Rebecca Spain

Assistant Professor

  • 744 Citations
  • 16 h-Index
20092020
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Research Output 2009 2020

2020

Conducting dietary intervention trials in people with multiple sclerosis: Lessons learned and a path forward

Fitzgerald, K. C., Sand, I. K., Senders, A., Spain, R., Giesser, B., Sullivan, P., Baer, D. J., LaRocca, N., Zackowski, K. & Mowry, E. M., Jan 2020, In : Multiple sclerosis and related disorders. 37, 101478.

Research output: Contribution to journalReview article

Multiple Sclerosis
Diet
Population
2019
Phosphocreatine
Multiple Sclerosis
Magnetic Resonance Spectroscopy
Exercise
Fatigue
5 Citations (Scopus)

Lipoic Acid and Other Antioxidants as Therapies for Multiple Sclerosis

Waslo, C., Bourdette, D., Gray, N., Wright, K. & Spain, R., Jun 1 2019, In : Current Treatment Options in Neurology. 21, 6, 26.

Research output: Contribution to journalReview article

Thioctic Acid
Multiple Sclerosis
Antioxidants
Oxidative Stress
Therapeutics
2018
2 Citations (Scopus)
Thioctic Acid
Relapsing-Remitting Multiple Sclerosis
Monocytes
Blood Cells
B-Lymphocytes
2 Citations (Scopus)

Effects of lipoic acid on walking performance, gait, and balance in secondary progressive multiple sclerosis

Loy, B. D., Fling, B., Horak, F., Bourdette, D. & Spain, R., Dec 1 2018, In : Complementary Therapies in Medicine. 41, p. 169-174 6 p.

Research output: Contribution to journalArticle

Chronic Progressive Multiple Sclerosis
Thioctic Acid
Gait
Walking
Placebos
5 Citations (Scopus)

Gender Inequities in the Multiple Sclerosis Community: A Call for Action

International Women in MS, Dec 1 2018, In : Annals of Neurology. 84, 6, p. 958-959 2 p.

Research output: Contribution to journalLetter

Open Access
Multiple Sclerosis

Myelin Oligodendrocyte Glycoprotein Antibody-Associated Demyelination Comorbid with Leber Hereditary Optic Neuropathy

Bittner, F., Falardeau, J. & Spain, R., Jan 1 2018, (Accepted/In press) In : JAMA Neurology.

Research output: Contribution to journalArticle

Myelin-Oligodendrocyte Glycoprotein
Leber's Hereditary Optic Atrophy
Demyelinating Diseases
Antibodies
18 Citations (Scopus)
Optical Coherence Tomography
Optic Nerve
Multiple Sclerosis
Optic Neuritis
Angiography
2017
3 Citations (Scopus)
Multiple Sclerosis
Leg
Ankle
Pressure
Hip
31 Citations (Scopus)

Lipoic acid in secondary progressive MS

Spain, R., Powers, K., Murchison, C., Heriza, E., Winges, K., Yadav, V., Cameron, M., Kim, E., Horak, F., Simon, J. & Bourdette, D., 2017, In : Neurology: Neuroimmunology and NeuroInflammation. 4, 5, 374.

Research output: Contribution to journalArticle

Thioctic Acid
Brain
Atrophy
Placebos
Compliance
4 Citations (Scopus)

Lipoic acid pharmacokinetics at baseline and 1 year in secondary progressive MS

Bittner, F., Murchison, C., Koop, D., Bourdette, D. & Spain, R., 2017, In : Neurology: Neuroimmunology and NeuroInflammation. 4, 5, 380.

Research output: Contribution to journalShort survey

Thioctic Acid
Pharmacokinetics
3 Citations (Scopus)

Lipoic Acid Stimulates cAMP Production in Healthy Control and Secondary Progressive MS Subjects

Fiedler, S. E., Yadav, V., Kerns, A. R., Tsang, C., Markwardt, S., Kim, E., Spain, R., Bourdette, D. & Salinthone, S., Nov 15 2017, (Accepted/In press) In : Molecular Neurobiology. p. 1-13 13 p.

Research output: Contribution to journalArticle

Chronic Progressive Multiple Sclerosis
Thioctic Acid
Cyclic AMP
Multiple Sclerosis
Dinoprostone
4 Citations (Scopus)
Chronic Progressive Multiple Sclerosis
Optic Atrophy
Optical Coherence Tomography
Atrophy
Nerve Fibers
2016
10 Citations (Scopus)

Characterization of Compensatory Stepping in People With Multiple Sclerosis

Peterson, D. S., Huisinga, J. M., Spain, R. & Horak, F., 2016, (Accepted/In press) In : Archives of Physical Medicine and Rehabilitation.

Research output: Contribution to journalArticle

Multiple Sclerosis
Foot
Cross-Sectional Studies
Outcome Assessment (Health Care)
Databases

Dietary supplements and other alternative substances for the treatment of multiple sclerosis

Senders, A., Spain, R. & Yadav, V., Apr 19 2016, Nutraceuticals and Health: Review of Human Evidence. CRC Press, p. 327-351 25 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Dietary supplements
sclerosis
Dietary Supplements
Multiple Sclerosis
dietary supplements
19 Citations (Scopus)

Longitudinal associations between brain structural changes and fatigue in early MS

Nourbakhsh, B., Azevedo, C., Nunan-Saah, J., Maghzi, A. H., Spain, R., Pelletier, D. & Waubant, E., Jan 1 2016, In : Multiple Sclerosis and Related Disorders. 5, p. 29-33 5 p.

Research output: Contribution to journalArticle

Multiple Sclerosis
Fatigue
Brain
Atrophy
Riluzole
13 Citations (Scopus)

Longitudinal associations between MRI and cognitive changes in very early MS

Nourbakhsh, B., Nunan-Saah, J., Maghzi, A. H., Julian, L. J., Spain, R., Jin, C., Lazar, A., Pelletier, D. & Waubant, E., Jan 1 2016, In : Multiple Sclerosis and Related Disorders. 5, p. 47-52 6 p.

Research output: Contribution to journalArticle

Multiple Sclerosis
Magnetic Resonance Imaging
Riluzole
Brain
Placebos
27 Citations (Scopus)

Low-fat, plant-based diet in multiple sclerosis: A randomized controlled trial

Yadav, V., Marracci, G., Kim, E., Spain, R., Cameron, M., Overs, S., Riddehough, A., Li, D. K. B., McDougall, J., Lovera, J., Murchison, C. & Bourdette, D., Sep 1 2016, In : Multiple Sclerosis and Related Disorders. 9, p. 80-90 11 p.

Research output: Contribution to journalArticle

Multiple Sclerosis
Randomized Controlled Trials
Fats
Diet
Fatigue
4 Citations (Scopus)
Dual (Psychiatry) Diagnosis
Panniculitis
Localized Scleroderma
Injections
Sclerosis
4 Citations (Scopus)

Subcortical grey matter volumes predict subsequent walking function in early multiple sclerosis

Nourbakhsh, B., Azevedo, C., Maghzi, A. H., Spain, R., Pelletier, D. & Waubant, E., Jul 15 2016, In : Journal of the Neurological Sciences. 366, p. 229-233 5 p.

Research output: Contribution to journalArticle

Multiple Sclerosis
Walking
Putamen
Globus Pallidus
Thalamus
81 Citations (Scopus)

The contemporary spectrum of multiple sclerosis misdiagnosis

Solomon, A. J., Bourdette, D., Cross, A. H., Applebee, A., Skidd, P. M., Howard, D. B., Spain, R., Cameron, M., Kim, E., Mass, M., Yadav, V., Whitham, R., Longbrake, E. E., Naismith, R. T., Wu, G. F., Parks, B. J., Wingerchuk, D. M., Rabin, B. L., Toledano, M., Tobin, W. O. & 4 others, Kantarci, O. H., Carter, J. L., Keegan, B. M. & Weinshenker, B. G., Sep 27 2016, In : Neurology. 87, 13, p. 1393-1399 7 p.

Research output: Contribution to journalArticle

Diagnostic Errors
Multiple Sclerosis
Neurologic Manifestations
Neuromyelitis Optica
Fibromyalgia
2015
8 Citations (Scopus)

Retinal axonal loss in very early stages of multiple sclerosis

Maghzi, A. H., Graves, J., Revirajan, N., Spain, R., Liu, S., Mcculloch, C. E., Pelletier, D., Green, A. J. & Waubant, E., Jul 1 2015, In : European Journal of Neurology. 22, 7, p. 1138-1141 4 p.

Research output: Contribution to journalArticle

Multiple Sclerosis
Nerve Fibers
Atrophy
Relapsing-Remitting Multiple Sclerosis
Optical Coherence Tomography
2014
23 Citations (Scopus)

A randomized controlled phase II trial of riluzole in early multiple sclerosis

Waubant, E., Maghzi, A. H., Revirajan, N., Spain, R., Julian, L., Mowry, E. M., Marcus, J., Liu, S., Jin, C., Green, A., McCulloch, C. E. & Pelletier, D., May 1 2014, In : Annals of Clinical and Translational Neurology. 1, 5, p. 340-347 8 p.

Research output: Contribution to journalArticle

Riluzole
Multiple Sclerosis
Placebos
Brain
Nerve Fibers
24 Citations (Scopus)
Gait
Multiple Sclerosis
Walking
Longitudinal Studies
Technology
19 Citations (Scopus)

Magnetic resonance imaging correlates of clinical outcomes in early multiple sclerosis

Maghzi, A. H., Revirajan, N., Julian, L. J., Spain, R., Mowry, E. M., Liu, S., Jin, C., Green, A. J., McCulloch, C. E., Pelletier, D. & Waubant, E., 2014, In : Multiple Sclerosis and Related Disorders. 3, 6, p. 720-727 8 p.

Research output: Contribution to journalArticle

Multiple Sclerosis
Magnetic Resonance Imaging
Brain
Atrophy
Foot
105 Citations (Scopus)

Optical coherence tomography angiography of optic nerve head and parafovea in multiple sclerosis

Wang, X., Yali, J., Spain, R., Potsaid, B., Liu, J. J., Baumann, B., Hornegger, J., Fujimoto, J. G., Wu, Q. & Huang, D., Oct 1 2014, In : British Journal of Ophthalmology. 98, 10, p. 1368-1373 6 p.

Research output: Contribution to journalArticle

Optic Disk
Optical Coherence Tomography
Optic Neuritis
Multiple Sclerosis
Angiography
24 Citations (Scopus)

Postural response latencies are related to balance control during standing and walking in patients with multiple sclerosis

Huisinga, J. M., St George, R. J., Spain, R., Overs, S. & Horak, F., 2014, In : Archives of Physical Medicine and Rehabilitation. 95, 7, p. 1390-1397 8 p.

Research output: Contribution to journalArticle

Reaction Time
Multiple Sclerosis
Walking
2012
136 Citations (Scopus)

Body-worn motion sensors detect balance and gait deficits in people with multiple sclerosis who have normal walking speed

Spain, R., St. George, R. J., Salarian, A., Mancini, M., Wagner, J. M., Horak, F. & Bourdette, D., Apr 2012, In : Gait and Posture. 35, 4, p. 573-578 6 p.

Research output: Contribution to journalArticle

Gait
Multiple Sclerosis
Yaws
Walking Speed
Articular Range of Motion
30 Citations (Scopus)

Mind-body medicine for multiple sclerosis: A systematic review

Senders, A., Wahbeh, H., Spain, R. & Shinto, L., 2012, In : Autoimmune Diseases. 1, 1, 567324.

Research output: Contribution to journalArticle

Mind-Body Therapies
Yoga
Multiple Sclerosis
Mindfulness
Meditation
2011
60 Citations (Scopus)

Inflammatory neurological disease in patients treated with tumor necrosis factor alpha inhibitors

Solomon, A. J., Spain, R., Kruer, M. C. & Bourdette, D., 2011, In : Multiple Sclerosis. 17, 12, p. 1472-1487 16 p.

Research output: Contribution to journalArticle

Tumor Necrosis Factor-alpha
Therapeutics
Veterans Hospitals
Peripheral Nervous System
Natural History
15 Citations (Scopus)

The radiologically isolated syndrome: Look (again) before you treat

Spain, R. & Bourdette, D., Oct 2011, In : Current Neurology and Neuroscience Reports. 11, 5, p. 498-506 9 p.

Research output: Contribution to journalArticle

Multiple Sclerosis
Neuroimaging
Magnetic Resonance Imaging
Therapeutics
2009
21 Citations (Scopus)

Recent developments in multiple sclerosis therapeutics

Spain, R., Cameron, M. & Bourdette, D., Dec 7 2009, In : BMC Medicine. 7, 74.

Research output: Contribution to journalArticle

Multiple Sclerosis
Pathology
CNS Demyelinating Autoimmune Diseases
Therapeutics
Inflammation
19 Citations (Scopus)
Pyramidal Tracts
Nerve Fibers
Multiple Sclerosis
Optical Coherence Tomography
Interviews
25 Citations (Scopus)

When metals compete: A case of copper-deficiency myeloneuropathy and anemia

Spain, R., Leist, T. P. & De Sousa, E. A., 2009, In : Nature Clinical Practice Neurology. 5, 2, p. 106-111 6 p.

Research output: Contribution to journalArticle

Dentures
Zinc
Anemia
Copper
Metals