Qiuming Gong

Research Assistant Professor

  • 3972 Citations
  • 28 h-Index
1990 …2018

Research output per year

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Research Output

  • 3972 Citations
  • 28 h-Index
  • 43 Article
  • 2 Chapter
  • 2 Review article
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Article
2018

Regulation of Kv11.1 potassium channel C-terminal isoform expression by the RNA-binding proteins HuR and HuD

Gong, Q., Stump, M. R. & Zhou, Z., Dec 21 2018, In : Journal of Biological Chemistry. 293, 51, p. 19624-19632 9 p.

Research output: Contribution to journalArticle

Upregulation of functional Kv11.1a isoform expression by modified U1 small nuclear RNA

Gong, Q., Stump, M. R. & Zhou, Z., Jan 30 2018, In : Gene. 641, p. 220-225 6 p.

Research output: Contribution to journalArticle

2 Scopus citations
2015

Brief report: Oxidative stress mediates cardiomyocyte apoptosis in a human model of danon disease and heart failure

Hashem, S. I., Perry, C. N., Bauer, M., Han, S., Clegg, S. D., Ouyang, K., Deacon, D. C., Spinharney, M., Panopoulos, A. D., Izpisua Belmonte, J. C., Frazer, K. A., Chen, J., Gong, Q., Zhou, Z., Chi, N. C. & Adler, E. D., Jul 1 2015, In : Stem Cells. 33, 7, p. 2343-2350 8 p.

Research output: Contribution to journalArticle

44 Scopus citations
2014

Identification of Kv11.1 isoform switch as a novel pathogenic mechanism of long-QT syndrome

Gong, Q., Stump, M. R., Deng, V., Zhang, L. & Zhou, Z., Aug 1 2014, In : Circulation: Cardiovascular Genetics. 7, 4, p. 482-490 9 p.

Research output: Contribution to journalArticle

5 Scopus citations

Position of premature termination codons determines susceptibility of hERG mutations to nonsense-mediated mRNA decay in long QT syndrome

Gong, Q., Stump, M. R. & Zhou, Z., Apr 15 2014, In : Gene. 539, 2, p. 190-197 8 p.

Research output: Contribution to journalArticle

10 Scopus citations
6 Scopus citations
2013
10 Scopus citations
2012
16 Scopus citations

Isoform-specific dominant-negative effects associated with hERG1 G628S mutation in long QT syndrome

Stump, M. R., Gong, Q. & Zhou, Z., Aug 2 2012, In : PloS one. 7, 8, e42552.

Research output: Contribution to journalArticle

7 Scopus citations
2011
22 Scopus citations
6 Scopus citations

Nonsense-mediated mRNA decay caused by a frameshift mutation in a large kindred of type 2 long QT syndrome

Zarraga, I. G., Zhang, L., Stump, M. R., Gong, Q., Vincent, G. M. & Zhou, Z., Aug 1 2011, In : Heart Rhythm. 8, 8, p. 1200-1206 7 p.

Research output: Contribution to journalArticle

17 Scopus citations
2010

Alternative splicing and polyadenylation contribute to the generation of hERG1 C-terminal isoforms

Gong, Q., Stump, M. R., Dunn, A. R., Deng, V. & Zhou, Z., Oct 15 2010, In : Journal of Biological Chemistry. 285, 42, p. 32233-32241 9 p.

Research output: Contribution to journalArticle

12 Scopus citations

A major role for hERG in determining frequency of reentry in neonatal rat ventricular myocyte monolayer

Hou, L., Deo, M., Furspan, P., Pandit, S. V., Mironov, S., Auerbach, D. S., Gong, Q., Zhou, Z., Berenfeld, O. & Jalife, J., Dec 10 2010, In : Circulation research. 107, 12, p. 1503-1511 9 p.

Research output: Contribution to journalArticle

39 Scopus citations
2008

A splice site mutation in hERG leads to cryptic splicing in human long QT syndrome

Gong, Q., Zhang, L., Moss, A. J., Vincent, G. M., Ackerman, M. J., Robinson, J. C., Jones, M. A., Tester, D. J. & Zhou, Z., Mar 1 2008, In : Journal of molecular and cellular cardiology. 44, 3, p. 502-509 8 p.

Research output: Contribution to journalArticle

18 Scopus citations

Recurrent intrauterine fetal loss due to near absence of HERG: Clinical and functional characterization of a homozygous nonsense HERG Q1070X mutation

Bhuiyan, Z. A., Momenah, T. S., Gong, Q., Amin, A. S., Ghamdi, S. A., Carvalho, J. S., Homfray, T., Mannens, M. M. A. M., Zhou, Z. & Wilde, A. A. M., Apr 2008, In : Heart Rhythm. 5, 4, p. 553-561 9 p.

Research output: Contribution to journalArticle

44 Scopus citations
2007

Nonsense mutations in hERG cause a decrease in mutant mRNA transcripts by nonsense-mediated mRNA decay in human long-QT syndrome

Gong, Q., Zhang, L., Vincent, G. M., Horne, B. D. & Zhou, Z., Jul 1 2007, In : Circulation. 116, 1, p. 17-24 8 p.

Research output: Contribution to journalArticle

86 Scopus citations

The mechanistic rote of KCNH2 gene L413P and L559H mutations in long QT syndrome

Li, C. L., Hu, D. Y., Liu, W. L., Qi, S. Y., Wang, H. T., Li, L., Gong, Q. M. & Zhou, Z. F., Oct 2007, In : Zhonghua nei ke za zhi [Chinese journal of internal medicine]. 46, 10, p. 838-841 4 p.

Research output: Contribution to journalArticle

2006

Mechanisms of pharmacological rescue of trafficking-defective hERG mutant channels in human long QT syndrome

Gong, Q., Jones, M. A. & Zhou, Z., Feb 17 2006, In : Journal of Biological Chemistry. 281, 7, p. 4069-4074 6 p.

Research output: Contribution to journalArticle

66 Scopus citations

Most LQT2 mutations reduce Kv11.1 (hERG) current by a class 2 (trafficking-deficient) mechanism

Anderson, C. L., Delisle, B. P., Anson, B. D., Kilby, J. A., Will, M. L., Tester, D. J., Gong, Q., Zhou, Z., Ackerman, M. J. & January, C. T., Jan 1 2006, In : Circulation. 113, 3, p. 365-373 9 p.

Research output: Contribution to journalArticle

295 Scopus citations

Stimulation of insulin release by glyceraldehyde may not be similar to glucose

MacDonald, M. J., Chaplen, F. W. R., Triplett, C. K., Gong, Q. & Drought, H., Mar 15 2006, In : Archives of Biochemistry and Biophysics. 447, 2, p. 118-126 9 p.

Research output: Contribution to journalArticle

15 Scopus citations
2005

Degradation of trafficking-defective long QT syndrome type II mutant channels by the ubiquitin-proteasome pathway

Gong, Q., Keeney, D. R., Molinari, M. & Zhou, Z., May 13 2005, In : Journal of Biological Chemistry. 280, 19, p. 19419-19425 7 p.

Research output: Contribution to journalArticle

82 Scopus citations
2004

Defective assembly and trafficking of mutant HERG channels with C-terminal truncations in long QT syndrome

Gong, Q., Keeney, D. R., Robinson, J. C. & Zhou, Z., Dec 1 2004, In : Journal of molecular and cellular cardiology. 37, 6, p. 1225-1233 9 p.

Research output: Contribution to journalArticle

49 Scopus citations
39 Scopus citations

Postmortem molecular screening in unexplained sudden death

Chugh, S. S., Senashova, O., Watts, A., Tran, P. T., Zhou, Z., Gong, Q., Titus, J. L. & Hayflick, S. J., May 5 2004, In : Journal of the American College of Cardiology. 43, 9, p. 1625-1629 5 p.

Research output: Contribution to journalArticle

143 Scopus citations
2002

Role of glycosylation in cell surface expression and stability of HERG potassium channels

Gong, Q., Anderson, C. L., January, C. T. & Zhou, Z., Jul 10 2002, In : American Journal of Physiology - Heart and Circulatory Physiology. 283, 1 52-1, p. H77-H84

Research output: Contribution to journalArticle

107 Scopus citations
2001

Cocaine blocks HERG, but not KvLQT1+minK, potassium channels

Zhang, S., Rajamani, S., Chen, Y., Gong, Q., Rong, Y., Zhou, Z., Ruoho, A. & January, C. T., Jan 1 2001, In : Molecular pharmacology. 59, 5, p. 1069-1076 8 p.

Research output: Contribution to journalArticle

62 Scopus citations
2000

Functional analysis of two promoters for the human mitochondrial glycerol phosphate dehydrogenase gene

Gong, Q., Brown, L. J. & MacDonald, M. J., Dec 1 2000, In : Journal of Biological Chemistry. 275, 48, p. 38012-38021 10 p.

Research output: Contribution to journalArticle

14 Scopus citations
1999

Block of HERG potassium channels by the antihistamine astemizole and its metabolites desmethylastemizole and norastemizole

Zhou, Z., Vorperian, V. R., Gong, Q., Zhang, S. & January, C. T., Jan 1 1999, In : Journal of cardiovascular electrophysiology. 10, 6, p. 836-843 8 p.

Research output: Contribution to journalArticle

173 Scopus citations
258 Scopus citations

Mechanism of block and identification of the verapamil binding domain to HERG potassium channels

Zhang, S., Zhou, Z., Gong, Q., Makielski, J. C. & January, C. T., May 14 1999, In : Circulation research. 84, 9, p. 989-998 10 p.

Research output: Contribution to journalArticle

Open Access
296 Scopus citations

Novel mechanism associated with an inherited cardiac arrhythmia: Defective protein trafficking by the mutant HERG (G601S) potassium channel

Furutani, M., Trudeau, M. C., Hagiwara, N., Seki, A., Gong, Q., Zhou, Z., Imamura, S. I., Nagashima, H., Kasanuki, H., Takao, A., Momma, K., January, C. T., Robertson, G. A. & Matsuoka, R., May 4 1999, In : Circulation. 99, 17, p. 2290-2294 5 p.

Research output: Contribution to journalArticle

Open Access
160 Scopus citations
1998

HERG channel dysfunction in human long QT syndrome. Intracellular transport and functional defects

Zhou, Z., Gong, Q., Epstein, M. L. & January, C. T., Aug 14 1998, In : Journal of Biological Chemistry. 273, 33, p. 21061-21066 6 p.

Research output: Contribution to journalArticle

302 Scopus citations

In vivo expression of an alternatively spliced human tumor message that encodes a truncated form of cathepsin B. Subcellular distribution of the truncated enzyme in COS cells

Mehtani, S., Gong, Q., Panella, J., Subbiah, S., Peffley, D. M. & Frankfater, A., May 22 1998, In : Journal of Biological Chemistry. 273, 21, p. 13236-13244 9 p.

Research output: Contribution to journalArticle

59 Scopus citations

Properties of HERG channels stably expressed in HEK 293 cells studied at physiological temperature

Zhou, Z., Gong, Q., Ye, B., Fan, Z., Makielski, J. C., Robertson, G. A. & January, C. T., Jan 1998, In : Biophysical Journal. 74, 1, p. 230-241 12 p.

Research output: Contribution to journalArticle

Open Access
591 Scopus citations
48 Scopus citations
1997

Blockage of the HERG human cardiac K+ channel by the gastrointestinal prokinetic agent cisapride

Mohammad, S., Zhou, Z., Gong, Q. & January, C. T., Jan 1 1997, In : American Journal of Physiology - Heart and Circulatory Physiology. 273, 5 42-5, p. H2534-H2538

Research output: Contribution to journalArticle

174 Scopus citations

Study of the promoter regions of human mitochondria!- Glycerol-3-phosphate dehydrogenase

Gong, Q., Brown, L. J., Statten, S. R. & MacDonald, M. J., Dec 1 1997, In : FASEB Journal. 11, 9, p. A938

Research output: Contribution to journalArticle

1995

Molecular modeling of the substrate specificity of prohormone convertases SPC2 and SPC3

Lipkind, G., Gong, Q. & Steiner, D. F., Jan 1 1995, In : Journal of Biological Chemistry. 270, 22, p. 13277-13284 8 p.

Research output: Contribution to journalArticle

47 Scopus citations

Proteolytic processing mechanisms in the biosynthesis of neuroendocrine peptides: The subtilisin-like proprotein convertases

Rouillé, Y., Duguay, S. J., Lund, K., Furuta, M., Gong, Q., Lipkind, G., Oliva, A. A., Chan, S. J. & Steiner, D. F., Oct 1995, In : Frontiers in Neuroendocrinology. 16, 4, p. 322-361 40 p.

Research output: Contribution to journalArticle

297 Scopus citations
1993

Characterization of the Cathepsin B Gene and Multiple mRNAs in Human Tissues: Evidence for Alternative Splicing of Cathepsin B Pre-mRNA

Gong, Q., Chan, S. J., Bajkowski, A. S., Steiner, D. F. & Frankfater, A., May 1993, In : DNA and Cell Biology. 12, 4, p. 299-309 11 p.

Research output: Contribution to journalArticle

100 Scopus citations
1991

The expression of cathepsin B and other lysosomal proteinases in normal tissues and in tumors

Qian, F., Chan, S. J., Gong, Q., Bajkowski, A. S., Steiner, D. F. & Frankfater, A., Nov 20 1991, In : Biomedica Biochimica Acta. 50, 4-6, p. 531-540 10 p.

Research output: Contribution to journalArticle

37 Scopus citations
1990

Differences in targeting and secretion of cathepsins B and L by BALB/3T3 fibroblasts and Moloney murine sarcoma virus-transformed BALB/3T3 fibroblasts

Achkar, C., Gong, Q., Frankfater, A. & Bajkowski, A. S., Aug 31 1990, In : Journal of Biological Chemistry. 265, 23, p. 13650-13654 5 p.

Research output: Contribution to journalArticle

46 Scopus citations