen Lloyd, R., Jul 2014, In : Carcinogenesis. 35, 7, p. 1461-1468 8 p., bgu003.

Research output: Contribution to journalArticle

24 Scopus citations

Pyrosequencing: Applicability for studying DNA damage-induced mutagenesis

Minko, I. G., Earley, L. F., Larlee, K. E., Lin, Y. C. & Lloyd, R. S., Oct 1 2014, In : Environmental and Molecular Mutagenesis. 55, 8, p. 601-608 8 p.

Research output: Contribution to journalArticle

2 Scopus citations
2013

Inhibition of DNA glycosylases via small molecule purine analogs

Jacobs, A. C., Calkins, M. J., Jadhav, A., Dorjsuren, D., Maloney, D., Simeonov, A., Jaruga, P., Dizdaroglu, M., McCullough, A. K. & Stephen Lloyd, R., Dec 9 2013, In : PloS one. 8, 12, e81667.

Research output: Contribution to journalArticle

24 Scopus citations

Inhibition of HIV-1 Reverse Transcriptase-Catalyzed Synthesis by Intercalated DNA Benzo[a]Pyrene 7,8-Dihydrodiol-9,10-Epoxide Adducts

Chary, P., Beard, W. A., Wilson, S. H. & Lloyd, R. S., Sep 19 2013, In : PloS one. 8, 9, e72131.

Research output: Contribution to journalArticle

Leukotriene biosynthesis inhibitor MK886 impedes DNA polymerase activity

Ketkar, A., Zafar, M. K., Maddukuri, L., Yamanaka, K., Banerjee, S., Egli, M., Choi, J. Y., Lloyd, R. S. & Eoff, R. L., Feb 18 2013, In : Chemical Research in Toxicology. 26, 2, p. 221-232 12 p.

Research output: Contribution to journalArticle

14 Scopus citations

Mutagenic spectra arising from replication bypass of the 2,6-diamino-4-hydroxy-N5-methyl formamidopyrimidine adduct in primate cells

Earley, L. F., Minko, I. G., Christov, P. P., Rizzo, C. J. & Lloyd, R. S., Jul 15 2013, In : Chemical Research in Toxicology. 26, 7, p. 1108-1114 7 p.

Research output: Contribution to journalArticle

14 Scopus citations

Ring-opening of the γ-OH-PdG adduct promotes error-free bypass by the sulfolobus solfataricus DNA polymerase Dpo4

Shanmugam, G., Minko, I. G., Banerjee, S., Christov, P. P., Kozekov, I. D., Rizzo, C. J., Lloyd, R. S., Egli, M. & Stone, M. P., Sep 16 2013, In : Chemical Research in Toxicology. 26, 9, p. 1348-1360 13 p.

Research output: Contribution to journalArticle

2 Scopus citations

Sequence context modulation of polycyclic aromatic hydrocarbon-induced mutagenesis

Chary, P., Stone, M. P. & Lloyd, R. S., Oct 1 2013, In : Environmental and Molecular Mutagenesis. 54, 8, p. 652-658 7 p.

Research output: Contribution to journalArticle

1 Scopus citations

Translesion synthesis past acrolein-derived DNA adducts by human mitochondrial DNA polymerase γ

Kasiviswanathan, R., Minko, I. G., Lloyd, R. S. & Copeland, W. C., May 17 2013, In : Journal of Biological Chemistry. 288, 20, p. 14247-14255 9 p.

Research output: Contribution to journalArticle

19 Scopus citations
2012

8-Oxoguanine DNA Glycosylase (OGG1) Deficiency Increases Susceptibility to Obesity and Metabolic Dysfunction

Sampath, H., Vartanian, V., Rollins, M. R., Sakumi, K., Nakabeppu, Y. & Lloyd, R. S., Dec 17 2012, In : PloS one. 7, 12, e51697.

Research output: Contribution to journalArticle

63 Scopus citations

A Comprehensive Strategy to Discover Inhibitors of the Translesion Synthesis DNA Polymerase κ

Yamanaka, K., Dorjsuren, D., Eoff, R. L., Egli, M., Maloney, D. J., Jadhav, A., Simeonov, A. & Lloyd, R. S., Oct 8 2012, In : PloS one. 7, 10, e45032.

Research output: Contribution to journalArticle

22 Scopus citations

Carbinolamine formation and dehydration in a dna repair enzyme active site

Dodson, M. L., Walker, R. C. & Lloyd, R. S., Feb 22 2012, In : PloS one. 7, 2, e31377.

Research output: Contribution to journalArticle

DNA polymerase β gap-filling translesion DNA synthesis

Chary, P., Beard, W. A., Wilson, S. H. & Lloyd, R. S., Dec 17 2012, In : Chemical Research in Toxicology. 25, 12, p. 2744-2754 11 p.

Research output: Contribution to journalArticle

12 Scopus citations

Regulation of DNA glycosylases and their role in limiting disease

Sampath, H., McCullough, A. K. & Stephen Lloyd, R., Apr 1 2012, In : Free Radical Research. 46, 4, p. 460-478 19 p.

Research output: Contribution to journalReview article

28 Scopus citations

Replication bypass of N 2-deoxyguanosine interstrand cross-links by human DNA polymerases η and ι

Klug, A. R., Harbut, M. B., Lloyd, R. S. & Minko, I. G., Mar 19 2012, In : Chemical Research in Toxicology. 25, 3, p. 755-762 8 p.

Research output: Contribution to journalArticle

17 Scopus citations

Replication of the 2,6-diamino-4-hydroxy- N 5-(methyl)- formamidopyrimidine (MeFapy-dGuo) adduct by eukaryotic DNA polymerases

Christov, P. P., Yamanaka, K., Choi, J. Y., Takata, K. I., Wood, R. D., Guengerich, F. P., Lloyd, R. S. & Rizzo, C. J., Aug 20 2012, In : Chemical Research in Toxicology. 25, 8, p. 1652-1661 10 p.

Research output: Contribution to journalArticle

11 Scopus citations
2011

Modulation of the processive abasic site lyase activity of a pyrimidine dimer glycosylase

Ryabinina, O. P., Minko, I. G., Lasarev, M. R., McCullough, A. K. & Lloyd, R. S., Oct 10 2011, In : DNA Repair. 10, 10, p. 1014-1022 9 p.

Research output: Contribution to journalArticle

4 Scopus citations

Role of high-fidelity Escherichia coli DNA polymerase I in replication bypass of a deoxyadenosine DNA-peptide cross-link

Yamanaka, K., Minko, I. G., Finkel, S. E., Goodman, M. F. & Lloyd, R. S., Aug 1 2011, In : Journal of bacteriology. 193, 15, p. 3815-3821 7 p.

Research output: Contribution to journalArticle

13 Scopus citations

TAT-mediated delivery of a DNA repair enzyme to skin cells rapidly initiates repair of UV-induced DNA damage

Johnson, J. L., Lowell, B. C., Ryabinina, O. P., Lloyd, R. S. & McCullough, A. K., Mar 2011, In : Journal of Investigative Dermatology. 131, 3, p. 753-761 9 p.

Research output: Contribution to journalArticle

14 Scopus citations

The base excision repair pathway is required for efficient lentivirus integration

Yoder, K. E., Espeseth, A., Wang, X. H., Fang, Q., Russo, M. T., Lloyd, R. S., Hazuda, D., Sobol, R. W. & Fishel, R., Mar 28 2011, In : PloS one. 6, 3, e17862.

Research output: Contribution to journalArticle

22 Scopus citations

Variable penetrance of metabolic phenotypes and development of high-fat diet-induced adiposity in NEIL1-deficient mice.

Sampath, H., Batra, A. K., Vartanian, V., Carmical, J. R., Prusak, D., King, I. B., Lowell, B., Earley, L. F., Wood, T. G., Marks, D. L., McCullough, A. K. & R Stephen, L., Apr 1 2011, In : American journal of physiology. Endocrinology and metabolism. 300, 4, p. E724-734

Research output: Contribution to journalArticle

26 Scopus citations

γ-Hydroxy-1, N 2-propano-2′-deoxyguanosine DNA adduct conjugates the N-terminal amine of the KWKK peptide via a carbinolamine linkage

Huang, H., Wang, H., Voehler, M. W., Kozekova, A., Rizzo, C. J., McCullough, A. K., Lloyd, R. S. & Stone, M. P., Jul 18 2011, In : Chemical Research in Toxicology. 24, 7, p. 1123-1133 11 p.

Research output: Contribution to journalArticle

5 Scopus citations
2010

DNA cross-link induced by trans-4-hydroxynonenal

Huang, H., Kozekov, I. D., Kozekova, A., Wang, H., Lloyd, R. S., Rizzo, C. J. & Stone, M. P., Jul 1 2010, In : Environmental and Molecular Mutagenesis. 51, 6, p. 625-634 10 p.

Research output: Contribution to journalReview article

30 Scopus citations

Evidence for the involvement of DNA repair enzyme NEIL1 in nucleotide excision repair of (5′R)- and (5′S)-8,5′-Cyclo-2′- deoxyadenosines

Jaruga, P., Xiao, Y., Vartanian, V., Lloyd, R. S. & Dizdaroglu, M., Feb 16 2010, In : Biochemistry. 49, 6, p. 1053-1055 3 p.

Research output: Contribution to journalArticle

41 Scopus citations

Interstrand DNA Cross-Linking 1, N 2-Deoxyguanosine Adducts Derived from α,β-Unsaturated Aldehydes: Structure-Function Relationships

Stone, M. P., Huang, H., Cho, Y. J., Kim, H. Y., Kozekov, I. D., Kozekova, A., Wang, H., Harris, T. M., Rizzo, C. J., Minko, I. G. & Lloyd, R. S., Oct 11 2010, The Chemical Biology of DNA Damage. Wiley-VCH, p. 201-216 16 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Minor groove orientation of the KWKK peptide tethered via the N-terminal amine to the acrolein-derived 1, N 2-γ- hydroxypropanodeoxyguanosine lesion with a trimethylene linkage

Huang, H., Kozekov, I. D., Kozekova, A., Rizzo, C. J., McCullough, A. K., Lloyd, R. S. & Stone, M. P., Jul 27 2010, In : Biochemistry. 49, 29, p. 6155-6164 10 p.

Research output: Contribution to journalArticle

11 Scopus citations

Modulation of UvrD helicase activity by covalent DNA-protein cross-links

Kumari, A., Minko, I. G., Smith, R. L., Lloyd, R. S. & McCullough, A. K., Jul 9 2010, In : Journal of Biological Chemistry. 285, 28, p. 21313-21322 10 p.

Research output: Contribution to journalArticle

20 Scopus citations

Novel enzymatic function of DNA Polymerase v in translesion DNA synthesis past major groove DNA-peptide and DNA-DNA cross-links

Yamanaka, K., Minko, I. G., Takata, K. I., Kolbanovskiy, A., Kozekov, I. D., Wood, R. D., Rizzo, C. J. & Lloyd, R. S., Mar 15 2010, In : Chemical Research in Toxicology. 23, 3, p. 689-695 7 p.

Research output: Contribution to journalArticle

42 Scopus citations
2009

Chemistry and biology of DNA containing 1,N2-deoxyguanosine adducts of the α,β-unsaturated aldehydes acrolein, crotonaldehyde, and 4-hydroxynonenal

Minko, I. G., Kozekov, I. D., Harris, T. M., Rizzo, C. J., Lloyd, R. S. & Stone, M. P., May 18 2009, In : Chemical Research in Toxicology. 22, 5, p. 759-778 20 p.

Research output: Contribution to journalReview article

129 Scopus citations

Conformational interconversion of the trans-4-hydroxynonenal-derived (6S,8R,11S) l,N 2-deoxyguanosine adduct when mismatched with deoxyadenosine in DNA

Huang, H., Wang, H., Lloyd, R. S., Rizzo, C. J. & Stone, M. P., Jan 1 2009, In : Chemical Research in Toxicology. 22, 1, p. 187-200 14 p.

Research output: Contribution to journalArticle

11 Scopus citations

Deficiency of the oxidative damage-specific DNA glycosylase NEIL1 leads to reduced germinal center B cell expansion

Mori, H., Ouchida, R., Hijikata, A., Kitamura, H., Ohara, O., Li, Y., Gao, X., Yasui, A., Lloyd, R. S. & Wang, J. Y., Nov 2 2009, In : DNA Repair. 8, 11, p. 1328-1332 5 p.

Research output: Contribution to journalArticle

17 Scopus citations

Targeted deletion of the genes encoding NTH1 and NEIL1 DNA N-glycosylases reveals the existence of novel carcinogenic oxidative damage to DNA

Chan, M. K., Ocampo-Hafalla, M. T., Vartanian, V., Jaruga, P., Kirkali, G., Koenig, K. L., Brown, S., Lloyd, R. S., Dizdaroglu, M. & Teebor, G. W., Jul 4 2009, In : DNA Repair. 8, 7, p. 786-794 9 p.

Research output: Contribution to journalArticle

78 Scopus citations