Robert Klein

Professor

  • 3062 Citations
  • 25 h-Index
1985 …2020

Research output per year

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Research Output

  • 3062 Citations
  • 25 h-Index
  • 45 Article
  • 5 Chapter
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Article
2016
2 Scopus citations
2015

Neonatal estrogen exposure results in biphasic age-dependent effects on the skeletal development of male mice

Connelly, K., Larson, E. A., Marks, D. & Klein, R., Jan 1 2015, In : Endocrinology. 156, 1, p. 193-202 10 p.

Research output: Contribution to journalArticle

5 Scopus citations
2014

Distinct actions of Akt1 on skeletal architecture and function

Mukherjee, A., Larson, E. A., Klein, R. & Rotwein, P., Mar 24 2014, In : PLoS One. 9, 3, e93040.

Research output: Contribution to journalArticle

4 Scopus citations
2013

The bone disease associated with factor VIII deficiency in mice is secondary to increased bone resorption

Recht, M., Liel, M. S., Turner, R. T., Klein, R. & Taylor, J., Nov 2013, In : Haemophilia. 19, 6, p. 908-912 5 p.

Research output: Contribution to journalArticle

21 Scopus citations
2012

Congenic mice provide in vivo evidence for a genetic locus that modulates intrinsic transforming growth factor β1-mediated signaling and bone acquisition

Mukherjee, A., Larson, E. A., Carlos, A. S., Belknap, J., Rotwein, P. & Klein, R., Jun 2012, In : Journal of Bone and Mineral Research. 27, 6, p. 1345-1356 12 p.

Research output: Contribution to journalArticle

10 Scopus citations

Decreased bone density and bone strength in a mouse model of severe factor VIII deficiency

Liel, M. S., Greenberg, D. L., Recht, M., Vanek, C., Klein, R. & Taylor, J., Jul 2012, In : British Journal of Haematology. 158, 1, p. 140-143 4 p.

Research output: Contribution to journalArticle

18 Scopus citations

Melanocortin-3 receptor regulates the normal fasting response

Renquist, B. J., Murphy, J. G., Larson, E. A., Olsen, D., Klein, R., Ellacott, K. L. J. & Cone, R. D., Jun 5 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 23

Research output: Contribution to journalArticle

40 Scopus citations

Rare coding variants in ALPL are associated with low serum alkaline phosphatase and low bone mineral density

Nielson, C., Zmuda, J. M., Carlos, A. S., Wagoner, W. J., Larson, E. A., Orwoll, E. & Klein, R., Jan 2012, In : Journal of Bone and Mineral Research. 27, 1, p. 93-103 11 p.

Research output: Contribution to journalArticle

22 Scopus citations

Regulation of lean mass, bone mass, and exercise tolerance by the central melanocortin system

Braun, T. P., Orwoll, B., Zhu, X., Levasseur, P. R., Szumowski, M., Nguyen, M. L. T., Bouxsein, M. L., Klein, R. & Marks, D., Jul 27 2012, In : PLoS One. 7, 7, e42183.

Research output: Contribution to journalArticle

7 Scopus citations
4 Scopus citations
2010

Prolyl 3-hydroxylase 1 null mice display abnormalities in fibrillar collagen-rich tissues such as tendons, skin, and bones

Vranka, J., Pokidysheva, E., Hayashi, L., Zientek, K., Mizuno, K., Ishikawa, Y., Maddox, K., Tufa, S., Keene, D. R., Klein, R. & Bächinger, H. P., May 28 2010, In : Journal of Biological Chemistry. 285, 22, p. 17253-17262 10 p.

Research output: Contribution to journalArticle

55 Scopus citations

Prolyl 3-hydroxylase 1 null mice display abnormalities in fibrillar collagen-rich tissues such as tendons, skin, and bones (The Journal of Biological Chemistry (2010) 285, (17253-17262) DOI: 10.1074/jbc.A110.102228)

Vranka, J., Pokidysheva, E., Hayashi, L., Zientek, K., Mizuno, K., Ishikawa, Y., Maddox, K., Tufa, S., Keene, D. R., Klein, R. & Bachinger, H. P., Jun 25 2010, In : Journal of Biological Chemistry. 285, 26, p. 20421 1 p.

Research output: Contribution to journalArticle

2009

A loss-of-function nonsynonymous polymorphism in the osmoregulatory TRPV4 gene is associated with human hyponatremia

Tian, W., Fu, Y., Garcia-Elias, A., Fernández-Fernández, J. M., Vicente, R., Kramer, P. L., Klein, R., Hitzemann, R., Orwoll, E., Wilmot, B., McWeeney, S., Valverde, M. A. & Cohen, D., Aug 18 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 33, p. 14034-14039 6 p.

Research output: Contribution to journalArticle

67 Scopus citations
2008

Genetics of osteoporosis - Utility of mouse models

Klein, R., 2008, In : Journal of Musculoskeletal Neuronal Interactions. 8, 4, p. 287-290 4 p.

Research output: Contribution to journalArticle

5 Scopus citations

Nonpharmacological approaches to improve bone health and reduce osteoporosis

Schwab, P. & Klein, R., Mar 2008, In : Current Opinion in Rheumatology. 20, 2, p. 213-217 5 p.

Research output: Contribution to journalArticle

28 Scopus citations
2006

Human ALOX12, but not ALOX15, is associated with BMD in white men and women

Ichikawa, S., Koller, D. L., Johnson, M. L., Lai, D., Xuei, X., Edenberg, H. J., Klein, R., Orwoll, E., Hui, S. L., Foroud, T. M., Peacock, M. & Econs, M. J., Apr 2006, In : Journal of Bone and Mineral Research. 21, 4, p. 556-564 9 p.

Research output: Contribution to journalArticle

61 Scopus citations

Perioperative parathyroid hormone levels in thyroid surgery

Ghaheri, B. A., Liebler, S. L., Andersen, P., Schuff, K., Samuels, M., Klein, R. & Cohen, J., Apr 2006, In : Laryngoscope. 116, 4, p. 518-521 4 p.

Research output: Contribution to journalArticle

38 Scopus citations
2004

Regulation of Bone Mass in Mice by the Lipoxygenase Gene Alox15

Klein, R., Allard, J., Avnur, Z., Nikolcheva, T., Rotstein, D., Carlos, A. S., Shea, M., Waters, R. V., Belknap, J., Peltz, G. & Orwoll, E., Jan 9 2004, In : Science. 303, 5655, p. 229-232 4 p.

Research output: Contribution to journalArticle

237 Scopus citations
2002

Genetic regulation of bone mineral density in mice

Klein, R., 2002, In : Journal of Musculoskeletal Neuronal Interactions. 2, 3, p. 232-236 5 p.

Research output: Contribution to journalArticle

18 Scopus citations

Mapping quantitative trait loci that influence femoral cross-sectional area in mice

Klein, R., Turner, R. J., Skinner, L. D., Vartanian, K. A., Serang, M., Carlos, A. S., Shea, M., Belknap, J. & Orwoll, E., Oct 1 2002, In : Journal of Bone and Mineral Research. 17, 10, p. 1752-1760 9 p.

Research output: Contribution to journalArticle

82 Scopus citations
2001

Confirmation and fine mapping of chromosomal regions influencing peak bone mass in mice

Klein, R., Carlos, A. S., Vartanian, K. A., Chambers, V. K., Turner, R. J., Phillips, T., Belknap, J. & Orwoll, E., 2001, In : Journal of Bone and Mineral Research. 16, 11, p. 1953-1961 9 p.

Research output: Contribution to journalArticle

78 Scopus citations

Gender specificity in the genetic determinants of peak bone mass

Orwoll, E., Belknap, J. & Klein, R., 2001, In : Journal of Bone and Mineral Research. 16, 11, p. 1962-1971 10 p.

Research output: Contribution to journalArticle

157 Scopus citations

In silico mapping of complex disease-related traits in mice

Grupe, A., Germer, S., Usuka, J., Aud, D., Belknap, J., Klein, R., Ahluwalia, M. K., Higuchi, R. & Peltz, G., Jun 8 2001, In : Science. 292, 5523, p. 1915-1918 4 p.

Research output: Contribution to journalArticle

239 Scopus citations

Phenotypic characterization of mice bred for high and low peak bone mass

Klein, R., Shea, M., Gunness, M. E., Pelz, G. B., Belknap, J. & Orwoll, E., 2001, In : Journal of Bone and Mineral Research. 16, 1, p. 63-71 9 p.

Research output: Contribution to journalArticle

33 Scopus citations
1998

Quantitative trait loci affecting peak bone mineral density in mice

Klein, R., Mitchell, S. R., Phillips, T., Belknap, J. & Orwoll, E., Nov 1998, In : Journal of Bone and Mineral Research. 13, 11, p. 1648-1656 9 p.

Research output: Contribution to journalArticle

183 Scopus citations
1997

Alcohol-induced bone disease: Impact of ethanol on osteoblast proliferation

Klein, R., 1997, In : Alcoholism: Clinical and Experimental Research. 21, 3, p. 392-399 8 p.

Research output: Contribution to journalArticle

57 Scopus citations
1996

Ethanol inhibits human osteoblastic cell proliferation

Klein, R., Fausti, K. A. & Carlos, A. S., 1996, In : Alcoholism: Clinical and Experimental Research. 20, 3, p. 572-578 7 p.

Research output: Contribution to journalArticle

68 Scopus citations
1995

Inhibition of osteoblastic cell proliferation and ornithine decarboxylase activity by ethanol

Klein, R. & Carlos, A. S., 1995, In : Endocrinology. 136, 8, p. 3406-3411 6 p.

Research output: Contribution to journalArticle

32 Scopus citations

Osteoporosis in men

Orwoll, E. & Klein, R., 1995, In : Endocrine Reviews. 16, 1, p. 87-116 30 p.

Research output: Contribution to journalArticle

400 Scopus citations
1994

Bone loss in men: Pathogenesis and therapeutic considerations

Klein, R. & Orwoll, E., 1994, In : Endocrinologist. 4, 4, p. 252-269 18 p.

Research output: Contribution to journalArticle

15 Scopus citations
1993

Regulation of osteoblastic gene expression by lead

Klein, R. & Wiren, K., Jun 1993, In : Endocrinology. 132, 6, p. 2531-2537 7 p.

Research output: Contribution to journalArticle

38 Scopus citations
1992

The transiliac bone biopsy: When to get it and how to interpret it

Klein, R. & Gunness, M., 1992, In : Endocrinologist. 2, 3, p. 158-168 11 p.

Research output: Contribution to journalArticle

4 Scopus citations
1991

Pertussis toxin inhibits hormonal stimulation of bone resorption in fetal rat limb bones

Klein, R., Nissenson, R. A. & Strewler, G. J., 1991, In : Journal of Pharmacology and Experimental Therapeutics. 258, 3, p. 877-881 5 p.

Research output: Contribution to journalArticle

6 Scopus citations
1989

Increased serum levels of a parathyroid hormone-like protein in malignancy-associated hypercalcemia

Budayr, A. A., Nissenson, R. A., Klein, R., Pun, K. K., Clark, O. H., Diep, D., Arnaud, C. D. & Strewler, G. J., 1989, In : Annals of Internal Medicine. 111, 10, p. 807-812 6 p.

Research output: Contribution to journalArticle

188 Scopus citations
1988

Forskolin mimics the effects of calcitonin but not parathyroid hormone on bone resorption in vitro

Klein, R., Nissenson, R. A. & Strewler, G. J., 1988, In : Bone and Mineral. 4, 3, p. 247-256 10 p.

Research output: Contribution to journalArticle

5 Scopus citations

Vitamin D metabolites and bioactive parathyroid hormone levels during Spacelab 2

Morey-Holton, E. R., Schnoes, H. K., DeLuca, H. F., Phelps, M. E., Klein, R., Nissenson, R. H. & Arnaud, C. D., 1988, In : Aviation Space and Environmental Medicine. 59, 11, p. 1038-1041 4 p.

Research output: Contribution to journalArticle

39 Scopus citations
1987

Adrenocortical function in acquired immunodeficiency syndrome

Membreno, L., Irony, I., Dere, W., Klein, R., Biglieri, E. G. & Cobb, E., 1987, In : Journal of Clinical Endocrinology and Metabolism. 65, 3, p. 482-487 6 p.

Research output: Contribution to journalArticle

173 Scopus citations

Effect of age on circulating immunoreactive and bioactive parathyroid hormone levels in women.

Forero, M. S., Klein, R., Nissenson, R. A., Nelson, K., Heath, H., Arnaud, C. D. & Riggs, B. L., Oct 1987, In : Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2, 5, p. 363-366 4 p.

Research output: Contribution to journalArticle

58 Scopus citations

Parathyroid hormone-like adenylate cyclase-stimulating activity from a human carcinoma is associated with bone-resorbing activity

Klein, R., Strewler, G. J., Leung, S. C. & Nissenson, R. A., 1987, In : Endocrinology. 120, 2, p. 504-511 8 p.

Research output: Contribution to journalArticle

20 Scopus citations

Parathyroid hormonelike protein from human renal carcinoma cells. Structural and functional homology with parathyroid hormone

Strewler, G. J., Stern, P. H., Jacobs, J. W., Eveloff, J., Klein, R., Leung, S. C., Rosenblatt, M. & Nissenson, R. A., 1987, In : Journal of Clinical Investigation. 80, 6, p. 1803-1807 5 p.

Research output: Contribution to journalArticle

428 Scopus citations

Relationship of muscle capillary basement membrane thickness and diabetic retinopathy

Klein, R., Feingold, K. R., Morgan, C., Stern, W. H. & Siperstein, M. D., 1987, In : Diabetes Care. 10, 2, p. 195-199 5 p.

Research output: Contribution to journalArticle

17 Scopus citations
1986

A trial of amitriptyline and fluphenazine in the treatment of painful diabetic neuropathy

Mendel, C. M., Klein, R., Chappell, D. A., Dere, W. H., Gertz, B. J., Karam, J. H., Lavin, T. N. & Grunfeld, C., 1986, In : Journal of the American Medical Association. 255, 5, p. 637-639 3 p.

Research output: Contribution to journalArticle

A Trial of Amitriptyline and Fluphenazine in the Treatment of Painful Diabetic Neuropathy

Mendel, C. M., Klein, R., Chappell, D. A., Dere, W. H., Gertz, B. J., Karam, J. H., Lavin, T. N. & Grunfeld, C., Feb 7 1986, In : JAMA - Journal of the American Medical Association. 255, 5, p. 637-639 3 p.

Research output: Contribution to journalArticle

39 Scopus citations
1985

High performance liquid chromatography used to distinguish the autoimmune hypoglycemia syndrome from factitious hypoglycemia

Klein, R., Seino, S., Sanz, N., Nolte, M. S., Vinik, A. I. & Karam, J. H., 1985, In : Journal of Clinical Endocrinology and Metabolism. 61, 3, p. 571-574 4 p.

Research output: Contribution to journalArticle

12 Scopus citations

Use of the saline infusion test to diagnose the cause of primary aldosteronism

Arteaga, E., Klein, R. & Biglieri, E. G., 1985, In : The American journal of medicine. 79, 6, p. 722-728 7 p.

Research output: Contribution to journalArticle

39 Scopus citations