Robert Klein

Professor

  • 3047 Citations
  • 25 h-Index
1985 …2020
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Research Output 1985 2016

  • 3047 Citations
  • 25 h-Index
  • 45 Article
  • 5 Chapter
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Article
2016
2 Citations (Scopus)
Nomograms
Secondary Hyperparathyroidism
Primary Hyperparathyroidism
Parathyroid Hormone
Bariatric Surgery
2015
5 Citations (Scopus)

Neonatal estrogen exposure results in biphasic age-dependent effects on the skeletal development of male mice

Connelly, K., Larson, E. A., Marks, D. & Klein, R., Jan 1 2015, In : Endocrinology. 156, 1, p. 193-202 10 p.

Research output: Contribution to journalArticle

Estrogens
Bone Density
Bone and Bones
Gonadal Hormones
Puberty
2014
4 Citations (Scopus)

Distinct actions of Akt1 on skeletal architecture and function

Mukherjee, A., Larson, E. A., Klein, R. & Rotwein, P., Mar 24 2014, In : PLoS One. 9, 3, e93040.

Research output: Contribution to journalArticle

thighs
Thigh
osteoclasts
osteoblasts
Bone
2013
20 Citations (Scopus)

The bone disease associated with factor VIII deficiency in mice is secondary to increased bone resorption

Recht, M., Liel, M. S., Turner, R. T., Klein, R. & Taylor, J., Nov 2013, In : Haemophilia. 19, 6, p. 908-912 5 p.

Research output: Contribution to journalArticle

Bone Diseases
Hemophilia A
Bone Resorption
Osteogenesis
Factor VIII
2012
10 Citations (Scopus)

Congenic mice provide in vivo evidence for a genetic locus that modulates intrinsic transforming growth factor β1-mediated signaling and bone acquisition

Mukherjee, A., Larson, E. A., Carlos, A. S., Belknap, J., Rotwein, P. & Klein, R., Jun 2012, In : Journal of Bone and Mineral Research. 27, 6, p. 1345-1356 12 p.

Research output: Contribution to journalArticle

Congenic Mice
Genetic Loci
Transforming Growth Factors
Bone Density
Quantitative Trait Loci
17 Citations (Scopus)

Decreased bone density and bone strength in a mouse model of severe factor VIII deficiency

Liel, M. S., Greenberg, D. L., Recht, M., Vanek, C., Klein, R. & Taylor, J., Jul 2012, In : British Journal of Haematology. 158, 1, p. 140-143 4 p.

Research output: Contribution to journalArticle

Animal Disease Models
Factor VIII
Hemophilia A
Knockout Mice
Bone Density
40 Citations (Scopus)

Melanocortin-3 receptor regulates the normal fasting response

Renquist, B. J., Murphy, J. G., Larson, E. A., Olsen, D., Klein, R., Ellacott, K. L. J. & Cone, R. D., Jun 5 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 23

Research output: Contribution to journalArticle

Receptor, Melanocortin, Type 3
Fasting
White Adipose Tissue
Phenotype
Hyperphagia
20 Citations (Scopus)

Rare coding variants in ALPL are associated with low serum alkaline phosphatase and low bone mineral density

Nielson, C., Zmuda, J. M., Carlos, A. S., Wagoner, W. J., Larson, E. A., Orwoll, E. & Klein, R., Jan 2012, In : Journal of Bone and Mineral Research. 27, 1, p. 93-103 11 p.

Research output: Contribution to journalArticle

Bone Density
Alkaline Phosphatase
Serum
Phosphates
Gene Frequency
7 Citations (Scopus)

Regulation of lean mass, bone mass, and exercise tolerance by the central melanocortin system

Braun, T. P., Orwoll, B., Zhu, X., Levasseur, P. R., Szumowski, M., Nguyen, M. L. T., Bouxsein, M. L., Klein, R. & Marks, D., Jul 27 2012, In : PLoS One. 7, 7, e42183.

Research output: Contribution to journalArticle

Melanocortins
Exercise Tolerance
Receptor, Melanocortin, Type 4
Bone
exercise
4 Citations (Scopus)
Genetic Epigenesis
Sex Chromosomes
Sex Characteristics
Single Nucleotide Polymorphism
Hormones
2010
54 Citations (Scopus)

Prolyl 3-hydroxylase 1 null mice display abnormalities in fibrillar collagen-rich tissues such as tendons, skin, and bones

Vranka, J., Pokidysheva, E., Hayashi, L., Zientek, K., Mizuno, K., Ishikawa, Y., Maddox, K., Tufa, S., Keene, D. R., Klein, R. & Bächinger, H. P., May 28 2010, In : Journal of Biological Chemistry. 285, 22, p. 17253-17262 10 p.

Research output: Contribution to journalArticle

Fibrillar Collagens
Tendons
Skin
Bone
Tissue

Prolyl 3-hydroxylase 1 null mice display abnormalities in fibrillar collagen-rich tissues such as tendons, skin, and bones (The Journal of Biological Chemistry (2010) 285, (17253-17262) DOI: 10.1074/jbc.A110.102228)

Vranka, J., Pokidysheva, E., Hayashi, L., Zientek, K., Mizuno, K., Ishikawa, Y., Maddox, K., Tufa, S., Keene, D. R., Klein, R. & Bachinger, H. P., Jun 25 2010, In : Journal of Biological Chemistry. 285, 26, p. 20421 1 p.

Research output: Contribution to journalArticle

Fibrillar Collagens
Tendons
Skin
Bone
Tissue
2009
67 Citations (Scopus)

A loss-of-function nonsynonymous polymorphism in the osmoregulatory TRPV4 gene is associated with human hyponatremia

Tian, W., Fu, Y., Garcia-Elias, A., Fernández-Fernández, J. M., Vicente, R., Kramer, P. L., Klein, R., Hitzemann, R., Orwoll, E., Wilmot, B., McWeeney, S., Valverde, M. A. & Cohen, D., Aug 18 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 33, p. 14034-14039 6 p.

Research output: Contribution to journalArticle

TRPV Cation Channels
Hyponatremia
Sodium
Alleles
Osmotic Pressure
2008
5 Citations (Scopus)

Genetics of osteoporosis - Utility of mouse models

Klein, R., 2008, In : Journal of Musculoskeletal Neuronal Interactions. 8, 4, p. 287-290 4 p.

Research output: Contribution to journalArticle

Animal Disease Models
Inbred Strains Mice
Genetic Markers
Transgenic Mice
Osteoporosis
28 Citations (Scopus)

Nonpharmacological approaches to improve bone health and reduce osteoporosis

Schwab, P. & Klein, R., Mar 2008, In : Current Opinion in Rheumatology. 20, 2, p. 213-217 5 p.

Research output: Contribution to journalArticle

Osteoporosis
Exercise
Bone and Bones
Health
Weight-Bearing
2006
61 Citations (Scopus)

Human ALOX12, but not ALOX15, is associated with BMD in white men and women

Ichikawa, S., Koller, D. L., Johnson, M. L., Lai, D., Xuei, X., Edenberg, H. J., Klein, R., Orwoll, E., Hui, S. L., Foroud, T. M., Peacock, M. & Econs, M. J., Apr 2006, In : Journal of Bone and Mineral Research. 21, 4, p. 556-564 9 p.

Research output: Contribution to journalArticle

Spine
Genes
Single Nucleotide Polymorphism
Haplotypes
Osteoporosis
38 Citations (Scopus)

Perioperative parathyroid hormone levels in thyroid surgery

Ghaheri, B. A., Liebler, S. L., Andersen, P., Schuff, K., Samuels, M., Klein, R. & Cohen, J., Apr 2006, In : Laryngoscope. 116, 4, p. 518-521 4 p.

Research output: Contribution to journalArticle

Parathyroid Hormone
Thyroid Gland
Hypocalcemia
Sensitivity and Specificity
Recovery Room
2004
237 Citations (Scopus)

Regulation of Bone Mass in Mice by the Lipoxygenase Gene Alox15

Klein, R., Allard, J., Avnur, Z., Nikolcheva, T., Rotstein, D., Carlos, A. S., Shea, M., Waters, R. V., Belknap, J., Peltz, G. & Orwoll, E., Jan 9 2004, In : Science. 303, 5655, p. 229-232 4 p.

Research output: Contribution to journalArticle

Lipoxygenase
Osteoporosis
Bone and Bones
Bone Density
Genetic Hybridization
2002
17 Citations (Scopus)

Genetic regulation of bone mineral density in mice

Klein, R., 2002, In : Journal of Musculoskeletal Neuronal Interactions. 2, 3, p. 232-236 5 p.

Research output: Contribution to journalArticle

Bone Density
Quantitative Trait Loci
Human Genome
Multifactorial Inheritance
Genes
82 Citations (Scopus)

Mapping quantitative trait loci that influence femoral cross-sectional area in mice

Klein, R., Turner, R. J., Skinner, L. D., Vartanian, K. A., Serang, M., Carlos, A. S., Shea, M., Belknap, J. & Orwoll, E., Oct 1 2002, In : Journal of Bone and Mineral Research. 17, 10, p. 1752-1760 9 p.

Research output: Contribution to journalArticle

Quantitative Trait Loci
Thigh
Bone Density
Weights and Measures
Chromosomes, Human, Pair 7
2001
78 Citations (Scopus)

Confirmation and fine mapping of chromosomal regions influencing peak bone mass in mice

Klein, R., Carlos, A. S., Vartanian, K. A., Chambers, V. K., Turner, R. J., Phillips, T., Belknap, J. & Orwoll, E., 2001, In : Journal of Bone and Mineral Research. 16, 11, p. 1953-1961 9 p.

Research output: Contribution to journalArticle

Bone Density
Bone and Bones
Multifactorial Inheritance
Chromosomes, Human, Pair 4
Inbred Strains Mice
157 Citations (Scopus)

Gender specificity in the genetic determinants of peak bone mass

Orwoll, E., Belknap, J. & Klein, R., 2001, In : Journal of Bone and Mineral Research. 16, 11, p. 1962-1971 10 p.

Research output: Contribution to journalArticle

Bone Density
Bone and Bones
Quantitative Trait Loci
Body Weight
Phenotype
239 Citations (Scopus)

In silico mapping of complex disease-related traits in mice

Grupe, A., Germer, S., Usuka, J., Aud, D., Belknap, J., Klein, R., Ahluwalia, M. K., Higuchi, R. & Peltz, G., Jun 8 2001, In : Science. 292, 5523, p. 1915-1918 4 p.

Research output: Contribution to journalArticle

Computer Simulation
Inbred Strains Mice
Genetic Models
Single Nucleotide Polymorphism
Databases
32 Citations (Scopus)

Phenotypic characterization of mice bred for high and low peak bone mass

Klein, R., Shea, M., Gunness, M. E., Pelz, G. B., Belknap, J. & Orwoll, E., 2001, In : Journal of Bone and Mineral Research. 16, 1, p. 63-71 9 p.

Research output: Contribution to journalArticle

Bone Density
Bone and Bones
Thigh
Osteoporotic Fractures
Femur Neck
1998
183 Citations (Scopus)

Quantitative trait loci affecting peak bone mineral density in mice

Klein, R., Mitchell, S. R., Phillips, T., Belknap, J. & Orwoll, E., Nov 1998, In : Journal of Bone and Mineral Research. 13, 11, p. 1648-1656 9 p.

Research output: Contribution to journalArticle

Quantitative Trait Loci
Bone Density
Body Weight
Photon Absorptiometry
Genes
1997
57 Citations (Scopus)

Alcohol-induced bone disease: Impact of ethanol on osteoblast proliferation

Klein, R., 1997, In : Alcoholism: Clinical and Experimental Research. 21, 3, p. 392-399 8 p.

Research output: Contribution to journalArticle

Bone Diseases
Osteoblasts
Bone
Ethanol
Alcohols
1996
68 Citations (Scopus)

Ethanol inhibits human osteoblastic cell proliferation

Klein, R., Fausti, K. A. & Carlos, A. S., 1996, In : Alcoholism: Clinical and Experimental Research. 20, 3, p. 572-578 7 p.

Research output: Contribution to journalArticle

Cell proliferation
Osteoblasts
Ethanol
Cell Proliferation
Polyamines
1995
31 Citations (Scopus)

Inhibition of osteoblastic cell proliferation and ornithine decarboxylase activity by ethanol

Klein, R. & Carlos, A. S., 1995, In : Endocrinology. 136, 8, p. 3406-3411 6 p.

Research output: Contribution to journalArticle

Ornithine Decarboxylase
Polyamines
Osteoblasts
Ethanol
Cell Proliferation
398 Citations (Scopus)

Osteoporosis in men

Orwoll, E. & Klein, R., 1995, In : Endocrine Reviews. 16, 1, p. 87-116 30 p.

Research output: Contribution to journalArticle

Osteoporosis
Therapeutics
Skeleton
Causality
Androgens
1994
15 Citations (Scopus)

Bone loss in men: Pathogenesis and therapeutic considerations

Klein, R. & Orwoll, E., 1994, In : Endocrinologist. 4, 4, p. 252-269 18 p.

Research output: Contribution to journalArticle

Osteoporosis
Bone and Bones
Therapeutics
Bone Diseases
Phenotype
1993
38 Citations (Scopus)

Regulation of osteoblastic gene expression by lead

Klein, R. & Wiren, K., Jun 1993, In : Endocrinology. 132, 6, p. 2531-2537 7 p.

Research output: Contribution to journalArticle

Gene Expression Regulation
Osteoblasts
Messenger RNA
Alkaline Phosphatase
Lead
1992
4 Citations (Scopus)

The transiliac bone biopsy: When to get it and how to interpret it

Klein, R. & Gunness, M., 1992, In : Endocrinologist. 2, 3, p. 158-168 11 p.

Research output: Contribution to journalArticle

Biopsy
Bone and Bones
Physiologic Calcification
Bone Remodeling
Metabolic Bone Diseases
1991
6 Citations (Scopus)

Pertussis toxin inhibits hormonal stimulation of bone resorption in fetal rat limb bones

Klein, R., Nissenson, R. A. & Strewler, G. J., 1991, In : Journal of Pharmacology and Experimental Therapeutics. 258, 3, p. 877-881 5 p.

Research output: Contribution to journalArticle

Pertussis Toxin
Bone Resorption
Parathyroid Hormone
Extremities
GTP-Binding Proteins
1989
186 Citations (Scopus)

Increased serum levels of a parathyroid hormone-like protein in malignancy-associated hypercalcemia

Budayr, A. A., Nissenson, R. A., Klein, R., Pun, K. K., Clark, O. H., Diep, D., Arnaud, C. D. & Strewler, G. J., 1989, In : Annals of Internal Medicine. 111, 10, p. 807-812 6 p.

Research output: Contribution to journalArticle

Parathyroid Hormone-Related Protein
Hypercalcemia
Serum
Neoplasms
Hyperparathyroidism
1988
5 Citations (Scopus)

Forskolin mimics the effects of calcitonin but not parathyroid hormone on bone resorption in vitro

Klein, R., Nissenson, R. A. & Strewler, G. J., 1988, In : Bone and Mineral. 4, 3, p. 247-256 10 p.

Research output: Contribution to journalArticle

Calcitonin
Colforsin
Bone Resorption
Parathyroid Hormone
Bone
39 Citations (Scopus)

Vitamin D metabolites and bioactive parathyroid hormone levels during Spacelab 2

Morey-Holton, E. R., Schnoes, H. K., DeLuca, H. F., Phelps, M. E., Klein, R., Nissenson, R. H. & Arnaud, C. D., 1988, In : Aviation Space and Environmental Medicine. 59, 11, p. 1038-1041 4 p.

Research output: Contribution to journalArticle

Vitamins
Hormones
Metabolites
Parathyroid Hormone
Vitamin D
1987
172 Citations (Scopus)

Adrenocortical function in acquired immunodeficiency syndrome

Membreno, L., Irony, I., Dere, W., Klein, R., Biglieri, E. G. & Cobb, E., 1987, In : Journal of Clinical Endocrinology and Metabolism. 65, 3, p. 482-487 6 p.

Research output: Contribution to journalArticle

Acquired Immunodeficiency Syndrome
Steroids
AIDS-Related Complex
Adrenocorticotropic Hormone
18-Hydroxycorticosterone
58 Citations (Scopus)

Effect of age on circulating immunoreactive and bioactive parathyroid hormone levels in women.

Forero, M. S., Klein, R., Nissenson, R. A., Nelson, K., Heath, H., Arnaud, C. D. & Riggs, B. L., Oct 1987, In : Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2, 5, p. 363-366 4 p.

Research output: Contribution to journalArticle

Parathyroid Hormone
Immune Sera
Serum
Kidney
Adenylyl Cyclases
20 Citations (Scopus)

Parathyroid hormone-like adenylate cyclase-stimulating activity from a human carcinoma is associated with bone-resorbing activity

Klein, R., Strewler, G. J., Leung, S. C. & Nissenson, R. A., 1987, In : Endocrinology. 120, 2, p. 504-511 8 p.

Research output: Contribution to journalArticle

Conditioned Culture Medium
Parathyroid Hormone
Adenylyl Cyclases
Human Activities
Carcinoma
427 Citations (Scopus)

Parathyroid hormonelike protein from human renal carcinoma cells. Structural and functional homology with parathyroid hormone

Strewler, G. J., Stern, P. H., Jacobs, J. W., Eveloff, J., Klein, R., Leung, S. C., Rosenblatt, M. & Nissenson, R. A., 1987, In : Journal of Clinical Investigation. 80, 6, p. 1803-1807 5 p.

Research output: Contribution to journalArticle

Parathyroid Hormone-Related Protein
Parathyroid Hormone
Renal Cell Carcinoma
Hypercalcemia
Proteins
17 Citations (Scopus)

Relationship of muscle capillary basement membrane thickness and diabetic retinopathy

Klein, R., Feingold, K. R., Morgan, C., Stern, W. H. & Siperstein, M. D., 1987, In : Diabetes Care. 10, 2, p. 195-199 5 p.

Research output: Contribution to journalArticle

Diabetic Retinopathy
Basement Membrane
Muscles
Fluorescein Angiography
Quadriceps Muscle
1986

A trial of amitriptyline and fluphenazine in the treatment of painful diabetic neuropathy

Mendel, C. M., Klein, R., Chappell, D. A., Dere, W. H., Gertz, B. J., Karam, J. H., Lavin, T. N. & Grunfeld, C., 1986, In : Journal of the American Medical Association. 255, 5, p. 637-639 3 p.

Research output: Contribution to journalArticle

Fluphenazine
Amitriptyline
Diabetic Neuropathies
Placebos
Pain
38 Citations (Scopus)

A Trial of Amitriptyline and Fluphenazine in the Treatment of Painful Diabetic Neuropathy

Mendel, C. M., Klein, R., Chappell, D. A., Dere, W. H., Gertz, B. J., Karam, J. H., Lavin, T. N. & Grunfeld, C., Feb 7 1986, In : JAMA - Journal of the American Medical Association. 255, 5, p. 637-639 3 p.

Research output: Contribution to journalArticle

Fluphenazine
Amitriptyline
Diabetic Neuropathies
Placebos
Pain
1985
12 Citations (Scopus)

High performance liquid chromatography used to distinguish the autoimmune hypoglycemia syndrome from factitious hypoglycemia

Klein, R., Seino, S., Sanz, N., Nolte, M. S., Vinik, A. I. & Karam, J. H., 1985, In : Journal of Clinical Endocrinology and Metabolism. 61, 3, p. 571-574 4 p.

Research output: Contribution to journalArticle

High performance liquid chromatography
Hypoglycemia
High Pressure Liquid Chromatography
Insulin
Reverse-Phase Chromatography
39 Citations (Scopus)

Use of the saline infusion test to diagnose the cause of primary aldosteronism

Arteaga, E., Klein, R. & Biglieri, E. G., 1985, In : The American journal of medicine. 79, 6, p. 722-728 7 p.

Research output: Contribution to journalArticle

Hyperaldosteronism
Aldosterone
Adenoma
Mineralocorticoids
Renin