Richard Goodman

Professor

  • 20780 Citations
  • 69 h-Index
1971 …2019
If you made any changes in Pure, your changes will be visible here soon.

Research Output 1971 2019

  • 20780 Citations
  • 69 h-Index
  • 166 Article
  • 1 Chapter
  • 1 Comment/debate
2001
52 Citations (Scopus)

Consensus and Variant cAMP-regulated Enhancers Have Distinct CREB-binding Properties

Craig, J. C., Schumacher, M. A., Mansoor, S. E., Farrens, D., Brennan, R. G. & Goodman, R., Apr 13 2001, In : Journal of Biological Chemistry. 276, 15, p. 11719-11728 10 p.

Research output: Contribution to journalArticle

Cyclic AMP Response Element-Binding Protein
Protein Binding
Dimerization
DNA
Ions
9 Citations (Scopus)
Cyclic AMP Response Element Modulator
Cyclic AMP Response Element-Binding Protein
Phosphoenolpyruvate
CCAAT-Enhancer-Binding Proteins
Protein Binding
628 Citations (Scopus)

CREB-binding Protein and p300 in Transcriptional Regulation

Vo, N. & Goodman, R., Apr 27 2001, In : Journal of Biological Chemistry. 276, 17, p. 13505-13508 4 p.

Research output: Contribution to journalArticle

Genetic Transcription
CREB-Binding Protein
Biological Models
Trans-Activators
Interferon-beta
55 Citations (Scopus)
Cyclic AMP Response Element-Binding Protein
Calcium-Calmodulin-Dependent Protein Kinases
Neuronal Plasticity
Depolarization
Response Elements
166 Citations (Scopus)

MLL and CREB bind cooperatively to the nuclear coactivator CREB-binding protein

Ernst, P., Wang, J., Huang, M., Goodman, R. & Korsmeyer, S. J., 2001, In : Molecular and Cellular Biology. 21, 7, p. 2249-2258 10 p.

Research output: Contribution to journalArticle

CREB-Binding Protein
Leukemia
Transcriptional Activation
Aminoacylation
Amino Acid Substitution

The split-hybrid system. Uncoding multiprotein networks and defining mutations that affect protein interactions.

Goldman, P. S., DeMaggio, A. J., Goodman, R. & Hoekstra, M. F., 2001, In : Methods in molecular biology (Clifton, N.J.). 177, p. 261-270 10 p.

Research output: Contribution to journalArticle

Serine Endopeptidases
Recombinant Fusion Proteins
Genetic Transformation
Genetic Techniques
Bacterial Proteins
2000
102 Citations (Scopus)

Acetylation of adenovirus E1A regulates binding of the transcriptional corepressor CtBP

Zhang, Q., Yao, H., Vo, N. & Goodman, R., Dec 19 2000, In : Proceedings of the National Academy of Sciences of the United States of America. 97, 26, p. 14323-14328 6 p.

Research output: Contribution to journalArticle

Co-Repressor Proteins
Acetylation
Adenoviridae
Carrier Proteins
Protein Binding
112 Citations (Scopus)

Calcium and cAMP signals differentially regulate cAMP-responsive element-binding protein function via a Rap-1-extracellular signal-regulated kinase pathway

Grewal, S. S., Fass, D. M., Yao, H., Ellig, C. L., Goodman, R. & Stork, P., Nov 3 2000, In : Journal of Biological Chemistry. 275, 44, p. 34433-34441 9 p.

Research output: Contribution to journalArticle

Mitogen-Activated Protein Kinase 3
Carrier Proteins
Calcium
Extracellular Signal-Regulated MAP Kinases
Cyclic AMP-Dependent Protein Kinases
1285 Citations (Scopus)

CBP/p300 in cell growth, transformation, and development

Goodman, R. & Smolik, S., Jul 1 2000, In : Genes and Development. 14, 13, p. 1553-1577 25 p.

Research output: Contribution to journalArticle

Molecular Sequence Data
Embryonic and Fetal Development
Amino Acid Sequence Homology
Oncogenic Viruses
DNA Viruses
25 Citations (Scopus)

Cubitus interruptus requires Drosophila CREB-binding protein to activate wingless expression in the Drosophila embryo

Chen, Y., Goodman, R. & Smolik, S. M., Mar 2000, In : Molecular and Cellular Biology. 20, 5, p. 1616-1625 10 p.

Research output: Contribution to journalArticle

CREB-Binding Protein
Drosophila Proteins
Transcriptional Activation
Drosophila
Hedgehogs
63 Citations (Scopus)

Functional interaction between the coactivator Drosophila CREB-binding protein and ASH1, a member of the trithorax group of chromatin modifiers

Bantignies, F., Goodman, R. & Smolik, S. M., 2000, In : Molecular and Cellular Biology. 20, 24, p. 9317-9330 14 p.

Research output: Contribution to journalArticle

CREB-Binding Protein
Drosophila Proteins
Drosophila melanogaster
Chromatin
Proteins
47 Citations (Scopus)

Histone binding protein RbAp48 interacts with a complex of CREB binding protein and phosphorylated CREB

Zhang, Q., Vo, N. & Goodman, R., Jul 2000, In : Molecular and Cellular Biology. 20, 14, p. 4970-4978 9 p.

Research output: Contribution to journalArticle

CREB-Binding Protein
Histones
Carrier Proteins
Acetylation
Retinoblastoma-Binding Protein 4
139 Citations (Scopus)

Recruitment of CREB binding protein is sufficient for CREB-mediated gene activation

Cardinaux, J. R., Notis, J. C., Zhang, Q., Vo, N., Craig, J. C., Fass, D. M., Brennan, R. G. & Goodman, R., Mar 2000, In : Molecular and Cellular Biology. 20, 5, p. 1546-1552 7 p.

Research output: Contribution to journalArticle

CREB-Binding Protein
Transcriptional Activation
Sterols
Phosphorylation
Carrier Proteins
75 Citations (Scopus)

The N-terminal domain of p73 interacts with the CH1 domain of p300/CREB binding protein and mediates transcriptional activation and apoptosis

Zeng, X., Li, X., Miller, A., Yuan, Z., Yuan, W., Kwok, R. P. S., Goodman, R. & Lu, H., Feb 2000, In : Molecular and Cellular Biology. 20, 4, p. 1299-1310 12 p.

Research output: Contribution to journalArticle

CREB-Binding Protein
Transcriptional Activation
Apoptosis
Amino Acids
Small Cell Lung Carcinoma
121 Citations (Scopus)

The structure of a CREB bZIP·somatostatin CRE complex reveals the basis for selective dimerization and divalent cation-enhanced DNA binding

Schumacher, M. A., Goodman, R. & Brennan, R. G., Nov 10 2000, In : Journal of Biological Chemistry. 275, 45, p. 35242-35247 6 p.

Research output: Contribution to journalArticle

Dimerization
Divalent Cations
Carrier Proteins
Response Elements
Somatostatin
2 Citations (Scopus)

The yeast split-hybrid system

DeMaggio, A. J., Goldman, P., Shih, H. M., Goodman, R. & Hoekstra, M. F., 2000, In : Methods. 328, p. 128-137 10 p.

Research output: Contribution to journalArticle

Hybrid systems
Yeast
1999
14 Citations (Scopus)

Dream on without calcium

Mandel, G. & Goodman, R., Mar 4 1999, In : Nature. 398, 6722, p. 29-30 2 p.

Research output: Contribution to journalArticle

Kv Channel-Interacting Proteins
Repressor Proteins
Cyclic AMP Response Element-Binding Protein
Calcium-Binding Proteins
Protein Precursors
77 Citations (Scopus)

Mutants of cubitus interruptus that are independent of PKA regulation are independent of hedgehog signaling

Chen, Y., Cardinaux, J. R., Goodman, R. & Smolik, S. M., Aug 1999, In : Development. 126, 16, p. 3607-3616 10 p.

Research output: Contribution to journalArticle

Hedgehogs
Embryonic Development
Phosphorylation
Phenotype
Gene Expression
1998
16 Citations (Scopus)

Activation and repression in the nervous system

Goodman, R. & Mandel, G., Jun 1998, In : Current Opinion in Neurobiology. 8, 3, p. 413-417 5 p.

Research output: Contribution to journalArticle

Histone Acetyltransferases
Co-Repressor Proteins
Nervous System
Transcriptional Activation
Transcription Factors

CBP as a transcriptional organizer

Goodman, R. & Smolik, Y. S., 1998, In : FASEB Journal. 12, 8

Research output: Contribution to journalArticle

Phosphorylation
Drosophila
Processing
Genes
Hedgehogs
54 Citations (Scopus)

Long-distance transcriptional enhancement by the histone acetyltransferase PCAF

Krumm, A., Madisen, L., Yang, X. J., Goodman, R., Nakatani, Y. & Groudine, M., Nov 10 1998, In : Proceedings of the National Academy of Sciences of the United States of America. 95, 23, p. 13501-13506 6 p.

Research output: Contribution to journalArticle

Histone Acetyltransferases
Acetyltransferases
Simian virus 40
Reporter Genes
Transcriptional Activation
148 Citations (Scopus)

Protein kinase a directly regulates the activity and proteolysis of cubitus interruptus

Chen, Y., Gallaher, N., Goodman, R. & Smolik, S. M., Mar 3 1998, In : Proceedings of the National Academy of Sciences of the United States of America. 95, 5, p. 2349-2354 6 p.

Research output: Contribution to journalArticle

Cyclic AMP-Dependent Protein Kinases
Protein Kinases
Proteolysis
Mutant Proteins
Proteins
64 Citations (Scopus)

The coactivator CBP stimulates human T-cell lymphotrophic virus type I tax transactivation in vitro

Kashanchi, F., Duvall, J. F., Kwok, R. P. S., Lundblad, J., Goodman, R. & Brady, J. N., Dec 18 1998, In : Journal of Biological Chemistry. 273, 51, p. 34646-34652 7 p.

Research output: Contribution to journalArticle

CREB-Binding Protein
T-cells
Taxation
Viruses
Transcriptional Activation
62 Citations (Scopus)

The human T-cell leukemia virus-1 transcriptional activator tax enhances cAMP-responsive element-binding protein (CREB) binding activity through interactions with the DNA minor groove

Lundblad, J., Kwok, R. P. S., Laurance, M. E., Huang, M. S., Richards, J. P., Brennan, R. G. & Goodman, R., Jul 24 1998, In : Journal of Biological Chemistry. 273, 30, p. 19251-19259 9 p.

Research output: Contribution to journalArticle

Deltaretrovirus
T-cells
Response Elements
Taxation
Viruses
1997
58 Citations (Scopus)

Construction of a 1.2-Mb contig surrounding, and molecular analysis of, the human CREB-binding protein (CBP/CREBBP) gene on chromosome 16p13.3

Giles, R. H., Petrij, F., Dauwerse, H. G., Den Hollander, A. I., Lushnikova, T., Van Ommen, G. J. B., Goodman, R., Deaven, L. L., Doggett, N. A., Peters, D. J. M. & Breuning, M. H., May 15 1997, In : Genomics. 42, 1, p. 96-114 19 p.

Research output: Contribution to journalArticle

Cosmids
Rubinstein-Taybi Syndrome
Chromosomes
Genes
Acute Myeloid Leukemia
40 Citations (Scopus)

Differential activation of viral and cellular promoters by human T-cell lymphotropic virus-1 tax and cAMP-responsive element modulator isoforms

Laurance, M. E., Kwok, R. P. S., Huang, M. S., Richards, J. P., Lundblad, J. & Goodman, R., 1997, In : Journal of Biological Chemistry. 272, 5, p. 2646-2651 6 p.

Research output: Contribution to journalArticle

Cyclic AMP Response Element Modulator
Virus Activation
Phosphorylation
Human T-lymphotropic virus 1
T-cells
226 Citations (Scopus)

Drosophila CBP is a co-activator of cubitus interruptus in hedgehog signalling

Akimaru, H., Chen, Y., Dai, P., Hou, D. X., Nonaka, M., Smolik, S. M., Armstrong, S., Goodman, R. & Ishii, S., Apr 17 1997, In : Nature. 386, 6626, p. 735-738 4 p.

Research output: Contribution to journalArticle

Hedgehogs
Drosophila
Transcription Factors
Rubinstein-Taybi Syndrome
Haploinsufficiency
21 Citations (Scopus)

The CRE-binding protein dCREB-A is required for Drosophila embryonic development

Rose, R. E., Gallaher, N. M., Andrew, D. J., Goodman, R. & Smolik, S. M., Jun 1997, In : Genetics. 146, 2, p. 595-606 12 p.

Research output: Contribution to journalArticle

Cyclic AMP Response Element-Binding Protein
Drosophila
Embryonic Development
Cell Nucleus
Proventriculus
177 Citations (Scopus)

The Multifunctional Role of the Co-Activator CBP in Transcriptional regulation

Goldman, P. S., Tran, V. K. & Goodman, R., 1997, In : Recent Progress in Hormone Research. 52, p. 103-119 17 p.

Research output: Contribution to journalArticle

Transcription Factors
Cyclic AMP-Dependent Protein Kinases
Cyclic AMP
Genes
Viral Oncogene Proteins
8 Citations (Scopus)

The β-adrenergic receptor kinase interacts with the amino terminus of the G protein β subunit

Goldman, P. S., DeMaggio, A. J., Hoekstra, M. F. & Goodman, R., Nov 17 1997, In : Biochemical and Biophysical Research Communications. 240, 2, p. 425-429 5 p.

Research output: Contribution to journalArticle

Protein Subunits
GTP-Binding Proteins
Adrenergic Receptors
Phosphotransferases
G-Protein-Coupled Receptor Kinases
1996
110 Citations (Scopus)

Analysis of the structural properties of cAMP-responsive element-binding protein (CREB) and phosphorylated CREB

Richards, J. P., Bächinger, H. P., Goodman, R. & Brennan, R. G., 1996, In : Journal of Biological Chemistry. 271, 23, p. 13716-13723 8 p.

Research output: Contribution to journalArticle

Structural properties
Carrier Proteins
Phosphorylation
Cyclic AMP-Dependent Protein Kinases
DNA
83 Citations (Scopus)

A positive genetic selection for disrupting protein-protein interactions: Identification of CREB mutations that prevent association with the coactivator CBP

Shih, H. M., Goldman, P. S., Demaggio, A. J., Hollenberg, S. M., Goodman, R. & Hoekstra, M. F., Nov 26 1996, In : Proceedings of the National Academy of Sciences of the United States of America. 93, 24, p. 13896-13901 6 p.

Research output: Contribution to journalArticle

CREB-Binding Protein
Genetic Selection
Mutation
Phosphorylation
Proteins
301 Citations (Scopus)

Control of cAMP-regulated enhancers by the viral transactivator tax through CREB and the co-activator CBP

Kwok, R. P. S., Laurance, M. E., Lundblad, J., Goldman, P. S., Shih, H. M., Connor, L. M., Marriott, S. J. & Goodman, R., 1996, In : Nature. 380, 6575, p. 642-646 5 p.

Research output: Contribution to journalArticle

Trans-Activators
Cyclic AMP
tax Gene Products
Phosphorylation
Terminal Repeat Sequences
200 Citations (Scopus)

Fluorescence polarization analysis of protein-DNA and protein-protein interactions

Lundblad, J., Laurance, M. & Goodman, R., 1996, In : Molecular Endocrinology. 10, 6, p. 607-612 6 p.

Research output: Contribution to journalArticle

Fluorescence Polarization
DNA
Proteins
Technology
1995
510 Citations (Scopus)

Adenoviral ElA-associated protein p300 as a functional homologue of the transcriptional co-activator CBP

Lundblad, J., Kwok, R. P. S., Laurance, M. E., Harter, M. L. & Goodman, R., 1995, In : Nature. 374, 6517, p. 85-88 4 p.

Research output: Contribution to journalArticle

Cyclic AMP-Dependent Protein Kinases
Caenorhabditis elegans Proteins
Activator Appliances
CREB-Binding Protein
Gene Expression
926 Citations (Scopus)

Rubinstein-Taybi syndrome caused by mutations in the transcriptional co-activator CBP

Petrif, F., Giles, R. H., Dauwerse, H. G., Saris, J. J., Hennekam, R. C. M., Masuno, M., Tommerup, N., Van Ommen, G. J. B., Goodman, R., Peters, D. J. M. & Breuning, M. H., 1995, In : Nature. 376, 6538, p. 348-351 4 p.

Research output: Contribution to journalArticle

Rubinstein-Taybi Syndrome
CREB-Binding Protein
Mutation
Cyclic IMP
Chromosomes
1994
32 Citations (Scopus)

Modulatory function of CREB·CREMα heterodimers depends upon CREMα phosphorylation

Loriaux, M., Brennan, R. G. & Goodman, R., Nov 18 1994, In : Journal of Biological Chemistry. 269, 46, p. 28839-28843 5 p.

Research output: Contribution to journalArticle

Phosphorylation
Cyclic AMP-Dependent Protein Kinases
Carrier Proteins
Chemical activation
Proteins
1230 Citations (Scopus)

Nuclear protein CBP is a coactivator for the transcription factor CREB

Kwok, R. P. S., Lundblad, J., Chrivia, J. C., Richards, J. P., Bächinger, H. P., Brennan, R. G., Roberts, S. G. E., Green, M. R. & Goodman, R., Jul 21 1994, In : Nature. 370, 6486, p. 223-226 4 p.

Research output: Contribution to journalArticle

CREB-Binding Protein
Transcription Factors
Phosphorylation
Cyclic AMP-Dependent Protein Kinases
Transcription Factor TFIIB
1993
47 Citations (Scopus)
Leucine Zippers
Phosphorylation
Basic-Leucine Zipper Transcription Factors
Transcriptional Activation
Proteins
24 Citations (Scopus)

Isolation of Drosophila CREB-B: A novel CRE-binding protein

Usui, T., Smolik, S. M. & Goodman, R., 1993, In : DNA and Cell Biology. 12, 7, p. 589-595 7 p.

Research output: Contribution to journalArticle

Drosophila
Carrier Proteins
Genes
Transcriptional Activation
DNA
1671 Citations (Scopus)

Phosphorylated CREB binds specifically to the nuclear protein CBP

Chrivia, J. C., Kwok, R. P. S., Lamb, N., Hagiwara, M., Montminy, M. R. & Goodman, R., Oct 28 1993, In : Nature. 365, 6449

Research output: Contribution to journalArticle

CREB-Binding Protein
Nuclear Proteins
Protein Binding
Cyclic AMP-Dependent Protein Kinases
General Transcription Factors
1992
53 Citations (Scopus)

3′,5′-cyclic adenosine monophosphate-regulated enhancer binding (CREB) activity is required for normal growth and differentiated phenotype in the FRTL5 thyroid follicular cell line

Woloshin, P. I., Walton, K. M., Rehfuss, R. P., Goodman, R. & Cone, R. D., 1992, In : Molecular Endocrinology. 6, 10, p. 1725-1733 9 p.

Research output: Contribution to journalArticle

Cyclic AMP
Phenotype
Cell Line
Growth
Clone Cells
69 Citations (Scopus)
Leucine Zippers
Salivary Glands
Drosophila melanogaster
Cyclic AMP
Transcription Factors
199 Citations (Scopus)

A dominant repressor of cyclic adenosine 3′,5′-monophosphate (cAMP)-regulated enhancer-binding protein activity inhibits the cAMP-mediated induction of the somatostatin promoter in vivo

Walton, K. M., Rehfuss, R. P., Chrivia, J. C., Lochner, J. E. & Goodman, R., Apr 1992, In : Molecular Endocrinology. 6, 4, p. 647-655 9 p.

Research output: Contribution to journalArticle

Somatostatin
Adenosine
Carrier Proteins
Teratocarcinoma
Cyclic AMP-Dependent Protein Kinases
15 Citations (Scopus)

Targeted expression of somatostatin in vasopressinergic magnocellular hypothalamic neurons of transgenic mice

Rubinstein, M., Liu, B., Goodman, R. & Low, M. J., 1992, In : Molecular and Cellular Neuroscience. 3, 2, p. 152-161 10 p.

Research output: Contribution to journalArticle

Somatostatin
Transgenic Mice
Neurons
Transgenes
Vasopressins
14 Citations (Scopus)

Vasoactive intestinal polypeptide gene expression in the developing human gastrointestinal tract

Facer, P., Bishop, A. E., Moscoso, G., Terenghi, G., Liu, Y. F., Goodman, R., Legon, S. & Polak, J. M., 1992, In : Gastroenterology. 102, 1, p. 47-55 9 p.

Research output: Contribution to journalArticle

Vasoactive Intestinal Peptide
Gastrointestinal Tract
Gene Expression
Pregnancy
Ganglia
1991
61 Citations (Scopus)

Cyclic AMP- and phorbol ester-induced transcriptional activation are mediated by the same enhancer element in the human vasoactive intestinal peptide gene

Fink, J. S., Verhave, M., Walton, K., Mandel, G. & Goodman, R., Feb 25 1991, In : Journal of Biological Chemistry. 266, 6, p. 3882-3887 6 p.

Research output: Contribution to journalArticle

Vasoactive Intestinal Peptide
Phorbol Esters
Cyclic AMP
Transcriptional Activation
Genes
13 Citations (Scopus)

Primary structure and tissue distribution of anglerfish carboxypeptidase H

Roth, W. W., Mackin, R. B., Spiess, J., Goodman, R. & Noe, B. D., 1991, In : Molecular and Cellular Endocrinology. 78, 3, p. 171-178 8 p.

Research output: Contribution to journalArticle

Carboxypeptidase H
Tissue Distribution
Tissue
Fish
Fishes
171 Citations (Scopus)

The cAMP-regulated enhancer-binding protein ATF-1 activates transcription in response to cAMP-dependent protein kinase A

Rehfuss, R. P., Walton, K. M., Loriaux, M. & Goodman, R., Oct 5 1991, In : Journal of Biological Chemistry. 266, 28, p. 18431-18434 4 p.

Research output: Contribution to journalArticle

Transcription
Cyclic AMP-Dependent Protein Kinases
Carrier Proteins
CREB-Binding Protein
Phosphorylation
1990
11 Citations (Scopus)

A direct role for c-fos in AP-1-dependent gene transcription.

Herrera, R., Agarwal, S., Walton, K., Satterberg, B., Distel, R. J., Goodman, R., Spiegelman, B. M. & Roberts, T. M., Oct 1990, In : Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research. 1, 10, p. 483-490 8 p.

Research output: Contribution to journalArticle

Proto-Oncogene Proteins c-jun
Transcription Factor AP-1
Genes
Proto-Oncogene Proteins c-fos
Proteins