Qiuming Gong

Research Assistant Professor

    • 3625 Citations
    • 28 h-Index
    1990 …2018

    Research Output 1990 2018

    • 3625 Citations
    • 28 h-Index
    • 45 Article
    • 2 Chapter
    2018

    Nonsense-mediated mRNA decay of hERG mutations in long QT syndrome

    Gong, Q. & Zhou, Z. 2018 Methods in Molecular Biology. Humana Press Inc., Vol. 1684, p. 37-49 13 p. (Methods in Molecular Biology; vol. 1684)

    Research output: ResearchChapter

    Nonsense Mediated mRNA Decay
    Long QT Syndrome
    Nonsense Codon
    Ether
    Mutation
    2017

    Regulation of isoform expression by blocking polyadenylation signal sequences with morpholinos

    Gong, Q. & Zhou, Z. 2017 Methods in Molecular Biology. Humana Press Inc., Vol. 1565, p. 141-150 10 p. (Methods in Molecular Biology; vol. 1565)

    Research output: ResearchChapter

    Morpholinos
    Polyadenylation
    Protein Sorting Signals
    Protein Isoforms
    Gene Expression Regulation
    2015
    21 Citations

    Brief report: Oxidative stress mediates cardiomyocyte apoptosis in a human model of danon disease and heart failure

    Hashem, S. I., Perry, C. N., Bauer, M., Han, S., Clegg, S. D., Ouyang, K., Deacon, D. C., Spinharney, M., Panopoulos, A. D., Izpisua Belmonte, J. C., Frazer, K. A., Chen, J., Gong, Q., Zhou, Z., Chi, N. C. & Adler, E. D. Jul 1 2015 In : Stem Cells. 33, 7, p. 2343-2350 8 p.

    Research output: Research - peer-reviewArticle

    Glycogen Storage Disease Type IIb
    Induced Pluripotent Stem Cells
    Cardiac Myocytes
    Oxidative Stress
    Heart Failure
    2014
    1 Citations

    Identification of Kv11.1 isoform switch as a novel pathogenic mechanism of long-QT syndrome

    Gong, Q., Stump, M. R., Deng, V., Zhang, L. & Zhou, Z. Aug 1 2014 In : Circulation: Cardiovascular Genetics. 7, 4, p. 482-490 9 p.

    Research output: Research - peer-reviewArticle

    Long QT Syndrome
    Protein Isoforms
    Mutation
    Introns
    Polyadenylation
    7 Citations

    Position of premature termination codons determines susceptibility of hERG mutations to nonsense-mediated mRNA decay in long QT syndrome

    Gong, Q., Stump, M. R. & Zhou, Z. Apr 15 2014 In : Gene. 539, 2, p. 190-197 8 p.

    Research output: Research - peer-reviewArticle

    Nonsense Mediated mRNA Decay
    Long QT Syndrome
    Nonsense Codon
    Mutation
    Exons
    1 Citations
    Morpholinos
    Polyadenylation
    Antisense Oligonucleotides
    Introns
    Protein Isoforms
    2013
    7 Citations
    Long QT Syndrome
    Nonsense Codon
    Ether
    Genes
    Nonsense Mediated mRNA Decay
    2012
    11 Citations
    Long QT Syndrome
    Nonsense Codon
    Ether
    Genes
    Messenger RNA
    5 Citations

    Isoform-specific dominant-negative effects associated with hERG1 G628S mutation in long QT syndrome

    Stump, M. R., Gong, Q. & Zhou, Z. Aug 2 2012 In : PLoS One. 7, 8, e42552

    Research output: Research - peer-reviewArticle

    Long QT Syndrome
    Ether
    Protein Isoforms
    Mutation
    Genes
    2011
    18 Citations
    Nonsense Mediated mRNA Decay
    Long QT Syndrome
    Morpholinos
    Frameshift Mutation
    Antisense Oligonucleotides
    6 Citations
    Long QT Syndrome
    Ether
    Mutation
    Genes
    RNA Splice Sites
    15 Citations

    Nonsense-mediated mRNA decay caused by a frameshift mutation in a large kindred of type 2 long QT syndrome

    Zarraga, I. G., Zhang, L., Stump, M. R., Gong, Q., Vincent, G. M. & Zhou, Z. Aug 2011 In : Heart Rhythm. 8, 8, p. 1200-1206 7 p.

    Research output: Research - peer-reviewArticle

    Nonsense Mediated mRNA Decay
    Long QT Syndrome
    Frameshift Mutation
    Mutation
    Nonsense Codon
    2010
    9 Citations

    Alternative splicing and polyadenylation contribute to the generation of hERG1 C-terminal isoforms

    Gong, Q., Stump, M. R., Dunn, A. R., Deng, V. & Zhou, Z. Oct 15 2010 In : Journal of Biological Chemistry. 285, 42, p. 32233-32241 9 p.

    Research output: Research - peer-reviewArticle

    Polyadenylation
    Alternative Splicing
    Ether
    Protein Isoforms
    Genes
    33 Citations

    A major role for hERG in determining frequency of reentry in neonatal rat ventricular myocyte monolayer

    Hou, L., Deo, M., Furspan, P., Pandit, S. V., Mironov, S., Auerbach, D. S., Gong, Q., Zhou, Z., Berenfeld, O. & Jalife, J. Dec 10 2010 In : Circulation Research. 107, 12, p. 1503-1511 9 p.

    Research output: Research - peer-reviewArticle

    Ether
    Muscle Cells
    pamidronate
    Up-Regulation
    Action Potentials
    2008
    17 Citations

    A splice site mutation in hERG leads to cryptic splicing in human long QT syndrome

    Gong, Q., Zhang, L., Moss, A. J., Vincent, G. M., Ackerman, M. J., Robinson, J. C., Jones, M. A., Tester, D. J. & Zhou, Z. Mar 2008 In : Journal of Molecular and Cellular Cardiology. 44, 3, p. 502-509 8 p.

    Research output: Research - peer-reviewArticle

    Long QT Syndrome
    Ether
    Mutation
    Genes
    RNA Splice Sites
    33 Citations

    Recurrent intrauterine fetal loss due to near absence of HERG: Clinical and functional characterization of a homozygous nonsense HERG Q1070X mutation

    Bhuiyan, Z. A., Momenah, T. S., Gong, Q., Amin, A. S., Ghamdi, S. A., Carvalho, J. S., Homfray, T., Mannens, M. M. A. M., Zhou, Z. & Wilde, A. A. M. Apr 2008 In : Heart Rhythm. 5, 4, p. 553-561 9 p.

    Research output: Research - peer-reviewArticle

    Cardiac Arrhythmias
    Mutation
    Genes
    Ion Channels
    Aptitude
    2007
    75 Citations

    Nonsense mutations in hERG cause a decrease in mutant mRNA transcripts by nonsense-mediated mRNA decay in human long-QT syndrome

    Gong, Q., Zhang, L., Vincent, G. M., Horne, B. D. & Zhou, Z. Jul 2007 In : Circulation. 116, 1, p. 17-24 8 p.

    Research output: Research - peer-reviewArticle

    Nonsense Mediated mRNA Decay
    Long QT Syndrome
    Nonsense Codon
    Ether
    Messenger RNA

    The mechanistic rote of KCNH2 gene L413P and L559H mutations in long QT syndrome

    Li, C. L., Hu, D. Y., Liu, W. L., Qi, S. Y., Wang, H. T., Li, L., Gong, Q. M. & Zhou, Z. F. Oct 2007 In : Zhonghua nei ke za zhi [Chinese journal of internal medicine]. 46, 10, p. 838-841 4 p.

    Research output: Research - peer-reviewArticle

    Long QT Syndrome
    Mutation
    Genes
    Proteins
    Mutant Proteins
    2006
    58 Citations

    Mechanisms of pharmacological rescue of trafficking-defective hERG mutant channels in human long QT syndrome

    Gong, Q., Jones, M. A. & Zhou, Z. Feb 17 2006 In : Journal of Biological Chemistry. 281, 7, p. 4069-4074 6 p.

    Research output: Research - peer-reviewArticle

    Human Trafficking
    Long QT Syndrome
    Ether
    Pharmacology
    Genes
    260 Citations

    Most LQT2 mutations reduce Kv11.1 (hERG) current by a class 2 (trafficking-deficient) mechanism

    Anderson, C. L., Delisle, B. P., Anson, B. D., Kilby, J. A., Will, M. L., Tester, D. J., Gong, Q., Zhou, Z., Ackerman, M. J. & January, C. T. Jan 2006 In : Circulation. 113, 3, p. 365-373 9 p.

    Research output: Research - peer-reviewArticle

    Ether
    Phenotype
    Mutation
    Genes
    Protein Transport
    14 Citations

    Stimulation of insulin release by glyceraldehyde may not be similar to glucose

    MacDonald, M. J., Chaplen, F. W. R., Triplett, C. K., Gong, Q. & Drought, H. Mar 15 2006 In : Archives of Biochemistry and Biophysics. 447, 2, p. 118-126 9 p.

    Research output: Research - peer-reviewArticle

    Glyceraldehyde
    Insulin
    Glucose
    Metabolism
    Pyruvaldehyde
    2005
    73 Citations

    Degradation of trafficking-defective long QT syndrome type II mutant channels by the ubiquitin-proteasome pathway

    Gong, Q., Keeney, D. R., Molinari, M. & Zhou, Z. May 13 2005 In : Journal of Biological Chemistry. 280, 19, p. 19419-19425 7 p.

    Research output: Research - peer-reviewArticle

    Long QT Syndrome
    Proteasome Endopeptidase Complex
    Ubiquitin
    Proteins
    Degradation
    2004
    45 Citations

    Defective assembly and trafficking of mutant HERG channels with C-terminal truncations in long QT syndrome

    Gong, Q., Keeney, D. R., Robinson, J. C. & Zhou, Z. Dec 2004 In : Journal of Molecular and Cellular Cardiology. 37, 6, p. 1225-1233 9 p.

    Research output: Research - peer-reviewArticle

    Human Trafficking
    Long QT Syndrome
    Ether
    Genes
    Mutation
    38 Citations
    Human Trafficking
    Ether
    Pharmacology
    Genes
    Endoplasmic Reticulum
    133 Citations

    Postmortem molecular screening in unexplained sudden death

    Chugh, S. S., Senashova, O., Watts, A., Tran, P. T., Zhou, Z., Gong, Q., Titus, J. L. & Hayflick, S. J. May 5 2004 In : Journal of the American College of Cardiology. 43, 9, p. 1625-1629 5 p.

    Research output: Research - peer-reviewArticle

    Sudden Death
    Sudden Cardiac Death
    Genes
    Autopsy
    Cardiac Arrhythmias
    2002
    95 Citations
    Potassium Channels
    Glycosylation
    Ether
    Genes
    Proteins
    2001
    59 Citations

    Cocaine blocks HERG, but not KvLQT1+minK, potassium channels

    Zhang, S., Rajamani, S., Chen, Y., Gong, Q., Rong, Y., Zhou, Z., Ruoho, A. & January, C. T. 2001 In : Molecular Pharmacology. 59, 5, p. 1069-1076 8 p.

    Research output: Research - peer-reviewArticle

    Mink
    Potassium Channels
    Cocaine
    Sudden Death
    Cardiac Arrhythmias
    2000
    2 Citations

    Defective protein trafficking of HERG K+ channels in human congenital long QT syndrome

    January, C. T., Gong, Q. & Zhou, Z. 2000 In : Pharmaceutical News. 7, 4, p. 27-34 8 p.

    Research output: Research - peer-reviewArticle

    Long QT Syndrome
    Protein Transport
    Mutation
    Endoplasmic Reticulum
    Proteolysis
    14 Citations

    Functional analysis of two promoters for the human mitochondrial glycerol phosphate dehydrogenase gene

    Gong, Q., Brown, L. J. & MacDonald, M. J. Dec 1 2000 In : Journal of Biological Chemistry. 275, 48, p. 38012-38021 10 p.

    Research output: Research - peer-reviewArticle

    Functional analysis
    Glycerol
    Oxidoreductases
    Genes
    Phosphates
    90 Citations

    Long QT syndrome: Cellular basis and arrhythmia mechanism in LQT2

    January, C. T., Gong, Q. & Zhou, Z. 2000 In : Journal of Cardiovascular Electrophysiology. 11, 12, p. 1413-1418 6 p.

    Research output: Research - peer-reviewArticle

    Long QT Syndrome
    Cardiac Arrhythmias
    Mutation
    Ether
    Genes
    1999
    146 Citations

    Block of HERG potassium channels by the antihistamine astemizole and its metabolites desmethylastemizole and norastemizole

    Zhou, Z., Vorperian, V. R., Gong, Q., Zhang, S. & January, C. T. 1999 In : Journal of Cardiovascular Electrophysiology. 10, 6, p. 836-843 8 p.

    Research output: Research - peer-reviewArticle

    Astemizole
    Histamine Antagonists
    Potassium Channels
    Ether
    Genes
    233 Citations
    Long QT Syndrome
    Potassium Channels
    Protein Transport
    Ether
    Pharmacology
    270 Citations

    Mechanism of block and identification of the verapamil binding domain to HERG potassium channels

    Zhang, S., Zhou, Z., Gong, Q., Makielski, J. C. & January, C. T. May 14 1999 In : Circulation Research. 84, 9, p. 989-998 10 p.

    Research output: Research - peer-reviewArticle

    Potassium Channels
    Verapamil
    Mutation
    Diltiazem
    Nifedipine
    149 Citations

    Novel mechanism associated with an inherited cardiac arrhythmia: Defective protein trafficking by the mutant HERG (G601S) potassium channel

    Furutani, M., Trudeau, M. C., Hagiwara, N., Seki, A., Gong, Q., Zhou, Z., Imamura, S. I., Nagashima, H., Kasanuki, H., Takao, A., Momma, K., January, C. T., Robertson, G. A. & Matsuoka, R. May 4 1999 In : Circulation. 99, 17, p. 2290-2294 5 p.

    Research output: Research - peer-reviewArticle

    Potassium Channels
    Protein Transport
    Ether
    Cardiac Arrhythmias
    Genes
    1998
    279 Citations

    HERG channel dysfunction in human long QT syndrome. Intracellular transport and functional defects

    Zhou, Z., Gong, Q., Epstein, M. L. & January, C. T. Aug 14 1998 In : Journal of Biological Chemistry. 273, 33, p. 21061-21066 6 p.

    Research output: Research - peer-reviewArticle

    Defects
    Processing
    Proteins
    Long QT Syndrome
    Mutation
    55 Citations

    In vivo expression of an alternatively spliced human tumor message that encodes a truncated form of cathepsin B. Subcellular distribution of the truncated enzyme in COS cells

    Mehtani, S., Gong, Q., Panella, J., Subbiah, S., Peffley, D. M. & Frankfater, A. May 22 1998 In : Journal of Biological Chemistry. 273, 21, p. 13236-13244 9 p.

    Research output: Research - peer-reviewArticle

    Cathepsin B
    COS Cells
    Enzymes
    Neoplasms
    Tumors
    537 Citations

    Properties of HERG channels stably expressed in HEK 293 cells studied at physiological temperature

    Zhou, Z., Gong, Q., Ye, B., Fan, Z., Makielski, J. C., Robertson, G. A. & January, C. T. Jan 1998 In : Biophysical Journal. 74, 1, p. 230-241 12 p.

    Research output: Research - peer-reviewArticle

    HEK293 Cells
    Ether
    Temperature
    Genes
    Action Potentials
    47 Citations
    Pyruvate Carboxylase
    Gene expression
    Rats
    Insulin
    Insulin-Secreting Cells
    1997
    159 Citations
    Cisapride
    Gastrointestinal Agents
    Ether
    Genes
    Tail
    59 Citations
    Cisapride
    Gastrointestinal Agents
    Ether
    Genes
    Tail

    Study of the promoter regions of human mitochondria!- Glycerol-3-phosphate dehydrogenase

    Gong, Q., Brown, L. J., Statten, S. R. & MacDonald, M. J. 1997 In : FASEB Journal. 11, 9

    Research output: Research - peer-reviewArticle

    glycerol-3-phosphate dehydrogenase
    mitochondria
    promoter regions
    Glycerolphosphate Dehydrogenase
    Genetic Promoter Regions
    1996
    59 Citations

    The role of prohormone convertases in insulin biosynthesis: Evidence for inherited defects in their action in man and experimental animals

    Steiner, D. F., Rouillé, Y., Gong, Q., Martin, S., Carroll, R. & Chan, S. J. Apr 1996 In : Diabetes and Metabolism. 22, 2, p. 94-104 11 p.

    Research output: Research - peer-reviewArticle

    Proprotein Convertases
    Insulin
    Enzymes
    C-Peptide
    Secretory Vesicles
    1995
    45 Citations

    Molecular modeling of the substrate specificity of prohormone convertases SPC2 and SPC3

    Lipkind, G., Gong, Q. & Steiner, D. F. 1995 In : Journal of Biological Chemistry. 270, 22, p. 13277-13284 8 p.

    Research output: Research - peer-reviewArticle

    Proprotein Convertases
    Subtilisin
    Molecular modeling
    Substrates
    Substrate Specificity
    273 Citations

    Proteolytic Processing Mechanisms in the Biosynthesis of Neuroendocrine Peptides: The Subtilisin-like Proprotein Convertases

    Rouillé, Y., Duguay, S. J., Lund, K., Furuta, M., Gong, Q., Lipkind, G., Oliva, A. A., Chan, S. J. & Steiner, D. F. Oct 1995 In : Frontiers in Neuroendocrinology. 16, 4, p. 322-361 40 p.

    Research output: Research - peer-reviewArticle

    Peptide Biosynthesis
    Proprotein Convertases
    Furin
    Proinsulin
    Fats
    1993
    94 Citations

    Characterization of the cathepsin B gene and multiple mRNAs in human tissues: Evidence for alternative splicing of cathepsin B pre-mRNA

    Gong, Q., Shu Jin Chan, J. C., Bajkowski, A. S., Steiner, D. F. & Frankfater, A. 1993 In : DNA and Cell Biology. 12, 4, p. 299-309 11 p.

    Research output: Research - peer-reviewArticle

    Cathepsin B
    RNA Precursors
    Alternative Splicing
    Exons
    Messenger RNA
    1991
    36 Citations

    The expression of cathepsin B and other lysosomal proteinases in normal tissues and in tumors

    Qian, F., Chan, S. J., Gong, Q., Bajkowski, A. S., Steiner, D. F. & Frankfater, A. 1991 In : Biomedica Biochimica Acta. 50, 4-6, p. 531-540 10 p.

    Research output: Research - peer-reviewArticle

    Cathepsin B
    Peptide Hydrolases
    Neoplasms
    Tumors
    Tissue
    1990
    44 Citations

    Differences in targeting and secretion of cathepsins B and L by BALB/3T3 fibroblasts and Moloney murine sarcoma virus-transformed BALB/3T3 fibroblasts

    Achkar, C., Gong, Q., Frankfater, A. & Bajkowski, A. S. Aug 15 1990 In : Journal of Biological Chemistry. 265, 23, p. 13650-13654 5 p.

    Research output: Research - peer-reviewArticle

    Moloney murine sarcoma virus
    Cathepsin L
    Cathepsin B
    Glucuronidase
    Fibroblasts