Robert Hitzemann

Professor

  • 22865 Citations
  • 69 h-Index
1970 …2020

Research output per year

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Research Output

2020

Chronic Voluntary Ethanol Drinking in Cynomolgus Macaques Elicits Gene Expression Changes in Prefrontal Cortical Area 46

Walter, N. A. R., Zheng, C. L., Searles, R. P., McWeeney, S. K., Grant, K. A. & Hitzemann, R., Feb 1 2020, In : Alcoholism: Clinical and Experimental Research. 44, 2, p. 470-478 9 p.

Research output: Contribution to journalArticle

Open Access

RNA-Seq Analysis of Genetic and Transcriptome Network Effects of Dual-Trait Selection for Ethanol Preference and Withdrawal Using SOT and NOT Genetic Models

Kozell, L. B., Lockwood, D., Darakjian, P., Edmunds, S., Shepherdson, K., Buck, K. J. & Hitzemann, R., Apr 1 2020, In : Alcoholism: Clinical and Experimental Research. 44, 4, p. 820-830 11 p.

Research output: Contribution to journalArticle

Open Access
2019

Regional analysis of the brain transcriptome in mice bred for high and low methamphetamine consumption

Hitzemann, R., Iancu, O. D., Reed, C., Baba, H., Lockwood, D. R. & Phillips, T. J., Jul 2019, In : Brain Sciences. 9, 7, 155.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Scn4b regulates the hypnotic effects of ethanol and other sedative drugs

Blednov, Y. A., Bajo, M., Roberts, A. J., Da Costa, A. J., Black, M., Edmunds, S., Mayfield, J., Roberto, M., Homanics, G. E., Lasek, A. W., Hitzemann, R. J. & Harris, R. A., Jul 2019, In : Genes, Brain and Behavior. 18, 6, e12562.

Research output: Contribution to journalArticle

2018

A relationship between the aldosterone-mineralocorticoid receptor pathway and alcohol drinking: Preliminary translational findings across rats, monkeys and humans

Aoun, E. G., Jimenez, V. A., Vendruscolo, L. F., Walter, N. A. R., Barbier, E., Ferrulli, A., Haass-Koffler, C. L., Darakjian, P., Lee, M. R., Addolorato, G., Heilig, M., Hitzemann, R., Koob, G. F., Grant, K. K. & Leggio, L., Jun 1 2018, In : Molecular Psychiatry. 23, 6, p. 1466-1473 8 p.

Research output: Contribution to journalArticle

8 Scopus citations

Cross-species molecular dissection across alcohol behavioral domains

Farris, S. P., Riley, B. P., Williams, R. W., Mulligan, M. K., Miles, M. F., Lopez, M. F., Hitzemann, R., Iancu, O., Colville, A., Walter, N. A. R., Darakjian, P., Oberbeck, D. L., Daunais, J. B., Zheng, C., Searles, R., McWeeney, S., Grant, K. K. & Mayfield, R. D., Nov 1 2018, In : Alcohol. 72, p. 19-31 13 p.

Research output: Contribution to journalReview article

3 Scopus citations

Gender-Specific Effects of Selection for Drinking in the Dark on the Network Roles of Coding and Noncoding RNAs

Iancu, O., Colville, A. M., Wilmot, B., Searles, R., Darakjian, P., Zheng, C., McWeeney, S., Kawane, S., Crabbe, J. J., Metten, P., Oberbeck, D. & Hitzemann, R., Aug 1 2018, In : Alcoholism: Clinical and Experimental Research. 42, 8, p. 1454-1465 12 p.

Research output: Contribution to journalArticle

3 Scopus citations

Genes, behavior, and next-generation sequencing: The first 10 years

Hitzemann, R., Darakjian, P., Oberbeck, D., Zheng, C., Walter, N., Iancu, O. D., Searles, R., Harrington, C. A. & McWeeney, S., Jan 1 2018, Molecular-Genetic and Statistical Techniques for Behavioral and Neural Research. Elsevier, p. 289-308 20 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Regional differences and similarities in the brain transcriptome for mice selected for ethanol preference from HS-CC founders

Colville, A. M., Iancu, O. D., Lockwood, D. R., Darakjian, P., McWeeney, S. K., Searles, R., Zheng, C. & Hitzemann, R., Aug 28 2018, In : Frontiers in Genetics. 9, AUG, 300.

Research output: Contribution to journalArticle

4 Scopus citations
2017

Alignment of the transcriptome with individual variation in animals selectively bred for High Drinking-In-the-Dark (HDID)

Hitzemann, R., Oberbeck, D., Iancu, O., Darakjian, P., McWeeney, S., Spence, S., Schlumbohm, J., Metten, P. & Crabbe, J. J., May 1 2017, In : Alcohol. 60

Research output: Contribution to journalArticle

4 Scopus citations

Effects of selection for ethanol preference on gene expression in the nucleus accumbens of HS-CC mice

Colville, A. M., Iancu, O., Oberbeck, D. L., Darakjian, P., Zheng, C., Walter, N. A. R., Harrington, C. C., Searles, R., McWeeney, S. & Hitzemann, R., 2017, (Accepted/In press) In : Genes, Brain and Behavior.

Research output: Contribution to journalArticle

14 Scopus citations

NFAT5 and SLC4A10 loci associate with plasma osmolality

Böger, C. A., Gorski, M., McMahon, G. M., Xu, H., Chang, Y. P. C., Van Der Most, P. J., Navis, G., Nolte, I. M., De Borst, M. H., Zhang, W., Lehne, B., Loh, M., Tan, S. T., Boerwinkle, E., Grams, M. E., Sekula, P., Li, M., Wilmot, B., Moon, J. G., Scheet, P. & 86 others, Cucca, F., Xiao, X., Lyytikäinen, L. P., Delgado, G., Grammer, T. B., Kleber, M. E., Sedaghat, S., Rivadeneira, F., Corre, T., Kutalik, Z., Bergmann, S., Nielson, C. M., Srikanth, P., Teumer, A., Müller-Nurasyid, M., Brockhaus, A. C., Pfeufer, A., Rathmann, W., Peters, A., Matsumoto, M., De Andrade, M., Atkinson, E. J., Robinson-Cohen, C., De Boer, I. H., Hwang, S. J., Heid, I. M., Gögele, M., Concas, M. P., Tanaka, T., Bandinelli, S., Nalls, M. A., Singleton, A., Tajuddin, S. M., Adeyemo, A., Zhou, J., Doumatey, A., McWeeney, S., Murabito, J., Franceschini, N., Flessner, M., Shlipak, M., Wilson, J. G., Chen, G., Rotimi, C. N., Zonderman, A. B., Evans, M. K., Ferrucci, L., Devuyst, O., Pirastu, M., Shuldiner, A., Hicks, A. A., Pramstaller, P. P., Kestenbaum, B., Kardia, S. L. R., Turner, S. T., Study, L. C., Briske, T. E., Gieger, C., Strauch, K., Meisinger, C., Meitinger, T., Völker, U., Nauck, M., Völzke, H., Vollenweider, P., Bochud, M., Waeber, G., Kähönen, M., Lehtimäki, T., März, W., Dehghan, A., Franco, O. H., Uitterlinden, A. G., Hofman, A., Taylor, H. A., Chambers, J. C., Kooner, J. S., Fox, C. S., Hitzemann, R., Orwoll, E. S., Pattaro, C., Schlessinger, D., Köttgen, A., Snieder, H., Parsa, A. & Cohen, D. M., Aug 2017, In : Journal of the American Society of Nephrology. 28, 8, p. 2311-2321 11 p.

Research output: Contribution to journalArticle

8 Scopus citations

On the relationships in rhesus macaques between chronic ethanol consumption and the brain transcriptome

Iancu, O., Colville, A., Walter, N. A. R., Darakjian, P., Oberbeck, D. L., Daunais, J. B., Zheng, C., Searles, R., McWeeney, S., Grant, K. K. & Hitzemann, R., 2017, (Accepted/In press) In : Addiction Biology.

Research output: Contribution to journalArticle

14 Scopus citations
2016

Diversity outbred mice at 21: Maintaining allelic variation in the face of selection

Chesler, E. J., Gatti, D. M., Morgan, A. P., Strobel, M., Trepanier, L., Oberbeck, D., McWeeney, S., Hitzemann, R., Ferris, M., McMullan, R., Clayshultle, A., Bell, T. A., de Villena, F. P. M. & Churchill, G. A., 2016, In : G3: Genes, Genomes, Genetics. 6, 12, p. 3893-3902 10 p.

Research output: Contribution to journalArticle

20 Scopus citations
2015

Cosplicing network analysis of mammalian brain RNA-Seq data utilizing WGCNA and Mantel correlations

Iancu, O. D., Colville, A., Oberbeck, D., Darakjian, P., McWeeney, S. K. & Hitzemann, R., Jan 1 2015, In : Frontiers in Genetics. 6, MAY, 174.

Research output: Contribution to journalArticle

25 Scopus citations

Splicing landscape of the eight collaborative cross founder strains

Zheng, C. L., Wilmot, B., Walter, N. A. R., Oberbeck, D., Kawane, S., Searles, R. P., McWeeney, S. K. & Hitzemann, R., Feb 5 2015, In : BMC Genomics. 16, 1, 52.

Research output: Contribution to journalArticle

6 Scopus citations
2014

Coexpression and cosplicing network approaches for the study of mammalian brain transcriptomes

Iancu, O. D., Colville, A., Darakjian, P. & Hitzemann, R., Jan 1 2014, International Review of Neurobiology. Academic Press Inc., p. 73-93 21 p. (International Review of Neurobiology; vol. 116).

Research output: Chapter in Book/Report/Conference proceedingChapter

7 Scopus citations

Dual-Trait Selection for Ethanol Consumption and Withdrawal: Genetic and Transcriptional Network Effects

Metten, P., Iancu, O. D., Spence, S. E., Walter, N. A. R., Oberbeck, D., Harrington, C. A., Colville, A., Mcweeney, S., Phillips, T. J., Buck, K. J., Crabbe, J. C., Belknap, J. K. & Hitzemann, R. J., Dec 1 2014, In : Alcoholism: Clinical and Experimental Research. 38, 12, p. 2915-2924 10 p.

Research output: Contribution to journalArticle

20 Scopus citations

Introduction to sequencing the brain transcriptome

Hitzemann, R., Darakjian, P., Walter, N., Dan Iancu, O., Searles, R. & McWeeney, S., Jan 1 2014, International Review of Neurobiology. Academic Press Inc., p. 1-19 19 p. (International Review of Neurobiology; vol. 116).

Research output: Chapter in Book/Report/Conference proceedingChapter

12 Scopus citations
7 Scopus citations
2013

Differential Network Analysis Reveals Genetic Effects on Catalepsy Modules

Iancu, O. D., Oberbeck, D., Darakjian, P., Kawane, S., Erk, J., McWeeney, S. & Hitzemann, R., Mar 21 2013, In : PloS one. 8, 3, e58951.

Research output: Contribution to journalArticle

16 Scopus citations

Effects of sodium butyrate on methamphetamine-sensitized locomotor activity

Harkness, J. H., Hitzemann, R. J., Edmunds, S. & Phillips, T. J., Feb 15 2013, In : Behavioural Brain Research. 239, 1, p. 139-147 9 p.

Research output: Contribution to journalArticle

8 Scopus citations

Genes, behavior and next-generation RNA sequencing

Hitzemann, R., Bottomly, D., Darakjian, P., Walter, N., Iancu, O., Searles, R., Wilmot, B. & Mcweeney, S., Feb 1 2013, In : Genes, Brain and Behavior. 12, 1, p. 1-12 12 p.

Research output: Contribution to journalArticle

50 Scopus citations

Genetic factors involved in risk for methamphetamine intake and sensitization

Belknap, J. K., McWeeney, S., Reed, C., Burkhart-Kasch, S., McKinnon, C. S., Li, N., Baba, H., Scibelli, A. C., Hitzemann, R. & Phillips, T. J., Dec 1 2013, In : Mammalian Genome. 24, 11-12, p. 446-458 13 p.

Research output: Contribution to journalArticle

16 Scopus citations

Selection for drinking in the dark alters brain gene coexpression networks

Iancu, O. D., Oberbeck, D., Darakjian, P., Metten, P., Mcweeney, S., Crabbe, J. C. & Hitzemann, R., Aug 1 2013, In : Alcoholism: Clinical and Experimental Research. 37, 8, p. 1295-1303 9 p.

Research output: Contribution to journalArticle

49 Scopus citations
2012
5 Scopus citations

Gene networks and haloperidol-induced catalepsy

Iancu, O. D., Darakjian, P., Malmanger, B., Walter, N. A. R., McWeeney, S. & Hitzemann, R., Feb 1 2012, In : Genes, Brain and Behavior. 11, 1, p. 29-37 9 p.

Research output: Contribution to journalArticle

20 Scopus citations

Heritability of serum sodium concentration: Evidence for sex- and ethnic-specific effects

Wilmot, B., Saroja Voruganti, V., Chang, Y. P. C., Fu, Y., Chen, Z., Taylor, H. A., Wilson, J. G., Gipson, T., Shah, V. O., Umans, J. G., Flessner, M. F., Hitzemann, R., Shuldiner, A. R., Comuzzie, A. G., Mcweeney, S., Zager, P. G., Maccluer, J. W., Cole, S. A. & Cohen, D. M., Feb 2012, In : Physiological genomics. 44, 3, p. 220-228 9 p.

Research output: Contribution to journalArticle

13 Scopus citations

The genome architecture of the collaborative cross mouse genetic reference population

Iraqi, F. A., Mahajne, M., Salaymah, Y., Sandovski, H., Tayem, H., Vered, K., Balmer, L., Hall, M., Manship, G., Morahan, G., Pettit, K., Scholten, J., Tweedie, K., Wallace, A., Weerasekera, L., Cleak, J., Durrant, C., Goodstadt, L., Mott, R., Yalcin, B. & 110 others, Aylor, D. L., Baric, R. S., Bell, T. A., Bendt, K. M., Brennan, J., Brooks, J. D., Buus, R. J., Crowley, J. J., Calaway, J. D., Calaway, M. E., Cholka, A., Darr, D. B., Didion, J. P., Dorman, A., Everett, E. T., Ferris, M. T., Mathes, W. F., Fu, C. P., Gooch, T. J., Goodson, S. G., Gralinski, L. E., Hansen, S. D., Heise, M. T., Hoel, J., Hua, K., Kapita, M. C., Lee, S., Lenarcic, A. B., Liu, E. Y., Liu, H., McMillan, L., Magnuson, T. R., Manly, K. F., Miller, D. R., O'Brien, D. A., Odet, F., Pakatci, I. K., Pan, W., de Villena, F. P. M., Perou, C. M., Pomp, D., Quackenbush, C. R., Robinson, N. N., Sharpless, N. E., Shaw, G. D., Spence, J. S., Sullivan, P. F., Sun, W., Tarantino, L. M., Valdar, W., Wang, J., Wang, W., Welsh, C. E., Whitmore, A., Wiltshire, T., Wright, F. A., Xie, Y., Yun, Z., Zhabotynsky, V., Zhang, Z., Zou, F., Powell, C., Steigerwalt, J., Threadgill, D. W., Chesler, E. J., Churchill, G. A., Gatti, D. M., Korstanje, R., Svenson, K. L., Collins, F. S., Crawford, N., Hunter, K., Samir, N., Kelada, P., Peck, B. C. E., Reilly, K., Tavarez, U., Bottomly, D., Hitzeman, R., Mcweeney, S. K., Frelinger, J., Krovi, H., Phillippi, J., Spritz, R. A., Aicher, L., Katze, M., Rosenzweig, E., Shusterman, A., Nashef, A., Weiss, E. I., Houri-Haddad, Y., Soller, M., Williams, R. W., Schughart, K., Yang, H., French, J. E., Benson, A. K., Kim, J., Legge, R., Low, S. J., Ma, F., Martinez, I., Walter, J., Broman, K. W., Hallgrimsson, B., Klein, O., Weinstock, G., Warren, W. C., Yang, Y. V. & Schwartz, D., Feb 2012, In : Genetics. 190, 2, p. 389-401 13 p.

Research output: Contribution to journalArticle

268 Scopus citations

Utilizing RNA-Seq data for de novo coexpression network inference

Iancu, O. D., Kawane, S., Bottomly, D., Searles, R., Hitzemann, R. & McWeeney, S., Jun 2012, In : Bioinformatics. 28, 12, p. 1592-1597 6 p., bts245.

Research output: Contribution to journalArticle

84 Scopus citations
2011

Computational detection of alternative exon usage

Laderas, T. G., Walter, N. A. R., Mooney, M., Vartanian, K., Darakjian, P., Buck, K., Harrington, C. A., Belknap, J., Hitzemann, R. & McWeeney, S. K., 2011, In : Frontiers in Neuroscience. MAY, Article 69.

Research output: Contribution to journalArticle

9 Scopus citations

Evaluating gene expression in C57BL/6J and DBA/2J mouse striatum using RNA-Seq and microarrays

Bottomly, D., Walter, N. A. R., Hunter, J. E., Darakjian, P., Kawane, S., Buck, K. J., Searles, R. P., Mooney, M., McWeeney, S. K. & Hitzemann, R., 2011, In : PloS one. 6, 3, e17820.

Research output: Contribution to journalArticle

138 Scopus citations

Genome-wide and species-wide dissection of the genetics of arthritis severity in heterogeneous stock mice

Johnsen, A. K., Valdar, W., Golden, L., Ortiz-Lopez, A., Hitzemann, R., Flint, J., Mathis, D. & Benoist, C., Sep 1 2011, In : Arthritis and rheumatism. 63, 9, p. 2630-2640 11 p.

Research output: Contribution to journalArticle

16 Scopus citations

Modeling the diagnostic criteria for alcohol dependence with genetic animal models

Crabbe, J. C., Kendler, K. S. & Hitzemann, R. J., Sep 11 2011, In : Current topics in behavioral neurosciences. 13, p. 187-221 35 p.

Research output: Contribution to journalArticle

14 Scopus citations
16 Scopus citations
2010

A method for mapping intralocus interactions influencing excessive alcohol drinking

Phillips, T. J., Reed, C., Burkhart-Kasch, S., Li, N., Hitzemann, R., Yu, C. H., Brown, L. L., Helms, M. L., Crabbe, J. C. & Belknap, J. K., Feb 1 2010, In : Mammalian Genome. 21, 1-2, p. 39-51 13 p.

Research output: Contribution to journalArticle

17 Scopus citations

Genetic diversity and striatal gene networks: Focus on the heterogeneous stock-collaborative cross (HS-CC) mouse

Iancu, O. D., Darakjian, P., Walter, N. A. R., Malmanger, B., Oberbeck, D., Belknap, J., McWeeney, S. & Hitzemann, R., Oct 19 2010, In : BMC Genomics. 11, 1, 585.

Research output: Contribution to journalArticle

48 Scopus citations

Intraperitoneal catheter placement for pharmacological imaging studies in conscious mice

Boudreau, E., Chen, G., Li, X., Buck, K., Hitzemann, R. & Hickman, D., Jan 1 2010, In : Lab Animal. 39, 1, p. 23-25 3 p.

Research output: Contribution to journalArticle

3 Scopus citations
2009

A loss-of-function nonsynonymous polymorphism in the osmoregulatory TRPV4 gene is associated with human hyponatremia

Tian, W., Fu, Y., Garcia-Elias, A., Fernández-Fernández, J. M., Vicente, R., Kramer, P. L., Klein, R. F., Hitzemann, R., Orwoll, E. S., Wilmot, B., McWeeney, S., Valverde, M. A. & Cohen, D. M., Aug 18 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 33, p. 14034-14039 6 p.

Research output: Contribution to journalArticle

69 Scopus citations

Detection of reciprocal quantitative trait loci for acute ethanol withdrawal and ethanol consumption in heterogeneous stock mice

Hitzemann, R., Edmunds, S., Wu, W., Malmanger, B., Walter, N., Belknap, J., Darakjian, P. & McWeeney, S., May 1 2009, In : Psychopharmacology. 203, 4, p. 713-722 10 p.

Research output: Contribution to journalArticle

26 Scopus citations

Differential activation of limbic circuitry associated with chronic ethanol withdrawal in DBA/2J and C57BL/6J mice

Chen, G., Reilly, M. T., Kozell, L. B., Hitzemann, R. & Buck, K. J., Sep 1 2009, In : Alcohol. 43, 6, p. 411-420 10 p.

Research output: Contribution to journalArticle

28 Scopus citations

Electrolytic lesions of the medial nucleus accumbens shell selectively decrease ethanol consumption without altering preference in a limited access procedure in C57BL/6J mice

Dhaher, R., Finn, D. A., Oberbeck, D. L., Yoneyama, N., Snelling, C. C., Wu, W. & Hitzemann, R. J., Apr 1 2009, In : Pharmacology Biochemistry and Behavior. 92, 2, p. 335-342 8 p.

Research output: Contribution to journalArticle

15 Scopus citations

High throughput sequencing in mice: A platform comparison identifies a preponderance of cryptic SNPs

Walter, N. A. R., Bottomly, D., Laderas, T., Mooney, M. A., Darakjian, P., Searles, R. P., Harrington, C. A., McWeeney, S. K., Hitzemann, R. & Buck, K. J., Aug 17 2009, In : BMC Genomics. 10, 1 p., 1471.

Research output: Contribution to journalArticle

22 Scopus citations
2008

Characterization of the quantitative trait locus for haloperidol-induced catalepsy on distal mouse chromosome 1

Hofstetter, J. R., Hitzemann, R. J., Belknap, J. K., Walter, N. A. R., McWeeney, S. K. & Mayeda, A. R., Mar 1 2008, In : Genes, Brain and Behavior. 7, 2, p. 214-223 10 p.

Research output: Contribution to journalArticle

9 Scopus citations

Conclusions

Hitzemann, R. & Oberbeck, D., Dec 1 2008, In : Alcohol Research and Health. 31, 3, 1 p.

Research output: Contribution to journalShort survey

Involvement of the limbic basal ganglia in ethanol withdrawal convulsivity in mice is influenced by a chromosome 4 locus

Chen, G., Kozell, L. B., Hitzemann, R. & Buck, K. J., Sep 24 2008, In : Journal of Neuroscience. 28, 39, p. 9840-9849 10 p.

Research output: Contribution to journalArticle

15 Scopus citations
51 Scopus citations

Quantitative trait locus analysis: Multiple cross and heterogeneous stock mapping

Hitzemann, R., Belknap, J. K. & McWeeney, S. K., Dec 1 2008, In : Alcohol Research and Health. 31, 3, p. 261-265 5 p.

Research output: Contribution to journalReview article

4 Scopus citations
22 Scopus citations

Single-nucleotide polymorphism masking

Walter, N. A. R., McWeeney, S. K., Peters, S. T., Belknap, J. K., Hitzemann, R. & Buck, K. J., Dec 1 2008, In : Alcohol Research and Health. 31, 3, p. 270-271 2 p.

Research output: Contribution to journalShort survey