Qiuming Gong

Research Assistant Professor

  • 3795 Citations
  • 29 h-Index
1990 …2018
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Research Output 1990 2018

  • 3795 Citations
  • 29 h-Index
  • 46 Article
  • 2 Chapter
2018
2 Citations

Nonsense-mediated mRNA decay of hERG mutations in long QT syndrome

Gong, Q. & Zhou, Z., 2018, Methods in Molecular Biology. Humana Press Inc., Vol. 1684, p. 37-49 13 p. (Methods in Molecular Biology; vol. 1684)

Research output: Chapter in Book/Report/Conference proceedingChapter

Nonsense Mediated mRNA Decay
Long QT Syndrome
Nonsense Codon
Ether
Frameshift Mutation

Upregulation of functional Kv11.1a isoform expression by modified U1 small nuclear RNA

Gong, Q., Stump, M. R. & Zhou, Z., Jan 30 2018, In : Gene. 641, p. 220-225 6 p.

Research output: Contribution to journalArticle

Introns
Protein Isoforms
Up-Regulation
RNA Splice Sites
Polyadenylation
2017

Regulation of isoform expression by blocking polyadenylation signal sequences with morpholinos

Gong, Q. & Zhou, Z., 2017, Methods in Molecular Biology. Humana Press Inc., Vol. 1565, p. 141-150 10 p. (Methods in Molecular Biology; vol. 1565)

Research output: Chapter in Book/Report/Conference proceedingChapter

Morpholinos
Polyadenylation
Protein Sorting Signals
Protein Isoforms
Gene Expression Regulation
2015
29 Citations

Brief report: Oxidative stress mediates cardiomyocyte apoptosis in a human model of danon disease and heart failure

Hashem, S. I., Perry, C. N., Bauer, M., Han, S., Clegg, S. D., Ouyang, K., Deacon, D. C., Spinharney, M., Panopoulos, A. D., Izpisua Belmonte, J. C., Frazer, K. A., Chen, J., Gong, Q., Zhou, Z., Chi, N. C. & Adler, E. D., Jul 1 2015, In : Stem Cells. 33, 7, p. 2343-2350 8 p.

Research output: Contribution to journalArticle

Glycogen Storage Disease Type IIb
Induced Pluripotent Stem Cells
Lysosomal-Associated Membrane Protein 2
Cardiac Myocytes
Oxidative Stress
2014
3 Citations

Identification of Kv11.1 isoform switch as a novel pathogenic mechanism of long-QT syndrome

Gong, Q., Stump, M. R., Deng, V., Zhang, L. & Zhou, Z., Aug 1 2014, In : Circulation: Cardiovascular Genetics. 7, 4, p. 482-490 9 p.

Research output: Contribution to journalArticle

Long QT Syndrome
Protein Isoforms
Introns
Mutation
Polyadenylation
8 Citations

Position of premature termination codons determines susceptibility of hERG mutations to nonsense-mediated mRNA decay in long QT syndrome

Gong, Q., Stump, M. R. & Zhou, Z., Apr 15 2014, In : Gene. 539, 2, p. 190-197 8 p.

Research output: Contribution to journalArticle

Nonsense Mediated mRNA Decay
Long QT Syndrome
Nonsense Codon
Mutation
Exons
2 Citations
Morpholinos
Polyadenylation
Antisense Oligonucleotides
Introns
Protein Isoforms
2013
8 Citations
Long QT Syndrome
Nonsense Codon
Ether
Nonsense Mediated mRNA Decay
Genes
2012
12 Citations
Long QT Syndrome
Nonsense Codon
Ether
Genes
Nonsense Mediated mRNA Decay
6 Citations

Isoform-specific dominant-negative effects associated with hERG1 G628S mutation in long QT syndrome

Stump, M. R., Gong, Q. & Zhou, Z., Aug 2 2012, In : PLoS One. 7, 8, e42552

Research output: Contribution to journalArticle

Long QT Syndrome
Ether
ethers
Protein Isoforms
Genes
2011
20 Citations
Nonsense Mediated mRNA Decay
Long QT Syndrome
Morpholinos
Frameshift Mutation
Antisense Oligonucleotides
6 Citations
Long QT Syndrome
Ether
Mutation
Genes
RNA Splice Sites
17 Citations

Nonsense-mediated mRNA decay caused by a frameshift mutation in a large kindred of type 2 long QT syndrome

Zarraga, I. G., Zhang, L., Stump, M. R., Gong, Q., Vincent, G. M. & Zhou, Z., Aug 2011, In : Heart Rhythm. 8, 8, p. 1200-1206 7 p.

Research output: Contribution to journalArticle

Nonsense Mediated mRNA Decay
Long QT Syndrome
Frameshift Mutation
Nonsense Codon
RNA Stability
2010
11 Citations

Alternative splicing and polyadenylation contribute to the generation of hERG1 C-terminal isoforms

Gong, Q., Stump, M. R., Dunn, A. R., Deng, V. & Zhou, Z., Oct 15 2010, In : Journal of Biological Chemistry. 285, 42, p. 32233-32241 9 p.

Research output: Contribution to journalArticle

Polyadenylation
Alternative Splicing
Ether
Protein Isoforms
Genes
36 Citations

A major role for hERG in determining frequency of reentry in neonatal rat ventricular myocyte monolayer

Hou, L., Deo, M., Furspan, P., Pandit, S. V., Mironov, S., Auerbach, D. S., Gong, Q., Zhou, Z., Berenfeld, O. & Jalife, J., Dec 10 2010, In : Circulation Research. 107, 12, p. 1503-1511 9 p.

Research output: Contribution to journalArticle

pamidronate
Ether
Muscle Cells
Up-Regulation
Action Potentials
2008
17 Citations

A splice site mutation in hERG leads to cryptic splicing in human long QT syndrome

Gong, Q., Zhang, L., Moss, A. J., Vincent, G. M., Ackerman, M. J., Robinson, J. C., Jones, M. A., Tester, D. J. & Zhou, Z., Mar 2008, In : Journal of Molecular and Cellular Cardiology. 44, 3, p. 502-509 8 p.

Research output: Contribution to journalArticle

Long QT Syndrome
Ether
RNA Splice Sites
Mutation
Introns
38 Citations

Recurrent intrauterine fetal loss due to near absence of HERG: Clinical and functional characterization of a homozygous nonsense HERG Q1070X mutation

Bhuiyan, Z. A., Momenah, T. S., Gong, Q., Amin, A. S., Ghamdi, S. A., Carvalho, J. S., Homfray, T., Mannens, M. M. A. M., Zhou, Z. & Wilde, A. A. M., Apr 2008, In : Heart Rhythm. 5, 4, p. 553-561 9 p.

Research output: Contribution to journalArticle

Cardiac Arrhythmias
Mutation
Ion Channels
Genes
Aptitude
2007
84 Citations

Nonsense mutations in hERG cause a decrease in mutant mRNA transcripts by nonsense-mediated mRNA decay in human long-QT syndrome

Gong, Q., Zhang, L., Vincent, G. M., Horne, B. D. & Zhou, Z., Jul 2007, In : Circulation. 116, 1, p. 17-24 8 p.

Research output: Contribution to journalArticle

Nonsense Mediated mRNA Decay
Long QT Syndrome
Nonsense Codon
Ether
Messenger RNA

The mechanistic rote of KCNH2 gene L413P and L559H mutations in long QT syndrome

Li, C. L., Hu, D. Y., Liu, W. L., Qi, S. Y., Wang, H. T., Li, L., Gong, Q. M. & Zhou, Z. F., Oct 2007, In : Zhonghua nei ke za zhi [Chinese journal of internal medicine]. 46, 10, p. 838-841 4 p.

Research output: Contribution to journalArticle

Long QT Syndrome
Mutation
Genes
Mutant Proteins
Fluorescent Antibody Technique
2006
62 Citations

Mechanisms of pharmacological rescue of trafficking-defective hERG mutant channels in human long QT syndrome

Gong, Q., Jones, M. A. & Zhou, Z., Feb 17 2006, In : Journal of Biological Chemistry. 281, 7, p. 4069-4074 6 p.

Research output: Contribution to journalArticle

Human Trafficking
Long QT Syndrome
Calnexin
Ether
Genes
273 Citations

Most LQT2 mutations reduce Kv11.1 (hERG) current by a class 2 (trafficking-deficient) mechanism

Anderson, C. L., Delisle, B. P., Anson, B. D., Kilby, J. A., Will, M. L., Tester, D. J., Gong, Q., Zhou, Z., Ackerman, M. J. & January, C. T., Jan 2006, In : Circulation. 113, 3, p. 365-373 9 p.

Research output: Contribution to journalArticle

Ether
Phenotype
Mutation
Genes
Protein Transport
14 Citations

Stimulation of insulin release by glyceraldehyde may not be similar to glucose

MacDonald, M. J., Chaplen, F. W. R., Triplett, C. K., Gong, Q. & Drought, H., Mar 15 2006, In : Archives of Biochemistry and Biophysics. 447, 2, p. 118-126 9 p.

Research output: Contribution to journalArticle

Glyceraldehyde
Insulin
Glucose
Pyruvaldehyde
Metabolism
2005
79 Citations

Degradation of trafficking-defective long QT syndrome type II mutant channels by the ubiquitin-proteasome pathway

Gong, Q., Keeney, D. R., Molinari, M. & Zhou, Z., May 13 2005, In : Journal of Biological Chemistry. 280, 19, p. 19419-19425 7 p.

Research output: Contribution to journalArticle

Long QT Syndrome
Proteasome Endopeptidase Complex
Ubiquitin
Ether
Endoplasmic Reticulum
2004
47 Citations

Defective assembly and trafficking of mutant HERG channels with C-terminal truncations in long QT syndrome

Gong, Q., Keeney, D. R., Robinson, J. C. & Zhou, Z., Dec 2004, In : Journal of Molecular and Cellular Cardiology. 37, 6, p. 1225-1233 9 p.

Research output: Contribution to journalArticle

Human Trafficking
Long QT Syndrome
Ether
Genes
Mutation
38 Citations
Human Trafficking
Ether
Pharmacology
Endoplasmic Reticulum
Genes
137 Citations

Postmortem molecular screening in unexplained sudden death

Chugh, S. S., Senashova, O., Watts, A., Tran, P. T., Zhou, Z., Gong, Q., Titus, J. L. & Hayflick, S. J., May 5 2004, In : Journal of the American College of Cardiology. 43, 9, p. 1625-1629 5 p.

Research output: Contribution to journalArticle

Sudden Death
Sudden Cardiac Death
Autopsy
Genes
Cardiac Arrhythmias
2002
102 Citations
Potassium Channels
Glycosylation
Ether
Genes
Delayed Rectifier Potassium Channels
2001
61 Citations

Cocaine blocks HERG, but not KvLQT1+minK, potassium channels

Zhang, S., Rajamani, S., Chen, Y., Gong, Q., Rong, Y., Zhou, Z., Ruoho, A. & January, C. T., 2001, In : Molecular Pharmacology. 59, 5, p. 1069-1076 8 p.

Research output: Contribution to journalArticle

Mink
Potassium Channels
Cocaine
Sudden Death
Cardiac Arrhythmias
2000
2 Citations

Defective protein trafficking of HERG K+ channels in human congenital long QT syndrome

January, C. T., Gong, Q. & Zhou, Z., 2000, In : Pharmaceutical News. 7, 4, p. 27-34 8 p.

Research output: Contribution to journalArticle

Long QT Syndrome
Protein Transport
Mutation
Endoplasmic Reticulum
Proteolysis
14 Citations

Functional analysis of two promoters for the human mitochondrial glycerol phosphate dehydrogenase gene

Gong, Q., Brown, L. J. & MacDonald, M. J., Dec 1 2000, In : Journal of Biological Chemistry. 275, 48, p. 38012-38021 10 p.

Research output: Contribution to journalArticle

glycerol dehydrogenase
Functional analysis
Glycerol
Oxidoreductases
Genes
92 Citations

Long QT syndrome: Cellular basis and arrhythmia mechanism in LQT2

January, C. T., Gong, Q. & Zhou, Z., 2000, In : Journal of Cardiovascular Electrophysiology. 11, 12, p. 1413-1418 6 p.

Research output: Contribution to journalArticle

Long QT Syndrome
Cardiac Arrhythmias
Ether
Mutation
Genes
1999
155 Citations

Block of HERG potassium channels by the antihistamine astemizole and its metabolites desmethylastemizole and norastemizole

Zhou, Z., Vorperian, V. R., Gong, Q., Zhang, S. & January, C. T., 1999, In : Journal of Cardiovascular Electrophysiology. 10, 6, p. 836-843 8 p.

Research output: Contribution to journalArticle

Astemizole
Histamine Antagonists
Potassium Channels
Ether
Genes
245 Citations
Long QT Syndrome
Potassium Channels
Protein Transport
Ether
Thermal effects
276 Citations

Mechanism of block and identification of the verapamil binding domain to HERG potassium channels

Zhang, S., Zhou, Z., Gong, Q., Makielski, J. C. & January, C. T., May 14 1999, In : Circulation Research. 84, 9, p. 989-998 10 p.

Research output: Contribution to journalArticle

Potassium Channels
Verapamil
Diltiazem
Nifedipine
Mutation
154 Citations

Novel mechanism associated with an inherited cardiac arrhythmia: Defective protein trafficking by the mutant HERG (G601S) potassium channel

Furutani, M., Trudeau, M. C., Hagiwara, N., Seki, A., Gong, Q., Zhou, Z., Imamura, S. I., Nagashima, H., Kasanuki, H., Takao, A., Momma, K., January, C. T., Robertson, G. A. & Matsuoka, R., May 4 1999, In : Circulation. 99, 17, p. 2290-2294 5 p.

Research output: Contribution to journalArticle

Potassium Channels
Protein Transport
Long QT Syndrome
Ether
Cardiac Arrhythmias
1998
291 Citations

HERG channel dysfunction in human long QT syndrome. Intracellular transport and functional defects

Zhou, Z., Gong, Q., Epstein, M. L. & January, C. T., Aug 14 1998, In : Journal of Biological Chemistry. 273, 33, p. 21061-21066 6 p.

Research output: Contribution to journalArticle

Long QT Syndrome
Defects
Mutation
Chromosomes
Processing
57 Citations

In vivo expression of an alternatively spliced human tumor message that encodes a truncated form of cathepsin B. Subcellular distribution of the truncated enzyme in COS cells

Mehtani, S., Gong, Q., Panella, J., Subbiah, S., Peffley, D. M. & Frankfater, A., May 22 1998, In : Journal of Biological Chemistry. 273, 21, p. 13236-13244 9 p.

Research output: Contribution to journalArticle

Cathepsin B
COS Cells
Tumors
Enzymes
Neoplasms
562 Citations

Properties of HERG channels stably expressed in HEK 293 cells studied at physiological temperature

Zhou, Z., Gong, Q., Ye, B., Fan, Z., Makielski, J. C., Robertson, G. A. & January, C. T., Jan 1998, In : Biophysical Journal. 74, 1, p. 230-241 12 p.

Research output: Contribution to journalArticle

HEK293 Cells
Ether
Temperature
Genes
Action Potentials
47 Citations
Pyruvate Carboxylase
Insulin-Secreting Cells
Gene expression
Rats
Insulin
1997
56 Citations
Cisapride
Gastrointestinal Agents
Ether
Genes
Tail
168 Citations
Cisapride
Gastrointestinal Agents
Ether
Genes
Tail

Study of the promoter regions of human mitochondria!- Glycerol-3-phosphate dehydrogenase

Gong, Q., Brown, L. J., Statten, S. R. & MacDonald, M. J., 1997, In : FASEB Journal. 11, 9

Research output: Contribution to journalArticle

glycerol-3-phosphate dehydrogenase
Glycerolphosphate Dehydrogenase
Mitochondria
Genetic Promoter Regions
mitochondria
1996
60 Citations

The role of prohormone convertases in insulin biosynthesis: Evidence for inherited defects in their action in man and experimental animals

Steiner, D. F., Rouillé, Y., Gong, Q., Martin, S., Carroll, R. & Chan, S. J., Apr 1996, In : Diabetes and Metabolism. 22, 2, p. 94-104 11 p.

Research output: Contribution to journalArticle

Proprotein Convertases
Insulin
C-Peptide
Secretory Vesicles
Enzymes
1995
46 Citations

Molecular modeling of the substrate specificity of prohormone convertases SPC2 and SPC3

Lipkind, G., Gong, Q. & Steiner, D. F., 1995, In : Journal of Biological Chemistry. 270, 22, p. 13277-13284 8 p.

Research output: Contribution to journalArticle

Proprotein Convertases
Subtilisin
Molecular modeling
Substrate Specificity
Subtilisins
279 Citations

Proteolytic Processing Mechanisms in the Biosynthesis of Neuroendocrine Peptides: The Subtilisin-like Proprotein Convertases

Rouillé, Y., Duguay, S. J., Lund, K., Furuta, M., Gong, Q., Lipkind, G., Oliva, A. A., Chan, S. J. & Steiner, D. F., Oct 1995, In : Frontiers in Neuroendocrinology. 16, 4, p. 322-361 40 p.

Research output: Contribution to journalArticle

Peptide Biosynthesis
Proprotein Convertases
Furin
Proinsulin
Carboxypeptidase H
1993
96 Citations

Characterization of the cathepsin B gene and multiple mRNAs in human tissues: Evidence for alternative splicing of cathepsin B pre-mRNA

Gong, Q., Shu Jin Chan, J. C., Bajkowski, A. S., Steiner, D. F. & Frankfater, A., 1993, In : DNA and Cell Biology. 12, 4, p. 299-309 11 p.

Research output: Contribution to journalArticle

Cathepsin B
RNA Precursors
Alternative Splicing
Exons
Messenger RNA
1991
37 Citations

The expression of cathepsin B and other lysosomal proteinases in normal tissues and in tumors

Qian, F., Chan, S. J., Gong, Q., Bajkowski, A. S., Steiner, D. F. & Frankfater, A., 1991, In : Biomedica Biochimica Acta. 50, 4-6, p. 531-540 10 p.

Research output: Contribution to journalArticle

Cathepsin B
Tumors
Peptide Hydrolases
Tissue
Neoplasms
1990
46 Citations

Differences in targeting and secretion of cathepsins B and L by BALB/3T3 fibroblasts and Moloney murine sarcoma virus-transformed BALB/3T3 fibroblasts

Achkar, C., Gong, Q., Frankfater, A. & Bajkowski, A. S., Aug 15 1990, In : Journal of Biological Chemistry. 265, 23, p. 13650-13654 5 p.

Research output: Contribution to journalArticle

Moloney murine sarcoma virus
Cathepsin L
Cathepsin B
Glucuronidase
Fibroblasts